- Tytuł:
- p19 detected in the rat retina and pineal gland is a guanylyl cyclase-activating protein (GCAP).
- Autorzy:
-
Dejda, Agnieszka
Matczak, Izabela
Gorczyca, Wojciech - Powiązania:
- https://bibliotekanauki.pl/articles/1043693.pdf
- Data publikacji:
- 2002
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
pineal gland
rat
guanylyl cyclase
calcium-binding proteins
guanylyl cyclase-activating proteins
retina - Opis:
- The Ca2+-dependent activation of retina-specific guanylyl cyclase (retGC) is mediated by guanylyl cyclase-activating proteins (GCAPs). Here we report for the first time detection of a 19 kDa protein (p19) with GCAP properties in extracts of rat retina and pineal gland. Both extracts stimulate synthesis of cGMP in rod outer segment (ROS) membranes at low (30 nM) but not at high (1 mM) concentrations of Ca2+. At low Ca2+, immunoaffinity purified p19 activates guanylyl cyclase(s) in bovine ROS and rat retinal membranes. Moreover, p19 is recognized by antibodies against bovine GCAP1 and, similarly to other GCAPs, exhibits a Ca2+-dependent electrophoretic mobility shift.
- Źródło:
-
Acta Biochimica Polonica; 2002, 49, 4; 899-905
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł