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    Wyświetlanie 1-6 z 6
    Tytuł:
    Use of surface working for improving the working life of piston valves of combustion engines
    Autorzy:
    Filipowicz, Krzysztof
    Kuczaj, Mariusz
    Mikuła, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1841203.pdf
    Data publikacji:
    2020
    Wydawca:
    Politechnika Śląska. Wydawnictwo Politechniki Śląskiej
    Tematy:
    combustion engine
    engine valve
    burnishing
    damage
    silnik spalinowy
    zawór silnika
    nagniatanie
    uszkodzenie
    Opis:
    This paper deals with the issue of operating damage of combustion engine valves. It presents an innovative way and construction of a tool for strengthening piston engine valves by way of surface working. It presents the concept of machines for comprehensive surface working and for profiling the faces of combustion engine valves. It also includes the discussion of the methodology of working.
    Źródło:
    Transport Problems; 2020, 15, 3; 107-116
    1896-0596
    2300-861X
    Pojawia się w:
    Transport Problems
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Kronika
    Autorzy:
    Benincasa, Zuzanna
    Kowalczyk, Tomasz
    Fokt, Krzysztof
    Mikuła, Maciej
    Kanecki, Oscar
    Olszewski, Henryk
    Szymura, Mateusz
    Głuszak, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/915293.pdf
    Data publikacji:
    2017-07-26
    Wydawca:
    Uniwersytet im. Adama Mickiewicza w Poznaniu
    Źródło:
    Czasopismo Prawno-Historyczne; 2016, 68, 2; 393-407
    0070-2471
    Pojawia się w:
    Czasopismo Prawno-Historyczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Transcriptional changes between uninflamed ulcerative colitis and familial adenomatous polyposis pouch mucosa can be attributed to an altered immune response
    Autorzy:
    Paziewska, Agnieszka
    Horbacka, Karolina
    Goryca, Krzysztof
    Mikula, Michal
    Jarosz, Dorota
    Dabrowska, Michalina
    Krokowicz, Piotr
    Karon, Jacek
    Ostrowski, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1039136.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ulcerative colitis
    familial adenomatous polyposis
    pouch
    gene expression
    immune response
    Opis:
    A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is considered the surgery of choice for definitive management of familial adenomatous polyposis (FAP) and some patients with ulcerative colitis (UC). However, this surgical treatment is often associated with pouchitis, a long-term complication that occurs mostly in UC patients. The purpose of this study was to better define the molecular background of pouchitis. A microarray-based survey was performed using pouch mucosal samples collected from 28 and 8 patients undergoing surgery for UC and FAP, respectively. There were 4,770 genes that significantly differentiated uninflamed from inflamed mucosal samples, and their functional features were represented mostly by metabolic and cell proliferation pathways. In contrast, functional analyses of aberrantly expressed genes between UC and FAP samples, irrespective of mucosal inflammation status, revealed multiple pathways and terms that were linked to changes in immune response. Interestingly, the comparison of uninflamed UC and FAP samples identified a set of 29 altered probe sets, including an inflammation-related transcript encoding a Charcot-Leyden crystal (CLC) protein. The most distinct changes in gene expression profiles differentiating uninflamed UC and FAP pouch mucosal samples were attributed to the Gene Ontology category innate immune response. Our study confirmed that alterations in immune responses can be found between patients who underwent surgery for UC and FAP, independent of the pouch inflammation status. This observation may be important when managing IPAA patients.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 69-75
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Gene expression alterations induced by low molecular weight heparin during bowel anastomosis healing in rats
    Autorzy:
    Krześniak, Natalia
    Paziewska, Agnieszka
    Rubel, Tymon
    Skrzypczak, Magdalena
    Mikula, Michał
    Dzwonek, Artur
    Goryca, Krzysztof
    Wyrwicz, Lucjan
    Jarosz, Dorota
    Laubitz, Daniel
    Woszczyński, Marek
    Bielecki, Krzysztof
    Ostrowski, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1039955.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    heparins
    gene expression
    wound healing
    microarrays
    Opis:
    Colon anastomosis is therapeutically challenging because multiple, usually undetectable factors influence a spectrum of repair mechanisms. We hypothesized that low molecular weight heparins, routinely administered perioperatively, may differentially affect gene expression related to colon healing. Twenty pairs of untreated and enoxaparin-treated rats underwent left-side hemicolectomy with a primary end-to-end anastomosis. Normal colon and anastomotic bowel segments were resected on day 0 and on days 1, 3, 5, and 7 after surgery, respectively. Serial anastomosis transverse cross-sections were evaluated microscopically and by microarray (Rat Genome 230 2.0, Affymetrix). Differentially expressed probe sets were annotated with Gene Ontology. We also examined the influence of enoxaparin on fibroblast proliferation and viability in vitro. Among the 5476 probe sets, we identified differential expression at each healing time point, yielding 79 subcategories. Most indicated genes were involved in wound healing, including multicellular organismal development, locomotory behavior, immune response, cell adhesion, inflammatory response, cell-cell signaling, blood vessel development, and tissue remodeling. Although we found no intensity differences in histological features of healing between enoxaparin-treated and control rats, treatment did induce significant expression changes during early healing. Of these changes, 83 probe sets exhibited at least twofold changes and represented different functional annotations, including inflammatory response, regulation of transcription, regulation of apoptosis, and angiogenesis. Fibroblast culture confirmed an anti-viability effect of enoxaparin. Enoxaparin affects colon wound-related gene expression profiles, but further studies will resolve whether heparin treatment is a risk factor after intestinal surgery, at least in some patients.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 1; 79-87
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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