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Tytuł:
A dual-stator brushless doubly-fed generator for wind power application
Autorzy:
Liu, Hao
Song, Yakai
Bai, Chunlan
He, Guofeng
Yin, Xiaoju
Powiązania:
https://bibliotekanauki.pl/articles/27309959.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
doubly-fed machine
dual-stator
electromagnetic analysis
operational characteristics modes
wind power generation
Opis:
A novelty dual-stator brushless doubly-fed generator (DSBDFG) with magnetic-barrier rotor structure is put forward for application in wind power. Compared with a doubly-fed induction generator, the DSBDFG has virtues of high reliability and low maintenance costs because of elimination of brush and sliprings components. Therefore, the proposed structure has tremendous potential as a wind power generator to apply in wind power. According to the operating principle of electric machine, the DSBDFG is studied in wind power application. At first, the topology, the winding connecting, the rotor structure, the power flow chart of different operating models and the variable speed capability of electric machine are discussed and analyzed. Then, a 50 kW DSBDFG is designed. Based on the principal dimension of the design electric machine, the electromagnetic characteristics of the DSBDFG with different running modes are analyzed and calculated to adopt the numerical method. From the result, it meets the requests of electromagnetic consistency and winding connecting in the design electric machine. Meanwhile, it confirms the proposed DSBDFG has the strong ability of speed regulation.
Źródło:
Archives of Electrical Engineering; 2023, 72, 4; 1073--1087
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Activation of quartz flotation by Cu2+, Ni2+ in the sodium ethylxanthogenate (EX) system
Autorzy:
Liu, Yang
Tong, Xiong
Xie, Rui-Qi
Xie, Xian
Song, Qiang
Fan, Pei-Qiang
Powiązania:
https://bibliotekanauki.pl/articles/24085981.pdf
Data publikacji:
2023
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
quartz
flotation
ions activation
sodium ethylxanthogenate
adsorption mechanism
Opis:
During the flotation of metal sulfide minerals, due to the interference of unavoidable ions, the quartz also partially floats in some cases. The studies on the mechanism of quartz being activated and floating up are still insufficient. In this study, the influence of the Cu2+ and Ni2+ unavoidable ions on the floatation of quartz was studied by micro-flotation experiments, adsorption detection, zeta potential measurement, solution composition calculation, infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) analyses, and atomic force microscopy (AFM) observation. This provides a theoretical reference for further understanding the mechanism of sodium ethylxanthogenate and quartz surface, as well as the development of a new quartz depressant. The results of flotation showed that after activation by Cu2+ (1×10-4 mol/dm3) and Ni2+ (5×10-5 mol/dm3), the quartz was captured by sodium ethylxanthogenate (EX: 1.4×10-4 mol/dm3) under alkaline conditions (pH=10), while the best recoveries were obtained as 80% and 43%, respectively. The results of adsorption and zeta potential measurements showed that the precipitation rate of Cu2+ was greater than that of Ni2+ under alkaline conditions. Additionally, both Cu2+ and Ni2+ electrostatically adsorbed on the quartz surface and changed the zeta potential of quartz. The solution composition calculation further showed that Cu(OH)+, Cu(OH)2(s), and Ni(OH)+, Ni(OH)2(s) were the main components in the solution under alkaline conditions. The FT-IR and XPS analyses and AFM observations demonstrated that Cu and Ni species adsorbed on O atoms on the quartz surface, providing active sites for EX adsorption, and EX combines with Cu and Ni species on the quartz surface to generate -O-Cu-EX and -O-Ni-EX complexes. Finally, the quartz floated up due to the formation of hydrophobic products and firm adsorption.
Źródło:
Physicochemical Problems of Mineral Processing; 2023, 59, 2; art. no. 166368
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analytical solution for one-dimensional consolidation of unsaturated soils under dynamic load
Autorzy:
Liu, Zhi-Yi
Song, Yu
Zhou, Feng-Xi
Wang, Li-Ye
Powiązania:
https://bibliotekanauki.pl/articles/2200882.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
unsaturated soil
consolidation characteristic
dynamic load
analytical solution
numerical calculation
Opis:
Firstly, in this paper, based on the theory of the porous elastic medium and combined with the effective stress principle of unsaturated soil, a set of governing equations is established to describe consolidation of the unsaturated soil. Secondly, an analytical expression under any dynamic loads is obtained with the help of Laplace integral transformation. Finally, analysis of numerical examples under specific boundary conditions is made to discuss one-dimensional consolidation characteristics under harmonic loads and the influence of factors on the consolidation characteristics of unsaturated soil, such as excitation frequency and initial saturation.
Źródło:
Journal of Theoretical and Applied Mechanics; 2023, 61, 1; 11--22
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of co-disposal of sludge based on TTF-type precalciner on NOx emissions
Autorzy:
Liang, Ruru
Yuan, Guanglei
Liu, Renping
Duan, Erhong
Song, Jiale
Powiązania:
https://bibliotekanauki.pl/articles/27323978.pdf
Data publikacji:
2023
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
nitric oxide
cement production
ANSYS FLUENT
precalciner
tlenek azotu
produkcja cementu
prekalcynator
Opis:
To reduce the emission of nitrogen oxides (NOx) during the co-disposal of sludge in a TTF-type precalciner, an optimized co-disposal process of a TTF-type precalciner has been implemented in a cement plant in Hebei. The model was built using ANSYS FLUENT software. The effects of three single-factor perspectives (sludge input ratio, gas flow rate, and tertiary air temperature on NO concentration) were investigated. The response surface method of Box–Behnken design was used. When the sludge ratio increased from 0 to 25%, the NO concentration at the outlet was 122–297 mg/m³. Meanwhile, it increased from 192 mg/ m³ to 241 mg/ m³ since the airflow increased from 95 m³/s to 122 m³/s. The maximum NO concentration was 192 mg/ m³ when the tertiary air temperature was 1170 K. The inter-action between airflow and sludge ratio was more significant than any other interaction between other conditions (P < 0.05). Finally, the optimum conditions were a sludge ratio of 5%, airflow 109 m³/s, and tertiary air temperature 1280 K. NO concentration was 166.9 mg/m³ under this condition.
Źródło:
Environment Protection Engineering; 2023, 49, 3; 53--68
0324-8828
Pojawia się w:
Environment Protection Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tris(8-hydroxyquinoline)aluminium in a polymer matrix as an active layer for green OLED applications
Autorzy:
Sypniewska, Małgorzata
Pokladko-Kowar, Monika
Kaczmarek-Kedziera, Anna
Brumboiu, Iulia E.
Figà, Viviana
Apostoluk, Aleksandra
Song, Peng
Liu, Junyan
Szczesny, Robert
Gondek, Ewa
Derkowska-Zielinska, Beata
Powiązania:
https://bibliotekanauki.pl/articles/2204187.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Stowarzyszenie Elektryków Polskich
Tematy:
Tris(8-hydroxyquinoline)aluminium
OLED
photo-and electro-luminescence
spectroscopic ellipsometry
DFT calculation
Opis:
Tris(8-hydroxyquinoline)aluminium with poly(N-vinylcarbazole) (Alq₃:PVK) or polystyrene sulfonate (Alq₃:PSS) were deposited by spin-coating on glass and silicon substrates. SEM measurements show that relatively smooth thin films were obtained. Fourier transform infrared measurements were performed to confirm the composition of the samples. The optical properties of thin films containing Alq₃:PVK and Alq₃:PSS were characterised using absorption spectroscopy and spectroscopic ellipsometry. It was found that the absorption spectrum of Alq₃:PVK is characterised by four bands, while for Alq₃:PSS only three bands are visible. The photoluminescence of the studied thin layers shows a peak with a maximum at about 500 nm. Additionally, cyclic voltammetry of Alq₃ is also presented. Theoretical density functional theory calculations provide the insight into the interaction and nature of Alq₃:PVK and Alq₃:PSS excited states. Finally, the organic light-emitting diode (OLED) structure based on Alq₃:PVK was fabricated and showed strong electroluminescence with a green emission at 520 nm. The results of the device show that the ITO/PEDOT:PSS/Alq₃:PVK/Ca/Al system can be useful for the production of low-cost OLEDs with Alq₃:PVK as an active layer for future lighting applications.
Źródło:
Opto-Electronics Review; 2023, 31, 2; art. no. e146105
1230-3402
Pojawia się w:
Opto-Electronics Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of montmorillonite hydration and delamination on coal flotation
Autorzy:
Zhang, Lucheng
Zhang, Mingqing
Liu, Qi
Song, Shuoshuo
Tian, Yu
Barvora, Joshua Bosco
Powiązania:
https://bibliotekanauki.pl/articles/2175432.pdf
Data publikacji:
2022
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
coal flotation
montmorillonite
hydration
delamination
slime coating
Opis:
In this study, the influence of montmorillonite (MT) hydration and delamination on coal flotation was investigated through flotation tests using coal-MT mixtures. MT particles were subjected to hydration at different time intervals. The Fuerstenau upgrading curve was plotted to evaluate the change in overall flotation selectivity. The zeta potential and particle size distribution were used to characterize the delamination behavior of MT in deionized water at natural pH level. Atomic force microscopy (AFM) (colloidal probe) was used to analyze the interaction force between coal and MT particles. It was found that smaller particles (individual silicate layers or thin packets of layers) with higher zeta potentials appeared gradually, and their volume proportion increased with increasing hydration time. AFM results showed that a monotonous repulsive force was detected consistently throughout the separation distance between coal and these emerging smaller MT particles. The decrease of these MT coating on coal surface was responsible for the higher flotation recovery and better selectivity. A jump-into-contact phenomenon was observed in coal and MT interaction when MT hydrated incompletely. It showed that heterocoagulation between coal and MT occurred and MT coating on the coal surface was responsible for the depression of flotation.
Źródło:
Physicochemical Problems of Mineral Processing; 2022, 58, 6; art. no. 153085
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optical design of a short-wave infrared coded aperture snapshot spectral imager based on Offner–Wynne imaging spectrometer
Autorzy:
Song, Chong
Zhou, Liang
Liu, Zhaohui
Jiang, Kai
Liu, Kai
Powiązania:
https://bibliotekanauki.pl/articles/2086755.pdf
Data publikacji:
2022
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
Offner-Wynne imaging spectrometer
CASSI
coded aperture snapshot spectral imager
short-wave infrared
optical design
Opis:
A calculation model to obtain the optimal combination of Offner–Wynne imaging spectrometer parameters to balance the RMS spot radius of the chief ray over the entire field is established. On the basis of the calculation model, an Offner–Wynne imaging spectrometer is designed, and then it is applied in a short-wave infrared coded aperture snapshot spectral imager (CASSI). The optical system of the short-wave infrared CASSI is designed by a combination method of independent design and integrated optimization. The spectral smile and spectral keystone of the optical system which operates in the 900–1700 nm band are respectively less than half a pixel. The focal length of the optical system is 1200 mm, the total optical system length is 775mm, and its average spectral resolution is 16 nm. The optical system offers the advantages of excellent imaging quality, compact optical structure, high optical transmittance, reduced spectral smile and spectral keystone.
Źródło:
Optica Applicata; 2022, 52, 2; 143--161
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Research on parameters of MMC fracture criterion for advanced high strength dual-phase steel sheets
Autorzy:
Fu, Qiutao
Li, Di
Song, Hui
Liu, Xingfeng
Lu, Zipeng
Cui, Hongjian
Powiązania:
https://bibliotekanauki.pl/articles/2086969.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
advanced high strength dual-phase steel
plasticity
shear fracture
modified Mohr-Coulomb criterion
parameter correlation
Opis:
To predict the shear fracture, tests of advanced high-strength DP steels have been carried out, and fracture models of DP steels have been established using the MMC fracture model. The MMC fracture parameters were obtained through multiple sets of experiments and stress triaxiality solved by simulation. The result was verified by stretch-bending, Nakazima tests and simulations. It shows that the MMC criterion is suitable for predicting ductile fracture of DP980, 1180. The correlation between the parameters of the MMC criterion and DP steel material properties can reduce the amount of tests data required.
Źródło:
Journal of Theoretical and Applied Mechanics; 2022, 60, 2; 253--265
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biosorption of Pb(II) by the resistant Enterobacter sp. : Investigated by kinetics, equilibrium and thermodynamics
Autorzy:
Liu, Lei
Xia, Mengya
Hao, Jianwen
Xu, Haoxi
Song, Wencheng
Powiązania:
https://bibliotekanauki.pl/articles/2073764.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Pb(II)
biosorption
enterobacter sp.
kinetics
thermodynamics
Opis:
The Pb(II)-resistant bacterium was isolated from heavy metal-contained soils and used as a biosorbent to remove Pb(II). The strain was identified as Enterobacter sp. based on the 16S rRNA sequence analysis. The effect of biosorption properties (pH value, Pb(II) concentration, bacterial concentration and temperature) on Pb(II) was investigated by batch experiments. Results of FTIR and XPS showed that the biosorption process mainly involved some oxygen-containing groups (-OH and -COOH groups). The experimental results and equilibrium data were fitted by pseudo-second-order kinetic model and Langmuir model, respectively. The experimental biosorption isotherms fitted the Langmuir model, and the maximum biosorption capacity was 40.75 mg/g at 298 K. The calculated ΔGо and ΔHо were –4.06 and 14.91(kJ/mol), respectively, which indicated that biosorption process was spontaneous and endothermic. Results show that Enterobacter sp. will be an efficient biosorbent for Pb(II) removal.
Źródło:
Archives of Environmental Protection; 2021, 47, 3; 28--36
2083-4772
2083-4810
Pojawia się w:
Archives of Environmental Protection
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of Metal Oxides on the Thermal Decomposition Kinetics and Mechanisms of HAN/PVA Based Propellants
Autorzy:
Hu, Song-qi
Liu, Xue-li
Liu, Lin-Lin
Kang, Bo
Zhang, Yan
Powiązania:
https://bibliotekanauki.pl/articles/27787991.pdf
Data publikacji:
2021
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
HAN/PVA-based propellant
metal oxides
catalytic behaviour
kinetic parameters
Opis:
The thermal decomposition processes of HAN/PVA-based propellants have been investigated using a simultaneous thermogravimetric analysis (TGA) – differential scanning calorimetry (DSC), coupled with Fourier-Transform Infrared Spectroscopy (FTIR) and Mass Spectrometry (MS) system. The activation energy (Ea), pre-exponential factor A and reaction mechanism function f(α) of the decomposition processes have been determined by non-isothermal and Malek methods. The results showed that the decomposition process of an HAN/PVA sample occurs mainly in the temperature range 202.2~220.1 °C, with a mass loss, heat release and Ea of about 84.8%, 1474.18 and 88.76 kJ·mol–1, respectively. Of the seven metal oxides studied as catalysts, Al2O3, V2O5 and Fe2O3 have significant catalytic effects on an HAN/PVA-based propellant, in lowering the decomposition temperature, with Ea changing from 88.8 to 83.7, 85.6 and 113.6 kJ·mol–1, respectively. The f(α) of both HAN/PVA and HAN/PVA/Al2O3 samples can be expressed as f(α) = (1 – α)2, whereas f(α) = α or f(α) = α/2 fit well for the HAN/PVA/V2O5 and HAN/PVA/Fe2O3 samples.
Źródło:
Central European Journal of Energetic Materials; 2021, 18, 3; 322-338
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental and kinetic study of zinc leaching from metallurgical slag by 5-sulfosalicylic acid
Autorzy:
Wang, Long
Gao, Hanyu
Song, Shimin
Xue, Na
Zhang, Jinxia
Yang, Siyuan
Liu, Cheng
Powiązania:
https://bibliotekanauki.pl/articles/1447397.pdf
Data publikacji:
2021
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
zinc metallurgical slag
5-sulfosalicylic acid
leaching kinetics
resource recover
Opis:
As an organic acid with the characters of low corrosivity and extensive source, 5-sulfosalicylic acid (5-SSA) was firstly utilized as a potential leaching reagent for the recovery of zinc from metallurgical slag. Effects of stirring speed, leaching temperature, 5-SSA concentrations and size fraction on the leaching zinc leaching rate were investigated. A zinc leaching efficiency of 94.2% was achieved under the appropriate operating conditions (450 rpm of stirring speed, 50 ℃ of leaching temperature, 0.3 mol/L of 5-SSA concentration and d90=65 µm of size fraction), indicating that 5-SSA was an excellent leaching reagent of zinc oxide. SEM-EDS and specific surface aperture analyzer further reveal the well-developed micropores and cracks from zinc metallurgical slag, which could be assigned to the removal of zinc oxide encapsulated in the sample. In addition, the leaching kinetics of zinc metallurgical slag in the 5-SSA was studied. It was found that the surface chemical reaction model satisfactorily predicted the zinc leaching rate. A reaction kinetic equation was finally established for the zinc leaching rate.
Źródło:
Physicochemical Problems of Mineral Processing; 2021, 57, 3; 8-20
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Passenger’s routes planning in stochastic common-lines’ multi-modal transportation network through integrating Genetic Algorithm and Monte Carlo simulation
Autorzy:
Peng, Yong
Mo, Zhiyao
Liu, Song
Powiązania:
https://bibliotekanauki.pl/articles/1955092.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
stochastic networks
multimodal transportation
passengers’ route
genetic algorithm
Monte Carlo simulation
sieci stochastyczne
transport multimodalny
algorytm genetyczny
symulacja Monte Carlo
Opis:
In the urban transportation network, most passengers choose public transportation to travel. However, bad weather, accidents, traffic jams and other factors lead to uncertainty in transportation network. Besides, transport vehicles running on the same segments of routes and belonging to different modes or routes make the transportation network more complicated. In order to improve the efficiency of passenger’s travel, this paper aim to introducing an approach for optimizing passenger travel routes. This approach takes the travel cost and the number of transfers as constraints to finding the shortest total travel duration of passenger in urban transportation network. The running duration and dwell duration of the vehicles in the network are uncertain, and the vehicles are running according to the timetables. As transportation modes, bus, rail transit and walk are considered. In terms of methodological contribution, this paper combines Genetic Algorithm (GA) and Monte Carlo simulation to deal with optimization problem under stochastic conditions. This paper uses Monte Carlo simulation to simulate the running duration and dwell time of vehicles in different scenarios to deal with the uncertainty of the network. The shortest path of passenger’s travel is solved by GA. Two kinds of population management strategies including single population management strategy and multiple population management strategy are designed to guide the solution population evolving process. The two kinds of population management strategies of GA are tested in numerical example. The satisfactory convergence performance and efficiency of the model and algorithm is verified by the numerical example. The numerical example also demonstrated that the multiple population management strategy of GA can get better results in a shorter CPU time. At the same time, the influences of some significant variables on solution are performed. This paper is able to provide a scientific quantitative support to the path scheme selection under the influence of common-lines and timetables of different modes of transportation in stochastic urban multimodal transportation network.
Źródło:
Archives of Transport; 2021, 59, 3; 73-92
0866-9546
2300-8830
Pojawia się w:
Archives of Transport
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The mechanism study on deep eutectic solvent for desilication of magnetite by reverse flotation
Autorzy:
He, Zhan
Liu, Cai
Mei, Guangjun
Zhao, Yuanyuan
Cheng, Qian
Song, Xianwei
Powiązania:
https://bibliotekanauki.pl/articles/1845237.pdf
Data publikacji:
2021
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
reverse flotation
deep eutectic solvents collector
desilication
magnetie
quartz
Opis:
Magnetite reverse flotation using a new deep eutectic solvent synthesized by lactic acid and CTAC as the collector has been investigated in this work. The flotation test results were compared with dodecylamine. The CTAC/lactic acid DES increased the grade of total iron to 66.69%, and the reduce quartz content to 6.67%, which were preferable to dodecylamine (the grade of Fe in the concentrate is 63.47%, and the grade of quartz in the concentrate is 9.13%). The depression performance and adsorption mechanism of CTAC/lactic acid DES on surface of magnetite and quartz are investigated by FT-IR, zeta potential and XPS. The results show that the adsorption of CTAC/lactic acid DES on quartz surface is more effective than that of magnetite. Therefore, deep eutectic solvent is an effective reagent for reverse flotation of magnetite as collector.
Źródło:
Physicochemical Problems of Mineral Processing; 2021, 57, 6; 12-22
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The mechanism study on deep eutectic solvent for desilication of magnetite by reverse flotation
Autorzy:
He, Zhan
Liu, Cai
Mei, Guangjun
Zhao, Yuanyuan
Cheng, Qian
Song, Xianwei
Powiązania:
https://bibliotekanauki.pl/articles/2146858.pdf
Data publikacji:
2021
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
reverse flotation
deep eutectic solvents collector
desilication
magnetie
quarto
Opis:
Magnetite reverse flotation using a new deep eutectic solvent synthesized by lactic acid and CTAC as the collector has been investigated in this work. The flotation test results were compared with dodecylamine. The CTAC/lactic acid DES increased the grade of total iron to 66.69%, and the reduce quartz content to 6.67%, which were preferable to dodecylamine (the grade of Fe in the concentrate is 63.47%, and the grade of quartz in the concentrate is 9.13%). The depression performance and adsorption mechanism of CTAC/lactic acid DES on surface of magnetite and quartz are investigated by FT-IR, zeta potential and XPS. The results show that the adsorption of CTAC/lactic acid DES on quartz surface is more effective than that of magnetite. Therefore, deep eutectic solvent is an effective reagent for reverse flotation of magnetite as collector.
Źródło:
Physicochemical Problems of Mineral Processing; 2021, 57, 6; 12--22
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CAMPTOTHECIN INHIBITS MIGRATION, INVASION AND CLONOGENIC PROPERTY OF LIVER CANCER CELLS BY MODULATING MICRORNA EXPRESSION
Autorzy:
Liu, Zhenzhong
Wu, Song
Li, Xiaoqian
Powiązania:
https://bibliotekanauki.pl/articles/895460.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
Hepatocellular Carcinoma
cell proliferation
cell cycle
Camptothecin
miRNA
Opis:
Camptothecin (CPT), an alkaloid natural product, extracted from Camptotheca acuminata bark, has been reported to have potential antitumor activity in diverse cancers. MicroRNAs (MiRNAs) are a class of short, non-coding RNAs that plays a crucial role in the normal physiology by attenuating translation. Here, we showed that the CPT modulates the expression of miRNAs in hepatocellular carcinoma cells (HCC). Microarray analysis reveals that CPT modulates the expression of as many as 39 miRNAs in HCC cells (Huh7), 27 miRNAs were downregulated whereas 12 miRNAs were upregulated. miR-16 is the key miRNA upregulated by CPT and targets key prosurvival proteins (MMP-2, MMP-9 and cyclin D1). Our results demonstrate that CPT is inhibiting cell viability of HCC cells significantly when compared with the untreated cells. Wound healing and colony formation assay confirm inhibition of cell migration and clonogenic property of Huh7 cells respectively, upon the dose-dependent treatment of CPT. Furthermore, the Boyden chamber assay analysis revealed a significant inhibition of number of invasive cells in CPT treated cells with comparison to untreated Huh7 cells. Mechanistically, CPT upregulates miR-16 expression which targets MMP-2, MMP-9, cyclin D1 downregulation and subsequently upregulates the expression of E-cadherin, TIMP1, p21, and p27, thereby inhibits cell migration, invasion and clonogenic property of HCC cells. In summary, CPT treatment in Huh7 cells decreases cell viability and upregulates miR-16 expression, which results in inhibition of cell migration, invasion and clonogenic property of cells, by decreasing MMP-2, MMP-9, cyclin D1 and increasing the expression of cell cycle-regulated proteins p21 and p27.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 295-304
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 41

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