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Tytuł:
The use of high-performance concretes, ultra highperformance concretes, and additive manufacturing technology in increasing the ballistic protection level of field fortifications
Autorzy:
Wysoczański, Andrzej
Partyka, Jacek
Mackiewicz, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/28124259.pdf
Data publikacji:
2023
Wydawca:
Towarzystwo Wiedzy Obronnej
Tematy:
high-performance concrete
additive manufacturing
fortification
ballistic protection
Opis:
High-Performance Concretes (HPC) and Ultra High-Performance Concretes (UHPC) allow for the production of extremely durable construction elements when compared to those same elements made of C35/45 concrete. Increased compressive- and flexural strength markedly contribute to ballistic resistance reducing the area and depth of the “crater” which results from a potential impact of a projectile or a fragment. Additionally, the presence of dispersed fibres in these mixtures eliminates the need of using reinforcement bars, which, in turn, reduces the time expenditure and labour. The article compares the results of various ballistic tests of elements made of high-performance concrete mixtures to determine the viability of applying such elements in the defence sector. Furthermore, the authors present the possibility of adapting additive technologies for the performance of field fortification tasks by the military, as part of which the HPCs and UHPCs are used as working mixtures. The authors also show the possibility of fabricating construction elements without the use of formworks, as well as printing construction elements directly at the site of future operation of the buildings.
Źródło:
Wiedza Obronna; 2023, 3
0209-0031
2658-0829
Pojawia się w:
Wiedza Obronna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analiza wpływu profilaktyki steroidowej na parametry prenatalne i postnatalne płodów z wewnątrzmacicznym ograniczeniem wzrastania
Influence of steroid prophylaxis on prenatal and postnatal parameters in fetuses with intrauterine growth restriction
Autorzy:
Grzegórzko, Maksymilian
Gibała, Piotr
Gębicka, Kinga
Bujacz, Ewa
Gałuszka, Michalina
Kozubal, Tomasz
Mackiewicz, Mirosława
Surmiak, Piotr
Baumert, Małgorzata
Witek, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1035768.pdf
Data publikacji:
2018
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
profilaktyka
wewnątrzmaciczne ograniczenie wzrastania płodu
glikokortykosterydy
prophylaxis
intrauterine growth restriction
glicosteroids
Opis:
INTRODUCTION: The administration of steroids during pregnancy up to 34 weeks accelerates the development of fetal lungs and stimulates surfactant production, therefore, it protects premature neonates against infant respiratory distress syndrome. It has been proven that the administration of steroids causes a temporary decrease in the fetal heart rate in fetuses appropriate for gestational age (AGA). How long does the temporary decrease in fetal heart rate (FHR) after steroid administration persist in intrauterine growth restriction fetuses (IUGR)? MATERIAL AND METHODS: The study was conducted on 152 patients from the Clinic of Obstetrics and Gyneacology MUS in Katowice in 2013–2016, divided into two groups: AGA - 109 cases and IUGR – 43 cases. Steroid prophylaxis – betamethasone or dexamethasone was given in both groups. CTG and Monako records at admission and 24 and 48 hours after steroid administration were analysed with assessment of: FHR baseline, bradycardia episodes as well as LTV and STV parameters. All the results were analysed in the Statistica 12PL program. RESULTS: Bradycardia after steroids occurred more frequently in AGA than in IUGR. After the first dose of steroids significantly lower bradycardia was noticed in the AGA group than IUGR (p = 0.0001). The FHR decrease after the first dose of steroids was bigger in the AGA group than in the IUGR group (p = 0.0001). The average STV value after the second dose of steroids was significantly lower in group the AGA group than in the IUGR group (p = 0.006). Oxygen partial pressure was higher in the IUGR group (p = 0.001). CONCLUSIONS: In the light of the results, it seems that fetuses with intrauterine growth restriction exhibit better tolerance to steroid administration in the form of a less frequent occurrence of bradycardia, higher STV values and smaller fluctuations in FHR.
WSTĘP: Podawanie steroidów w ciąży do 34 hbd przyspiesza rozwój dojrzałości płuc płodu i stymuluje wydzielanie surfaktantu, przez co zapobiega występowaniu zespołu zaburzeń oddychania. Udowodniono, że podawanie steroidów prenatalnie powoduje czasowe obniżenie akcji serca płodu o adekwatnej masie ciała (AGA). W pracy podjęto próbę odpowiedzi na pytanie: jak długo utrzymuje się czasowe obniżenie akcji serca płodu (fetal heart rate – FHR) po podaniu steroidów u płodów z wewnątrzmacicznym ograniczeniem wzrastania? MATERIAŁ I METODY: Badanie przeprowadzono z udziałem 152 pacjentek Kliniki Ginekologii i Położnictwa SUM w Katowicach, hospitalizowanych w latach 2013–2016, podzielonych na dwie grupy: AGA – 109 przypadków, IUGR – 43 przypadki. W obu grupach została włączona profilaktyka steroidowa – betametazon lub deksametazon. Przeanalizowano zapisy KTG oraz MONAKO wykonane przy przyjęciu pacjentki oraz 24 i 48 godzin po podaniu steroidów, oceniając linię podstawową, epizody bradykardii oraz parametry zmienności LTV i STV. Wyniki opracowano w programie Statistica 12PL. WYNIKI: Bradykardia posteroidowa występowała częściej w grupie AGA niż w grupie IUGR. Po podaniu pierwszej dawki steroidów zauważono istotnie niższą wartość FHR w czasie trwania epizodów bradykardii w grupie AGA niż w grupie IUGR (p = 0,0001). Obniżenie FHR bez bradykardii było znamiennie większe w grupie AGA niż w grupie IUGR (p = 0,0001). Średnia wartość STV po podaniu drugiej dawki steroidów była znamiennie niższa w grupie AGA niż w grupie IUGR (p = 0,006). Ciśnienie parcjalne tlenu było wyższe w grupie IUGR (p = 0,001). WNIOSKI: W świetle powyższych wyników wydaje się, że płody z IUGR wykazują lepszą tolerancję podawanych steroidów manifestującą się rzadszym występowaniem bradykardii i wyższymi wartościami STV oraz mniejszymi wahaniami wartości FHR.
Źródło:
Annales Academiae Medicae Silesiensis; 2018, 72; 6-11
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kronika
Autorzy:
Madeja, Andrzej
Sudnik - Bardach, Wanda
Olszewski, Henryk
Maj, Marta
Urbańczyk, Michał
Adamczyk, Tomasz
Wiśniewska - Jóźwiak, Dorota
Mackiewicz, Marta
Szymański, Łukasz
Pomianowski, Piotr
Szewczak-Daniel, Mariola
Sobotka, Roman
Skomiał, Jakub
Andrzejewski, Jan
Kowalski, Grzegorz M.
Machut - Kowalczyk, Joanna
Głuszak, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/913093.pdf
Data publikacji:
2014-01-01
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Źródło:
Czasopismo Prawno-Historyczne; 2014, 66, 1; 549-573
0070-2471
Pojawia się w:
Czasopismo Prawno-Historyczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer - the DNA microarray assay
Autorzy:
Stojcev, Zoran
Banasiewicz, Tomasz
Kaszuba, Michał
Sikorski, Adam
Szczepkowski, Marek
Bobkiewicz, Adam
Paszkowski, Jacek
Krokowicz, Łukasz
Biczysko, Maciej
Szmeja, Jacek
Jurkowska, Monika
Majewski, Przemysław
Mackiewicz, Andrzej
Lamperska, Katarzyna
Drews, Michał
Wojciechowicz, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1039574.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
HNPCC
DNA microarray
colon cancer
Opis:
Detection of mutations in families with a hereditary predisposition to colon cancer gives an opportunity to precisely define the high-risk group. 36 patients operated on for colon cancer, with familiar prevalence of this malignancy, were investigated using the DNA microarrays method with the potential detection of 170 mutations in MLH1, MSH2, MSH6, CHEK2, and NOD2 genes. In microarrays analysis of DNA in 9 patients (25% of the investigated group), 6 different mutations were found. The effectiveness of genetic screening using the microarray method is comparable to the effectiveness of other, much more expensive and time-consuming methods.
Źródło:
Acta Biochimica Polonica; 2013, 60, 2; 195-198
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The CDKN2a common variants: 148 Ala/Thr and 500 C/G in 3 UTR, and their association with clinical course of melanoma
Autorzy:
Lamperska, Katarzyna
Przybyła, Anna
Kycler, Witold
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1041123.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
statistical analysis
CDKN2a polymorphisms
3' UTR
Opis:
Changes in CDKN2a gene are known to be linked with sporadic melanoma and hereditary predisposition to this cancer. In the Polish population mutations in the coding region of the CDKN2a gene are rather rare, therefore the attention has been focused on polymorphisms and alterations in uncoding regions such as 3' UTR. The aim of this study was to analyze two common polymorphisms, Ala148Thr and 500 C/G, and correlate them with the clinical course of melanoma. DNA from 285 patients was analyzed and found polymorphisms were correlated with the clinical parameters employing statistical methods. The obtained results allow us to conclude: (i) survival times of 500 C/G carriers vs. cumulating proportion surviving was not statistically significant; (ii) CDKN2a polymorphism 500 C/G correlated with Ala148Thr; (iii) no correlation was observed between the 500 C/G polymorphism and age of diagnosis, localization of primary melanoma and survival time; (iv) we did not find correlation between 500 C/G and type of cancer in the family; (v) changes in the CDKN2a gene were not found in patients with second cancer.
Źródło:
Acta Biochimica Polonica; 2007, 54, 1; 119-124
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of soluble recombinant TGF-β type II receptor fused with the Fc portion of human IgG1 (sTβRII-Fc) in NS0 cells
Autorzy:
Kwiatkowska, Eliza
Kazimierczak, Urszula
Mackiewicz, Andrzej
Kowalczyk, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/1041250.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
GS-NS0 expression system
chimeric receptor
TGF-β
TGF-βreceptor
TGF antagonist
Opis:
We have constructed and expressed recombinant chimeric soluble TGF-β type II receptor fused with the Fc portion of human IgG1 (sTβRII-Fc) in NS0 mouse myeloma cells and isolated cell lines constitutively secreting very high levels of biologically active protein. The GS-NS0 expression system takes advantage of the strong human cytomegalovirus immediate early promoter expression vector and glutamine synthetase as a selectable marker. The recombinant chimeric receptor could be produced in high amounts and efficiently purified by one step chromatography on a protein A column. Biochemical studies revealed that recombinant sTβRII-Fc binds native TGF-β1 and TGF-β3 isoforms and neutralizes their activity in vitro.
Źródło:
Acta Biochimica Polonica; 2006, 53, 2; 361-369
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optimization of a retroviral vector for transduction of human CD34 positive cells
Autorzy:
Szyda, Anna
Paprocka, Maria
Krawczenko, Agnieszka
Lenart, Katarzyna
Heimrath, Jerzy
Grabarczyk, Piotr
Mackiewicz, Andrzej
Duś, Danuta
Powiązania:
https://bibliotekanauki.pl/articles/1041181.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
transduction optimization
retroviral vector
CD34+ cells
Opis:
Human stem and progenitor cells have recently become objects of intensive studies as an important target for gene therapy and regenerative medicine. Retroviral vectors are among the most effective tools for genetic modification of these cells. However, their transduction efficiency strongly depends on the choice of the ex vivo transduction system. The aim of this study was to elaborate a system for retroviral vector transduction of human CD34 positive cells isolated from cord blood. The retroviral vector pMINV EGFP was chosen for transduction of two human erythroblastoid cell lines: KG-1a (CD34 positive) and K562 (CD34 negative). For vector construction, three promoters and two retroviral vector packaging cell lines were used. To optimize the physicochemical conditions of the transduction process, different temperatures of supernatant harvesting, the influence of centrifugation and the presence of transduction enhancing agents were tested. The conditions elaborated with KG-1a cells were further applied for transduction of CD34 positive cells isolated from cord blood. The optimal efficiency of transduction of CD34 positive cells with pMINV EGFP retroviral vector (26% of EGFP positive cells), was obtained using infective vector with LTR retroviral promoter, produced by TE FLY GA MINV EGFP packaging cell line. The transduction was performed in the presence of serum, at 37°C, with co-centrifugation of cells with viral supernatants and the use of transduction enhancing agents. This study confirmed that for gene transfer into CD34 positive cells, the detailed optimization of each element of the transduction process is of great importance.
Źródło:
Acta Biochimica Polonica; 2006, 53, 4; 815-823
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cancer immunotherapy using cells modified with cytokine genes.
Autorzy:
Kowalczyk, Dariusz
Wysocki, Piotr
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043434.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cancer
cancer vaccines
cytokines
dendritic cells
gene therapy
Opis:
The ability of various cytokines to hamper tumor growth or to induce anti-tumor immune response has resulted in their study as antitumor agents in gene therapy approaches. In this review we will concentrate on the costimulation of antitumor immune responses using modification of various cell types by cytokine genes. Several strategies have emerged such as (i) modification of tumor cells with cytokine genes ex vivo (whole tumor cell vaccines), (ii) ex vivo modification of other cell types for cytokine gene delivery, (iii) delivery of cytokine genes into tumor microenvironment in vivo, (iv) modification of dendritic cells with cytokine genes ex vivo. Originally single cytokine genes were used. Subsequently, multiple cytokine genes were applied simultaneously, or in combination with other factors such as chemokines, membrane bound co-stimulatory molecules, or tumor associated antigens. In this review we discuss these strategies and their use in cancer treatment as well as the promises and limitations of cytokine based cancer gene therapy. Clinical trials, including our own experience, employing the above strategies are discussed.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 613-624
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of mutations in the p16/ CDKN2A gene in sporadic and familial melanoma in the Polish population.
Autorzy:
Lamperska, Katarzyna
Karczewska, Aldona
Kwiatkowska, Eliza
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043764.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
familial melanoma
melanoma
mutations
CDKN2A
Opis:
Mutations in CDKN2A have been found in sporadic cutaneous malignant (CMM), in familial CMM and in other syndromes associated with melanoma. In this study DNA was obtained from 207 individuals and five cell lines. There were 157 CMM patients and 50 healthy members of melanoma patients families. The CMM group included patients with one or two melanoma cases in the family, families with dysplastic nevus syndrom (DNS) and patients with a spectrum of other types of cancers in the family. PCR-SSCP analysis and sequencing identified: six substitutions in codon 58 CGA/TGA (Arg/Stop), 16 substitutions GAC/GAT in codon 84 (Asp/Asp), six substitutions CGA /TGA in codon 148 (Arg/Thr), 14 substitutions G/C in 3'UTR and 4 double changes (two in codon 84 and 3'UTR; two in codon 148 and 3'UTR). The mutation identified in codon 58 was found in tissue only. Other substitutions were polymorphisms found in DNA from tissue and blood samples. Most of them were identified in sporadic CMM (six in codon 148 Ala /Thr, 12 in codon 84 Asp/Asp and six in 3'UTR). The frequency of the polymorphisms was also high in DNS and CMM/DNS families (four in codon 84 Asp/Asp and six in 3'UTR). No mutations or polymorphisms were found in CMM patients with one or two melanoma cases and CMM patients, with other cancers in family history. The analysis of the CDKN2A gene mutations in the Polish population demonstrated: (i) no germline mutations; (ii) a relatively high number of genetic changes in sporadic melanoma; (iii) a high number of polymorphisms in DNS and CMM/DNS families.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 369-376
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of p16 in sporadic primary uveal melanoma.
Autorzy:
Lamperska, Katarzyna
Mackiewicz, Krystyna
Kaczmarek, Aldona
Kwiatkowska, Eliza
Starzycka, Maria
Romanowska, Bożena
Heizman, Janina
Stachura, Jerzy
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043765.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
sporadic primary uveal melanoma
mutations
p16 protein
Opis:
Expression of p16 protein, intragenic mutations of CDKN2A and hypermethylation of CDKN2A promoter region in 41 sporadic primary uveal melanomas were studied. There were 2 cases of spindle cell B histological type, 11 of A + B and 28 of mixed type. All melanomas infiltrated sclera but in 28 cases infiltration was superficial while in 13 profound. In 7 cases the tumor infiltrated the optic nerve. Expression of p16 was studied by immunohistochemistry and recorded by assessment of the proportion of positive tumor cells and staining intensity. Results were expressed as staining index (IRS). Intragenic mutations were studied by PCR-SSCP followed by sequencing, while hypermethylation of the promoter region by CpG methylation assay. In 15% of cases less than 10% of melanoma cells were p16 positive, in 70% of cases less than 50% of cells, while in 7% more than 80% of cells stained for p16 (mean IRS for all cases was 4.87 ± 2.43). In B type the IRS was 8.5 ± 0.7, in A + B type 6.0 ± 2.1 and in the mixed type 4.17 ± 2.43 (differences statistically significant). In melanomas profoundly infiltrating sclera mean IRS was 4.16, while in those infiltrating optic nerve 3.71 (statistically not significant). Analysis of the intragenic mutations revealed in two patients a GAC/GAT substitution in codon 84 - a silent mutation. No hypermethylation of the CpG island of the p16 promoter region was found. In conclusion, we found that the degree of p16 expression is related to the histological type of tumor but not to the histological indicators of tumor invasiveness and that intragenic mutations and promoter hypermethylation are not major mechanisms of p16 inactivation in sporadic uveal melanoma.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 377-385
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of PiT1 and PiT2 retroviral receptors and transduction efficiency of tumor cells*.
Autorzy:
Grabarczyk, Piotr
Wysocki, Piotr
Gryska, Katarzyna
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043759.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
renal carcinoma
retroviral vectors
PiT1 and PiT2 retroviral receptors
human melanoma
Opis:
Recombinant retroviral vectors are still the most common gene delivery vehicles for gene therapy purposes, especially for construction of genetically modified tumor vaccines (GMTV). However, these vehicles are characterized by relatively low titre and in the case of many tumor cell lines, low transduction efficiency. We constructed bicistronic retroviral vector pseudotypes of amphotropic murine leukemia virus (A-MuLV) and gibbon ape leukemia virus (GaLV), encoding enhanced green fluorescent protein (EGFP) as a rapid and easily detectable reporter gene. Transduction of five different human melanoma and four renal carcinoma cell lines by these two virus pseudotypes revealed differences in transduction efficiency, which wase markedly lower for the renal carcinoma cell lines. Stimulation of retroviral receptor expression (PiT1 and PiT2) by phosphate depletion induced a limited increase of receptor mRNA levels, but did not improve the gene transfer efficiency. In contrast, simultaneous transduction with both vector pseudotypes markedly increased the transduction efficiency, compared to GaLV or A-MuLV alone. The same effect could be achieved by several repeated exposures of target cells to fresh vector preparation. Overexpression of GaLV receptor (PiT1) in target cells significantly increased the transduction rate and enabled retrovirus mediated gene transfer into the cells which normally are not transducible by GaLV pseudotypes. We demonstrated that, using different transduction strategies, the relatively inefficient, widely used retroviral vector systems could be significantly improved.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 333-339
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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