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    Wyświetlanie 1-6 z 6
    Tytuł:
    Application of the indicator analysis to assess and improve the quality of the assembly process of telecommunications installations - a case study
    Autorzy:
    Molenda, Michał
    Płonka, Dominika
    Powiązania:
    https://bibliotekanauki.pl/articles/1927442.pdf
    Data publikacji:
    2020
    Wydawca:
    Politechnika Śląska. Wydawnictwo Politechniki Śląskiej
    Tematy:
    KPI
    key performance indicators
    improvement
    process management
    Lean
    kluczowe wskaźniki efektywności
    doskonalenie
    zarządzanie procesami
    Opis:
    Purpose: The aim of the paper is to present a case of effective application of the indicator analysis to assess and improve the process of installing a fiber optic Internet network installation at the customer’s site. The processes carried out outside the company’s headquarters, in particular their limited possibility of supervision and direct contact with the customer, cause these processes to require a special approach to management. Design / methodology / approach: The assessment of the installation process was carried out by means of the indicator analysis. The key indicators and their target values were obtained on the basis of research conducted in one of the telecommunications companies. The assessment of the quality and efficiency of the process and the effectiveness of improvement actions was based on observations and analysis of data from the company’s reports from 2017 and 2019. The theoretical scope of the work concerns methods of improving the quality and efficiency of manufacturing processes. Findings: The research process identified a set of indicators that can be used to assess the process of installation of systems in the examined company or similar ones. The quality and efficiency of the analyzed process was evaluated. The key factors determining these process properties were identified, owing to which it was possible to determine the necessary improvement actions to be implemented in the examined organization. A comparative analysis was conducted to assess the effectiveness of the implemented solutions. Practical implications: The study allowed to broaden the knowledge about the analyzed process in terms of methods of its measurement and factors having a decisive influence on its quality and efficiency. The process under analysis has been effectively improved. Originality / value: Application of the indicator analysis to a process with limited supervisory capabilities, key impact on customer satisfaction and business costs. The paper is addressed to the managerial staff of telecommunications companies involved in the installation of Internet network systems outside the company’s headquarters. The paper contains identified indicators of the assembly process and factors, mainly organizational ones, affecting its characteristics.
    Źródło:
    Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska; 2020, 148; 511-523
    1641-3466
    Pojawia się w:
    Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Splenic melanosis in agouti and black mice
    Autorzy:
    Michalczyk-Wetula, Dominika
    Wieczorek, Justyna
    Płonka, Przemysław
    Powiązania:
    https://bibliotekanauki.pl/articles/1038982.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    agouti
    EPR
    hair cycle
    melanin
    spleen
    Opis:
    An interesting example of extradermal deposition of melanin in vertebrates, notably in mammals, is splenic melanosis. In particular, if the phenomenon of splenic melanosis is correlated with hair or skin pigmentation, it must reflect the amount and perhaps the quality of pigment produced in hair follicle melanocytes. The present paper is our first study on splenic pigmentation in mice of phenotype agouti. We used untreated mixed background mice C57BL/6;129/SvJ (black - a/a, agouti - A/a, A/A), and as a control - black C57BL/6 and agouti fur from 129/SvJ mice, Mongolian gerbils (Meriones unguiculatus) and golden hamsters (Mesocricetus auratus). After euthanasia skin and spleen was evaluated macroscopically, photographed and collected for further analysis using Fontana-Masson and hematoxylin-eosin staining and electron paramagnetic resonance (EPR) at X-band. Spleens of the agouti mice revealed splenic melanosis but were slightly weaker pigmented than their black counterparts, while the presence of pheomelanin was difficult to determine. The fur of both phenotypes was of similar melanin content, with the same tendency as in the spleens. The contribution of pheomelanin in the agouti fur was on the border of detectability by EPR. Histological and EPR analysis confirmed the presence of melanin in the melanotic spleens. The shape of the EPR signal showed a dominance of eumelanin in fur and in melanized spleens in both phenotypes of mice. Therefore, splenic melanosis does reflect the hair follicle pigmentation not only in black, but also in agouti mice.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 457-463
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Extradermal melanin transfer? Lack of macroscopic spleen melanization in old C57BL/6 mice with de-synchronized hair cycle
    Autorzy:
    Michalczyk, Dominika
    Popik, Malgorzata
    Salwinski, Aleksander
    Plonka, Przemyslaw
    Powiązania:
    https://bibliotekanauki.pl/articles/1040595.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    lipofuscin
    Fontana-Masson staining
    melanin degradation
    spleen melanosis
    ageing
    hair cycle
    Opis:
    In quest of alternate, extradermal path of melanin transfer from skin to the visceral organs, we suggested that some portions of such melanin may be deposited in the spleen, which in young black C57BL/6 mice is often melanized. Here, we confirm these observation using young C57BL/6 female mice (up to 17 weeks) and show that this phenomenon cannot be observed in old animals where the hair cycle is not synchronized any more. The experiments were carried out both on spontaneous and depilation-induced hair cycle. We have checked it as a side-observation over many other experiments carried out on young and old C57BL/6 female mice (up to 2.5 years of life). The presence or absence of melanin in the spleens was checked macroscopically, and histologically by Fontana-Masson (FM) staining, and synchronization of the hair cycle - by standard histomorphometric analysis of the back skin hair follicles. In about 40% of old spleens black FM-stainable 'debris' could be found under closer histological examination. This study shows that, at least in part, the phenomenon of splenic melanosis in C57BL/6 mice can be correlated with the synchronized skin melanization parallel to the hair cycle progress, and that splenic melanin undergoes gradual degradation during the mouse life.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 2; 343-354
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Splenic melanosis during normal murine C57BL/6 hair cycle and after chemotherapy
    Autorzy:
    Michalczyk-Wetula, Dominika
    Salwiński, Aleksander
    Popik, Małgorzata
    Jakubowska, Monika
    Płonka, Przemysław
    Powiązania:
    https://bibliotekanauki.pl/articles/1039525.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cyclophosphamide
    Fontana-Masson
    hematoxylin and eosin
    May-Grünwald-Giemsa
    melanin
    spleen
    Opis:
    Cancer chemotherapy is associated with serious side effects, including temporary hair loss and impairment of pigmentation. We suspect that ectopic melanin deposition occurring due to chemotherapy may add to these effects worsening the already unpleasant symptoms. We associated the ectopic occurrence of follicular melanin after chemotherapy with splenic melanosis - an interesting example of extradermal melanin localization - and we expected an increase in splenic melanin deposition after chemotherapy. Using the C57BL/6 murine model of synchronized hair cycle induced by depilation, we visualized splenic melanin by means of several histological and histochemical protocols of staining: hematoxylin and eosin, May-Grünwald-Giemsa and Fontana-Masson. Unexpectedly, the splenic deposition of melanin decreased due to application of cyclophosphamide (i.p. 120 mg/ kg body weight on day 9 post depilation). The drop was abrupt and lasted for at least 5 days (day 13-18 post depilation), as compared with normal hair cycle. Moreover, in mice with normal, depilation-induced hair cycle we observed a similar drop shortly before entering catagen (day 15 post depilation), followed by a slow and partial increase in splenic melanization up to day 27 post depilation in both groups. We conclude that cyclophosphamide negatively affects splenic melanization and/or extradermal transfer of ectopic melanin from the dystrophic hair follicles, but the most powerful down-regulator of splenic melanosis is normal and dystrophic catagen - the phase of hair follicle involution and re-modelling.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 3; 313-321
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Splenic eumelanin differs from hair eumelanin in C57BL/6 mice.
    Autorzy:
    Plonka, Przemyslaw
    Michalczyk, Dominika
    Popik, Malgorzata
    Handjiski, Bori
    Slominski, Andrzej
    Paus, Ralf
    Powiązania:
    https://bibliotekanauki.pl/articles/1041424.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    melanin degradation
    spin-lattice relaxation
    pigmentation
    hair cycle
    hair follicle
    EPR
    Opis:
    The presence of melanin in spleens of black C57BL/6 mice has been known for long. Although its origin and biological functions are still obscure, the relation of splenic melanin to the hair follicle and skin pigmentation was suggested. Here, we demonstrated using for the first time electron paramagnetic resonance spectroscopy that black-spotted C57BL/6 spleens contain eumelanin. Its presence here is a "yes or no" phenomenon, as even in the groups which revealed the highest percentage of spots single organs completely devoid of the pigment were found. Percentage of the spotted spleens decreased, however, with the progress of telogen after spontaneously-induced hair growth. The paramagnetic properties of the spleen eumelanin differed from the hair shaft or anagen VI skin melanin. The splenic melanin revealed narrower signal, and its microwave power saturability betrayed more heterogenous population of paramagnetic centres than in the skin or hair shaft pigment. Interestingly, the pigment of dry hair shafts and of the wet tissue of depilated anagen VI skin revealed almost identical properties. The properties of splenic melanin better resembled the synthetic dopa melanin (water suspension, and to a lesser degree - powder sample) than the skin/hair melanin. All these findings may indicate a limited degradation of splenic melanin as compared to the skin/hair pigment. The splenic eumelanin may at least in part originate from the skin melanin phagocyted in catagen by the Langerhans cells or macrophages and transported to the organ.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 433-441
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pulmonary metastases of the A549-derived lung adenocarcinoma tumors growing in nude mice. A multiple case study
    Autorzy:
    Jakubowska, Monika
    Śniegocka, Martyna
    Podgórska, Ewa
    Michalczyk-Wetula, Dominika
    Urbanska, Krystyna
    Susz, Anna
    Fiedor, Leszek
    Pyka, Janusz
    Płonka, Przemysław
    Powiązania:
    https://bibliotekanauki.pl/articles/1039526.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    adenocarcinoma
    histological analysis
    metastases
    nude mice
    photodynamic therapy
    zinc pheophorbide a
    Opis:
    Lung adenocarcinoma is a leading human malignancy with fatal prognosis. Ninety percent of the deaths, however, are caused by metastases. The model of subcutaneous tumor xenograft in nude mice was adopted to study the growth of control and photodynamically treated tumors derived from the human A549 lung adenocarcinoma cell line. As a side-result of the primary studies, observations on the metastasis of these tumors to the murine lungs were collected, and reported in the present paper. The metastasizing primary tumors were drained by a prominent number of lymphatic vessels. The metastatic tissue revealed the morphology of well-differentiated or trans-differentiated adenocarcinoma. Further histological and histochemical analyses demonstrated the presence of golden-brown granules in the metastatic tissue, similar to these found in the tumor tissue. In contrast to the primary tumors, the electron paramagnetic resonance spectroscopy revealed no nitric oxide - hemoglobin complexes (a source of intense paramagnetic signals), in the metastases. No metastases were found in other murine organs; however, white infarctions were identified in a single liver. Taken together, the A549-derived tumors growing subcutaneously in nude mice can metastasize and grow on site in the pulmonary tissue. Thus, they can represent an alternative for the model of induced metastatic nodule formation, following intravenous administration of the cancerous cells.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 3; 323-330
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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