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Wyszukujesz frazę "Nowak, Monika" wg kryterium: Autor


Tytuł:
In memoriam – wspomnienia pracowników Zakładu Pedagogiki Specjalnej o Profesorze Władysławie Dykciku
Autorzy:
Błachnio, Krystyna
Buchnat, Marzenna
Drozdowicz, Anna
Karwacka, Monika
Kopeć, Danuta
Krajczy, Sandra
Lauch-Żuk, Jolanta
Pawelczak, Katarzyna
Tylewska-Nowak, Beata
Załustowicz, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/919999.pdf
Data publikacji:
2013-01-01
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Źródło:
Interdyscyplinarne Konteksty Pedagogiki Specjalnej; 2013, 3; 157-162
2300-391X
Pojawia się w:
Interdyscyplinarne Konteksty Pedagogiki Specjalnej
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Children’s Metaphoric Expressions; The Meaning of Friendship. A Comparative Analysis Between the USA and Poland
Autorzy:
Bristley, Anastasia
Wiśniewska-Kin, Monika
Nowak-Fabrykowski, Krystyna
Powiązania:
https://bibliotekanauki.pl/articles/1997534.pdf
Data publikacji:
2017-12-31
Wydawca:
Wydawnictwo Adam Marszałek
Tematy:
friendship
metaphoric expressions
Opis:
The goal of this research project is to analyze children’s understanding of the concept of friendship by investigating symbolic representation in drawing and metaphoric expression in language. This research project is grounded in the conceptual metaphor theory (Lakoff & Johnson, 1980), in which metaphor is defined as a conceptual-linguistic mapping between a source and a target domain. It uses qualitative, ethnographic research based on Spradley’s (1979) theory stating that meanings are derived from symbolically coded concepts where X is a symbol and Y is a referent. The researchers in this study, one from the USA and one from Poland, asked a group of preschool children to draw pictures of their friends. When the children finished their drawings, the researchers asked them 4 questions: “What did you draw?” “Why are they friends?” and “A friend is like…”, “A friendship is like…”. The results demonstrate that preschool children have the cognitive ability to understand the concept of friend and even differentiate between friends and playmates. In the study, the children could determine the number of their real friends, and for most children in both countries, it was 1 or 2 friends. In the group of American children, friendship (X) had two basic meanings (Y): helping (YH) and playing (YP). In Poland, friendship meant playing (YP) and being together after school (YBT). The children in both countries associated friends (target domain) with (source domain) certain people (FP), character quality (FCH), activity (FA) and (FO) object/places. A comparison of the results demonstrates a difference in the number of friends the children claimed to have in Poland versus the USA. Additionally, the research showed that the American children drew only their friends without including themselves, while the Polish children included themselves in their pictures.
Źródło:
The New Educational Review; 2017, 50; 56-69
1732-6729
Pojawia się w:
The New Educational Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena dorobku legislacyjnego i orzeczniczego kształtującego definicję konsumenta na gruncie art. 22¹ kodeksu cywilnego
Evaluation of acquis legislation and jurisprudence in the shaping of the definition of the consumer on the basis of Article 221 of the Civil Code
Autorzy:
Chojecka, Monika
Nowak, Adam
Powiązania:
https://bibliotekanauki.pl/articles/507900.pdf
Data publikacji:
2016-05-31
Wydawca:
Uniwersytet Warszawski. Wydawnictwo Naukowe Wydziału Zarządzania
Tematy:
konsument
kodeks cywilny
definicja
Consumer
Civil Code
definition
Opis:
Artykuł zawiera analizę kodeksowej definicji pojęcia „konsument”. W publikacji przedstawiony jest rys historyczny obrazujący rozwój przedmiotowej kategorii prawnej oraz omówienie jej elementów składowych. Artykuł przybliża również orzecznictwo odnoszące się do interpretacji przedstawianej definicji legalnej.
The article contains the analysis of the definition of a consumer in the light of the provisions of the Polish Civil Code. The paper presents the historical development of the legal category in question as well as discusses its components. Included is also an analysis of selected jurisprudential lines that relate to the interpretation of the presented legal definition.
Źródło:
internetowy Kwartalnik Antymonopolowy i Regulacyjny; 2016, 5, 3; 68-79
2299-5749
Pojawia się w:
internetowy Kwartalnik Antymonopolowy i Regulacyjny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Telemedycyna na tle polskich regulacji prawnych – szansa czy zagrożenie?
Telemedicine against the background of Polish legal rules - opportunity or threat?
Autorzy:
Chojecka, Monika
Nowak, Adam
Powiązania:
https://bibliotekanauki.pl/articles/508330.pdf
Data publikacji:
2016-12-31
Wydawca:
Uniwersytet Warszawski. Wydawnictwo Naukowe Wydziału Zarządzania
Tematy:
telemedycyna
świadczenie zdrowotne
nowelizacja
telemedicine
health benefits
amendment
Opis:
Wykorzystywanie nowoczesnych technologii teleinformatycznych w procesie diagnozowania i leczenia pacjentów może być przyszłością medycyny. Tzw. telemedycyna jest również istotnym zagadnieniem legislacyjnym. W artykule analizie zostały poddane regulacje stanowiące postawę funkcjonowania tej dziedziny w polskim porządku prawnym. Szczególną uwagę poświęcono niedawnym pracom legislacyjnym tworzącym ramy nowego podejścia ustawodawcy do telemedycyny. Publikacja zawiera również ocenę skuteczności funkcjonowania ww. rozwiązań prawnych.
Modern technology found in the diagnostic and treatment process of patients can be the future of medicine. This so-called “telemedicine” is also an important legislative issue. The article analyzes legal rules which are the cornerstone of this field in the Polish legal system. Special attention is placed on recent works devoted to the creation by the legislator of a new approach to the legal framework for telemedicine. The paper also contains an assessment of the effectiveness of the func-tioning of these legal solutions.
Źródło:
internetowy Kwartalnik Antymonopolowy i Regulacyjny; 2016, 5, 8; 74-81
2299-5749
Pojawia się w:
internetowy Kwartalnik Antymonopolowy i Regulacyjny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Recenzje-sprawozdania
Autorzy:
Dawidowicz, Aneta
Nowak, Jakub
Cieciora, Monika
Powiązania:
https://bibliotekanauki.pl/articles/647458.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Źródło:
Annales Universitatis Mariae Curie-Skłodowska, sectio K – Politologia; 2014, 21, 2
1428-9512
2300-7567
Pojawia się w:
Annales Universitatis Mariae Curie-Skłodowska, sectio K – Politologia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in surface water microflora caused by discharge of purified sewage into rivers
Autorzy:
Godela, Agnieszka
Lewańska, Monika
Myga-Nowak, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1179554.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Sewage
river
sewage treatment plant
sewers
water microflora
Opis:
Progressive environmental degradation results in an increase in the number of waters that do not meet the standards in force. Surface waters are particularly vulnerable to pollution because they are receivers of purified water and agricultural or industrial wastewater flow. In addition, the local increase in temperature and the increase amount and availability of nutrients associated with wastewater discharged improves the microbial growth and thus increase their quantity. The treated sewage must meet certain requirements regarding their physicochemical and biological parameters. However, the regulations do not require to check microbiological quality by treatment plants, so the purpose of the study was to determine the impact of discharge of purified wastewater by the "Warta" sewage treatment plant down to Warta river. The study was conducted in 2008-2016 at three collection points near the place of discharge of purified sewage from Warta SA sewage treatment plant. It has been demonstrated that the process of sewage treatment is not enough in terms of microbiological pollution because the water samples collected at the points behind the discharge site of the effluent into the river were characterized by increased abundance and microbiological diversity.
Źródło:
World Scientific News; 2017, 75; 26-32
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stress and burnout syndrome among health care personnel during the COVID-19 pandemic
Stres i wypalenie zawodowe wśród pracowników ochrony zdrowia w okresie pandemii COVID-19
Autorzy:
Golec, Joanna
Nowak, Monika
Malinowski, Mateusz
Szczygieł, Elżbieta
Golec, Edward
Powiązania:
https://bibliotekanauki.pl/articles/8781323.pdf
Data publikacji:
2023
Wydawca:
Krakowska Akademia im. Andrzeja Frycza Modrzewskiego
Tematy:
COVID-19
SARS-CoV-2
burnout syndrome
mental health
health care workers
wypalenie zawodowe
zdrowie psychiczne
pracownicy ochrony zdrowia
Opis:
Introduction: During the COVID-19 pandemic, workload and physical and mental exhaustion became more extensive, especially among health care workers (HCWs). Material and Methods: This study involved 50 people aged 25 to 64, of whom 37 were women and 13 men. These HCWs were physiotherapists (48%), nurses (30%) and physicians (22%), all professionally active during the COVID-19 pandemic. The research was conducted between June and October 2020, using an on-line survey. The COPE, LBQ and ISI questionnaires were used. Results: Analysis of occupational burnout (LBQ) and its various aspects showed that the Deterioration of relations with clients (patients) was significantly higher among those with up to five years and between 15 and 24 years of experience than in the group with 25–35 years of experience. Sense of professional ineffectiveness and Disappointment were significantly higher (p %lt; 0.05) in the group with the most work experience. 30% of the medical workers surveyed obtained a result indicating subliminal insomnia (ISI) and 28% – clinical insomnia. Comparison of COPE and LBQ scores showed that Psychophysical exhaustion (LBQ) correlated negatively with Religious coping (p = 0.032). Deterioration of relations with clients (patients) (LBQ) correlated negatively with such strategies (COPE) as Active coping (p = 0.048), Planning (p=0.006), Positive reinterpretation and growth (p < 0.001). Sense of professional ineffectiveness (LBQ) correlated negatively with Acceptance strategies (p = 0.017) and Behavioral disengagement (p = 0.021). Disappointment correlated positively with the Positive reinterpretation and growth strategy (p = 0.024). Conclusions: The COVID-19 pandemic had an impact on the development of burnout amongst the HCWs surveyed, especially that related to psychophysical exhaustion, a sense of lack of effectiveness and a sense of disappointment. The sleep cycle was affected. Cognitive-behavioral oriented workshops are recommended when facing burnout.
Wprowadzenie: W trakcie trwania pandemii COVID-19 obciążenie pracą oraz fizyczne i psychiczne wyczerpanie były coraz większe, szczególnie wśród pracowników ochrony zdrowia (POZ). Materiał i metody: W badaniu wzięło udział 50 osób w wieku od 25 do 64 lat – 37 kobiet i 13 mężczyzn. Byli to: fizjoterapeuci (48%), pielęgniarki (30%), lekarze (22%), aktywni zawodowo w czasie pandemii COVID-19. Badanie przeprowadzono w okresie od czerwca do października 2020 r. w formie ankiety on-line. Wykorzystano kwestionariusze COPE, LBQ i ISI. Wyniki: Analiza wypalenia zawodowego (LBQ) i jego poszczególnych aspektów wykazała, że Brak zaangażowania w relacje z klientem (pacjentem) był istotnie wyższy w grupie ze stażem pracy do 5 lat oraz 15–24 lat niż w grupie ze stażem 25–35 lat. Poczucie braku skuteczności zawodowej i Rozczarowanie były istotnie wyższe (p %lt; 0.05) w grupie z najwyższym stażem pracy. 30% ankietowanych pracowników medycznych uzyskało wynik ISI wskazujący na obecność bezsenności podprogowej, a 28% bezsenności klinicznej. Analiza korelacji pomiędzy wynikami COPE a LBQ wykazała ujemną korelację pomiędzy Wyczerpaniem psychofizycznym (LBQ) a Zwrotem ku religii (p = 0,032). Brak zaangażowania w relacje z klientem (LBQ) ujemnie korelował z takimi strategiami (COPE) jak: Aktywne radzenie sobie (p = 0,048), Planowanie (p = 0,006), Pozytywne przewartościowanie i rozwój (p < 0.001). Poczucie braku skuteczności zawodowej (LBQ) było ujemnie skorelowane ze strategiami Akceptacji (p = 0,017) i Brakiem zaangażowania (p = 0,021). Rozczarowanie dodatnio korelowało ze strategią Pozytywne przewartościowanie i rozwój (p = 0,024). Wnioski: Pandemia COVID-19 miała wpływ na rozwój wypalenia zawodowego badanych pracowników ochrony zdrowia, zwłaszcza wypalenia związanego z wyczerpaniem psychofizycznym, poczuciem braku skuteczności i poczuciem rozczarowania. Wpłynęło to na cykl snu. W obliczu wypalenia sugeruje się warsztaty poznawczo-behawioralne.
Źródło:
Państwo i Społeczeństwo; 2023, XXIII, 1; 25-45
1643-8299
2451-0858
Pojawia się w:
Państwo i Społeczeństwo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Plant Identification and Significance in Funeral Traditions Exemplified by Pillow Filling from a Child Crypt Burial in Byszewo (18th/19th centuries)
Autorzy:
Jarosińska, Marta
Nowak, Sebastian
Noryśkiewicz, Agnieszka M.
Badura, Monika
Powiązania:
https://bibliotekanauki.pl/articles/498067.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Instytut Archeologii Uniwersytetu Rzeszowskiego. Muzeum Okręgowe w Rzeszowie
Tematy:
archaeobotany
funeral plants
crypts
child burial
Byszewo
Northern Poland
Opis:
Plants have always played an important role in funeral customs. To understand their true meaning, close cooperation between the archaeologist and the archaeobotanist is needed, not only during the final interpretation, but from the very beginning, at the stage of collecting materials. In the article, plants’ identification, using both pollen and macroremainsanalysis, was described, based on one of the children’s burial from the Holy Trinity Church in Byszewo (18th/19th centuries). The filling of the coffin pillow consisted of numerous hop (Humulus lupulus) macroremains, the representation of which was very low in pollen sample. This is due to the fact that only female specimens of hop were inserted into the coffin. To determine the reason for using hops in funeral practices in Byszewo, ethnobotanical data was used. The following research indicates the need for the cooperation between two methods of plant identification. It will allow misinterpretations of botanical findings to be avoided
Źródło:
Analecta Archaeologica Ressoviensia; 2019, 14; 187-197
2084-4409
Pojawia się w:
Analecta Archaeologica Ressoviensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A subjective sense of the quality of life in adolescents from the Świętokrzyskie Voivodship
Autorzy:
Jasińska, Małgorzata
Sikorski, Marek
Wójcik, Tomasz
Chmielewski, Jarosław
Florek-Łuszczki, Magdalena
Sierpiński, Radosław
Szpringer, Monika
Nowak-Starz, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/2085763.pdf
Data publikacji:
2021-06-28
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
self-assessment
adolescents
quality of live
KIDSCREEN-52 questionnaire
Świętokrzyskie Voivodship
diagnostic survey
Opis:
ObjectivesThe measurement of the health-related quality of life (HRQOL) is one of the most important methods for self-assessment of health, which makes it possible to identify irregularities in the physical, mental and social functioning. The aim of the research was to determine HRQOL using the Health Related Quality of Life Questionnaire for Children and Young People (the KIDSCREEN-52 questionnaire) – the instrument recommended by the World Health Organization – which makes it possible to distinguish groups of adolescents with a diversified subjective sense of the quality of life.Material and MethodsThe study involved a group of 871 adolescents, 411 boys and 460 girls, aged 13–16 years, residing in the Świętokrzyskie Voivodship. The method of a diagnostic survey was used in the research. The KIDSCREEN-52 questionnaire, which is an instrument for examining the HRQOL of adolescents, was employed in the study. The k-means clustering method was applied, which made it possible to establish 3 groups of adolescents with a different subjective sense of the quality of life.ResultsThree groups of adolescents with a diversified subjective sense of the quality of life (high, average, low) were identified using the KIDSCREEN-52 questionnaire. The subjective quality of life in the majority of the respondents was high, in particular in those living in rural areas. The surveyed boys with a high subjective quality of life showed a significantly higher self-esteem, acceptance and peer support than the surveyed girls.ConclusionsThe KIDSCREEN-52 questionnaire is an accurate and sensitive tool for assessing HRQOL. It allows identifying 3 groups of adolescents with a diversified subjective sense of the quality of life. It can form the basis for further diagnosis of the bio-psycho-social functioning of adolescents.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2021, 34, 3; 415-425
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Treated sewage as an additional source of dangerous bacteria in rivers such as Listeria spp.
Autorzy:
Lewańska, Monika
Godela, Agnieszka
Myga-Nowak, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1179558.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Listeria
Listeria monocytogenes
listeriosis
sewage sludge
treated sewage
wastewater
Opis:
Purified water daily discharged to surface water from local sewage treatment plants can cause illnesses people and animals in nearby areas. Sometimes they also contribute to the development of diseases in much bigger region range. Often the cause of such infections are pathogenic Listeria rods especially Listeria monocytogenes, which are not eliminated in the technological process of wastewater treatment carried out by local sewage treatment plants. Therefore, the purpose of the study was to investigate the influence of the sewage treatment plant on the presence of Listeria bacteria and to estimate the potential hazard resulting from its occurrence in the water of the Warta River. Research points were located on the Warta River before and after the discharge of purified sewage through the treatment plant, also a direct exit of purified wastewater was examined. Samples were filtered and then estimated the growth characteristics of typical colonies on the selected diagnostic media were estimated and isolated microorganisms were characterized. Samples were filtered and then it had been defining the growth characteristics of typical colonies on the selected diagnostic media, finally isolated microorganisms were described. Studies have shown that the local wastewater treatment plant has a strong influence on the microbial quality of the Warta River and has shown strong impurity with Listeria rods, including pathogenic strains. Bearing in mind the results obtained, it can be stated that direct or indirect contact with receivers of the water of purified sewage poses a real threat to the health and even life of humans and animals.
Źródło:
World Scientific News; 2017, 75; 50-55
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gelsolin in human colon adenocarcinoma cells with different metastatic potential
Autorzy:
Litwin, Monika
Mazur, Antonina
Nowak, Dorota
Mannherz, Hans
Malicka-Błaszkiewicz, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1040503.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
gelsolin
actin
cancer
Opis:
Gelsolin, one of a major actin-binding proteins, is involved in the regulation of actin cytoskeleton organization by its severing and capping activity towards actin filaments. Human colon adenocarcinoma cell line LS180 and its selected variants of different metastatic potential were used to check for a correlation between gelsolin level, its subcellular localization and the invasive capacity of cells. Based on immunoblotting experiments, a decreased level of gelsolin was detected in the most invasive 5W subline when compared to the parental cell line LS180. The intracellular distribution of actin filaments and gelsolin in colon adenocarcinoma cells was examined by confocal microscopy. In the 5W subline, unlike in the other examined cells, gelsolin was colocalized with filamentous actin at the cell periphery. In summary, in human colon adenocarcinoma cells, gelsolin level and its subcellular distribution seem to correlate with their metastatic potential.
Źródło:
Acta Biochimica Polonica; 2009, 56, 4; 739-743
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wykorzystanie metody elementów skończonych w modelowaniu pola magnetycznego
The use of finite element method in modeling the magnetic field
Autorzy:
MATYJASZCZYK-NOWAK, Monika
Powiązania:
https://bibliotekanauki.pl/articles/455083.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Rzeszowski
Tematy:
elektromagnetyzm
magnetyzm
metoda elementów skończonych
MES
dydaktyka
electromagnetism
magnetism
finite element method
teaching
Opis:
W artykule przedstawiono możliwości zastosowania metody elementów skończonych w analizie i pomiarach wielkości opisujących pole magnetyczne. Pomiary przeprowadzono w programie QuickField. Wykorzystanie metody symulacji w obrębie indukcyjności umożliwia ocenę pracy modelu w ustalonych warunkach zewnętrznych oraz wprowadzenie modyfikacji konstrukcyjnych układu. Program ten może być również środowiskiem dydaktycznym w kształceniu zdalnym i technicznym uczniów.
In the paper have been presented the possibility of using the finite element method in the analysis and measurements that describe the size of the magnetic field. Measurements were performed in program QuickField. The use of simulation methods within the inductance model allows evaluation of the work under specified conditions, external and structural modifications of the system. This program can be also using in environment educational in technical education students.
Źródło:
Edukacja-Technika-Informatyka; 2014, 5, 1; 642-647
2080-9069
Pojawia się w:
Edukacja-Technika-Informatyka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Influence of the 6-month Course of Nordic Walking on Patient with Parkinsons Disease - a Case Report
Autorzy:
Musiał, Paula
Michalik, Monika
Nowak, Ewelina
Szefler-Derela, Justyna
Powiązania:
https://bibliotekanauki.pl/articles/1055113.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
Nordic Walking
Parkinson’s disease
physiotherapy
Opis:
A person with Parkinson's disease has bigger problems with maintaining the stability than the healthy person. Nordic Walking is a safe kind of physical activity for elderly people. The aim of this study is to present the influence of a 6-month therapy of the Nordic Walking on the imbalance and the risk of falls for 66-years-old patient with Parkinson's disease. On the basis of results of 4 tests, performed both at the beginning and at the end of the Nordic Walking therapy, we have made a comparison of patient’s changes before and after 6 months of rehabilitation. the DGI test, the PD patient received 18 points. After he got 22 points. In the Functional Reach Test ( FR), while attempting to reach forward, reached out for 23 cm before the therapy, and 31 cm after the therapy. In the test and go up the patient got a time of 63 seconds, after therapy the time was reduced to 45 s. Nordic Walking is a safe kind of physical activity for people with Parkinson's disease. It reduces muscle tension, and improves joint function.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2017, 20, 4; 31-38
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
COMPARISON OF ARTIFICIAL HYDROPHILIC AND LIPOPHILIC MEMBRANES AND HUMAN SKIN TO EVALUATE NIACINAMIDE PENETRATION IN VITRO
Autorzy:
Nowak, Anna
Church, Martin K.
Duchnik, Wiktoria
Różewicka-Czabańska, Monika
Bielecka-Grzela, Stanisława
Prowans, Piotr
Pietriczko, Jan
Czapla, Norbert
Bargiel, Piotr
Klimowicz, Adam
Powiązania:
https://bibliotekanauki.pl/articles/895721.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
penetration
Franz diffusion cell
Niacinamide (Vitamin B3)
artificial membrane
human skin
Opis:
The evaluation of skin penetration of active substances from topical preparations is a pre-clinical requirement in the pharmaceutical industry. While in vitro preparations of human or animal skin are frequently used the development of artificial lipophilic and hydrophilic membranes with similar properties to human or animal skin need to be developed. This preliminary study compared the in vitro permeation of niacinamide (vitamin B3), which is used as a model drug, across artificial hydrophilic and lipophilic membranes with iv vitro penetration across human skin. The experiments were carried out in Franz diffusion cells. Artificial membranes were filter paper impregnated with either collodium (hydrophilic), stearic acid, cetyl alcohol or cetyl alcohol + cholesterol (lipophilic). Acidic and neutral hydrogel and emulsion (pH 5.4 and 7.4) containing 0.5% of niacinamide were applied to membranes for up to 4 hours. Niacinamide permeated hydrophilic better than lipophilic membranes. There were no significant differences between the cumulated amounts of niacinamide that penetrated artificial lipophilic membranes consisting of, stearic acid, cetyl alcohol and cholesterol as compared with human skin in vitro. Also, hydrogel and emulsion solvents gave similar results. In conclusion, these artificial membranes seem to be a promising alternative to human or animal skin.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 271-279
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł

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