Autor: Mazur, Maria - Katalog OPAC zbiorów

Tytuł:: Gelsolin in human colon adenocarcinoma cells with different metastatic potential
Autorzy:: Litwin, Monika
Mazur, Antonina
Nowak, Dorota
Mannherz, Hans
Malicka-Błaszkiewicz, Maria
Powiązania:: https://bibliotekanauki.pl/articles/1040503.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: gelsolin
actin
cancer
Opis:: Gelsolin, one of a major actin-binding proteins, is involved in the regulation of actin cytoskeleton organization by its severing and capping activity towards actin filaments. Human colon adenocarcinoma cell line LS180 and its selected variants of different metastatic potential were used to check for a correlation between gelsolin level, its subcellular localization and the invasive capacity of cells. Based on immunoblotting experiments, a decreased level of gelsolin was detected in the most invasive 5W subline when compared to the parental cell line LS180. The intracellular distribution of actin filaments and gelsolin in colon adenocarcinoma cells was examined by confocal microscopy. In the 5W subline, unlike in the other examined cells, gelsolin was colocalized with filamentous actin at the cell periphery. In summary, in human colon adenocarcinoma cells, gelsolin level and its subcellular distribution seem to correlate with their metastatic potential.
Źródło:: Acta Biochimica Polonica; 2009, 56, 4; 739-743
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein
Autorzy:: Olejnik, Kamil
Bucholc, Maria
Anielska-Mazur, Anna
Lipko, Agata
Kujawa, Martyna
Modzelan, Marta
Augustyn, Agnieszka
Kraszewska, Elzbieta
Powiązania:: https://bibliotekanauki.pl/articles/1039863.pdf
Data publikacji:: 2011
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: protein complexes
Nudix
AtNUDT7
Arabidopsis thaliana
heterotrimeric G protein
RACK1A
Opis:: Arabidopsis thaliana AtNUDT7 Nudix pyrophosphatase hydrolyzes NADH and ADP-ribose in vitro and is an important factor in the cellular response to diverse biotic and abiotic stresses. Several studies have shown that loss-of-function Atnudt7 mutant plants display many profound phenotypes. However the molecular mechanism of AtNUDT7 function remains elusive. To gain a better understanding of this hydrolase cellular role, proteins interacting with AtNUDT7 were identified. Using AtNUDT7 as a bait in an in vitro binding assay of proteins derived from cultured Arabidopsis cell extracts we identified the regulatory protein RACK1A as an AtNUDT7-interactor. RACK1A-AtNUDT7 interaction was confirmed in a yeast two-hybrid assay and in a pull-down assay and in Bimolecular Fluorescence Complementation (BiFC) analysis of the proteins transiently expressed in Arabidopsis protoplasts. However, no influence of RACK1A on AtNUDT7 hydrolase catalytic activity was observed. In vitro interaction between RACK1A and the AGG1 and AGG2 gamma subunits of the signal transducing heterotrimeric G protein was also detected and confirmed in BiFC assays. Moreover, association between AtNUDT7 and both AGG1 and AGG2 subunits was observed in Arabidopsis protoplasts, although binding of these proteins could not be detected in vitro. Based on the observed interactions we conclude that the AtNUDT7 Nudix hydrolase forms complexes in vitro and in vivo with regulatory proteins involved in signal transduction. Moreover, we provide the initial evidence that both signal transducing gamma subunits bind the regulatory RACK1A protein.
Źródło:: Acta Biochimica Polonica; 2011, 58, 4; 609-616
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: VDR gene single nucleotide polymorphisms and their association with risk of oral cavity carcinoma
Autorzy:: Małodobra-Mazur, Małgorzata
Paduch, Agnieszka
Lebioda, Arleta
Konopacka, Maria
Rogoliński, Jacek
Szymczyk, Cezary
Wierzgoń, Janusz
Maciejewski, Adam
Chmielik, Ewa
Jonkisz, Anna
Półtorak, Stanisław
Dobosz, Tadeusz
Powiązania:: https://bibliotekanauki.pl/articles/1039670.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: VDR gene
SNP
oral cavity cancer
Opis:: Vitamin D3 (1,25(OH)2D3 (1,25-dihydroxyvitamin D3)) is a hormone playing a crucial role in numerous biological processes in the human body, including induction and control of cell proliferation and differentiation. Numerous data relate the vitamin D3 level with various types of cancer. It has been suggested that SNPs in the vitamin D3 receptor (VDR) gene might influence both the risk of cancer occurrence and cancer progression. The aim of this study was to search for genetic correlations between individual SNPs in the VDR gene and the risk of oral cavity carcinoma. Two SNPs were selected based on the literature and our previous results. Seventy-three patients with squamous cell carcinoma of the head and neck and one hundred control subjects were investigated. Two SNPs in the VDR gene were genotyped in minisequencing reactions followed by capillary electrophoresis. Hardy-Weinberg equilibrium (HWE), the χ2 test and logistic regression were used for statistical analysis. The SNP rs2238135 in the VDR gene displayed statistical differences in frequency between the tested groups (p=0,0007). Furthermore, the G/C genotype of the rs2238135 in the VDR gene was characterized by a 3.16 fold increased risk of oral cavity carcinoma. The obtained results provide evidence for a genetic association between rs2238135 in the VDR gene and the occurrence and risk of oral cavity cancer.
Źródło:: Acta Biochimica Polonica; 2012, 59, 4; 627-630
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Zróżnicowanie poziomu życia w miastach Polski
Standard of living diversification in urban areas in Poland
Autorzy:: Mazur, Maria
Powiązania:: https://bibliotekanauki.pl/articles/1860422.pdf
Data publikacji:: 2012
Wydawca:: Uniwersytet Opolski
Tematy:: standard of living
urban areas
poziom życia
miasta
Opis:: W Polsce istnieje silne zróżnicowanie zamożności społeczeństwa wynikające ze zróżnicowanego rozwoju regionów, różnic pomiędzy miastem a wsią. W różnym tempie rozwijały sie miasta różnej wielkości, przy czym najszybsze tempo rozwoju zaobserwowano w dużych aglomeracjach. Duże miasta posiadały lepszą infrastrukturę społeczną i techniczną, większe zasoby wykwalifikowanej siły roboczej, rozbudowane funkcje miejskie, co pozwalało na ich efektywniejszy rozwój. Celem artykułu jest zbadanie, w jakim stopniu rozwój ekonomiczny miast wpływa na poziom życia ich mieszkańców, ponieważ – jak wiadomo – rozwój gospodarczy nie zawsze jest gwarantem rozwoju społecznego. W badaniach empirycznych wykorzystano wyniki europejskiego badania warunków życia ludności (Eu-sILc) z lat 2006–2009 przeprowadzonego przez GUS. Porównano z jednej strony podstawowe determinanty poziomu życia gospodarstw domowych, tj. wykształcenie i dochody, w klasach miast różnej wielkości, z drugiej zaś poziom zaspokojenia istotnych potrzeb materialnych.
In Poland there is a large diversity of society’s wealth resulting from differences in the development of regions, differences between urban and rural areas. The rate of development differed for the all size classes of cities, but the fastest growth rate was observed in large urban. Large cities had a better social and technical infrastructure, greater resources of the skilled labour, advanced urban functions, which contributed to their more efficient development. The goal of the studies is to examine how the economic development of urban areas affects the standard of living of their residents, because as it is known, the economic development is not always a guarantee of the social development. In the empirical studies were used the results of the research of European union statistics on Income and Living condition (Eu-sILc) concerned the years 2006–2009, conducted by the central statistical Office in Poland. There were compared, on the one hand, the main determinants of households’ living standard, i.e. the education and income level in different size classes of cities, on the other hand the level of meeting the essential material needs.
Źródło:: Studia Miejskie; 2012, 8; 159-170
2543-5302
2082-4793
Pojawia się w:: Studia Miejskie
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Introduction
Wstęp
Autorzy:: Urlińska, Maria, Marta
Ogrodzka-Mazur, Ewa
Powiązania:: https://bibliotekanauki.pl/articles/448986.pdf
Data publikacji:: 2016
Wydawca:: Akademia Ignatianum w Krakowie
Źródło:: Studia Paedagogica Ignatiana; 2016, 19, 4; 9-19
2450-5358
2450-5366
Pojawia się w:: Studia Paedagogica Ignatiana
Dostawca treści:: Biblioteka Nauki

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