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    Wyświetlanie 1-5 z 5
    Tytuł:
    Appraisal of Phytochemical Properties and Antidiabetic Activities of Tetracarpidium conophorum (Mull. Arg.) Ethanolic Leaves Extracts in Alloxan-Induced Diabetic Rats
    Autorzy:
    Eneh, Grace D. O.
    Okon, Okon G.
    Essien, Nsikak B.
    Okon, Joseph E.
    Powiązania:
    https://bibliotekanauki.pl/articles/1158773.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Albino Rats
    Alloxan
    Antidiabetic
    Diabetes
    Glibenclamide
    Phytochemicals
    Tetracarpidium conophorum
    Opis:
    The phytochemical properties of the ethanolic leaves extract of Tetracarpidium conophorum and its antidiabetic properties on alloxan-induced diabetic albino rats were evaluated. The qualitative phytochemical screening revealed the presence of alkaloids, tannins, saponins, terpenes, flavonoids, cardiac glycosides and anthraquinones in T. conophorum leaf extract. Quantitative phytochemical screening of T. conophorum revealed the presence of saponins (8.77 ± 1.15 mg/kg), tannins (7.84 ± 0.62 mg/kg), alkaloids (5.49 ± 0.14 mg/kg), flavonoids (5.26 ± 0.16 mg/kg), cardiac glycosides (2.13 ± 0.45 mg/kg), terpenes (1.47 ± 0.30 mg/kg) and anthraquinones (1.33 ± 0.18 mg/kg). The toxicity test of the extracts produced various degree of toxicity ranging from writhing, decreased respiration, convulsion to mortality. The intensities of these effects were proportional to the dose administered. The LD50 for T. conophorum was 1369.31 mg/kg. The results of the influence of ethanolic leaves of T. conophorum on alloxan-induced diabetic rats showed significant (p<0.05) reduction in the blood glucose level (BGL) as time of treatments increases. The leaves extracts of T. conophorum significantly (p<0.05) decreased the blood glucose level of diabetic rats on day 14 compared to diabetic untreated (control) rats. The BGL of diabetic rats treated with oral hypoglycemic agent alone were significantly (p<0.05) different from control group on day 14. The presence of these biologically active compounds suggest that the plant could serve as potential sources of drugs and their secondary metabolites could exert some biological activities when taken by animals. The extracts of T. conophorum also produced a similar reduction in blood sugar level as the standard hypoglycemic drug (Glibenclamide). This may be due to its ability to enhance insulin secretion like the standard drug. This positive result confirms why herbalists use this leaf for the management of diabetes.
    Źródło:
    World Scientific News; 2018, 114; 218-229
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Phytochemicals, nutraceuticals and antinutritional factors assessment of young leaves of Colocasia esculenta (L) Schott
    Autorzy:
    Eneh, Grace D. O.
    Okon, Okon G.
    Imabong, Fidelis E.
    Mfoniso, Ekanem J.
    Olajumoke, Ilesanmi O.
    Powiązania:
    https://bibliotekanauki.pl/articles/1109349.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Antinutrients
    Colocasia esculenta
    minerals
    oxalates
    phytates
    phytochemicals
    proximate
    Opis:
    Phytochemicals, proximate, minerals and anti-nutrient compositions of young cocoyam (Colocasia esculenta) leaves were determined using standard methods. Qualitative and quantitative analyses for phytochemicals confirmed the presence of bioactive constituents such as alkaloids, flavonoids and saponins in appreciable amounts, while terpenes, cardiac glycocides and tannins were only present in trace concentrations. Mineral analysis revealed that K recorded the highest content - with 214.00 ± 2.11 mg/100g, followed by Ca - 157.10 ± 1.47 mg/100g, Mg - 63.00 ± 0.58 mg/100g, P - 32.00 ± 0.61 mg/100g, while Fe had the lowest value - 0.10 ± 0.14 mg/100g. Proximate composition analysis of C. esculenta leaves indicated that CHO, protein and crude fibre were present in high quantities (35.22, 17.10 and 16.41 % respectively), while fat was at the lowest content (8.82%). Anti-nutritional factor analysis of young leaves of C. esculenta indicated that phytates was present in huge quantity - 11.03 ± 0.12mg/g, followed by oxalates - 7.62 ± 0.14 mg/g, while tannins recorded the lowest anti-nutritional contents - 0.12 ± 0.06 mg/g. This study has also revealed that the young leaves of C. esculenta contain appreciable levels of bioactive components (phytochemicals such as as alkaloids, flavonoids and saponins; minerals K, Ca, Mg, P and Fe) and appreciable amounts of CHO, protein and crude fibre. The results of anti-nutrients analysis showed high contents of phytate and oxalate. The last is probably responsible for the itching effect and also interferes with the utilization of essential nutrients. Thus, young leaves of C. esculenta provide appreciable quantities of nutrients and thus can rival other conventional vegetables normally consumed in Nigeria.
    Źródło:
    World News of Natural Sciences; 2018, 20; 12-22
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Enhancement of salt tolerance via glomus geosporum inoculation in Telfairia occidentalis Hook. F. seedlings
    Autorzy:
    Okon, O.G.
    Eneh, G.D.O.
    Uboh, G.D.
    Uyon, P.P.
    Powiązania:
    https://bibliotekanauki.pl/articles/11032.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Źródło:
    International Letters of Natural Sciences; 2019, 76
    2300-9675
    Pojawia się w:
    International Letters of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence and antimicrobial susceptibility of Klebsiella pneumoniae isolated from hospitalized patients at General Hospital, Etim Ekpo, Akwa Ibom State, Nigeria
    Autorzy:
    Anosike, I. Kelechi
    Edet, U. Okon
    Umoafia, G. E.
    Agbo, B. E.
    Ejelonu, V. O.
    Onyesoro, V.
    Powiązania:
    https://bibliotekanauki.pl/articles/1030832.pdf
    Data publikacji:
    2020
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Antibiotic susceptibility
    Klebsiella pneumonia
    Nosocomial
    Prevalence
    Resistance
    Opis:
    Klebsiella pneumoniae (KP) was investigated in respondents presenting signs and symptoms of urinary tract infection (UTI) in a rural community. Using simple random sampling, a total of 360 respondents (144 males and 216 females) were recruited into the study following informed consent and ethical approval. Mid-stream urine samples were collected from all the respondents aseptically using standard protocol. Isolation of K. pneumoniae was done using morphological characteristics and various biochemical tests while antibiotic sensitivity testing using various antibiotics was done using guidelines of Clinical and Laboratory Standard Institute. A total of 16 samples gave positive culture representing an overall prevalence of 4.4%. Furthermore, prevalence rates of 2.8%, 5.6%, 47.82%, 4.9%, 3.50%, and 8.60% for males, females, diabetics, in-patients, out-patients, and respondents above 60 years of age respectively were obtained. Resistance to antibiotics ranged from 37.50 to 56.25% for gentamycin and nalidixic, and tarivid, respectively. There is need for preventive measures aimed at sensitization of dwellers in community settings.
    Źródło:
    World Scientific News; 2020, 145; 222-233
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Metastatic and non-metastatic sentinel inguinofemoral lymph nodes in vulvar cancer show an increased lymphangiogenesis
    Autorzy:
    Piechowicz, M.
    Mikos, M.
    Banas, T.
    Okon, K.
    Pietrus, M.
    Balajewicz-Nowak, M.
    Szczudlik, L.
    Kojs, Z.
    Czerw, A.
    Juszczyk, G.
    Pityński, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085422.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    anti-D2–40 antibody
    lymphatic vessel density
    immunohistochemistry
    sentinel lymph node
    vulvar cancer
    Opis:
    Introduction and objective. Lymph node involvement is a strong predictor of disease recurrence and patient survival in vulvar cancer. The aim of the study was to evaluate the feasibility of sentinel lymph node (SLN) screening, the incidence of skip metastases, and lymph node lymphangiogenesis. Materials and method. Fifty-five patients participated in this prospective, single centre study. A double SLN screening method was employed using radiocolloid (technetium-99 sulfur colloid) and 1.0% Isosulfan Blue. Immunohistochemistry, using a mouse monoclonal antibody against D2–40, was used to evaluate lymphatic vessel density (LVD). All calculations were performed using STATISTICA software v. 10 (StatSoft, USA, 2011); p<0.05 was considered significant. Results. Using both methods of SLN detection, 100% accuracy was achieved, and skip metastases were diagnosed in only one woman (1.82%). Peri-tumour median LVD was significantly increased compared with matched intra-tumour samples (p<0.001), while median LVD was significantly lower in negative, compared with positive SLN, regardless of whether matched non-SLN were negative (p<0.001) or positive (p=0.005). Metastatic SLN exhibited significantly higher median LVD compared with matched negative non-SLN (p=0.015), while no significant difference in median LVD was detected between positive SLN and matched positive non-SLN. However, negative SLN had a significantly higher median LVD compared with matched negative non-SLN (p = 0.012). Conclusions. SLN detection is a safe and feasible procedure in vulvar cancer. In patients without nodular involvement, SLN, compared with non-SLN, exhibited significantly higher median LVD, which may be an indication of its preparation to host metastases, and thus requires further investigation.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 123-128
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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