- Tytuł:
- Cyclooxygenase-2 – characteristics, functions and possible use as a biomarker in human and animal oncology – A review
- Autorzy:
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Szweda, M.
Rychlik, A.
Babińska, I.
Kaczmar, E.
Szweda, W.
Makowska, K. - Powiązania:
- https://bibliotekanauki.pl/articles/53370806.pdf
- Data publikacji:
- 2024
- Wydawca:
- Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
- Opis:
- Neoplastic diseases are currently one of the most common causes of mortality in both animals and humans. Therefore, much of the recent research focuses on the search for biomarkers to enable qualitative and temporal improvement in the detectability as well as prognostic and predictive assessments in patients suffering from neoplastic diseases. One such biomarker seems to be cyclooxygenase-2 (COX-2), also known as prostaglandin G/H synthase (PTGS). The wide dissemination of COX isoforms and prostanoids synthesized with their involvement in the tissues indicates the significant role they serve in the regulation of the functioning of several organs and systems, particularly the gastrointestinal, nervous, circulatory, reproductive, urinary and respiratory systems. Until recently, COX-2 has only been associated with the response to stress and inflammation initiators. It is currently known that its expression increases significantly in the course of numerous pathological processes that involve inflammation, pain or fever. Results obtained during previous studies demonstrated a significant increase in COX-2 expression in several types and subtypes of neoplasms in humans and animals, particularly in dogs and cats, the two animal species that have been studied the most frequently. COX-2 has not been adopted yet as one of the biomarkers for routine oncological diagnostics, which indicates the possibility for wider use of the assessment of its expression in the diagnostics and therapy of neoplasms in humans and animals. It may therefore be possible to use an assessment of COX-2 overexpression to improve cancer diagnostics and therapy and for prognostic and/or predictive purposes.
- Źródło:
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Journal of Elementology; 2024, 29, 1; 175-191
1644-2296 - Pojawia się w:
- Journal of Elementology
- Dostawca treści:
- Biblioteka Nauki