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Tytuł:
THE USE OF SULFONAMIDES IN THE PHARMACOTHERAPY OF INFECTIOUS DISEASES OF HUMANS AND ANIMALS AND THE ASSOCIATED ENVIRONMENTAL RISK
ZASTOSOWANIE SULFONAMIDÓW W FARMAKOTERAPII CHORÓB ZAKAŹNYCH LUDZI I ZWIERZĄT ORAZ ZWIĄZANE Z TYM ZAGROŻENIA DLA ŚRODOWISKA
Autorzy:
PODKOWA, Adrian
WŁODARCZYK, Anna
OPOKA, Włodzimierz
MUSZYŃSKA, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/956843.pdf
Data publikacji:
2018
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
environmental
mushroom enzymes
sulfonamides
Opis:
Sulfonamides are one of the oldest antibacterial drugs that remain still in use in humans and animals treatment. These compounds block the biosynthesis of folate in bacterial cells, thus inhibiting growth of bacteria. In order to potentiate the pharmacological activity, sulfonamides are often combined with trimethoprim. The role of those bacteriostatic agents has decreased over the years, mainly due to increasing bacterial resistance which is an effect of the inappropriate use of sulfonamides. There are still several compounds which are administered in humans to treat not only bacterial infections, but also protozoan ones (e.g. toxoplasmosis), for instance sulfamethoxazole, sulfacetamide, sulfathiazole. More number of sulfonamides is used in veterinary. According to this fact, there is a considerable adverse effect of those compounds on the environment: sulfonamides, after having been excreted from animal organisms, are present in soil and water, including groundwater. Hence there is a strong need to find effective methods of sulfonamides degradation in order to protect the environment.
Źródło:
Medicina Internacia Revuo; 2018, 28, 110; 4-10
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Właściwości biologiczne i fizyko-chemiczne talu
Biological and physico-chemical properties of thallium
Autorzy:
MUSZYŃSKA, Bożena
ROJOWSKI, Jacek
DOBOSZ, Konrad
OPOKA, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1033799.pdf
Data publikacji:
2015
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"201Tl"
"Thallium"
"elements"
"toxicity of Thallium"
Opis:
Thallium is a toxic and quite common element in the environment, but it is poorly examined, despite the known toxic activity of this metal. The ionic radius of the element is similar to the ionic radius of potassium, and at the same valence (K+,Tl+) allows substitution of this element in the nervous system and muscle, which results in its toxic activity. Thallium interferes with many enzymes and also has a strong affinity to the group – SH. The most dangerous symptoms of poisoning come from central nervous system. This element is easily cumulated by many living organisms, which poses a serious threat. In the past, it was used in rodenticides, and despite the risks, in many countries is still used for this purpose due to its low production costs. Contamination of this element of industrial areas is associated with the steel industry and cement production, while residents of these areas are often not aware of the threat and grow in these area vegetables that can absorb thallium, and in particular here talking about the Brassicaceae family. This element in the environment should be constantly monitored. Its isotope such as 201Tl (Thallium-201) has some significance in medicine, as radiopharmaceutical.
Źródło:
Medicina Internacia Revuo; 2015, 26, 105; 180-185
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rola wolnych rodników w regulacji procesów fizjologicznych
Role of free radicals in physiological processes
Autorzy:
Gdula- Argasińska, Joanna
Tyszka- Czochara, Małgorzata
Paśko, Paweł
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1033782.pdf
Data publikacji:
2012
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
hormeza
reaktywne formy azotu RFN
reaktywne formy tlenu RFT
regulacja procesów fizjologicznych
równowaga redox
wolne rodniki
Opis:
Free radicals containing one or more unpaired electrons have considerable reactivity. Those radicals derived from oxygen represent the most important class of such species. Free radicals generated in organism are reactive oxygen species (ROS) and reactive nitrogen species (RNS) well recognised for playing a dual role as both deleterious and beneficial species. The cumulative production of ROS/RNS is termed oxidative stress and were discovered in pathomechanism of many of diseases. It was observed that in medium concentration ROS and RNS are play a role in inflammation, apoptosis and as secondary messengers in intracellular signalling cascades.
Źródło:
Medicina Internacia Revuo; 2012, 25, 99; 41-46
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oznaczenie cynku w ekstraktach biomasy z kultur pędowych Bacopa monnieri do sztucznych soków trawiennych
Zinc determination in extracts from bacopa monnieri shoot cultures into simulated gastric fluids
Autorzy:
MUSZYŃSKA, Bożena
ROJOWSKI, Jacek
ŁOJEWSKI, Maciej
DZIWULSKA, Karolina
OPOKA, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1033794.pdf
Data publikacji:
2015
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"Bacopa monnieri"
"DP-ASV method"
"in vitro culture"
"zinc"
Opis:
Bacopa monnieri (Water hyssop) is a hydrophyte occurring in Asia and the southern US states. This plant is known in India as Brahmi and has been used in Ayurvedic medicine for 5,000 years as sedative, supporting the treatment of insomnia and improving cerebral circulation. For the biological effect in this species are responsible triterpenoids saponins – bacosides. The aim of the study was to obtain the biomass of B. monnieri shoot in vitro cultures, and then evaluating the biomass growth and content of zinc. B. monnieri derived from in vitro culture on Murashige-Skoog medium (MS) and on the same medium, but enriched in organic additives and elements may be a good source of Zinc for the human body. The experiment was also conducted on the commercial formulations containing B. monnieri. For the determination of zinc ions DP ASV method was used. It was found that the use of highly mineralized water (mineral water “Stefan” – Spa Szczawnica) for extraction of B. monnieri biomass from in vitro culture provided the highest concentration of zinc in the material and for the biomass from MS medium with the addition of As (163.52, and 167.23 mg/mL, respectively). The lowest content was found in B. monnieri biomass from MS medium supplemented with serine, and the capsules product (13.54 and 14.57 mg/mL). For extracts of B. monnieri biomass from MS medium enriched with Zn salts into digestive juices the highest concentration of zinc was determined in gastric juice (6.88 mg/mL).
Źródło:
Medicina Internacia Revuo; 2015, 26, 105; 175-179
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
EVALUATION OF NUTRITIONAL AND MEDICINAL PROPERTIES OF BACOPA MONNIERI BIOMASS AND PREPARATIONS
Autorzy:
Muszyńska, Bożena
krakowska, Agata
Lazur, Jan
Szewczyk, Agnieszka
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/895242.pdf
Data publikacji:
2018-12-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
dietary supplements
phenolic compounds
Bacopa monnieri
artificial digestive juices
bioelements
Opis:
Bacopa monnieri (Scrophulariaceae) is a well-known plant and has been used by humans for several thousand years. In traditional Hindu medicine, it is one of the most important medicinal plants. The aim of the work was to determine the content of Fe, Mg, and Zn and selected organic compounds before and after extraction into the artificial digestive juices obtained from preparations containing B. monnieri. Commercial preparations in the form of tablets and capsules and B. monnieri shoot cultures were used in the experiment. The metal content in the considered mineralized samples was analyzed by atomic absorption spectrometry and organic compounds by RP-HPLC method. The maximum measured content of the metals released into the digestive juices was as follows: Fe – 32.85; Mg – 367.51; and Zn – 16.41 mg/100 g of the preparation. The existing research shows that metals are best released into the artificial digestive juices from the B. monnieri shoot cultures, and least efficiently from the commercial preparations available in the form of tablets. The phenolic compounds analyzed in the methanol extracts and the extracts of the artificial digestive juices were as follows: protocatechuic acid, p-hydroxybenzoic acid, neochlorogenic acid, chlorogenic acid, isochlorogenic acid, caffeic acid, ferulic acid, cynaroside, trifolin, and luteolin. Bacoside A was only determined in the extracts from the B. monnieri shoot cultures. The experimental results revealed that B. monnieri distributed in the form of tablets did not break down in the artificial digestive juices during the considered time intervals.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1353-1361
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
L-tryptophan and its deriviates in edible mushroom species.
Autorzy:
MUSZYŃSKA, Bożena
KOMENDACKI, Paweł
KAŁA, Katarzyna
OPOKA, Włodzimierz
ROJOWSKI, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1033762.pdf
Data publikacji:
2014
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
L–tryptophan
antidepressant agent
antioxidant activity
edible mushrooms
indole compounds
Opis:
Mushrooms are able to accumulate both primary and secondary metabolites. Medicinal and antioxidant properties of mushrooms are an excellent combination of their nutrition value. Recent studies have demonstrated that edible mushroom species contain non–hallucinogenic indole compounds and their derivatives. The indole skeleton is the basis of the substances serving important functions in the human body, such as serotonin and melatonin. These compounds fulfill the role of neurotransmitters or their precursors, exhibit antioxidant, anticancer, anti–aging actions, regulate the diurnal cycle in humans and participate in blood coagulation. These compounds and their derivatives are also anti– inflammatory and analgesic therapeutics.
Źródło:
Medicina Internacia Revuo; 2014, 26, 103; 82-88
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
QUANTITATIVE AND QUALITATIVE ANALYSIS OF FIXED-DOSE-COMBINATION PRODUCTS (FDC, POLYPILL) APPLIED IN POLYTHERAPY OF HYPERTENSIVE DISEASE. REVIEW
Autorzy:
Stolarczyk, Mariusz
Apola, Anna
Maślanka, Anna
Kwiecień, Anna
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/895565.pdf
Data publikacji:
2018-10-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
analysis
fixed-dose-combination
Opis:
Problems in polytherapy of hypertension combined with hyperlipidemia and the need of application of several pharmaceutical preparations have been widely explored by patients, physicians, and the pharmaceutical industry through testing and introduction of a fixed-dose-combination products (FDC). The paper presents different analytical methods of qualitative and quantitative analysis or stability testing of FDC preparations and laboratory prepared mixtures of composition consistent with the FDC products collected on the basis of publications from the last decade. It can significantly facilitate the study of the methods and conditions for the determination of active substances in polypills which contain at least three APIs, especially in cases involving this type of preparations used or tested for their application in polytherapy of hypertension.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1083-1094
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tricholoma equestre species as a source of indole compounds and zinc released into artificial digestive juices
Autorzy:
KAŁA, Katarzyna
SUŁKOWSKA-ZIAJA, Katarzyna
ROJOWSKI, Jacek
OPOKA, Włodzimierz
MUSZYŃSKA, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1034031.pdf
Data publikacji:
2016
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"artificial digestive juices"
"fruiting bodies
"in vitro culture"
"zinc"
Tricholoma equestre"
indole compounds"
Opis:
The research goals of presented work consisted of determination of zinc and indole compounds that are released into artificial digestive juices from Tricholoma equestre species. During the experiment freeze-dried samples of wild growing fruiting bodies and mycelia from in vitro cultures from liquid Oddoux medium were extracted to artificial digestive juices (saliva, gastric juice and intestinal juice). In the next step the determination of examined compounds was done by RP-HPLC for indole compounds and DP ASV for zinc. Furthermore it was decided to check weather this species has any beneficial properties for health. The extraction of researched material in conditions imitating human digestive tract allows determination of true amounts of elements released to artificial digestive juices and their beneficial influence (a specially designed and constructed apparatus Gastroel-2014 was applied). The indole compound with the highest quantity was 5-hydroxy-L-tryptophan, both in fruiting bodies and in biomass from in vitro cultures of T. equestre (up to 352.47 mg/100 g d.w.). Serotonin and L-tryptophan was determined in all analysed samples, but their amounts were significantly lower than the ones found for 5-hydroxy-L-tryptophan. The amounts of zinc on the other hand showed that the biggest concentration of zinc can be obtained for fruiting bodies and biomass from in vitro cultures to both artificial saliva and gastric juice after 120 minutes of digestion (6.83 14.4 mg/100 g d.w. retrospectively) in conditions that imitate human digestive track.
Źródło:
Medicina Internacia Revuo; 2016, 27, 106; 35-39
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wybrane nieoperacyjne sposoby leczenia szyjnego odcinka kręgosłupa
Some Non-Operative Ways of Cervical Spine Treatment
Autorzy:
Piechowicz, Jacek
Tęsiorowski, Maciej
Jasiewicz, Barbara
Sobol, Jacek
Piechowicz, Mateusz
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1034040.pdf
Data publikacji:
2013
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
cervical spine
dyscopathy
physiotherapy
Opis:
Though cervical spine disorders occur less frequently than lumbar spine problems, their course and final results may have severe implications for patients. Despite significant development in operative treatment of cervical spine; patients, if possible, choose conservative methods basing mainly on pharmacotherapy and rehabilitation (physiotherapy). A case report of non-operative treatment with use of selected techniques of manual therapy and physiotherapy is described. Achieved improvement allowed postponing the surgery, but we cannot exclude the necessity of operation in the future.
Źródło:
Medicina Internacia Revuo; 2013, 25, 100; 119-123
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wybrane nieoperacyjne metody leczenia dyskopatii lędźwiowego odcinka kręgosłupa – opis przypadku
Some Non-Operative Ways of Lumbar Disc Herniation Treatment – Case Report
Autorzy:
SOBOL, Jacek
TĘSIOROWSKI, Maciej
WILK-FRAŃCZUK, Magdalena
JASIEWICZ, Barbara
PIECHOWICZ, Jacek
OPOKA, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1033819.pdf
Data publikacji:
2013
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
disc herniation
discopathy
lumbar spine
physiotherapy
Opis:
Discogenic back pain is an increasing problem in the modern world. Conservative treatment of discopathy is comparatively popular and may be an alternative to surgery. The authors describethe case of a 32 year old male with acute back pain, sciatica and numbness in the left lower leg. On the base of MRI imagesL4-L5 and L5-S1 two-level disc herniation was diagnosed. The patient did not decide on surgery, so complex conservative treatment was applied, including pharmacology and rehabilitation techniques. The symptoms resolved with permanent improvement in one year of follow up. Additionally, the patient was encouraged to apply “healthy habits” in physical activity. Conservative treatment in some cases of massive lumbar disc herniation may be successful.
Źródło:
Medicina Internacia Revuo; 2013, 25, 101; 156- 162
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Edible Mushrooms in Prophylaxis and Treatment of Human Diseases
Autorzy:
MUSZYNSKA, Bożena
SUŁKOWSKA-ZIAJA, Katarzyna
ŁOJEWSKI, Maciej
OPOKA, Włodzimierz
ZAJĄC, Magdalena
ROJOWSKI, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1033825.pdf
Data publikacji:
2013
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
Basidiomycota
chitosans
ergothioneine
hypercholesterolemia
statins
Opis:
In recent years an increase in the consumption of edible mushrooms has been observed. In many countries mushrooms have been a popular delicacy, as they add flavor and texture to a meal. Mushrooms are able to accumulate both primary and secondary metabolites. Some of them may play an antioxidant role, e.g. phenolic and indole compounds, flavonoids, terpenoids, sterols, ascorbic acid, ergothioneine and carotenoids and are a source of elements, e.g. selenium. Indole compounds fulfill the role of neurotransmitters or their precursors, exhibit antioxidant, anticancer, anti-inflammatory and anti-aging actions, regulate the diurnal cycle in humans and take part in blood coagulation. Biologically and therapeutically active metabolites of fungi are used to treat such serious diseases as cardiovascular diseases, diabetes, atherosclerosis and cancer. The intake of mushrooms clearly has a cholesterol-lowering effect or hypocholesterolemic effect by different mechanisms such as decreasing VLDL, improving lipid metabolism, inhibiting of activity of HMG-CoA reductase, and consequently preventing the development of atherosclerosis. The antioxidant and anti-inflammatory compounds occurring in mushrooms also may contribute to reduce the atherosclerosis risk.
Źródło:
Medicina Internacia Revuo; 2013, 25, 101; 170-183
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
Autorzy:
Grzywacz, Agata
Gdula-Argasińska, Joanna
Muszyńska, Bożena
Tyszka-Czochara, Małgorzata
Librowski, Tadeusz
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1038990.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
metal responsive-transcription factor 1
cell signaling
inflammation
NF-κB
Opis:
Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. MTF-1 acts in the process of binding of toxic metal ions in the cell, due to the activation of the expression of metallothioneins (MTs). Additionally, MTF-1 regulates transcription of genes involved in the sequestration of zinc and its intracellular transport. Disruption of zinc and MT homeostasis has an indispensable influence on the development of several pathological states. Moreover, by increasing MT activity, MTF-1 can effectively protect cells from oxidative and hypoxic stresses. The mechanism of MTF-1 action in cells includes the regulation of the proper immune response through activation/repression of anti- and pro-inflammatory cytokines. MTF-1 function in immune response is related to nuclear factor-κB (NF-κB) activity. Synthesis of insulin is also related to the activity of this transcription factor and zinc balance. Insulin transport also depends on zinc. In pancreatic β-cells, several types of the zinc transporters are found. Zinc transporters coordinated action is crucial for the synthesis and secretion of insulin. Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 491-498
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zinc, the Trace Element Essential in Living Organisms
Autorzy:
SOLÉ PASCUAL, Anna
TYSZKA-CZOCHARA, Małgorzata
GDULA-ARGASIŃSKA, Joanna
LIBROWSKI, Tadeusz
GRZYWACZ, Agata
OPOKA, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1033792.pdf
Data publikacji:
2012
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
biochemistry of zinc
zinc functions
Opis:
Zinc is a metallic element, of symbol Zn and atomic number 30, that is placed in the group 12 of the periodic table. As an essential trace element, zinc is required to support human biochemical processes. It is found in nearly 200 specific enzymes in the living organisms, and it also serves as structural cofactor for many cellular proteins. [1] Zinc may exert pleiotropic effects in organism; for that, deficits of cellular zinc content can have catastrophic consequences and are linked to major pathophysiology, such as diabetes, stroke and malformations of brain function [2]. The complexity and importance of zinc homeostasis is reflected by the large variety and number of zinc-related proteins found in almost every cell compartment; for example, this biometal is transported through ZnT (Zn2+ transporter) family and ZIP family, proteins that are completely dedicated to zinc transport [2]. It is also noticeable, that between three and ten percent of all protein products of genes in mammalian genomes bind zinc, which is essential for their folding, activity or conformational change [2].
Źródło:
Medicina Internacia Revuo; 2012, 25, 99; 55-59
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The importance of screening in the evaluation Of faulty posture in children
Autorzy:
Kuciel-Lewandowska, Jadwiga
Paprocka-Borowicz, Małgorzata
Kierzek, Andrzej
Pozowski, Andrzej
Boerner, Ewa
Ratajczak, Barbara
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1033835.pdf
Data publikacji:
2012
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
body posture
program
prophylaxis
Opis:
The aim of the following work is to evaluate faulty posture rate among kindergarten children. The following article describes the objective and the character of the promotional and prophylactic program conducted by the Wrocław City Council (Urząd Miasta Wrocławia) concerning the “Keep straight” (“Trzymaj się prosto”) campaign. The program includes youth between age of seven and seventeen in whom slight symptoms of faulty posture, concerning lower limbs and the spine, were revealed during examination. The only prophylactic activity assumed by the “Keep it straight” campaign are corrective exercises in gymnasium and swimming pool. The screening of the children and youth also allows introductional diagnostics and recognition of permanent faults and direction of the patients to specialist treatment in orthopedic and rehabilitation clinics. The screening was conducted on the verge of October and November 2007. A physical posture examination method was used to evaluate the faults that appeared. The children from five of Wrocław`s kindergartens were examined. The following work presents the symptomatology of the most frequent faults and highlights the necessity of conducting prophylactic activity at a very young age. The faulty posture is a serious diagnostic and therapeutic problem among young children and can be a source of severe health problems in their future. 373 children were examined. Faulty posture was revealed among 295 what represents 79,08% of the patients; 78 were described as healthy (20,92%). There were 160 boys (80,8%) and 135 girls (77,14%) in the group with faulty posture. There were 38 (19,2%) boys without faulty posture and 40 (22,86%) girls in the same group.
Źródło:
Medicina Internacia Revuo; 2012, 25, 98; 21-26
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determination of in vitro metabolism of new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy)propyl]piperidine
Autorzy:
Kryczyk-Poprawa, Agata
Szafarz, Małgorzata
Palak, Aneta Palak
Łażewska, Dorota
Kuś, Kamil
Opoka, Włodzimierz
Szymura-Oleksiak, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/895240.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
1-[3-(4-tert-butylphenoxy)propyl]piperidin
well-stirred model
parallel tube model
non-imidazole histamine H3 receptor antagonist
Opis:
Early understanding of the pharmacokinetics of drug candidates is essential during the evaluation of drug development process. DL76 1-[3-(4-tert-butylphenoxy)propyl]piperidine is a novel promising non-imidazole H3 receptor antagonist. Presented study was undertaken to compare with each other the predicted hepatic clearance values of DL76 calculated, using two most common mathematical models “well-stirred” and “parallel tube”, based on the data obtained in in vitro experiments. The metabolic intrinsic clearance of DL76 equaled to 0.4848 mL/min/mg protein was scaled up and the values of hepatic clearance estimated from "well-stirred" and "parallel tube" models were 55.47 mL/min/kg and 58.80 mL/min/kg, respectively. They were further compared with pharmacokinetic parameters calculated based on the concentration-time profile obtained following intravenous administration of DL76 to rats at the dose of 6 mg/kg. The estimated systemic serum clearance value of 144.5 mL/h/kg and blood clearance value of 81.17 mL/min/kg indicate the potential extrahepatic metabolism of the investigated compound. This study demonstrates the utility of rat liver microsomes for the prediction of DL76 hepatic clearance.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 877-884
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 16

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