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    Wyświetlanie 1-6 z 6
    Tytuł:
    The amide of galacturonic acid with lysine as an immunodominant component of the lipopolysaccharide core region from Proteus penneri 42 strain
    Autorzy:
    Palusiak, Agata
    Maciejewska, Anna
    Ługowski, Czesław
    Różalski, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/1039351.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    amide of galacturonic acid with lysine
    anti-conjugate serum
    core region
    lipopolysaccharide
    Proteus
    Opis:
    Most Proteus lipopolysaccharides (LPSs) contain uronic acids or their amides with different amino acids, which together with other negatively charged components account for the acidic character of such LPS molecules. Previous studies have shown the significance of an amide of galacturonic acid with lysine [D-GalA(L-Lys)] for serological specificity of O-antigens from few P. mirabilis strains. In this work, the immunodominant role of GalALys was indicated for the P. penneri 42 LPS core region. The studies also showed the serological identity of core oligosaccharides from P. penneri 42 (O71), P. mirabilis 51/57 (O28) and R14/S1959 strains.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 1; 129-132
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Self-Organization and the Theory of Evolution
    Autorzy:
    Nowiński, Czesław
    Ługowski, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/42565530.pdf
    Data publikacji:
    2024
    Wydawca:
    Polska Akademia Nauk. Instytut Filozofii i Socjologii PAN
    Tematy:
    Synthetic theory of evolution
    driving (and other) factors of evolution
    theory of stabilizing selection
    historical variability of factors and mechanisms of evolution
    Opis:
    The author distinguishes three types of evolutionary theories: 1) ahistorical theories, constructed according to the methodological patterns of classical physics (mechanics), 2) supra-historical theories, in which the historical nature of the evolutionary process is reflected in a more complete (than only in the sense of the chronology of events) and richer, but its mechanism remains unchanged—“taken out of history,” 3) fully historical theories, recognizing that the factors and mechanisms of evolution themselves are entangled in history: are subject to changes in the course of historical development. A prominent representative of the third type is the theory of Ivan I. Schmalhauzen. Some peculiarities of its methodological structure are analyzed. This analysis allowed to reveal the premises of the process of evolution understood as a process of self-organization and to determine the basis on which it can be concluded that the general theory of evolution is nothing else than a theory of biological organization.
    Źródło:
    Filozofia i Nauka; 2024, 12; 95-117
    2300-4711
    2545-1936
    Pojawia się w:
    Filozofia i Nauka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of serological specificity of anti-endotoxin sera directed against whole bacterial cells and core oligosaccharide of Escherichia coli J5-tetanus toxoid conjugate*.
    Autorzy:
    Lukasiewicz, Jolanta
    Jachymek, Wojciech
    Niedziela, Tomasz
    Malik-Gebicka, Malgorzata
    Dzieciatkowska, Monika
    Lugowski, Czeslaw
    Powiązania:
    https://bibliotekanauki.pl/articles/1043742.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    antibody
    endotoxin
    Escherichia coli J5
    neoglycoconjugate
    core region
    Opis:
    The rough mutants of Gram-negative bacteria are widely used to induce protective antisera but the nature of the target epitope for such antibodies is not precisely defined. Endotoxin is one of several antigens present on the surface of bacterial cells, which are able to elicit specific antibodies. We studied the specificity of antibodies produced against a conjugate of E. coli J5 endotoxin core oligosaccharide with tetanus toxoid. The use of chemically defined antigen for immunisation excludes the possibility of production of antibodies against other cell surface antigens. A comparison of this monospecific anti-endotoxin serum with antiserum against E. coli J5 whole cells was performed in order to distinguish the role that endotoxin core oligosaccharide plays in the interaction with humoral host defences from that of other potentially important Gram-negative bacterial surface antigens. The reactivity of both sera with smooth and rough lipopolysaccharides was determined in ELISA, immunoblotting and by flow cytometry. Both antisera reacted with similar specificity with most lipopolysaccharides of identical or related core type. Less distinct reactions with endotoxins of the antibacterial serum in comparison with the anti-conjugate serum were found in all serological tests. LPS of E. coli O100 that showed the strongest reactions with both sera was used to stimulate IL-6, TNFα and nitric oxide production by the J-774A.1 cell line. Both sera were used to inhibit that stimulation and no inhibitory effects of the examined sera in comparison with non-immune serum were observed.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 3; 721-734
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Structural and serological characterization of Hafnia alvei lipopolysaccharide core region
    Autorzy:
    Ługowski, Czesław
    Niedziela, Tomasz
    Jachymek, Wojciech
    Klonowska, Agnieszka
    Czarny, Anna
    Rowiński, Stefan
    Petersson, Carl
    Kenne, Lennart
    Powiązania:
    https://bibliotekanauki.pl/articles/1045281.pdf
    Data publikacji:
    1995
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1995, 42, 1; 51-54
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lactoferrin-monophosphoryl lipid a complex enhances immunity of mice to Plesiomonas shigelloides CNCTC 138/92
    Autorzy:
    Chodaczek, Grzegorz
    Zimecki, Michal
    Lukasiewicz, Jolanta
    Lugowski, Czesław
    Powiązania:
    https://bibliotekanauki.pl/articles/1040820.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    lactoferrin
    Plesiomonas shigelloides
    adjuvant
    monophosphoryl lipid A
    Opis:
    Our previous study showed the efficacy of lactoferrin-monophosphoryl lipid A isolated from Hafnia alvei LPS complex (LF-MPLH.a.) as an adjuvant in stimulation of humoral and cellular immune response in mice to conventional antigens and a lower pyrogenicity of the complex as compared with MPLH.a. alone. In the present investigation we demonstrated that LF-MPLH.a. complex enhanced the immunity of BALB/c mice immunized with Plesiomonas shigelloides CNCTC 138/92 bacterial vaccine, against P. shigelloides infection. The adjuvant effect was evidenced by a significant increase of the antigen-specific serum IgG, IgG2a, and IgG1 and elevation of antigen-specific serum IgA concentrations. In addition, application of the adjuvant facilitated better clearance of the bacteria in spleens and livers of infected mice when compared with MPLH.a. alone. These features of the new adjuvant may predispose it for vaccination protocols in humans.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 1; 91-96
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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