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Tytuł:
The presence of Chlamydia phage PhiCPG1 capsid protein VP1 genes and antibodies in patients infected with Chlamydia trachomatis
Autorzy:
Ma, Jingyue
Liu, Yuan
Liu, Yuanjun
Li, Lingjie
Hou, Shuping
Gao, Xibo
Qi, Manli
Liu, Quanzhong
Powiązania:
https://bibliotekanauki.pl/articles/1038770.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Chlamydia trachomatis
Chlamydia bacteriophage
capsid protein
VP1
Opis:
Chlamydia phage PhiCPG1 has been found in Chlamydia caviae in a guinea pig model for inclusion conjunctivitis, raising the possibility that Chlamydia phage is also present in patients infected with C. trachomatis (Ct). In the present study, we assayed for presence of Chlamydia phage capsid protein VP1 genes and antibodies in 84 non-Ct controls and 206 Ct patients using an enzyme-linked immunoassay (ELISA), followed by verification with Western blot. None of the subjects were exposed to an antibiotic treatment or had a C. pneumoniae infection. The VP1 antibody test was positive in both, the ELISA and Western blot assay, in 4 Ct patients. PCR amplification experiments revealed presence of the VP1 gene in 5 Ct patients. The results suggest that Chlamydia phage capsid protein VP1 may exist in some Ct patients.
Źródło:
Acta Biochimica Polonica; 2016, 63, 3; 501-504
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of pollution accumulation on coating aging of UHV line insulators with different suspension height in coal-ash polluted area
Autorzy:
Lan, Lei
Mu, Lin
Wang, Yu
Yuan, Xiaoqing
Wang, Wei
Li, Zhenghui
Powiązania:
https://bibliotekanauki.pl/articles/140717.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
aging
pollution component
pollution degree
RTV coating
Opis:
Room temperature vulcanized (RTV) silicone rubber is widely used to prevent pollution flashover with its excellent hydrophobicity and hydrophobicity transfer. However, RTV coatings are at the risk of deterioration and failure in heavily polluted operating environment. In this paper, RTV coated insulators with different suspension heights operating in coal ash polluted areas were sampled. Pollution degree, pollution composition and aging degree of coatings were tested. The result shows that the insoluble pollution contains Al(OH)3 filler precipitated from RTV coating, which indicates the aging of the RTV coating. The top surface coating is more affected by ultraviolet and rainwater than the bottom surface resulting in more serious degradation. As the pollution degree of the lower phase insulator is heavier than that of the upper phase insulator, the erosion effect of pollution on the RTV coating is more intense. The fillers and rubber molecules of RTV continuously precipitate into the pollution layer, leading to further aging. Therefore, the overall aging degree of the lower insulator coating is more serious than that of the upper insulator coating.
Źródło:
Archives of Electrical Engineering; 2020, 69, 1; 39-56
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of air inlet layout on the inner flow field for a vertical turbo air classifier
Autorzy:
Yu, Yuan
Li, Xingshuai
Zhang, Yu
Jiao, Zhiwei
Liu, Jiaxiang
Powiązania:
https://bibliotekanauki.pl/articles/27323654.pdf
Data publikacji:
2023
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
turbo air classifier
powder technology
air inlet layout
numerical simulation
classification performance
Opis:
In this study, the influence of air inlet layout on the flow field distribution and particle movement trajectory for the vertical turbo air classifier are analyzed comparatively using the numerical simulation method. The air inlet layout adjustment can increase the axial velocity and turbulent dissipation rate at the feeding inlet and do not generate the axial negative velocity, which improves powder material pneumatic transportation and dispersion capacity; the air inlet layout adjustment can match the airflow rotation direction with the rotation direction of the rotor cage, which can eliminate the vortices in the rotor cage channel effectively. Moreover, the particle movement time is shortened and fast classification is completed, which can decrease the particle agglomeration probability and weaken the ‘fish-hook’ effect. The optimization scheme of the air inlet layout is Type-BC. In accordance with the numerical simulation results, the calcium carbonate classification experimental results indicate that the classification performance of the classifier is improved using Type-BC.
Źródło:
Physicochemical Problems of Mineral Processing; 2023, 59, 6; art. no. 175859
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The depression mechanism on pyrite in a low-alkaline system with combined depressants : Experiment, HSC, DFT and ToF–SIMS studies
Autorzy:
Li, Suqi
Yuan, Jiaqiao
Ding, Zhan
Li, Jie
Yu, Anmei
Wen, Shuming
Bai, Shaojun
Powiązania:
https://bibliotekanauki.pl/articles/24085821.pdf
Data publikacji:
2023
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
pyrite
calcium hypochlorite
lime
depression
low alkaline system
Opis:
Depression of pyrite in a low-alkaline system has sparked soaring interests for the multi-metal sulfide minerals flotation recently. This study investigates effects of combined depressants (Ca(ClO)2 and CaO) on pyrite flotation with butyl xanthate (KBX). Micro-flotation experiments indicate that the addition of 200 mg/L combined depressants (a mass ratios of CaO to Ca(ClO) 2 of 2:3) and 1.0×10−3 mol/L KBX at pH 9.5 can effectively depresses the flotation of pyrite, and a minimum pyrite recovery rate of 12.5% is obtained. Basic thermodynamic evaluation results confirm the participation of Ca(ClO) 2 significantly decrease the negative Gibbs free energies of pyrite oxidation reaction. Besides, the calcium species (Ca(OH) 2, Ca2+ and Ca(Cl) 2) will spontaneously transform into CaCO3,and it is the ultimate dominant calcium species in the CO32- system. Density functional theory (DFT) results indicate that CaCO3 can chemically adsorb onto the pyrite surface with an adsorption energy of –671.13 kJ/mol. The O1 and Ca atoms mainly contribute to the bonding process and are responsible for the stable adsorption of CaCO3. ToF-SIMS results provide strong evidence that the combined depressants increase the amount of hydrophilic species and decrease dixanthogen adsorption onto the pyrite surface. The thickness of the whole formed hydrophilic species is approximately 50 nm. Semiquantitative amounts of hydrophilic species follow the order of hydroxy calcium>iron carbonyl>calcium carbonate. Overall, hydrophilic species repulse adsorption of dixanthogen and significantly reduce the flotation performance of pyrite.
Źródło:
Physicochemical Problems of Mineral Processing; 2023, 59, 3; art. no. 168454
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The analysis of surface deformation controlled by key strata groups and separation in strip mining
Autorzy:
Luan, Yuan-Zhong
Li, Zeng-Xin
Weng, Li-Yuan
Zhang, Ming-Xin
Powiązania:
https://bibliotekanauki.pl/articles/1402348.pdf
Data publikacji:
2020
Wydawca:
Politechnika Wrocławska. Wydział Geoinżynierii, Górnictwa i Geologii. Instytut Górnictwa
Tematy:
key strata groups
separation
breaking distance
surface deformation
probability integration
Opis:
In this paper, the key stratum theory is introduced in view of the small surface deformation value of the mining of thick coal mines in Gucheng Coal Mine. The analysis of geological drilling data in Gucheng Goal Mine determines three key strata groups and one main key stratum for controlling the surface deformation of the stratum above the No. 3 coal according to the stiffness and strength condition of the stratum. The breaking distance of the main key stratum in this Mine is determined to be 302–373.7 m in terms of the elastic foundation beam theory and the surface measured basin data. In addition, a large-scale separation model of the main key stratum of the five strip mining face of this Mine is established, and the quantitative calculation formula of the limit spanning of rock beam is proposed and applied to. Finally, the probability integral method is used to predict the surface deformation problem of multiple working faces, and the partition prediction is performed according to the key stratum breaking distance to obtain prediction values of surface deformation consistent with the fracture of key stratum in the study area.
Źródło:
Mining Science; 2020, 27; 303-322
2300-9586
2353-5423
Pojawia się w:
Mining Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Systematic Analyses of the Genus Architricha and Pleurotricha curdsi (Ciliophora, Oxytrichidae), with Redescriptions of Their Morphology
Autorzy:
Xu, Yuan
LI, Lifang
Fan, Xinpeng
Pan, Hongbo
GU, Fukang
Al-Farraj, Saleh A.
Powiązania:
https://bibliotekanauki.pl/articles/763754.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Opis:
Two oxytrichids Architricha indica Gupta et al., 2006 and Pleurotricha curdsi (Shi et al. 2002) Gupta et al., 2003 collected in East China, were studied using live observation and the silver staining method. The description and morphometric characterization of the new populations were supplied. The Shanghai population of A. indica differs from the Indian population in the number of cirri in the third right marginal row (average of 16.8 vs. 21.1). The Shanghai population of P. curdsicorresponds well with the Indian population, but it differs from the other Chinese population in the number of right marginal rows (two vs. three). The early process of reorganization of A. indica was studied, and a difference on the formation of anlage V was found compared to the original report. The small subunit rRNA genes of both species were sequenced for the first time. The phylogenetic analyses based on SSU rRNA gene sequence data revealed that Architricha is sister to the assemblage of Pseudouroleptus caudatus and two Strongylidium, while P. curdsi clusters with its congener P. lanceolata and is located in Stylonychinae.
Źródło:
Acta Protozoologica; 2015, 54, 3
1689-0027
Pojawia się w:
Acta Protozoologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study on synthesis and photoelectric properties of AgInS2 quantum dots
Autorzy:
Yuan, Binxia
Luo, Zige
Sun, Yongjun
Cao, Sheng
Cao, Lan
Li, Min
Powiązania:
https://bibliotekanauki.pl/articles/2106479.pdf
Data publikacji:
2022
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
AgInS
Quantum dots
Optical properties
Photocatalytic hydrogen production
Opis:
AgInS2 Quantum dots (AIS QDs) have high quantum yield and catalytic performance, which is promising materials in photo-catalytic and optoelectronic fields. In the paper, it adopted a simple and non-toxic method to synthesize AIS QDs. The effect of reaction temperature on the growth mechanism, optical and physical properties of AIS had been extensively investigated by using L-cysteine as the sulfur source, and their application in catalytic hydrogen production was also studied. The results demonstrated that the fluorescence properties will be quenched with the increase of temperature, indicating that the separation speed of electron hole pairs of samples obtained at higher temperature was faster. Meantime, the electron transport capacity and the photocurrent had also improved with the increase of reaction temperature. Finally, the sample obtained at 100 oC had higher hydrogen production rate.
Źródło:
Polish Journal of Chemical Technology; 2022, 24, 2; 21--26
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of Cotton Matured Fibre Quality and the Super-Molecular Structure in Upland Cotton RILs
Analiza jakości dojrzałych włókien bawełny Upland i jej struktury nadcząsteczkowej
Autorzy:
Wang, Y.
Li, C
Shang, H
Li, B
Liu, A
Yuan, Y
Powiązania:
https://bibliotekanauki.pl/articles/231848.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Biopolimerów i Włókien Chemicznych
Tematy:
upland cotton
recombinant inbred lines
fibre super-molecular structure
fibre quality
dojrzałe włókna bawełny
bawełna Upland
zmodyfikowana genetycznie bawełna
cechy włókniste bawełny
super-molekularna struktura włókien
jakość włókna
Opis:
A RIL(recombinant inbred lines) population with 196 F6:9 lines was developed from an F2 population of upland cotton (Gossypium hirsutum L.) cross of sGK9708×0-153. sGK9708 is a commercial transgenic variety with Bt+CpTI genes resistant to budworm and 0-153 with high fibre quality. Five materials with high fibre strength and five materials with low fibre strength from the recombinant inbred lines were researched [1]. Ten materials of super-molecular structure and fibre quality were studied by X-ray diffraction and the HVI900 technique. The results indicated that cotton matured fibre quality should mainly depend on the decrease in the orientational parameter in the crystalline section, especially the orientational separate and orientational distribution angles. The correlation of fibre maturity, linear density and the fibre super-molecular structure is an innovation in the study. Studies on the correlation of cotton fibre quality and the fibre super-molecular structure provide a scientific basis for the improvement cotton fibre quality.
Artykuł dotyczy badań jakości dojrzałych włókien bawełny amerykańskiej Upland i jej struktury nadcząsteczkowej. Uzyskano zmodyfikowany genetycznie gatunek bawełny amerykańskiej Upland za pośrednictwem sztucznego samozapylenia bawełny wykazującej cechy włókniste (linii wsobnej). Dla uzyskanych w opisany sposób włókien bawełny przeprowadzono wszechstronne badania właściwości fizycznych, a także struktury nadcząsteczkowej. Uzyskane wyniki badań skonfrontowano z właściwościami fizycznymi i strukturą nadczasteczkową tradycyjnej bawełny amerykańskiej Upland posiłkując się w tym celu analizą korelacyjną.
Źródło:
Fibres & Textiles in Eastern Europe; 2014, 5 (107); 28-33
1230-3666
2300-7354
Pojawia się w:
Fibres & Textiles in Eastern Europe
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structure and Properties of Chain Branched Nitrocellulose
Autorzy:
Liu, Yanhua
Shao, Ziqiang
Yuan, Jingjing
Jia, Shuai
Wang, Feijun
Li, Yonghong
Guo, Bingyi
Yang, Zhonglin
Zuo, Yingying
Powiązania:
https://bibliotekanauki.pl/articles/27787917.pdf
Data publikacji:
2021
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
nitrate glycerol ether cellulose
NGEC
mechanical properties
compatibility
propellant
energy
Opis:
Nitrocellulose (NC) with a semi-rigid polymer chain is one of the typical traditional cellulose derivatives. Optimization of its mechanical properties is of great significance for improving the performance of NC-based propellants. The nitrate glycerol ether cellulose (NGEC) was prepared by introducing glycerol onto the unreacted, free hydroxyl groups on NC through a three-step process (alkalization, etherification, and nitration). The effects of both the nitration process and the degree of etherification on the NGEC nitrogen content were qualitatively explored. By adding NGEC into modified double-base propellant, a standard engine grain with a diameter of 50 mm was produced by adsorption, granulation, and screw extrusion. The heat of explosion, and other physical properties of NGEC were characterized and the variation in mechanical properties and performance after storage for 6 years was investigated. The results indicated that the sensitivity was improved, and the stability was slightly decreased on increasing the nitrogen content of NGEC. Compared with NC containing similar nitrogen levels, NGEC exhibited a slightly higher heat of explosion, similar compatibility, and lower sensitivity. Additionally, the solubility of NGEC in ethanol/ether exceeded 99.7%. Through branched-chain chemical modification, the glycerol ether played a significant role in achieving internal plasticization among the cellulose chains.
Źródło:
Central European Journal of Energetic Materials; 2021, 18, 4; 448--476
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Statistical Optimization of Underwater Lower-Frequency Sound Insulation for Locally Resonant Sonic Material Using Genetic Algorithm
Autorzy:
Yuan, Bo
Chen, Yong
Tan, Bilian
Li, Bo
Powiązania:
https://bibliotekanauki.pl/articles/177461.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
underwater acoustic
sound insulation
local resonance
statistical optimization
global optimum
Opis:
The locally resonant sonic material (LRSM) is an artificial metamaterial that can block underwater sound. The low-frequency insulation performance of LRSM can be enhanced by coupling local resonance and Bragg scattering effects. However, such method is hard to be experimentally proven as the Best optimizing method. Hence, this paper proposes a statistical optimization method, which first finds a group of optimal solutions of an object function by utilizing genetic algorithm multiple times, and then analyzes the distribution of the fitness and the Euclidean distance of the obtained solutions, in order to verify whether the result is the global optimum. By using this method, we obtain the global optimal solution of the low-frequency insulation of LRSM. By varying parameters of the optimum, it can be found that the optimized insulation performance of the LRSM is contributed by the coupling of local resonance with Bragg scattering effect, as well as a distinct impedance mismatch between the matrix of LRSM and the surrounding water. This indicates coupling different effects with impedance mismatches is the Best method to enhance the low-frequency insulation performance of LRSM.
Źródło:
Archives of Acoustics; 2019, 44, 2; 365-374
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Small mammal fauna from Wulanhuxiu (Nei Mongol, China) implies the Irdinmanhan–Sharamurunian (Eocene) faunal turnover
Autorzy:
LI, QIAN
WANG, YUAN-QING
FOSTOWICZ-FRELIK, ŁUCJA
Powiązania:
https://bibliotekanauki.pl/articles/945478.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Instytut Paleobiologii PAN
Tematy:
mammalia
rodentia
duplicidentata
anagalidae
eocene
ulan shireh formation
china
erlian basin
Opis:
Wulanhuxiu, a middle Eocene locality in the Erlian Basin, Nei Mongol (China) has been commonly regarded as belonging to the Ulan Shireh Formation, equated with the Irdin Manha Formation. We recognized two separate mammalian faunas of different age from the beds exposed at Wulanhuxiu. The lower fossiliferous horizon contains an anagalid, uncommon duplicidentate representatives (Gomphos progressus sp. nov., Mimolagus, Erenlagus, and Strenulagus), and diverse perissodactyls. This combination of taxa points to an Irdinmanhan age, but one element of the fauna (Schlosseria) may represent an Arshantan relic. Overall, the assemblage comprises “paleoplacental” mammals mixed with “neoplacentals”. The upper horizon is less species-rich and the only paleoplacentals present are scarce creodonts. However, this horizon is marked by abundant remains (including postcranial material) of the lagomorph Gobiolagus and by the presence of an advanced form of Gobiomys (Rodentia), and is most probably Sharamurunian in age. Thus, Wulanhuxiu documents replacement, albeit incomplete, of paleoplacentals by neoplacentals in the Chinese Eocene record.
Źródło:
Acta Palaeontologica Polonica; 2016, 61, 4; 759-776
0567-7920
Pojawia się w:
Acta Palaeontologica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Selective agglomeration of magnetite in entlandite-serpentine system and implication for their separation
Autorzy:
Lu, J.
Yuan, Z.
Liu, J.
Li, L.
Wang, N.
Meng, Q.
Powiązania:
https://bibliotekanauki.pl/articles/110411.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
serpentine
pentlandite
magnetite
selective magnetic agglomeration
magnetic separation
Opis:
In nickel sulfide processing, magnesium silicates (serpentines) can easily form slime coatings or hetero-aggregation on pentlandite surfaces, and hence decrease the pentlandite flotation rate and recovery. In this work, magnetic separation of pentlandite from serpentine using selective magnetic coating through adding magnetite fines as magnetic seeds was investigated. Interactions of magnetite-pentlandite and magnetite-serpentine were calculated by the DLVO (Derjaguin-Landau-Verwey-Overbeek) theory. The results show that the interaction of magnetite-pentlandite was obviously stronger than that of magnetite-serpentine with an external weak magnetic field (4776 A/m-1). Therefore, fine magnetite fractions selectively adhered to the pentlandite surfaces and enhanced its magnetism, resulting in being separated from serpentine by magnetic separation, which was further verified by magnetic coating-magnetic separation and SEM observations.
Źródło:
Physicochemical Problems of Mineral Processing; 2017, 53, 2; 943-955
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Research on dose correction method of vehicle-borne environmental radiation measurement equipment
Autorzy:
Xu, Jie
Ren, Jizhou
Yang, Jianbo
Fan, Jiawen
Li, Rui
Li, Hui
Huang, Weiqi
Yuan, Biao
Powiązania:
https://bibliotekanauki.pl/articles/2055679.pdf
Data publikacji:
2021
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
dose correction factor
reference radiation field
vehicle-borne environmental radiation measurement equipment
Opis:
This study establishes a near-ground reference radiation field based on typical radionuclides of the Fukushima accident in response to the need for vehicle-borne environmental radiation measurement equipment that can accurately evaluate the environmental dose of nuclear accidents. The Monte Carlo code FLUKA is used to study the environmental dose of such equipment in the early and mid-late reference radiation fields of nuclear accidents. Results of the air dose rate at 1 m above the ground were corrected to eliminate data difference between diverse measurement platforms. Simulation results show that t he dose correction factor (CF) fluctuates at approximately 0.8813 in the early reference radiation field and at approximately 0.6711 in the mid-late reference radiation field . This deviation of the dose CF in the early and mid-late reference radiation field s is within 2% and is not affected by the change in detector position. This research can be applied to obtain more accurate measurement of an ambient dose in the near-ground radiation field and support the vehicle-borne environmental radiation measurement technology.
Źródło:
Nukleonika; 2021, 66, 3; 103--110
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Real-time optical demultiplexing with the chirped pulses
Autorzy:
Li, Y.
Zhang, X.
Yuan, J.
Kang, Z.
Sang, X.
Kang, S.
Kang, X.
Yan, B.
Wang, K.
Yu, C.
Powiązania:
https://bibliotekanauki.pl/articles/175106.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
linearly chirped pulse
parametric process
real-time optical demultiplexing
Opis:
A scheme for real-time optical demultiplexing is proposed by utilizing the time-broadened and linearly chirped pulses instead of the conventional mode-locked pulses. The copies of the optical-time-division-multiplexed signal are acquired through a dual-pump parametric gate and used as the parametric multicast block. Simulation results show that the demultiplexing from 160 Gb/s down to sixteen 10 Gb/s tributaries can be achieved only by using a sampling source of 10 GHz. The proposed scheme can effectively reduce the complexity of parallel processing, and find important applications in the high-speed all-optical signal processing.
Źródło:
Optica Applicata; 2018, 48, 4; 621-632
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Phyllodulcin Protects PC12 Cells Against the Injury Induced by Oxygen and Glucose Deprivation-Restoration
Autorzy:
Hu, Chang-Long
Ge, Lu
Tang, Yong
Li, Jie
Wu, Chun-Hui
Hu, Jiang-Hong
Yuan, Jin-Tao
Fan, Yong-Zhong
Powiązania:
https://bibliotekanauki.pl/articles/895391.pdf
Data publikacji:
2019-12-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
apoptosis
oxidative stress
PC12 cells
phyllodulcin
oxygen and glucose deprivation/restoration
Opis:
Phyllodulcin is a natural coumarin derivative found in Hydrangea macrophylla. To discover effective therapeutics for cerebral ischemia-reperfusion injury, we investigated the protective effects of phyllodulcin on PC12 cells injury induced by oxygenation and glucose deprivation/restoration (OGD/R). As a result, phyllodulcin can improve the cell viability and attenuate the extracellular lactate dehydrogenase release. Meanwhile, phyllodulcin can ameliorate the dysfunction of mitochondria through reducing reactive oxygen species production, decreasing the intracellular calcium level and increasing the mitochondrial membrane potential. ROS-associated OGD/R can induce cell apoptosis through the mitochondrial pathway. Phyllodulcin can inhibit apoptosis of PC12 cells through down-regulation of Caspase-3 and Bax as well as up-regulation of Bcl-2. These results indicate phyllodulcin can protect PC12 cells against the damage induced by OGD/R. This investigation gives promising evidences for the therapy of cerebral ischemia-reperfusion injury.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 1043-1050
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
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