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Wyszukujesz frazę "Malicka-Blaszkiewicz, Maria" wg kryterium: Autor

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    Wyświetlanie 1-9 z 9
    Tytuł:
    The effect of methotrexate on actin and invasiveness of hepatoma Morris 5123 cells in culture.
    Autorzy:
    Otrocka, Magdalena
    Verschueren, Hendrik
    Malicka-Błaszkiewicz, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1044048.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    hepatoma Morris 5123
    invasiveness
    methotrexate
    actin
    Opis:
    Monomeric (G), total (T) and filamentous (F) actin and the state of actin polymerisation (F:G) were determined and actin filaments were visualized in hepatoma Morris 5123 cells cultured in the presence of methotrexate (MTX) at various concentration. The exposure of the cells to this drug resulted in a decrease of total and polymerised actin in cytoplasm and in some changes in actin filament organization. This coincided with a decrease of the cells' ability to migrate through Matrigel coated filters and with inhibition of tumour formation after reimplantation of the methotrexate treated cells to experimental rats.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 4; 1051-1060
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Actin in human colon adenocarcinoma cells with different metastatic potential.
    Autorzy:
    Nowak, Dorota
    Krawczenko, Agnieszka
    Duś, Danuta
    Malicka-Błaszkiewicz, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1043684.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    state of actin polymerization
    colon adenocarcinoma cell lines
    actin
    Opis:
    Four human colon adenocarcinoma cell line variants with different metastatic potential were used to examine whether a correlation exists between actin level, state of actin polymerization and invasiveness of tumour cells. Monomeric (G), total (T) and filamentous (F) actin were determined in the cytosolic fraction of these cells. A statistically significant decrease in G actin level and increase in the state of actin polymerization (measured by F:G actin ratio) were found in the cytosol of three cell variants with higher metastatic potential and invasiveness (EB3, 3LNLN, 5W) compared with the parental cell line (LS180). Our experimental data lead to the conclusion that there is a correlation between the metastatic capacity of human colon adenocarcinoma cells and the state of actin polymerization.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 4; 823-828
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Beta-actin in human colon adenocarcinoma cell lines with different metastatic potential.
    Autorzy:
    Nowak, Dorota
    Skwarek-Maruszewska, Aneta
    Zemanek-Zboch, Magdalena
    Malicka-Błaszkiewicz, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1041430.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    actin cytoskeleton
    β-actin
    colon adenocarcinoma
    invasiveness
    Opis:
    Human colon adenocarcinoma LS180 parental cell line and selected variants, characterized by different metastatic capacity were used to examine, whether a correlation exists between β-actin expression, its subcellular distribution and metastatic potential of these cells. Cytosolic fraction (supernatant 105000 × g), isolated from the tumor cells was used as a source for actin quantification. The higher level of β-actin was observed in the cytosol of three selected sublines to compare with LS180 parental line. Statistically significant increase of β-actin level in highly motile EB3 cells variant should be underlined to compare with the other sublines. Distinct differences in the phenotype of adenocarcinoma cell variants were found, such as the changes in cells shape, cells spreading and ability to attach to the surface of culture dish. Actin cytoskeleton was visualized with fluorescence microscopy application and microfilaments rhodamine-conjugated phalloidin staining. β-actin subcellular localization was done by immunofluorescence staining with monoclonal anti-β actin antibodies. In the elongated cells (LS180, 3LNLN), this isoactin is dispersed in the whole cell body and concentrates in pseudopods and at the leading edges, when in the rounded variant (EB3) β-actin dominates mainly in cortical ring under cellular membrane and it is also seen in the subtle protrusions. Summary of our former (Nowak et al., 2002, Acta Biochim. Polon., 49: 823) and current data lead to the conclusion that there is a distinct correlation between metastatic capacity of examined human colon adenocarcinoma cells, the state of actin polymerization, actin cytoskeleton organization and β-actin expression.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 461-468
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Identification of actin from hepatoma Morris 5123 cells
    Autorzy:
    Nowak, Dorota
    Kochman, Agata
    Malicka-Błaszkiewicz, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1044454.pdf
    Data publikacji:
    1999
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    actin isoforms
    affinity chromatography
    hepatoma Morris 5123
    actin
    Opis:
    The hepatoma Morris 5123 tumor growth is accompanied by changes in actin content and polymerization (Malicka-Błaszkiewicz et al. (1995) Mat. Med. Pol., 27, 115-118;  Nowak et al. (1995) J. Exp. Cancer Res. 14, 37-40). Presently actin isoforms from cytosol and  cytoskeleton fractions were separated by SDS/PAGE and identified with antibodies directed against different actin isoforms. Actin isolated from the cytosol by affinity chromatography on DNase I bound to agarose shows the presence of only one protein spot on 2D gel electrophoresis corresponding to the mobility of the rabbit α skeletal muscle actin (M^r 43000) and isoelectric point equal to 5.3. It interacts only with monoclonal anti β actin isoform antibodies, posing the question of differential affinity of actin isoforms to DNase I.
    Źródło:
    Acta Biochimica Polonica; 1999, 46, 4; 949-959
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ovocystatin affects actin cytoskeleton organization and induces proapoptotic activity
    Autorzy:
    Malicka-Blaszkiewicz, Maria
    Filipczak, Nina
    Gołąb, Krzysztof
    Juszczyńska, Katarzyna
    Sebzda, Tadeusz
    Gburek, Jakub
    Powiązania:
    https://bibliotekanauki.pl/articles/1039207.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ovocystatin
    egg white cystatin
    actin cytoskeleton
    apoptosis
    Opis:
    Ovocystatin is a chicken egg white protein, generally known for its inhibitory activity against cysteine proteases. However, biological activity of ovocystatin does not seem to be well recognized in respect to other possible cellular effects. Our attention has been focused on ovocystatin cytotoxic effects in relation to its influence on actin cytoskeleton organization and apoptosis induction. In vitro studies with human melanoma A375, human cervix HeLa cancer cells and normal human fibroblasts - NHDF were done. Cytotoxic activity of ovocystatin was seen in respect to apoptosis induction - manifested by cell shape changes, phosphatydylserine translocation and actin cytoskeleton reorganization. Normal human fibroblasts have shown lower sensitivity to ovocystatin as compared with human melanoma A375 and human cervix HeLa cancer cells. In conclusion, ovocystatin affects actin cytoskeleton organization and displays proapoptotic activity towards applied cell lines. This implicates its application as a potential anticancer drug. However, its adverse effects on normal cells should be taken into consideration.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 4; 753-758
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Gelsolin in human colon adenocarcinoma cells with different metastatic potential
    Autorzy:
    Litwin, Monika
    Mazur, Antonina
    Nowak, Dorota
    Mannherz, Hans
    Malicka-Błaszkiewicz, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1040503.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    gelsolin
    actin
    cancer
    Opis:
    Gelsolin, one of a major actin-binding proteins, is involved in the regulation of actin cytoskeleton organization by its severing and capping activity towards actin filaments. Human colon adenocarcinoma cell line LS180 and its selected variants of different metastatic potential were used to check for a correlation between gelsolin level, its subcellular localization and the invasive capacity of cells. Based on immunoblotting experiments, a decreased level of gelsolin was detected in the most invasive 5W subline when compared to the parental cell line LS180. The intracellular distribution of actin filaments and gelsolin in colon adenocarcinoma cells was examined by confocal microscopy. In the 5W subline, unlike in the other examined cells, gelsolin was colocalized with filamentous actin at the cell periphery. In summary, in human colon adenocarcinoma cells, gelsolin level and its subcellular distribution seem to correlate with their metastatic potential.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 4; 739-743
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Acid phosphatase from liver of the frog Rana esculenta, separation and partial characterization of multiple forms
    Autorzy:
    Kubicz, Aleksandra
    Dratewka, Ella
    Malicka-Błaszkiewicz, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1046240.pdf
    Data publikacji:
    1978
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1978, 25, 4; 349-359
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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