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Wyświetlanie 1-6 z 6
Tytuł:
Studies on the potable water quality in certain districts of West Bengal and its effect on human health
Autorzy:
Pal, Partha
Powiązania:
https://bibliotekanauki.pl/articles/1182816.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Coliforms
Districts of West Bengal
Pathogenic strains
Potable water
Opis:
The public health protection in any part of the world depends largely on adequate supply of pure and safe drinking water. The increasing human population has posed a great problem in this endeavour. The presence of harmful toxic inorganic and organic chemicals as well as detection of pathogens including the coliform group in concentration greater than the permissible limits has led to public health hazards. The aim of this work is to compare the water quality in certain thickly populated districts of West Bengal India to assess the current scenario of potable water sources. The physical, biochemical and bacteriological parameters are tested in water samples collected from different open water bodies and domestic sources in different districts of West Bengal and the data are compared. The sources of this pollutants in the water are also ascertained and suitable remedial measures are suggested in those areas where the WHO permissible limits exceeded for human consumption and uses. For the bacteriological analyses the presence/absence of coliforms are carried out to authenticate the contamination of harmful pathogenic strains which indicated the sewage contamination of the drinking water and is not safe for human health. This study also reflected the fact that mostly the overcrowded congested districts are more prone to polluted water where suitable purification systems are inadequate. Moreover open water bodies are mostly polluted due to anthropogenic effects where disposal of human wastes as well as domestic wastes are dumped. The presence of highly pathogenic strains including V. cholerae, Salmonella sp. have been detected in open water body sources such as ponds in different areas tested in this study. The presence of pathogenic strains and alterations of both physical and chemical parameters of potable water is a serious problem and remedial measures for establishment of suitable purification system is of utmost need in the well-being of the people residing in those areas. This study will throw some light on the present situation of the water quality on a comparative basis in certain districts of West Bengal including the highly congested Kolkata district so that improvement of safe and pure water supply can be made following WHO guidelines in areas where water pollution are recorded.
Źródło:
World Scientific News; 2017, 64; 1-17
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Current status of Helicobacter pylori associated human gastric cancer and the therapeutic approaches – A Review
Autorzy:
Pal, Partha
Powiązania:
https://bibliotekanauki.pl/articles/1189965.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Helicobacter pylori
Gastric carcinoma
Peptic ulcers
Antibiotic treatment
Opis:
In the recent years one of the common causes of cancer related deaths in humans is associated with the development of gastric carcinoma leading to gastric cancer. It had long before reported that the potent agent that is intimately related with the gastric cancer is the infection of the bacterium Helicobacter pylori (H. pylori). H. pylori infection in humans is characterised by the development of acute peptic ulcers which creates a lots of gastroenterological symptoms. Co-existence of H. pylori in the human gastric environment is well adapted by the pathogen by evading the immune responses of the host. Gastric biopsy in patients suffering from H. pylori infection reported the development of gastric lesions having the chance to proceed towards development gastric cancer. Recently it was reported that eradication of the H. pylori colonization is not possible even after continued current antibiotic treatment over long periods and even combined regimes are unsuccessful.Moreover alterations of the genetic background of the host gastric cells were also reported along with infection of H. pylori, the primary concern for the evolution of the genetically transformed cells which is the hallmark for the development of malignancy. Clinical studies have reported the limited efficacy in decreasing the incidence of gastric carcinoma even after the eradication therapy has been completed for the bacterial colonization. Research based on the biopsy specimens obtained from conventional gastric endoscopy of affected patients has revealed some genetic or epigenetic alterations in the gastric mucosa. The cause of concern to human life lies in the fact that the number of sporadic cases of primary or metachronous gastric carcinoma has increased after successful eradication.The purpose of the present review is to assess the current status of the research based on the concept of development of gastric carcinoma in association with H. pylori infection in humans and to throw some light in the remedial measures against the pathogen which is a chronic burden in the well-being of the human society.
Źródło:
World Scientific News; 2016, 52; 162-180
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of quality of water samples collected from different areas of Kolkata district of West Bengal, India
Autorzy:
Pal, Partha
Powiązania:
https://bibliotekanauki.pl/articles/1191493.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Potable water
Bacteriological
Kolkata
Pathogen
Opis:
As a result of rapid urbanization and huge increase in population in city like Kolkata in West Bengal, India, limits the adequate supply of pure and safe potable water to the city-dwellers. Overcrowding in a congested city like Kolkata possesses threats for contamination of potable water supply which may deteriorate the physical, chemical as well as the bacteriological quality. The sanitary effluents when contaminate the drinking water supply sources which may cause potential health hazards to a huge number of residents and can even lead to spread of infective pathogenic bacterial strains within the population. Keeping this view the present study aims in the survey of potable water samples collected from different sources in and around the Kolkata district. Direct contact and intake of those water samples are very common phenomenon for the people residing in a congested city like Kolkata. A number of water samples from different areas consisting of varying population densities and also having numerous sources are collected and analyzed using commercially available kits. The study mainly based on observing the physical parameters as well as the chemical and bacteriological quantity and quality of the source sample of drinking water mainly from domestic sources as well as the water collected from open water bodies and the municipality supplies including tap water and deep tube wells. The presence of pathogenic bacterial strains along with the coliform contamination of the sample water tested signified a threat to the suitable drinking water in certain selected areas of this crowded city like Kolkata. If the contaminated water sources are not purified the surviving outrageous intensity of fecal E. coli, Vibrio cholera, Salmonella species and other pathogens will pose unfavorable difficulty by upgrading recurrence of water borne infection. The present survey will throw light on the current situation of the quality of potable water in certain areas of Kolkata so that necessary action should be undertaken in those areas to cope up with the situation for the benefit of the people residing there and to provide safe and pure drinking water following WHO guidelines.
Źródło:
World Scientific News; 2016, 40; 248-263
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Insect natural products as potential source for alternative medicines - A Review
Autorzy:
Roy, Spandita
Saha, Sumana
Pal, Partha
Powiązania:
https://bibliotekanauki.pl/articles/1193952.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Insects
alternative medicine
medicinal drugs
natural products
Opis:
Developments in bioengineering natural products from insects with potential use in modern medicines as well as in utilisation of insects as models for studying essential mammalian processes such as immune responses to pathogens are discussed in this review. The significant recent advances in developing insect derived natural products as potential new medicinal drugs and the use of medicinal plants for the treatment of human diseases has long been practised since the beginning of human civilization. To date, insects have been relatively neglected as sources of modern drugs although they have provided valuable natural products, including honey and silk, for at least 4-7000 years. The use of insect derived products as an alternative medicinal source is an exciting and rapidly expanding new field since insects are hugely variable and have a high biodiversity index. Insects products, such as silk and honey, have already been utilised commercially for thousands of years and extracts of insects used to produce for use in folk medicine around the world, nowadays several other insect products such as venoms which insects use for prey capture and defences, are also used to produce new medicinal drugs which are capable of fighting against a number of diseases like arthritis, inflammation, several cancers, neurological diseases and AIDS too. In the present decade the increasing price of biochemical medicines for the treatment of certain deadly diseases like cancer, AIDS etc is creating a huge economical burden to the common people in the developing countries like India. The search for alternative cost effective and easily available medicines for combating the upcoming diseases is an utmost need in the present decade. The emergence of this kind of alternative medicinal sources like that from the adult insects as well as from their different life history stages or their secretions which are available in plenty in the nature will open up new vistas in the recent researches based on development of medicinal drugs for human diseases.
Źródło:
World Scientific News; 2015, 19; 69-83
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Activities of human telomerase in cancer development, detection and therapeutics - A Review
Autorzy:
Pal, Partha
Ray, Spandita
De (Dutta), Koly
Powiązania:
https://bibliotekanauki.pl/articles/1190141.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Chromosomes
End-replication
Telomere
Telomerase
Cancer
Therapeutic
Opis:
Telomeres are the specialized nucleoprotein structures associated with eukaryotic chromosomal ends, which are essential for maintaining the stability of the linear eukaryotic chromosomes. Progressive telomere shortening is an inevitable occurrence in normal somatic cells due to the end-replication problem leading to limited replication efficiency. The hallmark characteristics of human cancer cells include infinite reproductive potential, uncontrolled proliferation and immortality. These abilities of transformed cancerous cells are mainly due to the maintenance of their telomeres since degradation of chromosomal telomeric ends leads to cellular senescence or death. Thus telomere biology is important in the study of human cancer development. The mechanism by virtue the cancer cells are able to divide indefinitely is by maintaining telomeres. Activity of telomerase, a telomere-elongating ribonucleoprotein reverse transcriptase enzyme, is responsible for inducing the property of immortality to cancer cells. In humans nearly about 80% to 90% cancer cells activate telomerase and elongate their telomeres to overcome the end-replication problem. Telomere shortening suppresses cancer formation in contrast according to certain reports it sometimes promotes genomic instability which leads to enhancement of carcinogenesis and consequently the development of malignancy. Majority of cancer cells activate telomerase, but it remains mysterious as to find the reasons of the fact that certain cancer cells often show shorter telomeres in comparison to the cells in the surrounding normal tissues. This controversial role of telomerase associated with certain transformed cells leading to the cancerous state in relation to its role in normal cells is an interesting field to study which points out to the fact of development of cancer cells targeting drugs based on telomerase activities as an alternative weapon in combating against this dreaded human disease. The present review focuses on the activity of telomerase in telomere maintenance in the development of cancerous cells in humans, the use of telomerase as an assay technique for cancer detection as well as the anti-cancer therapeutic approach of targeting the telomerase in the current era of treatment of human cancer.
Źródło:
World Scientific News; 2016, 42; 87-100
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Medicinal value of animal venom for treatment of Cancer in Humans - A Review
Autorzy:
Pal, Partha
Roy, Spandita
Chattopadhyay, Swagata
Pal, Tapan Kumar
Powiązania:
https://bibliotekanauki.pl/articles/1193921.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Cancer
animal venom
anticancer drug
medicinal value
Opis:
Since cancer is one of the leading causes death worldwide and there is an urgent need to find better treatment. In recent years remarkable progress has been made towards the understanding of proposed hallmarks of cancer development and treatment. Anticancer drug developments from natural resources are ventured throughout the world. Venoms of several animal species including snake, scorpion, frog, spider etc. and their active components in the form of peptides, enzymes etc. have shown promising therapeutic potential against cancer. In the present review, the anticancer potential of venoms as well as their biochemical derivatives from some vertebrates like snake or frog or some venomous arthropods like scorpion, honey bee, wasps, beetles, caterpillars, ants, centipedes and spiders has been discussed. Some of these molecules are in the clinical trials and may find their way towards anticancer drug development in the near future. The recognition that cancer is fundamentally a genetic disease has opened enormous opportunities for preventing and treating the disease and most of the molecular biological based treatment are cost effective. The search for alternative economical and natural sources for cancer medicines is of utmost need for the future in combating this dreadful disease that is spreading at fast rate in the present era.
Źródło:
World Scientific News; 2015, 22; 91-107
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-6 z 6

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