Autor: Librowski, T. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Pharmacological profile of three different gamma-butyrolactone derivatives in mice
Autorzy:: Salat, K.
Librowski, T.
Filipek, B.
Powiązania:: https://bibliotekanauki.pl/articles/3034.pdf
Data publikacji:: 2010
Wydawca:: Instytut Medycyny Wsi
Tematy:: pharmacological profile
gamma-butyrolactone derivative
mice
mouse
hot plate
capsaicin
toxicity
Źródło:: Journal of Pre-Clinical and Clinical Research; 2010, 04, 1
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The use of selected anaesthetic drugs in search of a method for improving earthworms’ welfare
Autorzy:: Podolak-Machowska, A
Kostecka, J.
Librowski, T
Plytycz, B
Powiązania:: https://bibliotekanauki.pl/articles/124203.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:: local anaesthetics (LA)
pharmacological screening
MS-222
earthworms
Dendrobaena veneta Rosa
welfare of laboratory animals
Opis:: This paper describes selected effects of body contact of earthworms Dendrobaena veneta Rosa with local anaesthetic (LA) drugs used for human anesthesia (lidocaine and prilocaine) and anaesthetics for aquatic animals (MS-222). The findings showed safe and effective immobilization of earthworms with prilocaine at a concentration of 0.25-1%. At the applied concentrations lidocaine was safe, but less effective. On the other hand, MS-222, at the applied concentrations had a strongly irritating effect for earthworms and induced convulsive body movements connected with a discharge of coelomic fluid. The results may be relevant both for improving the welfare of earthworms during experiments and for the organization of research involving testing drugs on invertebrates. In this case, by using earthworms as an experimental model and by applying the method for measuring their mobility after contact with anaesthetics, which has been described in this article, it might be possible to replace experiments on guinea pigs, rabbits, rats and mice, which are expensive and require an approval of an ethics committee, with laboratory tests on earthworms.
Źródło:: Journal of Ecological Engineering; 2013, 14, 3; 83-88
2299-8993
Pojawia się w:: Journal of Ecological Engineering
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Structural Characterization of Carane Derivative Stereoisomers - Potent Local Anesthetics
Autorzy:: Grochowski, J.
Serda, P.
Pasenkiewicz-Gierula, M.
Czarnecki, R.
Librowski, T.
Lochyński, S.
Frąckowiak, B.
Powiązania:: https://bibliotekanauki.pl/articles/2030630.pdf
Data publikacji:: 2002-05
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:: 82.30.Qt
61.10.-i
Opis:: The paper reports on structural investigation and phase analysis of a newly synthesized potent local anesthetic with chiral molecular structure. Absolute structure and absolute configuration on four chiral centres was determined using microcrystalline single-crystal diffraction with anomalous scattering of X-ray radiation azimuthal scan technique. Phase analysis for new compound (KP23SS) and its epimer (KP23RS) was carried out using classical and synchrotron radiation powder diffraction. Enantiopurity of the bulk material was verified for both isomers by comparison of experimental and simulated high-resolution powder diffraction diagrams. The presence of two new polymorphic phases of KP23RS was documented. Comparative conformational analysis was carried out using differential Fourier synthesis and least-squares molecule overlap technique. A model of epimeric disorder was discussed for the homochiral phase.
Źródło:: Acta Physica Polonica A; 2002, 101, 5; 665-674
0587-4246
1898-794X
Pojawia się w:: Acta Physica Polonica A
Dostawca treści:: Biblioteka Nauki

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