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Wyszukujesz frazę "Liu, Ping" wg kryterium: Autor


Wyświetlanie 1-14 z 14
Tytuł:
The Generalized Saddle-Node Bifurcation of Degenerate Solution
Autorzy:
Liu, Ping
Wang, Yu-Wen
Powiązania:
https://bibliotekanauki.pl/articles/746396.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Matematyczne
Tematy:
Operator equation
bifurcation
generalized inverse of operator
Opis:
In this paper we discuss the bifurcation problem for the abstract operator equation of the form \(F (u, \lambda) = \theta\) with a parameter \(\lambda\), where \(F\colon X \times R \to Y\) is a \(C^1\) mapping, \(X, Y\) are Banach spaces. By the bounded linear generalized inverse \(A^+\) of \(A = F_u (u_0 , \lambda_0 )\), an abstract bifurcation theorem for the case \(\operatorname{dim}N (F_u (u_0 , \lambda_0 )) \geq \operatorname{codim} R(F_u (u_0 , \lambda_0 )) = 1\) has been obtained.
Źródło:
Commentationes Mathematicae; 2005, 45, 2
0373-8299
Pojawia się w:
Commentationes Mathematicae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
EF1α is a suitable housekeeping gene for RT-qPCR analysis during osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells
Autorzy:
Chen, Xingyun
Zhang, Bo
Zhao, Yan
Liu, Ping
Zhou, Yuanguo
Powiązania:
https://bibliotekanauki.pl/articles/1039535.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
EF1α; RGS4; 18S rRNA; RT-qPCR; RPL 13a; CCG-1986
Opis:
The expression of predominant housekeeping genes used in RT-qPCR can vary during development and differentiation. The frequently used housekeeping genes (ACTB, GAPDH, 18S rRNA, EF1α and RPL 13a) were evaluated during an early stage of the osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells (mMSCs) (under normal conditions or treated with CCG-4986) to identify housekeeping genes whose expression remained constant during osteogenic differentiation. When we used RGS4 mRNA, which was determined as copy number per μg of total RNA, to normalize gene expression, we observed that the relative EF1α expression profile was consistent with RGS4 expression after treatment with CCG-4986. All the relative expression profiles of the EF1α, 18S rRNA, and RPL13a housekeeping genes were consistent with RGS4 profiles determined by measuring mRNA copies under normal osteogenic differentiation conditions. The expression profiles calibrated by ACTB and GAPDH were not consistent with those determined using mRNA copy number in untreated cells or cells treated with CCG-4986 under osteogenic differentiation conditions. Under normal osteogenic differentiation conditions, EF1α, 18S rRNA, and RPL 13a are suitable housekeeping genes for RT-qPCR analysis. However, EF1α is the only suitable gene upon CCG-4986 treatment.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 381-386
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Flow-capture location model with link capacity constraint over a mixed traffic network
Autorzy:
Liu, Ping
Cao, Jinde
Luo, Yiping
Guo, Jianhua
Huang, Wei
Powiązania:
https://bibliotekanauki.pl/articles/2147143.pdf
Data publikacji:
2022
Wydawca:
Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
Tematy:
traffic assignment problem
link capacity constraint
charging location
pathmdistance constraint
Opis:
This paper constructs and settles a charging facility location problem with the link capacity constraint over a mixed traffic network. The reason for studying this problem is that link capacity constraint is mostly insufficient or missing in the studies of traditional user equilibrium models, thereby resulting in the ambiguous of the definition of road traffic network status. Adding capacity constraints to the road network is a compromise to enhance the reality of the traditional equilibrium model. In this paper, we provide a two-layer model for evaluating the efficiency of the charging facilities under the condition of considering the link capacity constraint. The upper level model in the proposed bi-level model is a nonlinear integer programming formulation, which aims to maximize the captured link flows of the battery electric vehicles. Moreover, the lower level model is a typical traffic equilibrium assignment model except that it contains the link capacity constraint and driving distance constraint of the electric vehicles over the mixed road network. Based on the Frank-Wolfe algorithm, a modified algorithm framework is adopted for solving the constructed problem, and finally, a numerical example is presented to verify the proposed model and solution algorithm.
Źródło:
Journal of Artificial Intelligence and Soft Computing Research; 2022, 12, 3; 223--234
2083-2567
2449-6499
Pojawia się w:
Journal of Artificial Intelligence and Soft Computing Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification and tissue distribution of a novel rat glucocorticoid receptor splice variant
Autorzy:
Ju, Huiming
Wang, Xia
Liu, Zongping
Liu, Ping
Zhao, Yan
Xiong, Renping
Zhou, Yuanguo
Chen, Xingyun
Powiązania:
https://bibliotekanauki.pl/articles/1040640.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
glucocorticoid
glucocorticoid receptor
receptor isoform
splice variant
Opis:
Glucocorticoid receptor (GR) is a steroid hormone receptor that has been shown to play important roles in diverse cellular and physiological processes. More and more evidence has revealed that the effects of glucocorticoids are mediated by the glucocorticoid receptor through genomic or nongenomic mechanisms. A growing number of glucocorticoid receptor splice variants have been identified in human tissues, but few are known in rat tissues. In this work, a novel rGR cDNA, called rGRβ, was cloned from Sprague Dawlay (SD) rat liver. Sequence analysis revealed that the rGRβ mRNA was 39 base pairs (bp) shorter than the rGR mRNA reported earlier. The deleted segment is located in exon 1 and encodes 13 repeated glutamine residues. Both the rGR and rGRβ mRNAs were quantitated by Northern blot hybridization using non-homologous glucocorticoid cDNA probes. Results showed that the rGR and rGRβ mRNAs were most abundant in the lung, the least abundant in the heart, and there were more rGR and rGRβ mRNAs in the kidney than in the liver. The identification of rGRβ may contribute to the understanding of the genomic or nongenomic effects of glucocorticoids.
Źródło:
Acta Biochimica Polonica; 2009, 56, 1; 109-113
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dexamethasone inhibits U937 cell adhesion via the down-regulation of ROCK1 activity
Autorzy:
Liu, Dong
Chen, Xing
Xiong, Ren
Ning, Ya
Li, Ping
Peng, Yan
Liu, Ping
Zhao, Yan
Yang, Nan
Zhou, Yuan
Powiązania:
https://bibliotekanauki.pl/articles/1039650.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
dexamethasone
ROCK1
fasudil
non-genomic effects
Opis:
Objective. To explore the effect of dexamethasone (DEX) on monocyte adhesion function and its underlying mechanism. Methods. The effects of DEX and fasudil on adhesion of cultured U937 monocytes to human umbilical vein endothelial cells (HUVEC) following stimulation with phorbol myristate acetate (PMA) were studied; Changes in the Rho-associated coiled-coil protein kinase 1 (ROCK1) protein content and activity were evaluated. Results. DEX and fasudil significantly inhibited U937 cell adhesion rates under PMA stimulation and inhibited ROCK1 activity. Mifepristone (RU-486) and cycloheximide (CHX) did not alter these effects of DEX. Conclusions. DEX interferes with the adhesion function of U937 cells through the inhibition of ROCK1 activity.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 557-560
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Age Structures and Air Pollution: What Role Does Gender Play?
Struktura wiekowa i zanieczyszczenie powietrza: jaką role odgrywa płeć?
Autorzy:
Liu, Jiliang
Wang, Wei
Chen, Yin E
Chang, Chun-Ping
Powiązania:
https://bibliotekanauki.pl/articles/371266.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Komitet Człowiek i Środowisko PAN
Tematy:
age structure
gender
carbon emission
panel cointegration
panel causality
struktura wiekowa
płeć
emisja ditlenku węgla
kointegracja paneli
przyczynowość panelu
Opis:
We investigate the influence of age structure and gender on air pollution, dividing the age structure into four groups and use CO2 emissions as a measure of air pollution, which can be separated into four categories to ob-tain more complete findings, then employing panel cointegration techniques and panel-based error correction models. The data are collected from 29 OECD and 40 non-OECD countries in the period 1990-2014. For case of total CO2 emissions, younger (people under 30) and older people (people 65 and above) emit less than people in the intermediate age group, but the impact of age group on CO2 emissions is different when looking at CO2 emissions from coal, gas, and oil. While we take gender into account, the causality between age structure and CO2 emissions becomes significant, especially for the relationship between population and total CO2 emissions in OECD and non-OECD countries. We also note that more people who are aged 15-29 increase total CO2 emis-sions in OECD countries and more people who are aged 30-44 decrease CO2 emissions from coal in non-OECD countries. Our findings suggest that an energy and environmental policy should consider both age structure and gender effects on environmental issues.
Artykuł przedstawia wyniki badań odnoszących się do wpływu zmiennych struktury wiekowej i płci na zanie-czyszczenia powietrza, wyróżniając cztery grupy wiekowe i wykorzystując poziom emisji CO2 jako wskaźnik zanieczyszczeń powietrza, który można podzielić na 4 kategorie, a następnie wykorzystaliśmy techniki kointe-gracji paneli i oparte na panelach modele korekcji błędów. Dane zebrano z 29 krajów należących do OECD i 40 spoza tej organizacji, obejmują one lata 1990-2014. W przypadku całkowitej emisji CO2 okazało się, że osoby młodsze (poniżej 30 roku życia) oraz starsze (powyżej 65 roku życia) odpowiedzialne są za mniejszą emisję niż osoby w wieku średnim, przy czym występują różnice odnoszące się do poszczególnych grup wiekowych w odniesieniu do emisji CO2 z różnych źródeł: węgla, gazu i ropy. Biorąc pod uwagę płeć, zależność pomiędzy strukturą wiekową a emisjami CO2 okazuje się być znaczącą, szczególnie w aspekcie relacji pomiędzy populacją a całkowitą emisją CO2. Zauważyliśmy ponadto, że osoby w wieku 15-29 z krajów OECD bardziej przyczyniają się do wzrostu całkowitej emisji CO2, a w przypadku krajów nie należących do OECD osoby w wieku 30-44 bardziej odpowiedzialne są za obniżenie emisji CO2 z węgla. Przeprowadzone badania umożliwiają postawienie hipotezy, według której polityka energetyczna i środowiskowa w kontekście zagadnień odnoszących się do środowiska powinna uwzględniać zarówno strukturę wieku jak i płci.
Źródło:
Problemy Ekorozwoju; 2019, 14, 1; 43-52
1895-6912
Pojawia się w:
Problemy Ekorozwoju
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In vitro co-stimulation of anti-tumor activity by soluble B7 molecules
Autorzy:
He, Wei
Hu, Zhong-Bo
Liu, Fang
Feng, Xian-Qi
Zou, Ping
Powiązania:
https://bibliotekanauki.pl/articles/1041178.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
immunotherapy
tumor escape
gene fusion
recombinant fusion proteins
Opis:
In order to investigate the anti-tumor activity of a soluble B7-1/immunoglobulin G fusion protein and explore an effective method to eliminate immune escape of tumor cells, a recombinant vector encoding this fusion protein was constructed and constitutively expressed in Chinese hamster ovary cells. After purification with protein G affinity chromatography, the soluble fusion protein was tested for bioactivity. Results showed that the fusion protein could significantly increase the density of B7-1 molecules on WEHI-3 cells, a mouse leukemia cell line. Through allogeneic mixed lymphocyte tumor cultures, it was demonstrated that, with the presence of the first signal, it could also significantly enhance T cell activation and killing activity against WEHI-3 cells and interleukin-2 secretion by activated mouse T lymphocytes. The conclusion can be drawn that the soluble B7-IgG fusion protein has a potent capacity to generate or enhance anti-tumor immune response in vitro, and its clinical value deserves further investigation.
Źródło:
Acta Biochimica Polonica; 2006, 53, 4; 807-813
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An approach to suppress low-frequency oscillation in the hybrid multi-Infeed HVDC of mixed H2/H∞ robust-based control theory
Autorzy:
Li, Congshan
Liu, Yan
Li, Yikai
He, Ping
Fang, Yan
Sheng, Tingyu
Powiązania:
https://bibliotekanauki.pl/articles/2042784.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
additional damping controller
CSP
HMIDC
LFO
mixed 2/∞ control
TLS-ESPRIT
Opis:
A hybrid multi-infeed HVDC (HMIDC) system is composed of line-commutated converter-based high-voltage direct current (LCC-HVDC) and voltage-source converterbased high-voltage direct current (VSC-HVDC), whose receiving ends have electrical coupling. To solve the problem of low-frequency oscillation (LFO) caused by insufficient damping in the HMIDC system, according to the multi-objective mixed 2/∞ output feedback control theory with regional pole assignment, an additional robust damping controller is designed in this paper, which not only has good robustness, but also has strong adaptability to the change of system operation mode. In the paper, the related oscillation modes and transfer function of the controlled plant are obtained, which are identified by the total least squares estimation of signal parameters via rotary invariance technology (TLS-ESPRIT). In addition, the control-sensitive point (CSP) for suppressing LFO based on the small disturbance test method is determined, which is suitable for determining the installation position of the controller. The results show that the control sensitivity factor of VSC-HVDC is greater than that of LCC-HVDC so that adding an additional damping controller to VSC-HVDC is better than LCC-HVDC in suppressing the LFO of HMIDC. Finally, a hybrid double infeed DC transmission system with three receiving terminals is built on PSCAD/EMTDC where the time-domain simulations are performed to verify the correctness of the CSP selection and the effectiveness of the controller.
Źródło:
Archives of Electrical Engineering; 2022, 71, 1; 109-124
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of Stab Resistance of Coated UHMWPE Fabric
Ocena odporności na przebicie powlekanej tkaniny z włókien polietylenowych o ultra wysokiej masie cząsteczkowej (UHMWPE)
Autorzy:
Yang, Wan-Qiu
Liu, Xiao-Yan
Yu, Yan-Ping
Yu, Wei-Dong
Powiązania:
https://bibliotekanauki.pl/articles/231896.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Biopolimerów i Włókien Chemicznych
Tematy:
stab resistance
fabric
hard particles
coating
odporność na przebicie
tkanina
twarde cząstki
powłoka
Opis:
In recent years, individual protection has attracted much attention in the area of personal safety, especially stab resistant clothing. Nowadays, fabrics of high performance fibre are often used in stab-resistant clothing. Therefore, in this paper ultra-high molecular weight polyethylene(UHMWPE) fibre fabrics were used to explore their distribution of boron carbide(B4C) particles. The effect of different processing techniques on stab resistance was discussed. Finally, it was found that when the particle dimension was 5 microns, the coating thickness 100 microns, the coating temperature 64 °C and the particle and binder ratio 2:3, the stab-resistance performance of the fabrics was best. The stab resistance of multi-layer fabrics was also discussed, and it was found that the relationship between energy absorber and the number of layers was changed by hard particles.
W ostatnich latach ochrona indywidualna przyciągnęła wiele uwagi w zakresie bezpieczeństwa osobistego, zwłaszcza w przypadku odzieży odpornej na przebicie. W dzisiejszych czasach tkaniny z wysokowydajnych włókien są często stosowane w odzieży odpornej na przebicie. Dlatego w artykule wykorzystano tkaniny z włókien polietylenowych o ultra wysokiej masie cząsteczkowej (UHMWPE) do zbadania ich rozkładu cząstek węglika boru (B4C). Omówiono wpływ różnych technik przetwarzania na odporność na przebicie. Stwierdzono, że w przypadku wymiaru cząstek równemu 5 mikronom, grubości powłoki 100 mikronów, temperaturze powlekania 64 °C i stosunku cząstek i spoiwa 2:3, odporność na przebicie tkanin była najlepsza. Omówiono również odporność na przebicie tkanin wielowarstwowych i stwierdzono, że zależność między pochłoniętą energią a liczbą warstw uległa zmianie przez twarde cząstki.
Źródło:
Fibres & Textiles in Eastern Europe; 2020, 2 (140); 76-79
1230-3666
2300-7354
Pojawia się w:
Fibres & Textiles in Eastern Europe
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and Curing of Allyl Urethane NIMMO-THF Copolyether with Three Functional Groups as a Potential Energetic Binder
Autorzy:
Wang, Xiaochuan
Li, Ping
Lu, Xianming
Mo, Hongchang
Xu, Minghui
Liu, Ning
Shu, Yuanjie
Powiązania:
https://bibliotekanauki.pl/articles/358158.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
energetic binder
copolyether
nitrile oxide
elastomer
Opis:
A tri-functional NIMMO-THF copolyether (T-NT) was synthesized by polymerization of 3-nitratomethyl-3-methyloxetane (NIMMO) and tetrahydrofuran (THF) in the presence of trimethylolpropane and catalyzed by BF3·OEt2. The allyl urethane NIMMO-THF copolyether with three functional groups (AUT-NT) was synthesized from tri-functional NIMMO-THF copolyether and allyl isocyanate. The polymer was characterized by FT-IR, 1H NMR, and 13C NMR. Furthermore, an elastomer that was prepared from allyl urethane NIMMO-THF copolyether with three functional groups and trimethylisophthalodinitrile oxide (TINO) had satisfactory mechanical properties and good thermal stability. The elastomer is expected to be used in composite solid propellants and polymer-bonded explosives (PBX).
Źródło:
Central European Journal of Energetic Materials; 2020, 17, 1; 141-163
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
High-grade mutant OmpF induces decreased bacterial survival rate
Autorzy:
Zhao, Zhi-ping
Liu, Ting-ting
Zhang, Li
Luo, Min
Nie, Xin
Li, Zai-xin
Pan, Yu
Powiązania:
https://bibliotekanauki.pl/articles/1039304.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
antibiotic resistance
mOmpF
OmpF
outer membrane protein
bacterial survival rate
Opis:
OmpF plays very important roles in the influx of antibiotics and bacterial survival in the presence of antibiotics. However, high-grade mutant OmpF and its function in decreasing bacterial survival rate have not been reported to date. In the present study, we cloned a high-grade mutant OmpF (mOmpF) and sequence analysis suggested that over 45 percent of the DNA sequence was significantly mutated, leading to dramatic changes in over 55 percent of the amino acid sequence. mOmpF protein was successfully expressed. When grown in the presence of antibiotic, the bacterial survival rate decreased and the antibiotic inhibition zone became larger with the increase of the mOmpF. It was concluded that concentration of high-grade mutant mOmpF dramatically influenced the bacterial survival rate. The study presented here may provide insights into better understanding of the relationships between structure and function of OmpF.
Źródło:
Acta Biochimica Polonica; 2014, 61, 2; 369-373
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of oleic acid in different solvent media on BRL 3A cell growth and viability
Autorzy:
Liu, Runqi
Yang, Wei
Xia, Cheng
Chen, Yuanyuan
Gao, Sansi
Dong, Zhihao
Huang, Baoyin
Li, Ruirui
He, Ping
Xu, Chuang
Powiązania:
https://bibliotekanauki.pl/articles/1038377.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
oleic acid
non-alcoholic fatty liver disease
liver lipid deposition
Opis:
Oleic acid (OA) is widely used in pathology studies of hepatocellular lipid deposition. Identifying the effects of different solvents on OA-induced liver lipid deposition would be beneficial for studies on hepatocytes. We treated BRL 3A cells with OA dissolved in different solvents. After 12 h incubation, cell viability was assessed using MTT assays. Reactive oxygen species (ROS), triglyceride (TG) and total cholesterol (TC) counts, and the expression level of glucose regulated protein (GRP78), sterol regulatory element binding protein (SREBP-1C) and fatty acid synthase (FAS) were analyzed. Water, PBS and DMSO were disadvantageous to the dissolution of OA and did not cause an OA-induced response in hepatocytes. In the alcohol+OA-treated cells, the severe ER stress, oxidative stress and cellular fat deposition were significantly increased. BSA promoted cell growth and the cells treated with 1.2% BSA+OA showed a lower grade TG and endoplasmic reticulum stress compared with KOH+OA and alcohol+OA treatments. KOH had no significant influence on BRL 3A cells viability. When treated with OA dissolved in KOH, BRL 3A cells showed a typical hepatocyte damage. KOH was considered the suitable choice for an OA solvent for BRL 3A cells in hepatic lipidosis research.
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 443-447
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ezetimibe prevents myocardial remodeling in an obese rat model by inhibiting inflammation
Autorzy:
Li, Xiao-Xing
Zhao, Lang
Chang, Ying
Liu, Bao-Shan
Xu, Feng
Zhang, Cheng
Ji, Xiao-Ping
Chen, Yu-Guo
Li, Chuan-Bao
Powiązania:
https://bibliotekanauki.pl/articles/1038380.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
obese
inflammation
remodeling
ezetimibe
IL-6
Opis:
Inflammation plays an important role in the development of many obesity-related diseases. This study aimed to investigate the effect of ezetimibe on inflammation and myocardial remodeling in obese rats. A rat model of obesity was established, and myocardial damage was examined by transmission electron microscopy and Masson staining. Twenty obese rats were divided into two groups (n=10): obese group and ezetimibe group. Ten SD rats were used as controls. Western blot was performed to monitor the expression of P-p38MAPK and interleukin (IL)-6. Immunohistochemical staining was used to monitor the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. In the obese rats group, we observed increased inflammatory factors and myocardial hypertrophy. In contrast, the ezetimibe group exhibited decreased expression of inflammatory factors and an improvement in myocardial remodeling compared to the obese group. Mechanistically, we found that ezetimibe decreased P-p38MAPK, IL-6, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 levels in the hearts of the obese rats. Taken together, these results indicate that ezetimibe may improve myocardial remodeling in obese rats by inhibiting inflammation.
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 465-470
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Myocardial remodeling in rats with metabolic syndrome: role of Rho-kinase mediated insulin resistance
Autorzy:
Li, Chuan-Bao
Li, Xiao-Xing
Chen, Yu-Guo
Gao, Hai-Qing
Bao, Cheng-Mei
Liu, Xiang-Qun
Bu, Pei-Li
Zhang, Juan
Zhang, Yun
Ji, Xiao-Ping
Powiązania:
https://bibliotekanauki.pl/articles/1039743.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Rat
Metabolism
Myocardium
Phosphorylation
Insulin resistance
Opis:
Insulin resistance (IR) plays a critical role in metabolic syndrome (MS). Previous studies have demonstrated that activated ROCK is increased in MS patients. However, the effect of Rho-kinase (ROCK) on IR has not been definitely determined. Thus, the aims of the present study were to determine whether ROCK activation induces IR or affects myocardial structure and function, as well as the possible mechanisms underlying this process. Wistar rats fed high fat, high glucose and high salt diet sewed as model of MS and we used transmission electron microscopy, echocardiogram technology, and terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling staining to identify any myocardial damage. The protein levels of MYPT-1 (characteristic of ROCK activation), IRS-1 and AKT were analyzed by immunohistochemistry and Western blotting. In hearts from MS rats, we found increased protein levels of phospho-MYPT-1 and phospho-IRS-1 (Ser307) and decreased phospho-AKT compared to levels in normal rats. In conclusion, the results suggest that ROCK-mediated IR is involved in the development of myocardial impairments in MS rats and that this effect is mediated probably via the IRS-1/PI3-kinase/AKT pathway.
Źródło:
Acta Biochimica Polonica; 2012, 59, 2; 249-254
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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