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    Wyświetlanie 1-7 z 7
    Tytuł:
    Modification of solid substrates by controlled adsorption of macroions
    Modyfikacja substratów stałych przez kontrolowaną adsorpcję makrojonów
    Autorzy:
    Morga, Maria
    Adamczyk, Zbigniew
    Powiązania:
    https://bibliotekanauki.pl/articles/1853726.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    adsorption of macroions
    electrokinetic characteristics of macroions
    PAH and PDDA adsorption
    macroion layers on solid substrates
    streaming potential measurements
    zeta potential of macroion molecules
    adsorpcja makrojonów
    charakterystyka makrojonów
    adsorpcja PAH i PDDA
    warstwa makrojonów na powierzchniach ciał stałych
    pomiary potencjału przepływu
    potencjał zeta makrocząstek
    Opis:
    Mechanisms of cationic macroion adsorption on negatively charged solid substrates comprising mica and silica were thoroughly discussed. Attention was focused on poly(allylamine hydrochloride) (PAH), poly(dimethyl-diallylammonium chloride) (PDDA) and poly-L-lysine (PLL) widely used in practice. The bulk physicochemical parameters controlling the macroion adsorption such as the diffusion coefficient, hydrodynamic diameter, intrinsic viscosity and electrophoretic mobility were discussed. The latter, experimentally accessible parameter, enables to determine the electrokinetic charge of macroion molecules, their isoelectric points and zeta potentials. On the other hand, the analysis of the hydrodynamic diameter and the intrinsic viscosity data confirmed a largely elongated shape of the molecules even for concentrated electrolyte solution. These results are used for a quantitative interpretation of macroion adsorption at solid substrates investigated using in situ streaming potential measurements. It is confirmed that the macroion mostly adsorb in the side-on orientation forming layers whose maximum coverage can be regulated by the ionic strength of the solution. This streaming potential method can also be used to determine the stability of the layers performing controlled desorption kinetic measurements. It is shown that at pH 7.4 the PDDA and PLL macroions form stable layers on solid substrates, which can be used for an efficient immobilization of negatively charged macroions and bioparticles comprising protein molecules and viruses.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 9-10; 1157-1179
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    HEALTH RELATED QUALITY OF LIFE OF THE PATIENT WITH IMMUNOGLOBULIN G4-RELATED CRANIAL HYPERTROPHIC PACHYMENINGITIS (IGG-HP) CAUSING DISTURBANCES OF COGNITIVE CONTROL TREATED WITH NEUROFEEDBACK
    Autorzy:
    Morga, Rafał
    Radwańska, Edyta
    Trystuła, Mariusz
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/2138049.pdf
    Data publikacji:
    2021-09-13
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    qEEG
    atDCS
    seizures
    cognitive control
    quality of life
    Opis:
    Health related quality of life (HRQoL) is the most desired patient centered outcome of medical care (Leplége et al. 1997). In patients with long term illness, such as Hypertrophic Pachymeningitis (HP) still under diagnosis, therefore no possible to properly cure, it might be the only outcome achievable (Netuveli et al. 2005; Trystuła 2017). The problem becomes even more serious when occurs in young person: starting a family and caring for children becomes hard or even impossible, because of his/her physical and psychical conditions. Most clinicians are aware of the importance for quality of life of this functional limitation, but there are no articles describing this problem in the literature. We aimed to fill this gap in knowledge. 29 year old patient, a car mechanic, married, with 4-year-old son, with the long his- tory of the illnes, and especially persistent, diffuse, non-specific headaches, frequent seizures and cognitive deterioration which have been particularly troublesome recently. He was finalny diagnosed with Hypertrophic Pachymeningitis (HP) associated with Immunoglobulin G4-related (IgG4) with the use of specific diagnostic criteria for HP associated with IgG4-RD (IgG4-HP), which rely on histopathologic analysis (Lindstrom et al. 2010; Lu et al 2014). Computed tomography (CT) of the head showed massive calcifications visible along the cerebellar tentorium on the right side, along the cerebral falx, as well as on dura mater on the cranial vault of both cerebral hemispheres. The patient was diagnosed with common variable immunodeficiency (D 83), thrombocytopenia, chronic EBV hepatitis and epilepsy. IgG4-HP was confirmed by CT, MRI and biopsy (IGg4-RHP antibody was detected). The treatment with steroids, and immunosuppressive therapy (RTX) was introduced (as it was suggested by Levraut et al. (2019). It should be stressed that he had a significantly reduced health-related quality of life (HRQoL), mainly because of long-lasting illness, diverse symptoms, often hospitalization, complex differential diagnosis, and especially biopsy which requires neurosurgical intervention, which affect his physical and mental well-being, especially cognitive control, and not possibility to take care of his family. To help the patient we introduce HBI methodology (Kropotov 2016), that is an evaluation of working brain in milliseconds. Quantitative electroencephalography (qEEG), event-related potentials (ERPs) and low-resolution sLORETA tomography were performed. We did not found any paroxysm of 3 Hz rhythm in Eyes Closed (EO) and in Eyes Open (EO) conditions, however the ERPs deviations from the reference indicate deficit of cognitive control (decrease of P3 NOGO wave in comparison to 100 persons from the normative data base from the Human Brain Index in Chur, Switzerland). Therefore, the patient was offered Transcranial Direct Current Stimulation (atDCS) combined with goal-oriented psychotherapy program. It was found that after 40 days of therapy, cognitive control returned, which was translated into a better quality of life related to the patient's health, measure in the 36-Item Short Form Survey (SF-36). The patient returned to his previous job as a head of car mechanic service. Final diagnosis of IgG4-HP and subsequently, proper farmacotherapy, and introduction of HBI methodology allowing for the selection of an adequate method of neurotherapy, for our patient the transcranial direct current stimulation (atDCS) combined with goal- oriented psychotherapy, was helpful in the improvement of his quality of life.
    Źródło:
    Acta Neuropsychologica; 2021, 19(3); 373-388
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of the effectiveness of electroencephalographic training with neurofeedback (EEG-NFB) for a patient with dysexecutive syndrome after neurosurgery of two brain aneurysms detected after COVID-19 disease
    Autorzy:
    Morga, Rafał
    Mirski, Andrzej
    Buczaj, Agnieszka
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/28763508.pdf
    Data publikacji:
    2023-08-07
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    brain fog
    cerebral aneurysm clipping
    executive dysfunction
    HBI methodology
    Opis:
    The purpose of this study is to evaluate the effectiveness of functional neuromarker- based electroencephalographic training with neurofeedback (EEG-NFB) for a patient with dysexecutive syndrome following neurosurgical operation of two brain aneurysms of the left and right middle cerebral artery (MCA) detected after COVID-19 disease. A right-handed, 56-years-old, not vaccinated, patient, became infected with SARS- CoV-2 and contracted COVID-19 with the manifestation of respiratory symptoms, high fever, dyspnea and low saturation of 79% Sa02. She was hospitalized at the Infectious Disease Unit, where a positive RT PCR test for COVID-19 was confirmed. The acute phase of COVID-19, during which oxygen therapy was administered, lasted two weeks and was complicated by brain fog and transient hypertension (175/100). There were no signs of focal damage to the central nervous system. She was discharged home in a good general and neurological condition. After returning home, the patient was unable to cope with daily functioning, as she said her brain fog continued to persist, manifesting itself as executive dysfunction. Eight weeks after the infection, the patient's neuropsychiatric condition worsened. On CT and MRI examination of the cerebral vessels, she was diagnosed with the presence of two aneurysms located on the left and right middle cerebral arteries (MCA). She was operated on at the Department of Neurosurgery and Neurotraumatology, where a pterional craniotomy and clipping of both brain aneurysms was performed. The Yasargil titanium clip was placed on the aneurysm neck. During the surgery procedures, performed two months apart, there were no signs of a history of subarachnoid haemorrhage and the post-operative period was uneventful, except for a drooping right-eye eyelid (after the second surgery) with a tendency to improve. Each time, the patient was mobilized and walked independently and was discharged home in a good general condition, with no neurological symptoms, except for executive dysfunction. Approximately five months after the SARS-CoV-2 infection (four weeks after the second surgery), her executive dysfunction worsened. Neuropsychological testing using Mindstreams™ Interaction Computer Tests revealed moderate Dysexecutive Syndrome (DES), while neurophysiological testing using qEEGs, ERPs and sLORETA tomography, a functional neuromarker of frontotemporal area dysfunction. The EEG pattern was characterized by excessive, slow (about 6 Hz) activity in frontotemporal areas, which indicated the progressive loss of cognitive control over time. The patient was offered an electroencephalographic training protocol with neurofeedback (EEG-NFB) based on the detected functional neuromarker, which reduced DES. The improvement achieved during therapy was statistically significant [compared to the normative database (Human Brain Index, HBI)]. In effect, the patient's quality of life improved, as she herself pointed out. Her symptoms of brain fog and DES disappeared and she returned to her previous work as a waitress. The Human Brain Index (HBI) methodology can be successfully used in the neurodiagnosis and implementation of individualized electroencephalographic training with neurofeedback (EEG-NFT) for patients with executive dysfunction after contracting longCOVID.
    Źródło:
    Acta Neuropsychologica; 2023, 21(3); 279-303
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The amelioration of behavioral disturbances in TBI patients with Chronic Frontal Syndrome after treatment in different rehabilitation programs
    Autorzy:
    Pąchalska, Maria
    Góral-Półrola, Jolanta
    Mirski, Andrzej
    Grzywniak, Celestyna
    Łuckoś, Maria
    Morga, Rafał
    Powiązania:
    https://bibliotekanauki.pl/articles/2106140.pdf
    Data publikacji:
    2019-08-23
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    neurological disturbances
    emotional disorders
    behavioral disorders
    cognitive impairment
    Frontal Behavioral Inventory
    Opis:
    We evaluated the effectiveness of three different rehabilitation programs for chronic behavioral disorders in traumatic brain injury (TBI) patients with orbito-frontal damage (OFC), incurred from 13 to 15 years prior to enrollment. From among 547 adult patients with severe TBIs treated neurosurgically from 1999 to 2003, 60 were selected for the study, divided into three groups of 20, matched for age and sex. Each group received one of three different rehabilitation protocols. Group A received a comprehensive program with two components: (1) a 6-month early neuropsychological rehabilitation program targeting cognitive deficits, beginning immediately post-injury, and (2) the “Academy of Life” program, with weekly meetings aimed at reducing behavioral disorders in social transactions. Group B received only cognitive rehabilitation, while Group C received only the “Academy of Life” progam. The Frontal Behavioral Inventory (FBInv) was used to assess behavioral disorders at baseline and again after completion of the study. At baseline, all 60 patients still displayed all or most of the common behavioral symptoms characteristic of frontal syndrome. The improvement achieved by group A (the comprehensive program) was significantly better upon completion of the study than that shown by the patients in groups B (cognitive only) and C (social skills only). A comprehensive program of rehabilitation, which combines early neuropsychological rehabilitation of cognitive deficits with the “Academy of Life” program, aimed at improving social skills, proved to be more effective than either of these two components administered without the other
    Źródło:
    Acta Neuropsychologica; 2019, 17(3); 245-260
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    THE LONG-TIME EFFECTS OF GROUP THERAPY INTERVENTION ON MARRIAGE COMMUNICATION BETWEEN FLUENT AND NON-FLUENT APHASIC PATIENTS AND THEIR SPOUSES: WHO BENEFITS THE MOST?
    Autorzy:
    Orłowska, Edyta
    Rasmus, Anna
    Góral-Półrola, Jolanta
    Morga, Rafał
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/2137748.pdf
    Data publikacji:
    2018-09-10
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    stroke
    aphasia therapy
    communicative abilities
    quality of life
    Opis:
    Our study aims to assess the long-time effects of group therapy intervention on marriage communication between fluent and non-fluent aphasic patients and their spouses. From the initial cohort of 150 couples four experimental groups have been selected, each comprising 20 subjects: (1) patients with fluent aphasia (FAP) (2) patients with fluent aphasia spouses (FAPS) (3) patients with non-fluent aphasia (NFAP) (4) patients with non-fluent aphasia spouses (NFAPS). All aphasic patients had mild or moderate fluent or nonfluent aphasia, as confirmed by the Cracow Neuropsychological Battery for Aphasia Examination – CNBA (Pąchalska, 1999). To assess the 3 aspects of interactions between spouses: support, engagement and depreciation we use the Communication in Marriage Questionnaire – KKM scores (Kaźmierczak, Plopa, 2008). These patients attended the groups sessions administered according to Pąchalska’s Model of Aphasia Group Therapy (1991a; 1991b) . It was found that after the long-time group intervention the experimental and the control groups of aphasic patients as well as their spouses differ one from another. NFAP as well as FAP therapy patients had higher KKM scores in the support received from their spouses and their spouses engagement in communication and lower scores in depreciation in their spouses’ behavior than did the controls. Also NFAPS evaluated support and engagement expressed by their aphasic partner higher than the control group. However FAPS and the control group KKM scores were quite similar, except for the support expressed by their aphasic partner. Long-time group therapy for patients with aphasia with the presence of caregivers not only improves the communication with significant others but also it is associated with better marital interactions and communication after therapy as reflected in the KKM scores than in the case of the controls, and improves the patient’s and caregivers’ perception of quality of life.
    Źródło:
    Acta Neuropsychologica; 2018, 16(3); 229-241
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    HEALTH-RELATED QUALITY OF LIFE OF A PATIENT FOLLOWING NEUROSURGERY ON GLIOBLASTOMA MULTIFORME (GBM)
    Autorzy:
    Morga, Rafał
    Moskała, Marek
    Adamek, Dariusz
    Góral-Półrola, Jolanta
    Herman-Sucharska, Izabela
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/2137744.pdf
    Data publikacji:
    2018-11-19
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    tumorectomy
    cognitive functions
    HRQoL
    Opis:
    Health-related quality of life (HRQoL) plays a role as a patient-centered meaningful endpoint, assessing the direct clinical benefit for a patient. The inclusion of HRQoL measurements in a glioma patient may provide important data to inform clinicians on treatment decision-making. The aim of the study was to evaluate cognitive decline and HRQoL in the clinical care of a patient following neurosurgery on of glioblastoma multiforme (GBM). A 69-year-old female developed malignant brain glioma in the right temporal-occipital area; this being confirmed by CT and MR study and neuropathological findings. She had complained of headaches, dizziness, nausea, vomiting as well as attention and memory loss, and anxiety, sadness and a slowing down in the performance of daily activities. The symptoms rapidly became worse and she was referred to a neurosurgery department for consultation. She was successfully neurosurgically operated on. She was examined with the use of ne uro psycho logical tests three times: the first examination was conducted before the neurosurgical operation, the second two weeks after, and the third half year after the neurosurgical operation. In the first examination by the standard Polish version of the Mindstreams™ Interactive Computer Tests disturbances for all the tested cognitive functions occurred. The greatest changes were to occur however in the areas of visual-spatial functions. attention, executive functions and memory. In the second test, a return to the norm was achieved for the disturbed cognitive and executive functions. In the third examination (half a year after the neurosurgical operation), the cognitive and executive functions were still not bad, but had slightly decreased. Similar trend was observed in HRQoL. A significant difference in the health profile between the 1 st and 2 nd as well as between 1 st and 3 rd examination was detected for the eight SF-36 domains - HRQoL was improved. While only slight but no significant changes occurred between 2 nd and 3 rd examination. HRQoL was still not bad, but had slightly decreased. The patient after the neurosurgical operation of glioblastoma multiforme (GBM) is capable of carrying out daily activities, but shows some level of reduced complains for functional capacity, pain, general health and vitality, emotional and social functioning for mental health which has led to the impaired HRQoL.
    Źródło:
    Acta Neuropsychologica; 2018, 16(3); 307-319
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Electrophysiological evaluation of the effectiveness of neurofeedback in ameliorating chronic Post-Traumatic Stress Disorder
    Autorzy:
    Morga, Rafał
    Adamek, Dariusz
    MacQueen, Weronika
    MacQueen, Bruce Duncan
    Góral-Półrola, Jolanta
    Bitner-Szulc, Joanna
    Kropotov, Juri D
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/2106173.pdf
    Data publikacji:
    2019-06-19
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    Post-traumatic stress disorder (PTSD)
    cued GO/NOGO task
    P3 NOGO
    neurofeedback
    Opis:
    The aim of our research was to evaluate the effectiveness of neurofeedback in reducing the symptoms of chronic Post Traumatic Stress Disorder (PTSD) in a patient who had developed the syndrome following a recurrence of sphenoid wing meningioma (SOM). EEG spectra and event-related potentials (ERPs) were used to construct an individual neurofeedback protocol and to provide objective monitoring of treatment efficacy. The patient, a 34-year-old female, was diagnosed with a sphenoid wing meningioma (SOM), which had been successfully operated. Three years later, however, the SOM had overgrown at the optic foramen and extended into the optic canal, and the patient had developed blurred vision. She was repeatedly operated, and recovered well. However, due to the recurrence she developed flashbacks, anxiety and sleep difficulties, such that she was unable to continue working in her profession. The symptoms had been occurring for 4 months. ERPs in a cued NOGO task, along with EEG spectra in the resting state and during task performance were used to assess brain functioning, providing the basis for a neurofeedback protocol. Twenty sessions of individually tailored neurofeedback were performed. The patient experienced a reduction of symptoms, accompanied by normalization of ERPs parameters. The results obtained in this case point to the possible benefits of individually tailored neurofeedback protocols in the treatment of PTSD.
    Źródło:
    Acta Neuropsychologica; 2019, 17(2); 179-188
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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