- Tytuł:
- Comparative study on cytotoxicity activity of N-α-acylarginine ethyl ester
- Autorzy:
-
Mhatre, J.D.
Singare, P.U. - Powiązania:
- https://bibliotekanauki.pl/articles/412185.pdf
- Data publikacji:
- 2013
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
cytotoxicity
arginine
IC50
microbicidal
monolaurin - Opis:
- Amino-acid derived compounds, for example N-α-lauroylarginine ethyl ester (LAE), N-α-myristoylarginine ethyl ester (MAE) and a 1:1 mixture of N-α-myristoylarginine ethyl ester with monolaurin (MAE + MLN) are examined for their cytotoxicity towards L929-Mouse connective tissue to explore their use as microbicidal agent, in comparison to sodium dodecylsulfate (SDS) as an anionic control detergent. MTT (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Cytotoxicity assay method was used to determine IC50 value. Cytotoxicity of MAE is found to be more toxic as compared to LAE, having IC50 value 0.052 mg/ml against 0.68 mg/ml of LAE. But MAE when mixed with monolaurin (1:1), showed less toxicity with IC50 0.89 mg/ml. These results suggest that a combination of MAE and Monolaurin can be a potential candidate for studying its microbicidal properties.
- Źródło:
-
International Letters of Chemistry, Physics and Astronomy; 2013, 8, 1; 1-7
2299-3843 - Pojawia się w:
- International Letters of Chemistry, Physics and Astronomy
- Dostawca treści:
- Biblioteka Nauki
Artykuł