Autor: Musik, Irena - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Lithium as a prooxidant? A possible protective role of selenium - in vitro study
Autorzy:: Musik, Irena
Kiełczykowska, Małgorzata
Rajtar, Barbara
Świątek, Łukasz
Polz-Dacewicz, Małgorzata
Kocot, Joanna
Powiązania:: https://bibliotekanauki.pl/articles/991060.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: lithium carbonate
sodium selenite
total antioxidant status
antioxidants
fadu (atcc htb-43) cells
vero (ecacc no.
84113001) cells
Opis:: Introduction and objective. Lithium is used in medicine but its application may cause diverse side effects. Selenium has been found to show protective properties against negative influence of different harmful factors. This study was aimed at evaluating the influence of non-toxic dose of lithium on antioxidant parameters in FaDu (ATCC HTB-43) and Vero (ECACC No. 84113001) cell lines as well as the possible protective effect of non-toxic concentration of sodium selenite. Materials and method.The cells were subjected to 0.17 mmol/L of Li2CO3 and/or 2.9 μmol/L of Na2SeO3 · 5H2O for Vero as well as 0.47 mmol/L of Li2CO3 and/or 3.0 μmol/L of Na2SeO3 · 5H2O for FaDu cells. The incubation was continued for the subsequent 72 h. In the cells total antioxidant status (TAS) values, activities of antioxidant enzymes – superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as the reduced glutathione concentration (GSH) were determined. Results and conclusion. In Vero cells lithium decreased all studied parameters, particularly GPx. Selenium co-treatment showed a distinct protective effect. In FaDu cells the similar effect was observed only in case of GSH. The results point to differences in action of lithium and selenium in physiological and pathological state. As long-term lithium therapy is applied in psychiatric patients the results regarding Vero line let suggest that selenium might be considered as an adjuvant alleviating side effects of Li-treatment.
Źródło:: Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Homeostasis of chosen microelements in liver of rats receiving lithium and/or selenium orally
Autorzy:: Kiełczykowska, Małgorzata
Kopciał, Ewelina
Marzec, Zbigniew
Musik, Irena
Powiązania:: https://bibliotekanauki.pl/articles/972530.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: lithium
selenium
iron
manganese
copper
zinc
male rats
liver
Opis:: Introduction and objective. Lithium and selenium have been the subjects of extensive research for many years. Concern about the physiological action of these elements results from the application of lithium in medicine, as well as the beneficial influence of selenium supplementation in different pathological states. However, little data are available concerning their effect on the homeostasis of essential microelements in organs. Therefore, the aim of the current study was to evaluate the influence of lithium and/or selenium administration on homeostasis of iron, zinc, copper and manganese in the liver of rats. Materials and method. The experiment was carried on 24 male Wistar rats (4 groups of 6 animals) subjected to the treatment with: group I (control) – saline; group II – lithium carbonate at a dose of 2.7 mg Li/kg b.w.; group III – sodium selenite at a dose of 0.5 mg Se/kg b.w.; group IV – both lithium carbonate and sodium selenite at the doses mentioned above. Administration was performed for 6 weeks, once a day by stomach tube, in the form of water solutions. Results. The tissue content of zinc, iron and manganese showed no statistical differences among the studied groups. Zn was slightly decreased in group III vs. control and group II. Fe was insignificantly enhanced in groups II and IV vs. control. Mn in group IV was slightly increased vs. groups II and III. Cu in group III was significantly decreased vs. group IV and slightly depleted vs. groups I and II. Conclusion. With the exception of Cu in the Se-treated group, lithium and/or selenium did not affect the studied microelements’ liver homeostasis in a significant way. These results may contribute to the knowledge of essential microelements homeostasis in human organisms undergoing lithium therapy, and/or selenium supplementation.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 132-135
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Glutathione level and glutathione reductase activity in serum of coronary heart disease patients
Autorzy:: Zuzak, Ewa
Horecka, Anna
Kiełczykowska, Małgorzata
Dudek, Aneta
Musik, Irena
Kurzepa, Joanna
Kurzepa, Jacek
Powiązania:: https://bibliotekanauki.pl/articles/972495.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: glutathione reductase
glutathione
coronary heart disease
oxidative stress
Opis:: Introduction. Oxidative stress induced by the generation of excess reactive oxygen species is one of the cause of atherosclerosis finally leading to coronary heart disease (CHD). Glutathione reductase (GR), a flavoprotein antioxidant enzyme, regenerates glutathione (GSH) from its oxidized form, which is essential for scavenging of hydrogen peroxide by glutathione peroxidase. The aim of this study was to analyze the activity of GR and GSH level in serum of patients with various stages of CHD. Materials and method. Sixty consecutive patients with diagnosis of stable angina (SA, n=20), unstable angina (UA, n=20) and non-fatal myocardial infarction (MI, n=20) together with 20 healthy control subjects were enrolled. Venous blood samples were collected just before the coronary catheterization procedure (in study patients). GR activities and GSH concentration was determined using commercially available colorimetric kits. Results. The highest GR activity and GSH serum level was noticed in UA patients. However, statistical evaluation showed that only glutathione reductase activity was significantly higher in serum obtained from myocardial infarction patients, compared to stable angina pectoris patients (19.52 ± 13.88 vs 11.63 ± 5.45 nmol/min/ml for MI and SA, respectively; p<0.048). There were no significant differences in GSH between the CHD patients and controls. Conclusion. The elevated activity of glutathione reductase in serum of patients with unstable angina pectoris and myocardial infarction suggests the role of antioxidant system acute coronary syndromes.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 103-105
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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