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    Wyświetlanie 1-3 z 3
    Tytuł:
    Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats
    Autorzy:
    Zou, Liu
    Xiong, Shujuan
    Deng, Xiangping
    Liu, Juan
    Xiong, Runde
    Wang, Zhe
    Cao, Xuan
    Chen, Yanming
    Guo, Yu
    Tang, Guotao
    Powiązania:
    https://bibliotekanauki.pl/articles/895637.pdf
    Data publikacji:
    2018-12-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    scutellarin
    TPGS
    polymeric micelles
    antithrombotic drugs
    Opis:
    To improve the clinical effect of scutellarin by extending the action time in vivo, scutellarin loaded polymeric micelles were developed by D-alpha tocopherol polyethylene glycol 1000 succinate (Scu/TPGS). Scu/TPGS were prepared using film solvent diffusion methods and characterized on the basis of their particle size, zeta potential, and drug encapsulation efficiency. Dynamic dialysis was used to study the release behavior of the polymeric micelles in vitro. Its pharmacokinetic characteristics and antithrombotic efficacy were studied by intravenous injection in rats. The results showed that Scu/TPGS were spherical, 20.09±2.62 nm in size and a slow release in vitro. The pharmacokinetic parameter T1/2 of Scu/TPGS was 762.12±46.56 min compared with commercial injection of 59.30±10.67 min (p<0.05). At the 1 mg/kg dose, the thrombolysis effect of micellar group was stronger than that of the commercial group (p<0.05). In conclusion, TPGS polymer micelles provided a valid strategy in chemotherapy for cerebrovascular diseases with poor water solubility and poor lipid solubility drugs such as scutellarin.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1305-1312
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Adsorption of CO2 by surface modified coal-based activated carbons: kinetic and thermodynamic analysis
    Autorzy:
    Xinzhe, Liu
    Mingyang, Zhang
    Juan, Chen
    Zhengyu, Hu
    Shuaifei, Xian
    Mingxuan, Tang
    Chenchen, Zhang
    Powiązania:
    https://bibliotekanauki.pl/articles/2174813.pdf
    Data publikacji:
    2022
    Wydawca:
    Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
    Tematy:
    Surface modification
    CO2 adsorption capacity
    adsorption kinetics
    thermodynamic parameters
    Opis:
    The effects of different surface modifiers on the CO2 adsorption capacity of coal-based activated carbons were studied, and the diffusion behavior, adsorption kinetics and thermodynamic parameters of CO2 in activated car-bons were analyzed. The results show that compared with ethylene glycol, 1,2-propylenediamine and zinc chloride, potassium hydroxide and sodium hydroxide can greatly improve CO2 adsorption capacity. The adsorption rate is faster, and the adsorption capacity is larger, with the maximum CO2 adsorption capacity being 33.54 mL/g. Fick’s law can well describe the diffusion behavior of CO2 in activated carbon. The addition of a surface modifier can increase the diffusion coefficient. The diffusion of CO2 in activated carbon falls into the category of crystal diffusion. The adsorption kinetics of CO2 before and after surface modification follow the Bangham equation. During the adsorption process, δ H < 0, δ G < 0, δ S < 0. Surface modification can reduce adsorption heat and promote adsorption, and the adsorption process is dominated by physisorption.
    Źródło:
    Polish Journal of Chemical Technology; 2022, 24, 3; 19--28
    1509-8117
    1899-4741
    Pojawia się w:
    Polish Journal of Chemical Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Myocardial remodeling in rats with metabolic syndrome: role of Rho-kinase mediated insulin resistance
    Autorzy:
    Li, Chuan-Bao
    Li, Xiao-Xing
    Chen, Yu-Guo
    Gao, Hai-Qing
    Bao, Cheng-Mei
    Liu, Xiang-Qun
    Bu, Pei-Li
    Zhang, Juan
    Zhang, Yun
    Ji, Xiao-Ping
    Powiązania:
    https://bibliotekanauki.pl/articles/1039743.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Rat
    Metabolism
    Myocardium
    Phosphorylation
    Insulin resistance
    Opis:
    Insulin resistance (IR) plays a critical role in metabolic syndrome (MS). Previous studies have demonstrated that activated ROCK is increased in MS patients. However, the effect of Rho-kinase (ROCK) on IR has not been definitely determined. Thus, the aims of the present study were to determine whether ROCK activation induces IR or affects myocardial structure and function, as well as the possible mechanisms underlying this process. Wistar rats fed high fat, high glucose and high salt diet sewed as model of MS and we used transmission electron microscopy, echocardiogram technology, and terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling staining to identify any myocardial damage. The protein levels of MYPT-1 (characteristic of ROCK activation), IRS-1 and AKT were analyzed by immunohistochemistry and Western blotting. In hearts from MS rats, we found increased protein levels of phospho-MYPT-1 and phospho-IRS-1 (Ser307) and decreased phospho-AKT compared to levels in normal rats. In conclusion, the results suggest that ROCK-mediated IR is involved in the development of myocardial impairments in MS rats and that this effect is mediated probably via the IRS-1/PI3-kinase/AKT pathway.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 2; 249-254
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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