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Tytuł:
One cabin equipment location method based on the visibility human-factor potential field
Metoda rozmieszczania przyrządów pokładowych oparta na pojęciach potencjałowego pola widoczności oraz potencjałowego pola czynnika ludzkiego
Autorzy:
Ge, Z.
Wu, F.
Yang, Y.
Luo, X.
Powiązania:
https://bibliotekanauki.pl/articles/301748.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
cabin equipment
human-factor potential field (HFPF)
visibility potential field(VPF)
layout optimization
particle swarm optimization (PSO)
przyrządy pokładowe
potencjałowe pole czynnika ludzkiego (HFPF)
potencjałowe pole widoczności (VPF)
optymalizacja rozmieszczenia
optymalizacja rojem cząstek (PSO)
Opis:
The visibility is the basic condition for cabin equipment location. For the description of human, object and obstacle, the humanfactor potential field concept is proposed in this paper, concluding the visibility potential field, the reachability potential field. The cabin equipment layout problem is modeled based on the basic visibility potential field model. The optimal layout optimization method is studied based on the particle swarm optimization (PSO) algorithm by natural selection. Finally, the applicability of the proposed idea is illustrated by numerical studies.
Widoczność jest podstawowym warunkiem przy projektowaniu rozmieszczenia przyrządów pokładowych. W przedstawionej pracy zaproponowano pojęcie potencjałowego pola czynnika ludzkiego (human-factor potential field, HFPF), które służy do opisu czynnika ludzkiego, przedmiotów oraz przeszkód. HFPF obejmuje pojęcia potencjałowego pola widoczności oraz potencjałowego pola dostępu. Problem umiejscowienia elementów wyposażenia kabiny zamodelowano na podstawie podstawowego modelu potencjałowego pola widoczności. Metodę optymalizacji rozmieszczenia elementów wyposażenia badano w oparciu o algorytm optymalizacji rojem cząstek (PSO), metodą naturalnej selekcji. Zastosowanie proponowanej koncepcji zilustrowano na przykładzie badań numerycznych.
Źródło:
Eksploatacja i Niezawodność; 2015, 17, 2; 236-242
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mean failure mass and mean failure repair time: parameters linking reliability, maintainability and supportability
Średnia masa uszkodzenia i średni czas naprawy uszkodzenia: parametryłączące niezawodność, obsługiwalność i utrzymywalność
Autorzy:
Yang, Y.
Lu, Z.
Luo, X.
Ge, Z.
Qian, Y.
Powiązania:
https://bibliotekanauki.pl/articles/301018.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
średnia masa uszkodzenia
średni czas naprawy uszkodzenia
niezawodność
obsługiwalność
LRU
mean failure mass
mean failure repair time
reliability
maintainability
Opis:
Jak dotąd w inżynierii niezawodności nie istniały parametry łączące niezawodność, obsługiwalność i utrzymywalność. Wskaźniki takie jak gotowość mogą być stosowane w celu sprawdzenia zgodności tych cech RAM (Reliability, Availability, Maintainability – Niezawodność, Gotowość, Obsługiwalność) dopiero po uzyskaniu indywidualnego wskaźnika każdej charakterystyki, takich jak MTBF, MTTR, itp. W ten sposób dostępne metody równoważenia owych trzech cech nie są wystarczająco skuteczne i bezpośrednie w fazie projektowania produktu . Niniejszy artykuł przedstawia pojęcia średniej masy uszkodzenia i średniego czasu naprawy uszkodzenia. Badając zależność prawdopodobieństwa uszkodzenia i masy produktu, uzyskuje się cechę łączącą niezawodność i utrzymywalność. Podobnie, badając zależność prawdopodobieństwa uszkodzenia i średniego czasu naprawy produktu, uzyskuje się cechę łączącą niezawodność i obsługiwalność. Na bazie powyższych definicji osiągnięto kompromisowe podejście do niezawodności, obsługiwalności i utrzymywalności podczas fazy projektowania. Skuteczności obu nowych koncepcji dowodzi przykład równoważenia niezawodności i obsługiwalności podsystemu stacji kosmicznej.
Up to now, no parameters linking reliability, maintainability and supportability directly are available in reliability engineering. Index such as availability can be used to check the compatibility of those RAM features only after individual index of every characteristic is obtained such as MTBF, MTTR, etc. Thus available methods to balance those three features are not efficient and direct during the product design phase. In this paper, concepts of mean failure mass and mean failure repair time are presented. By investigating the relationship of the failure probability and the mass of a product, a feature linking reliability and supportability is obtained. Similarly, by studying the relationship of the failure probability and the mean time to repair of a product, a feature linking reliability and maintainability is obtained. Based on above definitions, an approach of reliability, maintainability and supportability trade-off during design phase is achieved. Effectiveness of both of the new concepts is demonstrated by an example of balancing the maintainability and supportability of a subsystem of a space station.
Źródło:
Eksploatacja i Niezawodność; 2014, 16, 2; 307-312
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Flotation separation of scheelite from calcite using sodium polyacrylate as depressant
Autorzy:
Zhang, Y.
Chen, R.
Li, Y.
Wang, Y.
Luo, X.
Powiązania:
https://bibliotekanauki.pl/articles/110896.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
scheelite
calcite
flotation
sodium polyacrylate
selective depression
Opis:
The depressing properties of sodium polyacrylate (PA-Na) for calcite from scheelite were studied by microflotation experiments, zeta potentials, X-ray photoelectron spectroscopy (XPS) and density functional theory (DFT) calculation. Flotation results revealed that the selective depression effect of PA-Na was better than that of sodium silicate (Na2SiO3), and PA-Na can depress calcite more effectively than scheelite. The flotation recovery of scheelite and calcite kept at about 75% and 15% respectively at the pulp pH 9.3~9.6 and PA-Na concentration from 37.5 mg/dm3 to 50 mg/dm3. The zeta potentials of the minerals were significantly altered and the zeta potential of calcite became more negative than scheelite. XPS analysis deduced the occurrence of chemisorption between PA-Na and mineral surfaces, and the chemisorption of PA-Na on calcite was stronger than on scheelite. The results from DFT calculation demonstrated that the absolute value of the adsorption energy in the presence of PA-Na on the surface of calcite {104} was larger than on the surface of scheelite {111}. With the combination of the analysis, it could be concluded that calcite was more easily depressed than scheelite, and this finding remarkably matched with the microflotation experimental results. Furthermore, by using PA-Na as depressant, the flotation separation of scheelite from calcite can be achieved by controlling the flotation pH and PA-Na dosage.
Źródło:
Physicochemical Problems of Mineral Processing; 2018, 54, 2; 505-516
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of dissolved mineral species in quartz flotation and siderite solubility simulation
Autorzy:
Luo, X.
Wang, Y.
Ma, M.
Song, S.
Zhang, Y.
Deng, J.
Liu, J.
Powiązania:
https://bibliotekanauki.pl/articles/109459.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
quartz
solubility
siderite
calcium ion
temperature
flotation
Opis:
Quartz is, in most cases, the major gangue mineral found in the iron ores. Although it can be activated by calcium at strong alkaline pH, quartz nevertheless, reports to the concentrate with Fe when the iron ores contain siderite. It causes a poor concentrate grade and separation between quartz and iron minerals. The effect of siderite on reverse anionic flotation of quartz from hematite was studied in our previous investigations. In this work, the effect of siderite dissolution on the quartz recovery in the froth product and the effect of pH, ions and temperature on siderite dissolution were investigated. Microflotation, PHREEQC simulation, solution chemistry calculation and Fourier transform infrared spectroscopy (FTIR) measurements were conducted. It was observed that the dissolved species of siderite exhibited negative impact on quartz flotation. This influence became weak to some extent by either stripping the dissolved species or shortening dissolution time. Siderite was easily dissolved in the presence of calcium ion under strong alkaline conditions and its solubility increased with increasing the calcium ion concentrate and temperature. When the calcium ion was added as an activator of quartz under strong alkaline conditions (pH>9.96), calcium existed mainly in the CaCO3 precipitation form according to the solubility rule in the presence of siderite. This form could adsorb onto quartz surfaces and further the chemical reaction between starch and quartz was monitored by FTIR measurements. This study provides a further supplement for previous study. A potential strategy is suggested that finding a collector used at low temperature or flotation under neutral (or weak alkaline) medium is helpful to the reverse flotation of iron ores containing siderite.
Źródło:
Physicochemical Problems of Mineral Processing; 2017, 53, 2; 1241-1254
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Were mammals originally venomous?
Autorzy:
Hurum, J H
Luo, Z.X.
Kielan-Jaworowska, Z.
Powiązania:
https://bibliotekanauki.pl/articles/23010.pdf
Data publikacji:
2006
Wydawca:
Polska Akademia Nauk. Instytut Paleobiologii PAN
Tematy:
Gobiconodon
Monotremata
mammal
os calcaris
Zhangheotherium
cornu calcaris
fossil mammal
Multituberculata
paleontology
Opis:
The extratarsal spur in extant monotremes consists of an os calcaris and a cornu calcaris. A poisonous extratarsal spur occurs only in the platypus (Ornithorhynchus); a possibly secondarily non−poisonous spur is present in echidnas (Tachyglossus and Zaglossus). Some therian mammals (e.g., bats), reptiles (Chamaeleo), and amphibians have a spur−like structure in the ankle, but this is not homologous to the extratarsal spur of monotremes. Among fossil mammals, the co−ossified os calcaris and ossified cornu calcaris have been found in the eutriconodontan Gobiconodon and in the spalacotheroid “symmetrodontan” Zhangheotherium. Here we describe the os calcaris in several multituberculate mammals from the Late Cretaceous of the Gobi Desert, Mongolia. The multituberculate os calcaris is a large, flat bone, generally similar to that in males of the extant monotreme species, but the cornu calcaris is not ossified. In Gobiconodon and Zhangheotherium the ossified cornu calcaris is fused to the os calcaris probably to provide the bony support for the keratinous spur. We hypothesize that the os calcaris in these Mesozoic mammal groups is homologous to that of monotremes. However, the extratarsal spur has not been found in non−mammalian cynodonts nor in other synapsids. A platypus−like os calcaris might be an apomorphic characteristic of basal Mesozoic mammals and is secondarily lost in crown therians; the os calcaris is confirmed to be absent in well−preserved tarsal structures of the earliest known crown therian mammals. We speculate that the os calcaris, the cornu calcaris, and its associated venom gland might have served the function of a defensive structure during the “dark ages” of mammalian history, when dinosaurs ruled the Earth. This structure is a plesiomorphic character retained in extant monotremes and cannot be used as an autapomorphy of Monotremata.
Źródło:
Acta Palaeontologica Polonica; 2006, 51, 1
0567-7920
Pojawia się w:
Acta Palaeontologica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In quest for a phylogeny of Mesozoic mammals
Autorzy:
Luo, Z X
Kielan-Jaworowska, Z.
Cifelli, R.L.
Powiązania:
https://bibliotekanauki.pl/articles/23509.pdf
Data publikacji:
2002
Wydawca:
Polska Akademia Nauk. Instytut Paleobiologii PAN
Tematy:
Monotremata
phylogenesis
Mesozoic
Boreosphenida
mammal
parsimony analysis
Mammalia
Australosphenida
Allotheria
Eutriconodonta
paleontology
Opis:
We propose a phylogeny of all major groups of Mesozoic mammals based on phylogenetic analyses of 46 taxa and 275 osteological and dental characters, using parsimony methods (Swofford 2000). Mammalia sensu lato (Mammaliaformes of some authors) are monophyletic. Within mammals, Sinoconodon is the most primitive taxon. Sinoconodon, morganucodontids, docodonts, and Hadrocodium lie outside the mammalian crown group (crown therians + Monotremata) and are, successively, more closely related to the crown group. Within the mammalian crown group, we recognize a fundamental division into australosphenidan (Gondwana) and boreosphenidan (Laurasia) clades, possibly with vicariant geographic distributions during the Jurassic and Early Cretaceous. We provide additional derived characters supporting these two ancient clades, and we present two evolutionary hypotheses as to how the molars of early monotremes could have evolved. We consider two alternative placements of allotherians (haramiyids + multituberculates). The first, supported by strict consensus of most parsimonious trees, suggests that multituberculates (but not other alllotherians) are closely related to a clade including spalacotheriids + crown therians (Trechnotheria as redefined herein). Alternatively, allotherians can be placed outside the mammalian crown group by a constrained search that reflects the traditional emphasis on the uniqueness of the multituberculate dentition. Given our dataset, these alternative topologies differ in tree−length by only ~0.6% of the total tree length; statistical tests show that these positions do not differ significantly from one another. Similarly, there exist two alternative positions of eutriconodonts among Mesozoic mammals, contingent on the placement of other major mammalian clades. Of these, we tentatively favor recognition of a monophyletic Eutriconodonta, nested within the mammalian crown group. We suggest that the “obtuse−angle symmetrodonts” are paraphyletic, and that they lack reliable and unambiguous synapomorphies.
Źródło:
Acta Palaeontologica Polonica; 2002, 47, 1
0567-7920
Pojawia się w:
Acta Palaeontologica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of matrine on reducing damage to bovine mammary epithelial cells induced by Staphylococcus aureus alpha-hemolysin
Autorzy:
Feng, F.
Ma, W.W.
Luo, H.X.
Guan, C.P.
Zhou, X.Z.
Powiązania:
https://bibliotekanauki.pl/articles/2087720.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
α-hemolysin
BMECs
matrine
cell damage
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 2; 409-413
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of Temperature Field, Heat and Fluid Flow of Two-Phase Zone Continuous Casting Cu–Sn Alloy Wire
Autorzy:
Luo, J.
Liu, X.
Wang, X.
Powiązania:
https://bibliotekanauki.pl/articles/380230.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
continuous casting
two-phase zone continuous casting
alloy Cu-Sn
numerical simulation
temperature field
heat flow
fluid flow
odlewanie ciągłe
strefa odlewania dwufazowego
stop Cu-Sn
symulacja numeryczna
pole temperatury
przepływ ciepła
przepływ płynu
Opis:
Cu–4.7 wt. % Sn alloy wire with Ø10 mm was prepared by two-phase zone continuous casting technology, and the temperature field, heat and fluid flow were investigated by the numerical simulated method. As the melting temperature, mold temperature, continuous casting speed and cooling water temperature is 1200°C, 1040°C, 20 mm/min and 18°C, respectively, the alloy temperature in the mold is in the range of 720°C–1081°C, and the solid/liquid interface is in the mold. In the center of the mold, the heat flow direction is vertically downward. At the upper wall of the mold, the heat flow direction is obliquely downward and deflects toward the mold, and at the lower wall of the mold, the heat flow deflects toward the alloy. There is a complex circular flow in the mold. Liquid alloy flows downward along the wall of the mold and flows upward in the center.
Źródło:
Archives of Foundry Engineering; 2016, 16, 1; 33-40
1897-3310
2299-2944
Pojawia się w:
Archives of Foundry Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental study of a small gas-puff Z-pinch device
Autorzy:
Luo, C.
Wang, X.
Zou, X.
Powiązania:
https://bibliotekanauki.pl/articles/147416.pdf
Data publikacji:
2006
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
Z-pinch plasma
plasma diagnostics
multi-frame interferometry
electron density
energy spectra of ion beams
Opis:
A small gas puff Z-pinch device has been constructed and operated. The device has the parameters: the capacitance of energy storage capacitors 16 mi F, charging voltage 22 kV, peak current 210 kA and a quarter of current period 2.4 mi s. A three-frame Mach-Zehnder interferometer and a compact Thomson ion energy analyzer were developed for Z-pinch plasma experiment. According to the results of diagnostics, the electron density ne of the plasma right before pinch instant is larger than 5.4 × 1019/cm3, the corresponding pinch velocity v of the plasma sheath is 9.0 cm/ěs. Clear parabolas produced by neon ions Ne+, Ne2+, Ne3+ and Ne4+ on CR-39 target have been observed. The energy spectra dN/dTdů for Ne+, Ne2+, Ne3+ and Ne4+ ions were determined. The highest energies of Ne+, Ne2+, Ne3+ and Ne4+ ions emitted from our Z-pinch plasma are below 1.3 MeV.
Źródło:
Nukleonika; 2006, 51, 1; 43-46
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pseudo-static experiment and analysis on seismic behavior of the RC columns strengthened by GHPFRCC
Autorzy:
Li, X.
Wang, J.
Luo, M.
Powiązania:
https://bibliotekanauki.pl/articles/259179.pdf
Data publikacji:
2015
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
green high performance fiber reinforced cementitious composites (GHPFRCC)
pseudo-static test
reinforced concrete column
strengthening
seismic performance
Opis:
Green high performance fiber reinforced cementitious composites (GHPFRCC) are a new class of sustainable cementitious composites, employing a high volume of fly ash to replace cement. In addition to increasing the sustainability of the construction environment, GHPFRCC exhibits a high tensile ductility and multiple cracking behaviors in the strainhardening state. These materials can effectively improve the structural energy dissipation capacity and structural durability. In this study, the optimum mixture ratio of GHPFRCC is presented established using an orthogonal experiment for a specific engineering application. The described GHPFRCC sustains the mechanical performance of concrete and is employed as the outer cladding to strengthen concrete columns. The finite element analysis of the material was based on the software ABAQUS and pseudo static experiments were conducted to exhibit retrofitting of GHPFRCC applied in the rehabilitation of seismic-damaged concrete columns. The computed and experimental results showed that GHPFRCC, while incorporating high volume fly ash, can retain significant multiple cracking behaviors. The energy dissipation capacity of the GHPFRCC reinforced concrete (RC) column is better than the comparable unreinforced column.
Źródło:
Polish Maritime Research; 2015, S 1; 56-60
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of various factors on the viv-induced fatigue damage in the cable of submerged floating tunnel
Autorzy:
Luo, G.
Chen, J.
Zhou, X.
Powiązania:
https://bibliotekanauki.pl/articles/259555.pdf
Data publikacji:
2015
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
submerged floating tunnel cable
vortex induced vibration
fatigue damage
factor analysis
Opis:
According to the modal superposition method, the vortex vibration procedure of submerged floating tunnel cable was compiled using Matlab, based on the calculated results, the fatigue damage was predicted. The effects of various factors, such as cable density, cable length, and pretension and velocity distribution on vortex induced fatigue damage in the cable were studied. The results show that velocity distribution has more effect on the cable fatigue damage than cable length, cable density and pretension. Secondly, cable length has also relatively effect on the cable damage fatigue, cable density and pretension has limited in a certain range.
Źródło:
Polish Maritime Research; 2015, 4; 76-83
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of spreading cultivation with food waste culture medium on the degradation of organophosphorus pesticides by a microbial consortium OP-1
Autorzy:
Zhang, Y.
Jin, X.
Luo, W.
Powiązania:
https://bibliotekanauki.pl/articles/207212.pdf
Data publikacji:
2016
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
microbial consortium
DDVP
food waste
biodegradation
odpady spożywcze
pestycydy
konsorcja drobnoustrojów
odpady komunalne
biodegradacja
Opis:
A microbial consortium OP-1 was enriched from a pesticide production plant and spread cultivated on various food waste (FW) culture media. Results indicated that OP-1 can efficiently degrade organophosphorus pesticides (OPs): isocarbophos, dimethoate and dichlorvos (DDVP). The microbial consortium obtained from the spreading cultivation using FW culture maintained certain degradation capacity of OPs. However, it was decreased after spreading cultivation, probably due to the change of microbial community structure. The finding of this study provided scientific supporting for the development of microbial degradation technique for the environmental remediation.
Źródło:
Environment Protection Engineering; 2016, 42, 4; 37-48
0324-8828
Pojawia się w:
Environment Protection Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymer Reinforced DNAN/RDX Energetic Composites: Interfacial Interactions and Mechanical Properties
Autorzy:
Qian, W.
Chen, X.
Luo, G.
Powiązania:
https://bibliotekanauki.pl/articles/358170.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
energetic composites
dinitroanisole
molecular dynamics
interfacial interactions
mechanical properties
Opis:
2,4-Dinitroanisole (DNAN) has excellent properties as a replacement for 1,3,5-trinitrotoluene (TNT) in melt-cast explosives, and the polymeric modifier used is critical to the mechanical modification of the DNAN/RDX energetic composite. In our research, the typical polymeric modifier acrolein-pentaerythritol resin (APER) was successfully added experimentally to the DNAN/RDX system, and the effects of interfacial interactions on the mechanical properties of these polymers in reinforcing the DNAN/RDX energetic composites were investigated by molecular dynamics simulations, scanning electron microscopy (SEM) and mechanical testing. The results showed that strong attractive interactions exist between the polymer and the explosives, wherein van der Waals forces were found to play the main role. The morphological micro-images also showed tight binding between the polymer/explosive interfaces, which supported the calculated strong interfacial interactions. The mechanical tests confirmed that adding the polymers can obviously reinforce the mechanical strength and toughness of DNAN/RDX systems. The above observations revealed that the cooperative effects of the APER polymer can help to reinforce the interfacial interactions and mechanical properties of DNAN/RDX composites, which is of importance in the formulation and mechanical evaluation of advanced energetic composites.
Źródło:
Central European Journal of Energetic Materials; 2017, 14, 3; 726-741
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Excessive tensile strain induced the change in chondrocyte phenot
Autorzy:
Zhong, D.
Chen, X.
Luo, Z.-P.
Powiązania:
https://bibliotekanauki.pl/articles/306533.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
osteoartroza
fenotyp
chondrocyt
osteoarthritis
phenotype
chondrocytes
tensile strain
Opis:
Chondrocyte extracellular matrix type II collagen and proteoglycans ensure an important compression-bearing structure in synovial joint. However, much more type I collagen is generated in osteoarthritis, which implies the presence of abnormal tensile strain in cartilage. We hypothesize that tensile stress influences chondrocyte phenotype at the cellular level, leading to potential osteoarthritis. Methods: Chondrocytes were stimulated with cyclic excessive tensile (10%) or mild tensile or compressive strain (5%) at 0.5 Hz, 3 h per day for 3 days. Chondrocyte morphology and matrix proteoglycans level was separately determined by Rhodamine phalloidin and toluidine blue staining. The expression of cartilage marker molecules was measured using quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assays. Results: Chondrocytes demonstrated significant fibroblastic morphology, reduced proliferation and increased apoptosis following exposure to 10% tensile strain. The 10% tensile strain group induced the lowest matrix proteoglycans level. It observably reduced the expression of COL2A1, Acan and SOX9, and increased COL1A1 expression level. The 5% tensile (5% compression) group, maintained the chondrocyte phenotype. Conclusions: The findings identified the effects of different magnitudes of tensile stress on chondrocyte phenotype compared to compressive strain. Further studies on cartilage biomechanical micro-environment might benefit from this study.
Źródło:
Acta of Bioengineering and Biomechanics; 2018, 20, 2; 3-10
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 27

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