Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę "Olszewska, Katarzyna" wg kryterium: Autor


Wyświetlanie 1-9 z 9
Tytuł:
Antiproliferative activity of new benzimidazole derivatives
Autorzy:
Błaszczak-Świątkiewicz, Katarzyna
Olszewska, Paulina
Mikiciuk-Olasik, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/1039545.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
anticancer activity
ntiproliferation
apoptosis
benzmidazole
hypoxia
nitrobenzimidazole
Opis:
A series of new benzimidazole derivatives were synthesized and tested in vitro for possible anticancer activity. Their effect of proliferation into selected tumor cell lines at normoxia and hypoxia conditions was determined by WST-1 test. Additionally, apoptosis test (caspase 3/7 assay) was used to check the mode caused by the agents of cell death. Four of the examined compounds (7, 8, 13, 11) showed a very good antiproliferative effect and three of them were specific for hypoxia conditions (8, 14, 11). Compound 8 was the most cytotoxic against human lung adenocarcinoma A549 cells at hypoxic conditions. Hypoxia/ normoxia cytotoxic coefficient of compound 14 (4.75) is close to hypoxia/normoxia cytotoxic coefficient of tirapazamine (5.59) - a reference compound in our experiments and this parameter locates it between mitomycin C and 2-nitroimidazole (misonidazole). Screening test of caspase-dependent apoptosis proved that exposure to A549 cells of compounds 7-8 and 13-14 for 48 h promote apoptotic cell death. These results supplement our earlier study of the activity of new potentialy cytotoxic heterocyclic compounds against selected tumor cells.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 427-433
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zespół Kelleya-Seegmillera jako przyczyna nawracającego ostrego uszkodzenia nerek u 9-letniego chłopca
Kelley-Seegmiller syndrome as cause of recurrent acute kidney injury in 9-year-old boy
Autorzy:
Marciniak, Hanna
Jarmoliński, Tomasz
Safranow, Krzysztof
Jakubowska, Katarzyna
Olszewska, Maria
Chlubek, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/1036012.pdf
Data publikacji:
2017
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
zespół kelleya-seegmillera
niedobór fosforybozylotransferazy hipoksantynoguaninowej
ostre uszkodzenie nerek
hiperurykemia
hiperurykozuria
kelley-seegmiller syndrome
hypoxanthine-guanine phosphoribosyltransferase deficiency
acute kidney injury
hyperuricemia
hyperuricosuria
Opis:
Defekt fosforybozylotransferazy hipoksantynoguaninowej (HPRT) jest drugą co do częstości występowania po ksantynurii wrodzoną wadą metabolizmu puryn. Opisany w 1967 r. u pacjentów z dną moczanową i kamicą nerkową zespół Kelleya-Seegmillera wynika z częściowego niedoboru tego enzymu. Jego całkowity brak wywołuje ponadto ciężkie objawy neurobehawioralne i znany jest od 1964 r. jako zespół Lescha-Nyhana. Badania enzymatyczne i molekularne, pozwalające na dokładną diagnostykę tych wad, są w Polsce trudno dostępne, co wpływa na bardzo rzadkie ich rozpoznawanie. Przedstawiono przypadek 9-letniego chłopca z nawracającym ostrym uszkodzeniem nerek (4 epizody), u którego analiza obrazu klinicznego i proste testy laboratoryjne pozwoliły na wstępne rozpoznanie zespołu Kelleya-Seegmillera, potwierdzone badaniem aktywności HPRT.
Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency is the second most common, after xanthinuria, inherited defect of purine metabolism. Described in 1967 in patients with gout and nephrolithiasis, the Kelley-Seegmiller syndrome is caused by HPRT partial deficiency. A complete lack of enzyme activity leads to additional severe neurobehavioral symptoms with self-mutilation creating clinical a picture known since 1964 as the Lesh-Nyhan syndrome. Enzymatic and molecular analyses useful for precise diagnosis are not routinely available in Poland, so the prevalence of HPRT defects is very low. Here we presented a case of a 9-year-old boy suffering from recurrent acute kidney injury (4 episodes) with diagnosis of the Kelley-Seegmiller syndrome based on the clinical picture and simple laboratory tests confirmed by evaluation of HPRT enzyme activity.
Źródło:
Annales Academiae Medicae Silesiensis; 2017, 71; 116-121
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An analysis of the spatial and temporal changes on the Jakobshavn Glacier (Greenland) using remote sensing data
Autorzy:
Olszewska, Katarzyna
Borowiec, Natalia
Powiązania:
https://bibliotekanauki.pl/articles/2055846.pdf
Data publikacji:
2021
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
global warming
glaciers
ablation
glacier calving
remote sensing
Greenland
Opis:
This article presents the problem of climate warming and the effect of melting ice caps. The problem of climate warming is discussed in two stages. In the first stage, the factors affecting global warming are discussed in detail and the effects and risks of ablation extensively described. Analyses were conducted on data available online from NASA and Carbon Dioxide Information Analysis Center. The Greenland area (Jakobshavn Glacier) was selected to visualize glacier calving front changes. The analysis of changes was performed on the selected satellite images covering the summer period (June to September) provided by the Landsat program. Then, the changes in the position of the calving front of the Jakobshavn Glacier were visualized for the period 1985–2020, with a repeatability of every 5 years. Thus, our results addressed the challenges of environmental changes to remote sensing data processing. In addition to the visualization, a surface summary of these changes was presented in the study. The results were discussed in the context of climate change data processed by means of the GIS method. Furthermore, an analysis of the effects of greenhouse gases on glacier surface changes was performed. In summary, the results reveal that satellite imagery is an excellent source of data on which to visualize glacier calving rates, comparing individual layers showing the position of the glacier calving front and calculating the area of calved ice.
Źródło:
Geology, Geophysics and Environment; 2021, 47, 4; 187--201
2299-8004
2353-0790
Pojawia się w:
Geology, Geophysics and Environment
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Craniofacial morphology in overweight and obese orthodontic adolescent patients
Autorzy:
Olszewska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/972737.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
overweight
obesity
adolescents
craniofacial growth
cephalometrics
Opis:
Introduction and objective. There is an evidence suggesting that obesity may influence the timing of puberty and growth patterns. There are few research on the reactions of the craniofacial complex to an overall increase in the body mass. Thus the objective of the study was to investigate if overweight or obesity may influence craniofacial morphology in adolescent orthodontic patients. Material and methods. In total, 77 patients aged 11–16 years were selected for the retrospective analysis. The study group comprised 37 overweight or obese individuals (mean age: 13,45±2,15). The control group included 40 normal-weight subjects (mean age: 13.79±1.81). Body mass index (BMI) percentile of each patient was assessed with the use of BMI score and age- and sex specific growth charts in accordance with International Obesity Task Force (IOTF). Craniofacial measurements included in the study were performed on the tracings of lateral cephalometric radiographs. The data was analyzed by STATISTICA 10 for Windows Software. Results. Both females and males of the study group exhibited significantly greater mandible length (Cd-Gn), corpus length (Go-Pg), midfacial length (Cd-A) and lower anterior facial height (Ans-Me) (p<0.05), as well as SNB, SNPg and ML/SN angles (p<0.05) compared to the normal-weight controls. Moreover, high BMI females showed greater maxillary length (Pm-A) and SNA angle (p<0.05), whereas males exhibited greater posterior facial height (S-Go) (p<0.05) compared to the controls. Conclusions. Weight status is an important factor that can affect craniofacial growth pattern and should be taken into consideration when planning orthopaedic treatment in adolescent patients.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2017, 11, 1; 42-45
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Innowacje w oświacie
Autorzy:
Olszewska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1831447.pdf
Data publikacji:
2013
Wydawca:
Politechnika Gdańska
Tematy:
innowacje
innowacyjność
innowacje w oświacie
Opis:
W artykule przedstawiono pojęcie i istotę innowacji. Określono jej cechy oraz rodzaje. Scharakteryzowano innowacje w oświacie według różnych kryteriów oraz zaprezentowano rodzaje innowacji oświatowych realizowanych w mieście Elblągu.
Źródło:
Przedsiębiorstwo we współczesnej gospodarce - teoria i praktyka; 2013, 2, 5; 38-53
2084-6495
Pojawia się w:
Przedsiębiorstwo we współczesnej gospodarce - teoria i praktyka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Religia online, czyli o procesie wirtualizacji religii
Autorzy:
Przybył-Sadowska, Elżbieta
Olszewska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/640816.pdf
Data publikacji:
2007
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Opis:
RELIGION ONLINE COMMENTS ON THE PROCESS OF VIRTUALIZATION OF RELIGIONThe article constitutes an attempt to describe the functioning of religion in the Internet, and particularly of the religious practices which are conducted online. The authoresses of the article trace the transformations which have taken place in the use of the Internet as an instrument employed to conduct types of practices, beginning with the simplest communicators, through the use of videoconferences, up to the use of three-dimensional techniques. Special attention was devoted to virtual temples, that is those Internet sites where one can make a virtual sacrifice to a deity. In the article, the authoresses also draw attention to the ways of conducting these types of rituals and they present the views thanks to which the participants of these events may have an impression that they are actually taking part in religious practices, rather than just participating in a game. The article closes with an analysis of the ways of functioning of religion in the virtual worlds, with particular attention being drawn to the Second Life, which has become immensely popular in recent times. Apart from traditional religions which open up their sites of worship in Second Life, there also arise new cults in this world which are characteristic exclusively of ritualistic reality. The fundamental problem which has to be faced here by scholars is an attempt to answer the question, to what extent these are really new religious movements and to what extent they constitute an element of internet games and instruments which these games make use of.
Źródło:
Studia Religiologica; 2007, 40
0137-2432
2084-4077
Pojawia się w:
Studia Religiologica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-9 z 9

    Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies