- Tytuł:
-
Ocena eozynofilii, stezenia immunoglobuliny E i eozynofilowego białka kationowego podczas leczenia toksokarozy
Estimation of eosinophilia, immunoglobulin E and eosinophilic cationic protein concentration during the treatment of toxocariasis - Autorzy:
-
Niedworok, M.
Sordyl, B.
Borecka, A.
Gawor, J.
Małecka-Panas, E. - Powiązania:
- https://bibliotekanauki.pl/articles/2143788.pdf
- Data publikacji:
- 2008
- Wydawca:
- Polskie Towarzystwo Parazytologiczne
- Tematy:
-
toksokaroza
choroby pasozytnicze
eozynofile
parazytologia lekarska
eozynofilowe bialko kationowe zob.bialko ECP
leczenie
diagnostyka
immunoglobulina E
bialko ECP - Opis:
- Toxocara canis and Toxocara cati do not transform in human organism into a mature form and they circulate reaching various organs and tissues causing characteristic symptoms. Activated eosinophils, which play a significant role in parasitic invasion, contain in their granules eosinophilic cationic protein (ECP) of strong pro−inflammatory activity. The aim of the study was to estimate the concentration of immunoglobulin E, peripheral blood eosinophilia and serum concentration of eosinophilic cationic protein in children treated for toxocariasis and the analysis of their value as the markers of active invasion and the therapy efficacy. The study included 45 children, aged from 3 to 18 years with Toxocara canis infection diagnosed for the first time. The children were diagnosed and treated at the Department of Gastroenterology, in the Outpatient Gastrointestinal and Allergologic Clinic, Institute Polish Mother Health Centre. T. canis larva infection was diagnosed based on serological investigation using immunoenzymatic ELISA test (Bordier Affinity Products, Switzerland). The tests (percentage of eosinophilia in peripheral blood, ECP, IgE) were performed after diagnosis and every 3 months since the beginning of the therapy. In children with toxocariasis its covert form was diagnosed and mebendazole was administered. Among the children with toxocariasis eosinophilia was found in 14 (31.1%) before therapy. Mean percentage of peripheral blood eosinophils was 5.58% in children with toxocariasis. The concentration of IgE was elevated in these children and was significantly higher than in the control group (p=0.002). Mean IgE concentration after 3−and 6−month therapy decreased IgEI vs IgEIII (p=0.01), but it was still higher than normal value. In children with toxocariasis the ECP concentration was 30.19 µg/l before the therapy and was significantly higher than in the control group (p<0.05); after 6 months of the therapy it decreased significantly (p<0.05). Eosinophilic cationic protein and eosinophilia can be the markers of Toxocara canis infection activity. The determination of immunoglobulin E and eosinophilic cationic protein concentration may be useful for toxocariasis therapy monitoring.
- Źródło:
-
Wiadomości Parazytologiczne; 2008, 54, 3; 225-230
0043-5163 - Pojawia się w:
- Wiadomości Parazytologiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł