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    Wyświetlanie 1-4 z 4
    Tytuł:
    THREE TIMES E: HR CHALLENGES FOR TIMES OF CRISIS
    Trzy razy E. Wyzwania HR na czas kryzysu
    Autorzy:
    Narkiewicz-Tarlowska, Joanna
    Dziechciarz, Pawel
    Powiązania:
    https://bibliotekanauki.pl/articles/598480.pdf
    Data publikacji:
    2009-10-15
    Wydawca:
    Instytut Pracy i Spraw Socjalnych
    Tematy:
    HRM DURING CRISIS
    Opis:
    The broad wave of crisis spreading around the world is not conducive to investment in people. It arrests HR initiatives and blocks personnel budgets. The position of personnel departments is threatened. As was the case a few years ago at the start of the current decade, companies are taking up a strategy of surviving at any, often excessive, cost. On the other hand, it is universally known that the greatest careers start and develop during turning points. Crisis for HR departments may prove to be an opportunity not only for survival, but for a permanent improvement in the importance and status of the personnel function to the role of a strategic partner in the organization. Prerequisite is the proper identification of challenges that come with an economic downturn and facing those challenges.
    Źródło:
    Zarządzanie Zasobami Ludzkimi; 2009, 5(70); 15-22
    1641-0874
    Pojawia się w:
    Zarządzanie Zasobami Ludzkimi
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Znaczenie kliniczne ekspresji neuropiliny-1 u chorych na raka jajnika
    Clinical signifi cance of neuropilin-1 expression in patients with ovarian cancer
    Autorzy:
    Klasa-Mazurkiewicz, Dagmara
    Narkiewicz, Joanna
    Milczek, Tomasz
    Lipińska, Barbara
    Emerich, Janusz
    Wydra, Dariusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1030638.pdf
    Data publikacji:
    2009
    Wydawca:
    Medical Communications
    Tematy:
    angiogenesis
    lymphangiogenesis
    neuropilin
    ovarian cancer
    prognostic factors
    angiogeneza
    czynniki prognostyczne
    kluczowe: rak jajnika
    limfangiogeneza
    neuropilina
    Opis:
    Background: Angiogenesis is a key process in the development of a malignant tumor, enabling both growth of primary lesion and spread of metastases. Most potent stimulators of normal and pathological angiogenesis are proteins of the vascular endothelial growth factor (VEGF) family. Regulation of angiogenesis process is also mediated by neuropilin- 1 (NP-1), as coreceptor VEGFR-2. NP-1 plays a crucial role controlling both normal angiogenesis during embryonal development and pathological angiogenesis in malignant tumors. The aim of this paper was to assess NP-1 expression in ovarian cancer and to analyze correlations between NP-1 expression and selected clinical-pathological factors in a group of ovarian cancer patients. Material and method: Analyzed was the relative level of NP-1 in 168 surgical specimens collected during surgical procedures performed at the Department of Oncologic Gynecology of Medical University in Gdańsk. Tissue samples included: 32 healthy tissues, 42 benign tumors, 10 borderline tumors, 76 ovarian cancers, 8 metastatic tumors. Relative NP-1 level was assessed using Western blotting technology. Results: Overexpression of NP-1 was seen significantly more often in early clinical stages of ovarian cancer (p=0.01), in cancers other than serous (p=0.04) and in patients with peritoneal exudate (p=0.03). Log-rank test did not reveal any significant correlation between NP-1 expression and favorable response to chemotherapy, disease-free survival or total survival time. Conclusions. Elevated NP-1 level seen in initial clinical stages of ovarian cancer may indicate crucial role of neoangiogenesis in the early phase of tumor development.
    Źródło:
    Current Gynecologic Oncology; 2009, 7, 4; 237-247
    2451-0750
    Pojawia się w:
    Current Gynecologic Oncology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Escherichia coli small heat shock proteins IbpA/B enhance activity of enzymes sequestered in inclusion bodies.
    Autorzy:
    Kuczyńska-Wiśnik, Dorota
    Żurawa-Janicka, Dorota
    Narkiewicz, Joanna
    Kwiatkowska, Joanna
    Lipińska, Barbara
    Laskowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1041504.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    protein aggregation
    inclusion bodies
    IbpA/B
    Opis:
    Escherichia coli small heat shock proteins, IbpA/B, function as molecular chaperones and protect misfolded proteins against irreversible aggregation. IbpA/B are induced during overproduction of recombinant proteins and bind to inclusion bodies in E. coli cells. We investigated the effect of ΔibpA/B mutation on formation of inclusion bodies and biological activity of enzymes sequestered in the aggregates in E. coli cells. Using three different recombinant proteins: Cro-β-galactosidase, β-lactamase and rat rHtrA1 we demonstrated that deletion of the ibpA/B operon did not affect the level of produced inclusion bodies. However, in aggregates containing IbpA/B a higher enzymatic activity was detected than in the IbpA/B-deficient inclusion bodies. These results confirm that IbpA/B protect misfolded proteins from inactivation in vivo.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 4; 925-931
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster
    Autorzy:
    Zurawa-Janicka, Dorota
    Kobiela, Jaroslaw
    Stefaniak, Tomasz
    Wozniak, Agnieszka
    Narkiewicz, Joanna
    Wozniak, Michał
    Limon, Janusz
    Lipinska, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1040768.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    17-β-estradiol
    HtrA proteases
    estrogen-induced carcinogenesis
    oxidative stress
    Opis:
    Serine proteases HtrA1 and HtrA2 are involved in cellular stress response and development of several diseases, including cancer. Our aim was to examine the involvement of the HtrA proteins in acute oxidative stress response induced in hamster kidney by estrogen treatment, and in nephrocarcinogenesis caused by prolonged estrogenization of male Syrian hamster. We used semi-quantitative RT-PCR to estimate the HtrA1 and HtrA2 mRNA levels in kidney tissues, and Western blotting to monitor the amount of the HtrA proteins. Within the first five hours following estrogen administration both HtrA1 mRNA and the protein levels were increased significantly. No changes in the expression of HtrA2 were observed. This indicates that HtrA1 may be involved in the response against oxidative stress induced by estrogen treatment in hamster kidney. During prolonged estrogenization, a significant reduction of the HtrA1 mRNA and protein levels was observed after 6 months of estradiol treatment, while the expression of HtrA2 was significantly elevated starting from the third month. This suggests an involvement of the HtrA proteins in estrogen-induced nephrocarcinogenesis in hamster. Using fluorescence in situ hybridization we localized the HtrA1 gene at the qb3-4 region of Syrian hamster chromosome 2, the region known to undergo a nonrandom deletion upon prolonged estrogenization. It is possible that the reduced level of HtrA1 expression is due to this chromosomal aberration. A full-length cDNA sequence of the hamster HtrA1 gene was obtained. It codes for a 50 kDa protein which has 98 and 96% identity with mouse and human counterparts, respectively.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 1; 9-20
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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