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    Wyświetlanie 1-6 z 6
    Tytuł:
    Preparation and characterization of drug delivery carriers for local administration of sodium alendronate
    Autorzy:
    Posadowska, U.
    Moreira, A.
    Martins, R.
    Pamuła, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/284303.pdf
    Data publikacji:
    2013
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    nanocarriers
    microcarriers
    poly(lactide-co-glycolide) (PLGA)
    osteoporosis
    controlled drug delivery
    sodium alendronate
    Opis:
    Osteoporosis is often treated with the use of sodium alendronate - a drug that inhibits osteoclast-mediated bone resorption and regulates rate of bone turnover. However the disadvantage of oral administration of sodium alendronate is poor drug absorption from the gastrointestinal track and severe adverse effects. Therefore we propose local sustained drug delivery systems based on poly(lactide-co-glycolide) (PLGA) micro- and nanocarriers, which can be administered directly by simple injections to the required place in the body. In this study we encapsulated sodium alendronate into PLGA micro- and nanospheres via a double-emulsification technique. Emulsion formation in different shear rate conditions was used to optimize the size of the carriers. The prepared microspheres were observed under an inverted optical microscope which confirmed their micrometric size. The nanospheres were analyzed by atomic force microscopy, which allowed visualization of their shape and measurement of their size. Moreover the hydrodynamic diameter of the nanospheres, polydispersity index as well as zeta potential were examined by dynamic light scattering. The experiments show that drug release does not depend on the size of the carriers. Analyzed carriers do not cause cytotoxicity upon contact with osteoblast like-cells.
    Źródło:
    Engineering of Biomaterials; 2013, 16, 119; 8-12
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Defining a storage-assignment strategy for precedence-constrained order picking
    Autorzy:
    Trindade, Maria A. M.
    Sousa, Paulo S. A.
    Moreira, Maria R. A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2099652.pdf
    Data publikacji:
    2021
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    storage location assignment problem
    SLAP
    correlated policy
    precedence constrains
    Opis:
    A zero-one quadratic assignment model has been proposed for dealing with the storage location assignment problem when there are weight constraints. Our analysis shows that operations can be improved using our model. When comparing the strategy currently used in a real-life company with the designed model, we found that the new placement of products allowed a reduction of up to 22% on the picking distance. This saving is higher than that achieved with the creation of density zones, a procedure commonly used to deal with weight constraints, according to the literature.
    Źródło:
    Operations Research and Decisions; 2021, 31, 2; 147--160
    2081-8858
    2391-6060
    Pojawia się w:
    Operations Research and Decisions
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Does lean practices implementation impact on company performance? A meta-analytical research
    Autorzy:
    Gonçalves, Telma I. G.
    Sousa, Paulo S. A.
    Moreira, Maria R. A.
    Powiązania:
    https://bibliotekanauki.pl/articles/407127.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    lean manufacturing
    performance evaluation
    meta-analysis
    manufacturing system
    company
    Opis:
    Studies linking the use of lean practices to company performance have been increasing as markets are becoming more competitive and companies are eager for reducing waste and therefore implementing the Lean Management (LM) philosophy to improve performance. However, results from these studies have found various and different impacts and some light is needed. Extant literature was reviewed and, to achieve the research objective, a metaanalysis of correlations was carried out. The obtained results suggest a positive relationship between some lean practices and performance measures. Furthermore, the presence of moderators influencing the relationship between lean practices and performance outcomes is highlighted in our results. To our best knowledge, this is the first research that proposes a comparison of results from primary studies on Lean implementation, by analysing the linear relationship between lean practices and enterprise performance. It fills this gap and therefore represents an important contribution.
    Źródło:
    Management and Production Engineering Review; 2019, 10, 4; 11-24
    2080-8208
    2082-1344
    Pojawia się w:
    Management and Production Engineering Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A longitudinal assessment of myoelectric activity, postural sway, and low-back pain during pregnancy
    Autorzy:
    Moreira, L. S.
    Elias, L. A.
    Gomide, A. B.
    Vieira, M. F.
    Do Amaral, W. N.
    Powiązania:
    https://bibliotekanauki.pl/articles/307463.pdf
    Data publikacji:
    2017
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    elektromiografia
    stabilność postawy
    bóle kręgosłupa
    electromyography
    low back pain
    postural balance
    pregnancy trimesters
    stabilometry
    Opis:
    The present study aimed at investigating the control of upright quiet standing in pregnant women throughout pregnancy, and whether low-back pain exerts influence on this motor task. Methods: Myoelectric signals from postural muscles and stabilometric data were collected from 15 non-pregnant and 15 pregnant women during upright quiet standing. Electromyogram envelopes and center of pressure metrics were evaluated in the control group, as well as in pregnant women in their first and third trimester of pregnancy. A correlation analysis was performed between the measured variables and a low-back pain disability index. Results: Pregnant women exhibited a decreased maximum voluntary isometric activity for all postural muscles evaluated. Additionally, the activity of lumbar muscles during the postural task was significantly higher in the pregnant women in comparison to the non-pregnant controls. The soleus muscle maintained its activity at the same level as the gestation progressed. Higher postural oscillations were observed in the anteroposterior direction while mediolateral sway was reduced in the third trimester of pregnancy. No correlation was detected between the lowback pain disability index and neuromechanical variables. Conclusion: This study provides additional data regarding the functioning and adaptations of the postural control system during pregnancy. Also, we provide further evidence that postural control during quiet standing cannot be used to predict the occurrence of low-back pain. We hypothesize that the modifications in the neural drive to the muscles, as well as in postural sway may be related to changes in the biomechanics and hormonal levels experienced by the pregnant women.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2017, 19, 3; 77-83
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fatigue design and prevention in movable scaffolding systems
    Projektowanie ruchomych systemów rusztowań z uwzględnieniem obciążęń zmęczeniowych
    Autorzy:
    Coelho, H.
    Torres, A.
    Pacheco, P.
    Moreira, C.
    Silva, R.
    Soares, J. M.
    Pinto, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/396185.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Zielonogórski. Oficyna Wydawnicza
    Tematy:
    mosty
    Movable Scaffolding System
    MSS
    system ruchomych rusztowań
    obciążenia zmęczeniowe
    bridge construction
    fatigue
    Opis:
    The Movable Scaffolding System (MSS) is a heavy construction equipment used for casting situ of concrete bridge decks. In the past decades, MSSs have become increasingly complex and industrialized, enlarging its span ranges, incorporating auxiliary elevation machinery and increasing productivity. The tendency nowadays is for strong reutilization and the notion of MSS as a disposable or temporary structure is somehow reductive. The main structure of MSSs may be potentially exposed to fatigue, usually characterized by low number of cycles with significant stress amplitude. Fatigue may be prevented through adequate design; judicious selection of materials; demanding quality control and implementation of robust inspection and maintenance plans.
    System ruchomych rusztowań – Movable Scaffolding System (MSS) to ciężki konstrukcja budowlana wspomagająca wykonanie betonowych mostów. W ostatnich dekadach MSS stały się coraz bardziej skomplikowane i uniwersalne, stanowią element nośny dla wielu urządzeń zarówno podczas wykonywania mostu jak i podczas eksploatacji. Główna struktura systemów MSS może być narażona na efekt zmęczenia, obiążenia zwykle charakteryzują się niską liczbą cykli o znacznej amplitudzie naprężeń. Zmęczeniu można zapobiec poprzez odpowiedni projekt i rozsądny dobór materiałów. Jest to konstrukcja wymagająca ścisłej kontroli jakości i wdrożenia solidnych planów inspekcji i konserwacji.
    Źródło:
    Civil and Environmental Engineering Reports; 2017, No. 25(2); 77-88
    2080-5187
    2450-8594
    Pojawia się w:
    Civil and Environmental Engineering Reports
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Behavior of temporal parameters of the ground reactive forces for the walking of postmenopausal women
    Autorzy:
    Sousa, A. L. de
    Gabriel, R. E. C. dias
    Faria, A. M.
    Aragao, F. R.
    Moreira, M. H. R.
    Powiązania:
    https://bibliotekanauki.pl/articles/306799.pdf
    Data publikacji:
    2015
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    lokomocja
    własności temporalne
    siła
    menopauza
    bipedal locomotion
    temporal parameters
    force platform
    ground reactive force
    menopause
    visceral fat
    Opis:
    The study aimed to examine the influence of body composition and menopause characteristics on certain temporal parameters of the behavior of vertical and anteroposterior components of ground reactive forces, as well as the vertical and anteroposterior rates on the walking of postmenopausal women. The sample consisted of 67 postmenopausal women, average age 59 years. Body composition was assessed by octapolar bioimpedance and ground reactive force by the Kistler force platform. Vertical loading rate correlated positively with age (r = 0.02) and negatively with weight (r = –0.33). The relationship between the rates of vertical loading and unloading associated positively with menopause time (r = 0.27) but negatively with weight (r = –0.27). Vertical unloading rate showed a negative association with abdominal visceral adiposity (r = –0.27). The relationship between the times of the intermediate and final phases of the support correlated significantly with abdominal visceral adiposity (r = 0.25) and fat mass (r = 0.24). The study suggests that fat mass and abdominal visceral adiposity affect the support time, and increased abdominal visceral adiposity implies a slower pre-suspension phase during the walking of postmenopausal women. Hormone replacement therapy was shown to be an enhancer of steeper vertical loading and anteroposterior unloading and longer time in the double support phase, indicating a greater stability of postmenopausal women when walking.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2015, 17, 3; 119-127
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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