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Wyświetlanie 1-23 z 23
Tytuł:
Selenium – meaning in the prevention and therapy of cancer diseases
Selen – znaczenie w profilaktyce i terapii schorzeń nowotworowych
Autorzy:
Molenda, Anita
Muszyńska, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1033700.pdf
Data publikacji:
2017
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
Selol
anticancer activity
selenium compounds
Opis:
Selenium is a trace element supplied to the human body with food of plant and animal origin. It is a component of many enzymes with antioxidant activity, such as: glutathione peroxidase, seleniumprotein P, thioredoxin reductase and phospholipid hydroperoxide glutathione peroxidase. Being a component of enzymes, it protects cells against deformation and genetic damage thanks to the properties that inhibit the processes of lipid peroxidation, nucleic acids (DNA, RNA). The human body contains about 10-15 mg of selenium, 60% of which is found in erythrocytes, and 40% in blood. The problem of Poland and neighboring countries is the lack of this element in the soil, and therefore in the organisms of herbivorous farm animals. The lack of selenium in the meat of these animals causes significant deficiencies in the human body. In addition, due to the lack of this element in the soil, vegetables and preparations obtained from it do not constitute a suitable dietary source and intensify the problem of deficiency of this element in Europeans. Many studies indicate that both organic and inorganic selenium compounds reduce the progression of cancer by reducing the migration of cancer cells, inhibiting angiogenesis, and consequently reduce metastases.
Źródło:
Medicina Internacia Revuo; 2017, 28, 109; 272-279
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fitoterapia jako alternatywna metoda wspomagająca leczenie nadciśnienia
Phytotherapy as an alternative method to supp ort treatment of hypertension
Autorzy:
WYKURZ, Piotr
MUSZYŃSKA, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1033809.pdf
Data publikacji:
2017
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
hypertension
medicinal plants in hypertension
phototherapy
prophylactic of hypertension
Opis:
Hypertension is a dangerous chronic disease; it is the most common cause of death in Poland, Europe and the United States. In Poland, the estimated number of people with hypertension is about 36%. The development of this disease is progressive, a large proportion of people are unaware of their disease in the early stages. The use of basic recommendations for the prevention of hypertension i. e. stopping smoking, limiting alcohol intake and weight gain, increasing physical activity, limiting salt intake and changing eating habits can effectively lower blood pressure by 20-50 mm Hg. Such a considerable effect can significantly help a person with grade 2 hypertension (160-179 / 100-109 mm Hg). Phytotherapy is the branch of medicine that uses plants for medicinal purposes. Active compounds contained in plant raw materials can be used in heart and vascular diseases. They exhibit anti-arrhythmic, hypotensive, dilate peripheral, cerebral, coronary vessels, improving lipid profile, antioxidant, vasoprotective, antiplatelet, anti-inflammatory, immunostimulatory and diuretic. They exhibit negative chronotropic, but dromotropic and inotropic positive activity. Phytotherapy can be used as an alternative method to support the treatment of hypertension. In combination with basic preventive recommendations, it can delay the treatment by synthetic drugs for a very long time. It is therefore worth using herbs and their blends to improve the quality of our lives.
Źródło:
Medicina Internacia Revuo; 2017, 28, 108; 202-215
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Natural products in dentistry
Surowce naturalne w stomatologii
Autorzy:
Pytko-Polonczyk, Jolanta
Muszyńska, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1033719.pdf
Data publikacji:
2016
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"ether oils"
"eugenol"
"flavonoids"
"natural products in dentistry"
"zinc"
Opis:
Modern medicine used many methods of treatment; one of them is phytotherapy. It is documented that plants can not only prevent many diseases, but also cure diseases. Main activities of plant materials used in dentistry are anti-inflammatory, antibacterial, antiviral, decongestant, adtringent, anti-bleeding and regenerating. The natural materials used in dentistry are mainly in the form of lotions, tinctures, infusions, toothpaste, drops and gels. The most important group of active compounds in dental formulations of natural origin include essential oils, monoterpenoides, phenolic compounds, gums, resins, tannins, flavonoids, anthocyanins, carotenoids, chlorophyll, vitamins, elements such as especially zinc and minerals such as AlK(SO4)2. It occurs naturally and is used for control of bleeding, and as an antiseptic. The ideal antimicrobial agent should be effective in removing bacteria responsible for the periodontal disease process; to have the widest possible range of action, does not cause side effects and have a prolonged activity in the oral cavity. Accordingly natural products particularly as essential oils and phenol compounds can, fulfill these tasks.
Źródło:
Medicina Internacia Revuo; 2016, 27, 107; 68-75
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Długopole – The history of a Spa
Historia Uzdrowiska w Długopolu
Autorzy:
RYBECZKA–GACEK, Anna
PIWKOWSKI, Jerzy
MUSZYŃSKA, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1033773.pdf
Data publikacji:
2014
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
Długopole
balneology
groundwater
treatment
Opis:
Balneology (from Lat.: balneum - Steam, with gr,: lógos - science) the field of medicine spa known since antiquity that studies the healing properties of groundwater and mud, and using them in therapy. Balneology is especially effective treatment of chronic diseases such as rheumatoid arthritis, osteoarthritis and spine, post-traumatic and post-operative orthopedic osteoarthritis, gout, osteoporosis, coronary heart disease, post myocardial infarction, post alular and vascular diseases, hypertension, diseases of the nervous system and respiratory system. One of the most beautifully situated and rich in water treatment is a spa town in Dlugopole
Źródło:
Medicina Internacia Revuo; 2014, 26, 103; 126-132
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biologically active compounds from selected aphyllophorales mycelial cultures
Autorzy:
Sułkowska-Ziaja, Katarzyna
Muszyńska, Bożena
Firlej, Anna
Powiązania:
https://bibliotekanauki.pl/articles/765035.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
Basidiomycota
indole compounds
phenolic acids
sterols
Opis:
Grzyby z gromady Basidiomycota od dawna budzą zainteresowanie ze względu na występowanie w ich owocnikach szeregu związków o uznanych właściwościach leczniczych. Obiektem przeprowadzonych badań były kultury mycelialne dwóch gatunków grzybów afylloforoidalnych występujących na terenie Polski Hydnum repandum L. oraz Sparassis crispa (Wulf.) Fr. Celem podjętych badań była jakościowa i ilościowa analiza ekstraktów otrzymanych z kultur mycelialnych pod kątem występowania związków o udokumentowanej aktywności biologicznej: kwasów fenolowych, niehalucynogennych związków indolowych oraz steroli. Do oznaczeń wykorzystano wysokosprawną chromatografię cieczową faz odwróconych (RP-HPLC). Na podstawie analizy stwierdzono w ekstraktach z otrzymanej biomasy obecność ośmiu kwasów fenolowych: galusowego, gentyzynowego, p-hydroksybenzoesowego, kawowego, kumarowego, protokatechowego, syryngowego, wanilinowego oraz kwasu cynamonowego. Ilościowo dominującym związkiem był kwas protokatechowy w ilości 6,23 μg/g s.m. (H. repandum) oraz kwas hydroksybenzoesowy w ilości 4,52 μg/g s.m. (S. crispa). Spośród związków pochodnych indolu ilościowo oznaczono: indol, serotoninę, tryptaminę i tryptofan. Całkowita ich zawartość wynosiła 1,28 μg/g s. m. (ekstrakty z H. repandum) oraz 3,07 μg/g s.m. (ekstrakty z S.crispa). Ilościowo dominującym metabolitem był tryptofan. Spośród steroli oznaczono ergosterol w biomasie z kultur in vitro S. crispa (700,87 μg/g s.m). Uzyskane wyniki wskazują, że przebadane kultury mycelialne krajowych gatunków grzybów afylloforoidalnych są zdolne do akumulacji metabolitów aktywnych biologicznie.  
For a long time fungi belonging to Basidiomycota phylum have been in the center of attention because of the presence in their fruiting bodies of compounds with known therapeutic activity. Mycelial cultures of two aphyllophorales species occurring in Poland, Hydnum repandum L., and Sparassis crispa (Wulf.) Fr., were analyzed in our study. The main aim of the study was qualitative and quantitative analysis of extracts obtained from the mycelial cultures for the presence of known biologically active compounds, including phenolic acids, non-hallucinogenic indole compounds and sterols. For analyses a reversed-phase chromatography (RP-HPLC) method was used. The presence of eight phenolic acids including gallic, gentisic, p-hydroxybenzoic, caffeic, p-coumaric protocatechuic, syringic, vanillic and cinnamic acids was confirmed in the extracts obtained from the biomass. The quantitatively predominant metabolites in biomass from in vitro cultures of H. repandum and S. crispa were protocatechuic acid (6.23 μg/g DW) and p-hydroxybenzoic acid (4.52 μg/g DW). Derivatives of indole such as indole, serotonin, tryptamine and tryptophan were measured quantitatively. Their total content was estimated as 1.28 μg/g DW and 3.07 μg/g DW in H. repandum and S. crispa extracts, respectively. The major metabolite found was tryptophan. In addition, ergosterol, one of the sterols present in the biomass of in vitro cultures of S. crispa was analyzed (700.87 μg/g DW). The obtained results confirm the hypothesis that mycelial cultures of domestic species of aphyllophorales are able to accumulate biologically active metabolites. 
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2014, 10; 73-79
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Karotenoidy rola biologiczna i występowanie w owocnikach grzybów
Biological function of carotenoids and their occurrence in the fruiting bodies of mushrooms
Autorzy:
Muszyńska, Bożena
MASTEJ, Małgorzata
SUŁKOWSKA – ZIAJA, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1033726.pdf
Data publikacji:
2016
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"antioxidant activity"
"carotenoids"
"edible mushrooms"

β-carotene"
Opis:
Due to the valuable properties of carotenoidsthe interest in new methods of obtaining them is still increasing. For this purpose, since the 60s of the twentieth century, scientists conducted numerous studies to recognize the processes in which carotenoids could be produced . Carotenoids, revealing a strong antioxidant activity, act as free radical scavengers. These compounds can support many beneficial processes such as the stimulation of the immune system, the modulation of intracellular signaling pathways, the regulation of the cell cycle and apoptosis as well as theregulation of growth factors. Carotenoids were determined by spectrophotometric analysis in the following fungal species: Leucopaxillus giganteus, Sarcodon imbricatus, Lactarius piperatus, Lactarius deliciosus, Agaricus arvensis, Agaricus bisporus, Agaricus romagnesii, Agaricus silvaticus, Agaricus silvicola, Hypholoma fasciculare, Calocybe gambosa, Craterellus cornucopioides, Marasmius oreades. High performance liquid chromatography (HPLC) coupled with a UV detector detected β,β-carotene in Agaricus bisporus, Polyporus squamosus, Lepista nuda, Russula delica, Verpa conica, Pleurotus ostreatus and Hypsizgus marmoreus. β-carotene and lycopene were also found in three wild species of edible mushrooms: Leucopaxillus giganteus, Sarcodon imbricatus and Agaricus arvensi. These compounds were isolated in several species of the family Cantharellus as well. One example is Cantharellus cibarius, which contains mainly β,β-carotene and minor amounts of lycopene, α-carotene and other carotenoids, which may be δ – and γ – isomers.
Źródło:
Medicina Internacia Revuo; 2016, 27, 107; 113-122
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE USE OF SULFONAMIDES IN THE PHARMACOTHERAPY OF INFECTIOUS DISEASES OF HUMANS AND ANIMALS AND THE ASSOCIATED ENVIRONMENTAL RISK
ZASTOSOWANIE SULFONAMIDÓW W FARMAKOTERAPII CHORÓB ZAKAŹNYCH LUDZI I ZWIERZĄT ORAZ ZWIĄZANE Z TYM ZAGROŻENIA DLA ŚRODOWISKA
Autorzy:
PODKOWA, Adrian
WŁODARCZYK, Anna
OPOKA, Włodzimierz
MUSZYŃSKA, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/956843.pdf
Data publikacji:
2018
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
environmental
mushroom enzymes
sulfonamides
Opis:
Sulfonamides are one of the oldest antibacterial drugs that remain still in use in humans and animals treatment. These compounds block the biosynthesis of folate in bacterial cells, thus inhibiting growth of bacteria. In order to potentiate the pharmacological activity, sulfonamides are often combined with trimethoprim. The role of those bacteriostatic agents has decreased over the years, mainly due to increasing bacterial resistance which is an effect of the inappropriate use of sulfonamides. There are still several compounds which are administered in humans to treat not only bacterial infections, but also protozoan ones (e.g. toxoplasmosis), for instance sulfamethoxazole, sulfacetamide, sulfathiazole. More number of sulfonamides is used in veterinary. According to this fact, there is a considerable adverse effect of those compounds on the environment: sulfonamides, after having been excreted from animal organisms, are present in soil and water, including groundwater. Hence there is a strong need to find effective methods of sulfonamides degradation in order to protect the environment.
Źródło:
Medicina Internacia Revuo; 2018, 28, 110; 4-10
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Właściwości biologiczne i fizyko-chemiczne talu
Biological and physico-chemical properties of thallium
Autorzy:
MUSZYŃSKA, Bożena
ROJOWSKI, Jacek
DOBOSZ, Konrad
OPOKA, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1033799.pdf
Data publikacji:
2015
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"201Tl"
"Thallium"
"elements"
"toxicity of Thallium"
Opis:
Thallium is a toxic and quite common element in the environment, but it is poorly examined, despite the known toxic activity of this metal. The ionic radius of the element is similar to the ionic radius of potassium, and at the same valence (K+,Tl+) allows substitution of this element in the nervous system and muscle, which results in its toxic activity. Thallium interferes with many enzymes and also has a strong affinity to the group – SH. The most dangerous symptoms of poisoning come from central nervous system. This element is easily cumulated by many living organisms, which poses a serious threat. In the past, it was used in rodenticides, and despite the risks, in many countries is still used for this purpose due to its low production costs. Contamination of this element of industrial areas is associated with the steel industry and cement production, while residents of these areas are often not aware of the threat and grow in these area vegetables that can absorb thallium, and in particular here talking about the Brassicaceae family. This element in the environment should be constantly monitored. Its isotope such as 201Tl (Thallium-201) has some significance in medicine, as radiopharmaceutical.
Źródło:
Medicina Internacia Revuo; 2015, 26, 105; 180-185
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Culinary and medicinal mushrooms: insight into growing technologies
Autorzy:
Zięba, Piotr
Sękara, Agnieszka
Sułkowska-Ziaja, Katarzyna
Muszyńska, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/11543379.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
mushroom
mushroom cultivation
growing technology
Agaricus bisporus
Ganoderma lucidum
Lentinus edodes
Pleurotus
polysaccharide
terpenoid
cultivated mushroom
medicinal property
edible mushroom
Opis:
Humans have used mushrooms from the beginning of their history. However, during the last few decades, the market demand for these fruiting bodies has increased significantly owing to the spread in the capabilities of culinary and pharmacological exploitation. Natural mushroom resources have become insufficient to meet the support needs. Therefore, traditional methods of extensive cultivation as well as modern technologies have been exploited to develop effective growing recommendations for dozens of economically important mushroom species. Mushrooms can decompose a wide range of organic materials, including organic waste. They play a fundamental role in nutrient cycling and exchange in the environment. The challenge is a proper substrate composition, including bio-fortified essential elements, and the application of growing conditions to enable a continuous supply of fruiting bodies of market quality and stabilized chemical composition. Many mushroom species are used for food preparation. Moreover, they are treated as functional foods, because they have health benefits beyond their nutritional value, and are used as natural medicines in many countries. Owing to the rapid development of mushroom farming, we reviewed the growing technologies used worldwide for mushroom species developed for food, processing, and pharmacological industries.
Źródło:
Acta Mycologica; 2020, 55, 2; 5526
0001-625X
2353-074X
Pojawia się w:
Acta Mycologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Grzyby nadrewnowe z rodzaju Ganoderma źródłem biologicznie aktywnych triterpenów
Wood Decay Mushrooms of The Genus Ganoderma as A Source of Biologically Active Triterpenes
Autorzy:
Sułkowska-Ziaja, Katarzyna
Piechaczek, Małgorzata
Pacławska, Aneta
Muszyńska, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1033575.pdf
Data publikacji:
2017
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
Ganoderma sp.
anti-inflammatory
antitumor
terpenoids
Opis:
Species of the genus Ganoderma are an example of some of the most thoroughly studied representatives of Basidiomycota both in terms of chemical composition and biological activity. Among the compounds found in this kind, the therapeutic effect is primarily associated with the polysaccharides that are heteroglycans or β-D-glucans and terpenoids represented mainly by triterpenes. Triterpene compounds have a structure composed of 30 carbon atoms, usually forming a system of five six-membered rings. Characteristic of these structures are functional groups (hydroxyl, carboxyl or ketone) and double bonds. Mycochemical studies have led to the isolation of numerous triterpenes of the lanostane type (ganoderic acids, aldehydes, alcohols, esters), lucidenic acids and others from various species of the Ganoderma genus. The broad spectrum of biological activity determined by triterpene compounds includes anti- tumor, anti-inflammatory, antioxidant, hepatoprotective, antidiabetic, and antiviral effects. This work describes biologically active triterpenes in selected species of the genus Ganoderma: Ganoderma lucidum, Ganoderma applanatum, Ganoderma adspersum, Ganoderma pfeifferi, Ganoderma colossum and others. These species are sources of natural compounds valued for thousands of years in the traditional medicine of the Far East, while ongoing research has confirmed their medicinal properties nowadays.
Źródło:
Medicina Internacia Revuo; 2017, 28, 109; 237-245
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lentinula edodes (Shiitake) – biological activity
Autorzy:
MUSZYŃSKA, Bożena
PAZDUR, Przemysław
LAZUR, Jan
SUŁKOWSKA-ZIAJA, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1033807.pdf
Data publikacji:
2017
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
Lentinula edodes
eritadenine
immunostimulating effect
lentinan
shiitake
Opis:
Lentinula edodes (Berk.) Pegler (shiitake) is a species with medicinal properties that is used primarily in traditional medicine, but also in conventional oncology treatment. The first records of Lentinula edodes cultivation reach back to China under the Song dynast (960-1127). The Japanese adopted the Chinese technique of shiitake cultivation, thus becoming its main producer. Currently, shiitake is used in the treatment of lifestyle diseases. Polysaccharides contained in this species strengthen the immune system, eliminate side effects of chemo and radiotherapy and have strong antitumor, antiviral and antibacterial properties. The year 1972 saw a discovery of substances with anti-atherosclerotic effects, with the most important being eritadenine (2 (R), 3 (R)-dihydroxy-4 – (9-adanyl) butyric acid) and statin – lovastatin. L. edodes is of interest to researchers due to its content of therapeutic compounds. These substances have antitumor, antifungal, antibacterial, anti-inflammatory, hypocholesterolemic, antihypertensive, hypoglycaemic and antioxidant effects.
Źródło:
Medicina Internacia Revuo; 2017, 28, 108; 189-195
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oznaczenie cynku w ekstraktach biomasy z kultur pędowych Bacopa monnieri do sztucznych soków trawiennych
Zinc determination in extracts from bacopa monnieri shoot cultures into simulated gastric fluids
Autorzy:
MUSZYŃSKA, Bożena
ROJOWSKI, Jacek
ŁOJEWSKI, Maciej
DZIWULSKA, Karolina
OPOKA, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1033794.pdf
Data publikacji:
2015
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"Bacopa monnieri"
"DP-ASV method"
"in vitro culture"
"zinc"
Opis:
Bacopa monnieri (Water hyssop) is a hydrophyte occurring in Asia and the southern US states. This plant is known in India as Brahmi and has been used in Ayurvedic medicine for 5,000 years as sedative, supporting the treatment of insomnia and improving cerebral circulation. For the biological effect in this species are responsible triterpenoids saponins – bacosides. The aim of the study was to obtain the biomass of B. monnieri shoot in vitro cultures, and then evaluating the biomass growth and content of zinc. B. monnieri derived from in vitro culture on Murashige-Skoog medium (MS) and on the same medium, but enriched in organic additives and elements may be a good source of Zinc for the human body. The experiment was also conducted on the commercial formulations containing B. monnieri. For the determination of zinc ions DP ASV method was used. It was found that the use of highly mineralized water (mineral water “Stefan” – Spa Szczawnica) for extraction of B. monnieri biomass from in vitro culture provided the highest concentration of zinc in the material and for the biomass from MS medium with the addition of As (163.52, and 167.23 mg/mL, respectively). The lowest content was found in B. monnieri biomass from MS medium supplemented with serine, and the capsules product (13.54 and 14.57 mg/mL). For extracts of B. monnieri biomass from MS medium enriched with Zn salts into digestive juices the highest concentration of zinc was determined in gastric juice (6.88 mg/mL).
Źródło:
Medicina Internacia Revuo; 2015, 26, 105; 175-179
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
EVALUATION OF NUTRITIONAL AND MEDICINAL PROPERTIES OF BACOPA MONNIERI BIOMASS AND PREPARATIONS
Autorzy:
Muszyńska, Bożena
krakowska, Agata
Lazur, Jan
Szewczyk, Agnieszka
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/895242.pdf
Data publikacji:
2018-12-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
dietary supplements
phenolic compounds
Bacopa monnieri
artificial digestive juices
bioelements
Opis:
Bacopa monnieri (Scrophulariaceae) is a well-known plant and has been used by humans for several thousand years. In traditional Hindu medicine, it is one of the most important medicinal plants. The aim of the work was to determine the content of Fe, Mg, and Zn and selected organic compounds before and after extraction into the artificial digestive juices obtained from preparations containing B. monnieri. Commercial preparations in the form of tablets and capsules and B. monnieri shoot cultures were used in the experiment. The metal content in the considered mineralized samples was analyzed by atomic absorption spectrometry and organic compounds by RP-HPLC method. The maximum measured content of the metals released into the digestive juices was as follows: Fe – 32.85; Mg – 367.51; and Zn – 16.41 mg/100 g of the preparation. The existing research shows that metals are best released into the artificial digestive juices from the B. monnieri shoot cultures, and least efficiently from the commercial preparations available in the form of tablets. The phenolic compounds analyzed in the methanol extracts and the extracts of the artificial digestive juices were as follows: protocatechuic acid, p-hydroxybenzoic acid, neochlorogenic acid, chlorogenic acid, isochlorogenic acid, caffeic acid, ferulic acid, cynaroside, trifolin, and luteolin. Bacoside A was only determined in the extracts from the B. monnieri shoot cultures. The experimental results revealed that B. monnieri distributed in the form of tablets did not break down in the artificial digestive juices during the considered time intervals.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1353-1361
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
L-tryptophan and its deriviates in edible mushroom species.
Autorzy:
MUSZYŃSKA, Bożena
KOMENDACKI, Paweł
KAŁA, Katarzyna
OPOKA, Włodzimierz
ROJOWSKI, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1033762.pdf
Data publikacji:
2014
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
L–tryptophan
antidepressant agent
antioxidant activity
edible mushrooms
indole compounds
Opis:
Mushrooms are able to accumulate both primary and secondary metabolites. Medicinal and antioxidant properties of mushrooms are an excellent combination of their nutrition value. Recent studies have demonstrated that edible mushroom species contain non–hallucinogenic indole compounds and their derivatives. The indole skeleton is the basis of the substances serving important functions in the human body, such as serotonin and melatonin. These compounds fulfill the role of neurotransmitters or their precursors, exhibit antioxidant, anticancer, anti–aging actions, regulate the diurnal cycle in humans and participate in blood coagulation. These compounds and their derivatives are also anti– inflammatory and analgesic therapeutics.
Źródło:
Medicina Internacia Revuo; 2014, 26, 103; 82-88
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparaty zawierające algi źródłem substancji prozdrowotnych
Algae preparations as a source of beneficial healthy substances
Autorzy:
Jękot, Barbara
RZEWIŃSKA, Aleksandra
HAŁASZUK, Patrycja
ROJOWSKI, Jacek
MUSZYŃSKA, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1034034.pdf
Data publikacji:
2016
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
" Spirulina"
"Arthrospira sp"
"Eucaryot
"anti-aging activity"
"antioxidant activity"
Algae"
Opis:
Algae used in OTC preparations and as functional food are available in the form of finished formulations: powders – lyophilisates, tablets, pills, capsules, and are widely used in cosmetics. In these formulations most commonly used species of algae is cyanobacteria: Arthrospira platensis (Spirulina platensis) and Arthrospira maxima (Spirulina maxima), species of red algae – red algae of the genus Porphyra: Porphyra yezoensis and Porphyra tenera and brown algae – Fucus vesiculosus and green algae for example: Chlorella vulgaris. They are used in cosmetology, pharmacy, food industry, agriculture and environmental protection. Hence, getting to know the current state of the market and knowledge of the preparations containing algae and the promotion of knowledge about their effectiveness is expedient to influence effectively on the prevention of civilization diseases. Conducting a survey on knowledge of the preparations of algae, efficiency and preventive properties may allow to know the current state of knowledge in Poland, about the development of effective promotion in order to use of them. The aim of the study was to assess the knowledge and the possibility of using supplements and food additives containing algae and assessment of the effectiveness of activities in the first reinforcement and anti-aging preparations containing algae in the studied groups of people. Algae due to the fact that are a source of many substances such as amino acids, proteins, minerals, vitamins, polysaccharides, lipids, and polyamides, which are necessary for the proper functioning of the human body, have been used in various industries.
Źródło:
Medicina Internacia Revuo; 2016, 27, 106; 4-10
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tricholoma equestre species as a source of indole compounds and zinc released into artificial digestive juices
Autorzy:
KAŁA, Katarzyna
SUŁKOWSKA-ZIAJA, Katarzyna
ROJOWSKI, Jacek
OPOKA, Włodzimierz
MUSZYŃSKA, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1034031.pdf
Data publikacji:
2016
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"artificial digestive juices"
"fruiting bodies
"in vitro culture"
"zinc"
Tricholoma equestre"
indole compounds"
Opis:
The research goals of presented work consisted of determination of zinc and indole compounds that are released into artificial digestive juices from Tricholoma equestre species. During the experiment freeze-dried samples of wild growing fruiting bodies and mycelia from in vitro cultures from liquid Oddoux medium were extracted to artificial digestive juices (saliva, gastric juice and intestinal juice). In the next step the determination of examined compounds was done by RP-HPLC for indole compounds and DP ASV for zinc. Furthermore it was decided to check weather this species has any beneficial properties for health. The extraction of researched material in conditions imitating human digestive tract allows determination of true amounts of elements released to artificial digestive juices and their beneficial influence (a specially designed and constructed apparatus Gastroel-2014 was applied). The indole compound with the highest quantity was 5-hydroxy-L-tryptophan, both in fruiting bodies and in biomass from in vitro cultures of T. equestre (up to 352.47 mg/100 g d.w.). Serotonin and L-tryptophan was determined in all analysed samples, but their amounts were significantly lower than the ones found for 5-hydroxy-L-tryptophan. The amounts of zinc on the other hand showed that the biggest concentration of zinc can be obtained for fruiting bodies and biomass from in vitro cultures to both artificial saliva and gastric juice after 120 minutes of digestion (6.83 14.4 mg/100 g d.w. retrospectively) in conditions that imitate human digestive track.
Źródło:
Medicina Internacia Revuo; 2016, 27, 106; 35-39
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of indole derivatives in methanolic extracts from mycelium of Agaricus bisporus cultured in vitro on liquid Oddoux medium
Autorzy:
Muszyńska, Bożena
Sułkowska-Ziaja, Katarzyna
Hałaszczuk, Patrycja
Krężałek, Remigiusz
Łojewski, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/765001.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
Agaricus bisporus
in vitro culture
L-tryptophan
serotonin
Opis:
Lecznicze i przeciwutleniające właściwości grzybów są doskonałym połączeniem, które stanowi o ich wartości dietetycznej i umożliwia korzystanie z nich zarówno, jako żywności jak i dodatku żywieniowego. Celem niniejszej pracy była analiza zawartości fizjologicznie aktywnych związków indolowych w mycelium z kultur in vitro Agaricus bisporus (pieczarka dwuzarodnikowa). L-tryptofan, egzogenny aminokwas i jego pochodne, takie jak np. 5-hydroksytryptofan, muszą być dostarczane z pokarmem w codziennej diecie. Związki te mają działanie przeciwdepresyjne, są bezpośrednimi prekursorami serotoniny, a w przeciwieństwie do niej przekraczają barierę krew – mózg. Są też biogenetycznymi prekursorami innych związków indolowych, które pełnią funkcję neuroprzekaźników, co uzasadnia oznaczanie ich zawartości w grzybach jadalnych. Materiał do badań stanowiły owocniki A. bisporus pochodzenia komercyjnego. Z owocników A. bisporus wyprowadzono kultury in vitro na podłożu stałym Oddoux (1957). Eksperymentalne kultury in vitro prowadzono na płynnym, wytrząsanym podłożu Oddoux. Co dwa tygodnie prowadzenia kultur pasażowano je na świeżą pożywkę. Biomasę mrożono i suszono metodą liofilizacji. Otrzymaną biomasę z kultur in vitro analizowano jakościowo i ilościowo metodą HPLC na obecność niehalucynogennych związków indolowych. Po raz pierwszy zidentyfikowane i ilościowo oznaczone zostały związki indolowe w kulturach in vitro Agaricus bisporus na płynnym podłożu wg Oddoux. Analiza wykazała, że ekstrakty metanolowe otrzymane z grzybni zawierają sześć związków indolowych: L -tryptofan, 5 - hydroksytryptofan, serotoninę, melatoninę, tryptaminę i 5-metylotryptamię. Zawartości poszczególnych składników w biomasie z kultur in vitro były zróżnicowane w zakresie od 0,01 do 21,33 mg/100 g s. m. Dominującymi ilościowo związkami były: 5-hydroksytryptofan (12,50 mg/100 g s. m.), L-tryptofan (14,00 mg/100 g) i serotonina (7,00 mg/100 g). Całkowita zawartość związków indolowych w badanym materiale wynosiła 55,32 mg/100 g s. m. Biomasa z kultur in vitro badanego gatunku jest dobrym źródłem 5-hydroksytryptofanu i L- tryptofanu. Kultury in vitro A. bisporus mogą być wykorzystane jako model do badań nad akumulacją i metabolizmem związków indolowych.
Methanolic extracts obtained from biomass of Agaricus bisporus (J.E. Lange) Imbach cultured in vitro were analyzed for qualitative and quantitative composition of non-hallucinogenic indole compounds in order to compare their amount with fruiting bodies of these species. Extracts demonstrated to contain six indole compounds. Contents of individual compounds ranged from 0.01 to 21.33 mg/100 g d.w. in biomass from in vitro cultures. The quantitatively dominating compounds included: 5-hydroxytryptophan (12.50 mg/100 g d.w.), L-tryptophan (14.00 mg/100 g d.w.) and serotonin (7.00 mg/100 g d.w.). Total content of the remaining indole compounds under analysis in the study was 55.32 mg/100 g d.w.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2014, 10; 66-72
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mykosterole — charakterystyka i znaczenie biologiczne
Mycosteroles — Characteristics and Biological Importance
Autorzy:
SUŁKOWSKA-ZIAJA, Katarzyna
HAŁASZUK, Patrycja
MASTEJ, Małgorzta
PIECHACZEK, Małgorzata
MUSZYŃSKA, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1034021.pdf
Data publikacji:
2016
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
"edible mushrooms"
"ergosterol"
Basidiomycota
mycosterols"
Opis:
A group of natural sterols isolated from mushrooms are mycosterols, of which derivatives the most interesting is ergosterol (5,7,22-ergostatrien-3β-ol) and its peroxide, which are presented in the fruiting bodies of most of the representatives of the Basidiomycota taxon. Mushroom sterols are synthesized in a similar way, but the reaction sequence, which is squalene metabolism and the stereochemistry of the major products are different. As with many derivatives of isoprene, the basic unit of the synthesis of sterols is isopentenyl pyrophosphate (IPP), which in turn is synthesized from acetyl-CoA by alternately pass away of mevalonic acid. Mycosteroles, they are considered beneficial compounds that have health promoting effects. It has been proven their ability to lower serum cholesterol, may also be effective in the prevention of certain types of cancer. Ergosterol, which is common in mushrooms, as peroxidation products thereof, also exhibits many beneficial effects. It may have the potential health benefits and influence on the improvement of essential physiological functions of human body, including reduced pain associated with the activity of inflammation, reduction in the incidence of cardiovascular disease, inhibition of the enzyme cyclooxygenase (COX) and lowering cholesterol levels. It also has antioxidant properties and inhibit the growth of fungi and bacteria.
Źródło:
Medicina Internacia Revuo; 2016, 27, 106; 26-34
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-inflammatory activities of garlic sprouts, a source of α-linolenic acid and 5-hydroxy-l-tryptophan, in RAW 264.7 cells
Autorzy:
Gdula-Argasińska, Joanna
Paśko, Paweł
Sułkowska-Ziaja, Katarzyna
Kała, Katarzyna
Muszyńska, Bożena
Powiązania:
https://bibliotekanauki.pl/articles/1038621.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Allium sativum sprouts
indolic and phenolic compounds
α-linolenic acid
anti-inflammatory activity
RAW 264.7 cells
Opis:
The purpose of this study was to analyze the indolic, phenolic, and fatty acid content and antioxidant activity of garlic sprouts growing in the dark and in the daylight. The pro- or anti-inflammatory properties of the garlic sprout extract were investigated by evaluating the cyclooxygenase-2 (COX-2), prostaglandin E synthase (cPGES), glutathione S transferase (GSTM1), nuclear factor NF-κB, peroxisome proliferator-activated receptors (PPARs), and aryl hydrocarbon receptor (AhR) protein levels in the RAW 264.7 cells activated with lipopolysaccharide (LPS). The highest amount of total indolic (73.56 mg/100 g f.w.) and phenolic compounds (36.23 mg/100 g f.w.) was detected in garlic sprouts grown in the daylight. Studies on antioxidant activity (the FRAP and DPPH method) of garlic sprouts showed that this activity is significantly higher for sprouts grown in full access to light when compared to those grown in the dark. In garlic sprout extracts, α-linolenic acid (ALA) was found to be in greater amount. COX-2 and cPGES level was lower when compared to LPS alone activated cells. After garlic extract treatment, higher level of GSTM1, PPARΥ, cytosolic p50 and p65 protein, as well as a lower NF-ĸB p50/p65 activity was noted in the RAW 264.7 cells which suggested PPARs and AhR transrepression mechanism of NF-ĸB signalling. The obtained results indicate Allium sativum sprouts are a rich source of n-3 fatty acids, indolic and phenolic compounds characterized by anti-inflammatory and antioxidative activity, which may support their high therapeutic and dietary potential.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 551-559
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of the content of phenolic compounds in in vitro culture of some edible mushrooms (Basidiomycota)
Autorzy:
Muszyńska, Bożena
Kała, Katarzyna
Sułkowska-Ziaja, Katarzyna
Szewczyk, Agnieszka
Łojewski, Maciej
Rojowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1033831.pdf
Data publikacji:
2015
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
agaricus bisporus
boletus badius
cantharellus cibarius
medicinal mushroom
phenolic
acids
Opis:
Phenolic compounds, both derivatives of benzoic and cinnammic acid, possess biologically valuable properties: anti-inflammatory, antioxidant, anticarcinogenic and others. Studies of the accumulation of these compounds focused mostly on plant material. Rich sources of these compounds are representatives of Basidiomycota taxon. The aim of the study was qualitative and quantitative HPLC analysis of phenolic acids in biomass from in vitro culture of selected edible mushroom species belonging to the phylum Basidiomycota: Agaricus bisporus, Boletus badius, Cantharellus cibarius. The investigations revealed the presence of the following acids: p-hydroxybenzoic, syringic and galic acid. Both the composition and the amount of phenolic acids in biomass of A. bisporus and Boletus badius were diverse. The total amount ranged from 6.07 mg·100 g−1 DW in A. bisporus to 14.78 mg·100 g−1 DW in Boletus badius. Syryngic acid amounts fluctuated in the range of 1.75–9.66 mg·100 g−1 DW, with its maximum in Boletus badius. Gallic acid dominated in the biomass of the same species (5.12 mg·100 g−1 DW). p-Hydroxybenzoic acid was found in biomass from in vitro culture of A. bisporus at levels 0.70 mg/100 g DW. In biomass of in vitro culture of Cantharellus cibarius no phenolic compounds were found before and after hydrolysis. The results of HPLC analyses show that in vitro culture of B. badius and A. bisporus are a good dietary source of phenolic compounds with antioxidant activity.
Źródło:
Medicina Internacia Revuo; 2015, 26, 104; 146-152
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Edible Mushrooms in Prophylaxis and Treatment of Human Diseases
Autorzy:
MUSZYNSKA, Bożena
SUŁKOWSKA-ZIAJA, Katarzyna
ŁOJEWSKI, Maciej
OPOKA, Włodzimierz
ZAJĄC, Magdalena
ROJOWSKI, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1033825.pdf
Data publikacji:
2013
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
Basidiomycota
chitosans
ergothioneine
hypercholesterolemia
statins
Opis:
In recent years an increase in the consumption of edible mushrooms has been observed. In many countries mushrooms have been a popular delicacy, as they add flavor and texture to a meal. Mushrooms are able to accumulate both primary and secondary metabolites. Some of them may play an antioxidant role, e.g. phenolic and indole compounds, flavonoids, terpenoids, sterols, ascorbic acid, ergothioneine and carotenoids and are a source of elements, e.g. selenium. Indole compounds fulfill the role of neurotransmitters or their precursors, exhibit antioxidant, anticancer, anti-inflammatory and anti-aging actions, regulate the diurnal cycle in humans and take part in blood coagulation. Biologically and therapeutically active metabolites of fungi are used to treat such serious diseases as cardiovascular diseases, diabetes, atherosclerosis and cancer. The intake of mushrooms clearly has a cholesterol-lowering effect or hypocholesterolemic effect by different mechanisms such as decreasing VLDL, improving lipid metabolism, inhibiting of activity of HMG-CoA reductase, and consequently preventing the development of atherosclerosis. The antioxidant and anti-inflammatory compounds occurring in mushrooms also may contribute to reduce the atherosclerosis risk.
Źródło:
Medicina Internacia Revuo; 2013, 25, 101; 170-183
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
Autorzy:
Grzywacz, Agata
Gdula-Argasińska, Joanna
Muszyńska, Bożena
Tyszka-Czochara, Małgorzata
Librowski, Tadeusz
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1038990.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
metal responsive-transcription factor 1
cell signaling
inflammation
NF-κB
Opis:
Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. MTF-1 acts in the process of binding of toxic metal ions in the cell, due to the activation of the expression of metallothioneins (MTs). Additionally, MTF-1 regulates transcription of genes involved in the sequestration of zinc and its intracellular transport. Disruption of zinc and MT homeostasis has an indispensable influence on the development of several pathological states. Moreover, by increasing MT activity, MTF-1 can effectively protect cells from oxidative and hypoxic stresses. The mechanism of MTF-1 action in cells includes the regulation of the proper immune response through activation/repression of anti- and pro-inflammatory cytokines. MTF-1 function in immune response is related to nuclear factor-κB (NF-κB) activity. Synthesis of insulin is also related to the activity of this transcription factor and zinc balance. Insulin transport also depends on zinc. In pancreatic β-cells, several types of the zinc transporters are found. Zinc transporters coordinated action is crucial for the synthesis and secretion of insulin. Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 491-498
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
RELEASE OF BIOACTIVE SUBSTANCES FROM FORMULATIONS CONTAINING ARTHROSPIRA PLATENSIS (SPIRULINA PLATENSIS)
Autorzy:
Muszyńska, Bożena
Lazur, Jan
Jękot, Barbara
Krakowska, Agata
Szewczyk, Agnieszka
Sułkowska-Ziaja, Katarzyna
Zimmer, Łukasz
Poleszak, Ewa
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/895358.pdf
Data publikacji:
2018-10-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
zinc
phenolic compounds
artificial digestive juices
Arthrospira platensis
indole compounds
Opis:
Arthrospira platensis (Spirulina platensis) is a well-known microalga and has been utilized as a medicinal agent and foodstuff by humans since at least 16th century. The aim of this study was to determine zinc content as well as determine phenolic and indole compounds from commercial preparations containing Arthrospira platensis (lyophilizate, tablets, and capsules) before and after extraction with methanol and incubation with artificial digestive juices. The secondary aim of this study was to evaluate the quality of these preparations. The samples were incubated in artificial stomach juice and in intestinal juice. The samples were mineralized and their zinc(II) ions content was estimated using flame absorption atomic spectroscopy (F-AAS). The maximum zinc(II) ions content released into the digestive juices was found to be up to 1.6 mg 100 g-1 of the preparation. Phenolic compounds identified in the examined extracts are as follows: gallic acid; protocatechuic acid; 3,4-dihydroxyphenylacetic acid; p-hydroxybenzoic acid; syringe acid; cinnamic acid; and quercetin. Furthermore, indole compounds identified were 5-hydroxy-L-tryptophan, 5-methyl-L-tryptophan, L-tryptophan, tryptamine, and 5-methyltryptamine. Consequently, it was also found that the distributed Arthrospira platensis in the form of tablets does not disintegrate in the artificial digestive juices. Among the examined preparations, only hard capsules met the requirements of the European Pharmacopeia 8th ed.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1187-1199
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
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