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Wyszukujesz frazę "Moradkhani, S." wg kryterium: Autor

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    Wyświetlanie 1-5 z 5
    Tytuł:
    Production, quality control and initial imaging studies of [82mRb]RbCl for PET studies
    Autorzy:
    Rowshanfarzad, P.
    Jalilian, A.
    Kiyomarsi, M.
    Sabet, M.
    Karimian, A.
    Moradkhani, S.
    Mirzaii, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/146165.pdf
    Data publikacji:
    2006
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    rubidium-82m
    quality control
    animal study
    cyclotron
    Opis:
    Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/mAh was obtained.
    Źródło:
    Nukleonika; 2006, 51, 4; 209-215
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Development of 62Zn bleomycin as a possible PET tracer
    Autorzy:
    Jalilian, A.
    Fateh, B.
    Ghergherehchi, M.
    Karimian, A.
    Moradkhani, S.
    Kamali-Dehghan, M.
    Tabeie, F.
    Powiązania:
    https://bibliotekanauki.pl/articles/148678.pdf
    Data publikacji:
    2005
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    PET
    pharmacokinetics
    biodistribution
    62Zn
    bleomycin
    Opis:
    Abstract Bleomycin (BLM), labeled with radioisotopes, is widely used in therapy and diagnosis. In this study, BLM was labeled with 62Zn for oncologic PET studies. The complex was obtained at pH = 2 in saline at 90°C in 25 min. Radio-TLC showed an overall radiochemical yield of 95 97% (radiochemical purity > 97%). Stability of complex was checked in vitro in mice and human plasma/urine. Preliminary in vivo studies were performed to determine complex stability and distribution of 62Zn BLM in normal and fibrosarcoma-bearing mice. 62Zn BLM accumulated significantly in induced fibrosarcoma tumors in mice according to biodistribution/imaging studies. 62Zn BLM can be used in PET oncology studies due to its suitable physicochemical properties as a diagnostic complex in vitro and in vivo. Further studies should be performed for evaluation of the complex behavior in larger mammals.
    Źródło:
    Nukleonika; 2005, 50, 4; 143-148
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Development of 153Sm-DTPA-rituximab for radioimmunotherapy
    Autorzy:
    Bahrami-Samani, A.
    Ghannadi-Maragheh, M.
    Jalilian, A. R.
    Yousefnia, H.
    Garousi, J.
    Moradkhani, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/148154.pdf
    Data publikacji:
    2009
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    radiopharmaceutical
    samarium-153
    rituximab
    targeted therapy
    SPECT
    Opis:
    Combining beta-particle effect with therapeutic properties of anti-CD20 monoclonal antibody in lymphomas, Mabthera™ (rituximab) was targeted in this study. The antibody was labeled with 153Sm-samarium chloride (185 MBq) after conjugation with freshly prepared ccDTPA. Conjugated-rituximab was obtained by the addition of 1 ml of a rituximab pharmaceutical solution (5 mg/ml, in phosphate buffer, pH = 7.8) to a glass tube precoated with freshly prepared ccDTPA (0.01–0.1 mg) at 25 degrees centigrade. Sm-153 chloride was obtained by a thermal neutron flux (5 × 1013 nźcm–2źs–1) of an enriched 152Sm2O3 sample, dissolved in acidic media. Radiolabeling was performed in one hour by the addition of DTPA-rituximab conjugate at room temperature. Radiochemical purity of 96% (ITLC) and 98% (HPLC) were obtained for the final radioimmunoconjugate (specific activity = 120 TBq/mmol). The final isotonic 153Sm-rituximab complex was checked by gel electrophoresis for protein integrity retention. Biodistribution studies in normal rats were performed to determine radioimmunoconjugate distribution up to 24 h. SPECT images were also obtained using 103 keV photons up to 48 h.
    Źródło:
    Nukleonika; 2009, 54, 4; 271-277
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A study on heavy metals mobility from zinc plant residues in Iran
    Autorzy:
    Moradkhani, D.
    Eskandari, S.
    Sedaghat, B.
    Najafabadi, M. R.
    Powiązania:
    https://bibliotekanauki.pl/articles/110826.pdf
    Data publikacji:
    2013
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    heavy metals
    zinc leaching plant
    leaching filter cake
    column leaching
    Opis:
    The transport of heavy metals from mining disposal site to groundwater and surface water is one of the most serious environmental problems in the world. The transport of heavy metals such as Zn, Cd and Mn from leaching filter cake in RECo, Zanjan, Iran was examined by using column leaching. Parameters studied included: flow rate, pH of input solution and leaching time. In this study, the maximum dissolution percents of Zn, Cd and Mn in input solution pH of 5 were 45.50 %, 53.97% and 19.94%, respectively. To statistically analysis the experimental results, SPSS14 software was employed. The results of SPSS 14 indicated that for the Zn, Cd and Mn dissolution, time and flow rate were found respectively, the effective parameters for the pollution in zinc leach residues.
    Źródło:
    Physicochemical Problems of Mineral Processing; 2013, 49, 2; 567-574
    1643-1049
    2084-4735
    Pojawia się w:
    Physicochemical Problems of Mineral Processing
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    1.25GS/S 12bit and 2.27mW digital to analog converter (DAC) with 70.22 SNDR based on new hybrid R-C procedure in 180nm CMOS
    Autorzy:
    Mahdavi, S.
    Poreh, M.
    Alizadeh, L.
    Moradkhani, B.
    Ebrahimi, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/398146.pdf
    Data publikacji:
    2017
    Wydawca:
    Politechnika Łódzka. Wydział Mikroelektroniki i Informatyki
    Tematy:
    SAR ADC
    DAC
    high-resolution
    power consumption
    high-speed
    wysoka rozdzielczość
    pobór mocy
    Opis:
    This paper presents a novel fully differential high-speed and high-resolution Digital to Analog Converter (DAC) based on new reliable hybrid R-C technique. In the proposed idea the four LSB bits and eight MSB bits are implemented as a resistor string and new merged capacitor technique respectively. Applying the suggested method the SNDR and Effective Number of Bits (ENOB) of the proposed DAC achieve 70.22dB and 11.41 bit at the 1.25GS/s sampling rate correspondingly. In the proposed method the total capacitors of the 8 MSB bits are reduced up to 78% compared to the conventional one noticeably. As a result, the power consumption and speed of the suggested DAC are decreased and increased respectively. Moreover, the total power consumption of the proposed DAC is 2.27mW with the power supply of 1.8 volts as well. Meanwhile, for the correctness of the proposed 12bit DAC, 200 iterations in transient Monte-Carlo analysis (parasitic capacitance included ([symbol] mismatch = 1.2%)), and the SNDR simulation results versus different input frequency at fS=1.25GS/s sampling rate are applied too. The maximum Integral Nonlinearity (INL) and the maximum Differential Nonlinearity (DNL) are -0.47/+0.35LSB and -0.42/+0.29 LSB respectively. The proposed DAC structure is simulated in all process corners and performed using the HSPICE BSIM3 model of a 0.18μm CMOS technology.
    Źródło:
    International Journal of Microelectronics and Computer Science; 2017, 8, 4; 127-132
    2080-8755
    2353-9607
    Pojawia się w:
    International Journal of Microelectronics and Computer Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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