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Wyszukujesz frazę "Morawiec, Jan" wg kryterium: Autor

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    Tytuł:
    Retrospective analysis of local recurrence rate in breast cancer patients treated at the department of surgical oncology in Łódź between 2009 and 2013
    Autorzy:
    Morawiec, Jan
    Dziki, Adam
    Morawiec, Zbigniew
    Kołacińska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/1395718.pdf
    Data publikacji:
    2014-02-01
    Wydawca:
    Index Copernicus International
    Tematy:
    breast cancer
    local recurrence
    Opis:
    The aim of the study was to analyze clinicopathological features in breast cancer patients with local recurrence (LR). Material and methods. A retrospective analysis of database of breast cancer patients operated on in the Department of Surgical Oncology in Łódź from 2 January 2009 to 30 June 2013, identified 1080 women with primary breast cancer and 11 patients with LR. Results. LR rate was 0.23% per year. True recurrence (TR) occurred more frequently in patients with luminal B molecular subtype, in HER-2 positive and in triple-negative subgroups. In one patient with luminal -A subtype new primary (triple negative) occurred. TR were noted predominantly in patients with axillary lymph nodes metastases and with luminal B subtype who did not receive adjuvant chemotherapy but were given only endocrine therapy. LR were observed more frequently in patients who did not receive adjuvant radiotherapy or this treatment was delayed. Minimal surgical margins in postoperative specimens measured by pathologist were 4-25 mm, mean 9.5 mm. Conclusions. The LR rate in patients operated on breast cancer in the Department of Surgical Oncology between 2009 and 2013 was low. TR was diagnosed in patients with non- luminal A breast cancer despite wide surgical margins, especially if the patients did not receive optimal adjuvant systemic treatment or radiotherapy was delayed or omitted. Complete cancer excision followed by an immediate implementation of optimal adjuvant treatment seems to be crucial especially in patients with poor tumor biology.
    Źródło:
    Polish Journal of Surgery; 2014, 86, 2; 77-81
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Does the Choice of Hospital Increase a Chance of Survival in Rectal Cancer?
    Autorzy:
    Pawlak, Mariusz
    Morawiec, Zbigniew
    Dziki, Łukasz
    Morawiec, Jan
    Kolacińska, Agnieszka
    Dziki, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1397012.pdf
    Data publikacji:
    2012-12-01
    Wydawca:
    Index Copernicus International
    Tematy:
    rectal cancer
    prognostic factors
    hospital caseload
    5-year survival
    local recurrence
    Opis:
    was to assess the impact of hospital caseload on long-term outcomes of rectal cancer patients. We posed two questions: 1. Does the number of operations carried out in the surgical department influence five year survival and local recurrence rates? 2. Does surgery alone without adjuvant therapy performed in the particular department affect long-term results? Material and methods. 215 consecutive rectal cancer patients treated in six hospitals of the Łódź district between 1994 and 1998 were enrolled into this prospective study. We analyzed patients in whom local excision, low anterior resection, abdominoperineal resection and Hartmann’s procedure were performed. 27 percent of patients received adjuvant therapy such as radio- or chemotherapy or both. Long-term results were compared between high and low volume institutions by means of local recurrence and five year survival rates. Results. In high volume departments; 69.2% of five year survival rates were obtained versus 46.6% for low volume institutions (p=0.00433). Similar differences were noted comparing local recurrence rates between the aforementioned groups: 19.7% versus 36.5%, respectively (p=0.00430). In surgically treated patients who did not receive adjuvant therapy statistically significant differences were found: 76.5% of patients operated on in high volume hospitals survived five years as compared with 42.9% for low caseload institutions (p=0.00013). Local recurrence rates were 15.5% for high caseload institutions and 38.5% for low caseload hospitals (p=0.00042). Conclusions. High volume hospitals achieved better results in rectal cancer patients with regard to five year survival and local recurrence rates. Better outcomes were also obtained in high caseload departments regarding surgically treated patients who did not receive adjuvant therapy.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 12; 638-645
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wielkie mocarstwa wobec Polski : 1919-1945 od Wersalu do Jałty
    Autorzy:
    Karski, Jan.
    Współwytwórcy:
    Morawiec, Elżbieta. Tłumaczenie
    Data publikacji:
    1992
    Wydawca:
    Warszawa : Państwowy Instytut Wydawniczy
    Tematy:
    Rada Ambasadorów (1923)
    Granice Polska 1921-1923 r.
    Polityka wewnętrzna
    Opis:
    Oryg.: "The great powers and Poland: 1919-1945 from Versailles to Yauta" 1985.
    S. 64-74, Wschodnie, północne i południowe granice Polski: charakterystyka odrodzonego państwa.
    Bibliogr. s. 512-535. --- Indeks.
    Dostawca treści:
    Bibliografia CBW
    Książka
    Tytuł:
    Wielkie mocarstwa wobec Polski : 1919-1945 od Wersalu do Jałty
    Autorzy:
    Karski, Jan.
    Współwytwórcy:
    Morawiec, Elżbieta. Tłumaczenie
    Data publikacji:
    1992
    Wydawca:
    Warszawa : Państwowy Instytut Wydawniczy
    Tematy:
    Linia Curzona
    Wojna 1919-1920 r. polsko-rosyjska
    Konferencja w Spa (1920)
    Opis:
    Oryg.: "The great powers and Poland: 1919-1945 from Versailles to Yalta" 1985.
    S. 47-63, Wojna polsko-bolszewicka i Linia Curzona.
    Bibliogr. s. 512-535. --- Indeks.
    Dostawca treści:
    Bibliografia CBW
    Książka
    Tytuł:
    Wielkie mocarstwa wobec Polski 1919-1945 : od Wersalu do Jałty
    Autorzy:
    Karski, Jan.
    Kozielski, Jan
    Współwytwórcy:
    Morawiec, Elżbieta. Tłumaczenie
    Machcewicz, Paweł. Recenzja
    Data publikacji:
    1992
    Wydawca:
    Warszawa : Państwowy Instytut Wydawniczy
    Opis:
    Nazwa aut. Jan Kozielski.
    Wielkie mocarstwa a Polska w okresie międzywojennym (1919-1939), S. 9-336.
    Bibliogr. s. 512-535.
    Swoboda bezsilnych.
    Dostawca treści:
    Bibliografia CBW
    Książka
    Tytuł:
    Analysis of the G/C polymorphism in the 5-untranslated region of the RAD51 gene in breast cancer.
    Autorzy:
    Blasiak, Janusz
    Przybyłowska, Karolina
    Czechowska, Agnieszka
    Zadrożny, Marek
    Pertyński, Tomasz
    Rykała, Jan
    Kołacińska, Agnieszka
    Morawiec, Zbigniew
    Drzewoski, Józef
    Powiązania:
    https://bibliotekanauki.pl/articles/1043672.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    genetic polymorphism
    RAD51 gene
    RFLP-PCR
    breast cancer
    Opis:
    The breast cancer suppressor proteins BRCA1 and BRCA2 interact with RAD51, a protein essential for maintaining genomic stability by playing a central role in homology-dependent recombinational repair of the DNA double-strand breaks. Therefore, genetic variability in the RAD51 gene may contribute to the appearance and/or progression of breast cancer. A single nucleotide polymorphism in the 5'- untranslated region of RAD51 (a G to C substitution at position 135, the G/C polymorphism) is reported to modulate breast cancer risk. We investigated the distribution of genotypes and frequency of alleles of the G/C polymorphism in breast cancer. Tumor tissues were obtained from postmenopausal women with node-negative and node-positive breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The G/C polymorphism was determined by PCR-based MvaI restriction fragment length polymorphism. The distribution of the genotypes of the G/C polymorphism did not differ significantly (P >0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distribution and allele frequencies between node-positive and node-negative patients. There were no significant differences between distributions of the genotypes in subgroups assigned to histological grades according to Scarf-Bloom-Richardson criteria and the distribution predicted by Hardy-Weinberg equilibrium (P >0.05). Our study implies that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer and so it may not be useful as an independent marker in this disease.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 1; 249-253
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-10 z 10

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