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Wyszukujesz frazę "Li, Yong-Liang" wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Reliability optimization design method based on multi-level surrogate model
Autorzy:
Li, Yong-Hua
Liang, Xiao-Jia
Dong, Si-Hui
Powiązania:
https://bibliotekanauki.pl/articles/1841935.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
Kriging model
reliability-based optimization
multi-level surrogate model
adaptive dynamic penalty function
Opis:
In this work, a genetic-algorithm-based Kriging model with multi-point addition sequence optimization strategy is addressed to make up for the shortcomings of Kriging model with single point criterion. This approach combines the multi-point addition strategy with genetic algorithm to enable the Kriging model to efficiently capture the globally optimal solution. Based on this, a multi-level surrogate method is presented by employing a local surrogate model to modify the Kriging global surrogate model, and then applied to design optimization to improve the accuracy and efficiency of global optimization. Meanwhile, a reliability design optimization method based on multi-level surrogate model is studied by dealing with the reliability constraints with an adaptive reliability penalty function. Numerical examples show that the proposed method can find the optimal solution of the object problem with the least calculation cost under the condition of satisfying the reliability constraint.
Źródło:
Eksploatacja i Niezawodność; 2020, 22, 4; 638-650
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers
Autorzy:
Wu, Fen
Liu, Jing
Qiu, Yu-Lan
Wang, Wei
Zhu, Shou-Min
Sun, Pin
Miao, Wen-Bin
Li, Yong-Liang
Brandt-Rauf, Paul W.
Xia, Zhao-Lin
Powiązania:
https://bibliotekanauki.pl/articles/2179802.pdf
Data publikacji:
2013-03-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
vinyl chloride monomer
chromosome damage
MGMT
hMLH1
DNA methylation
Opis:
Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation-specifi c PCR. Chromosome damage in peripheral blood lymphocytes was measured by the cytokinesis-block micronucleus assay. The subjects were divided into chromosome damaged and non-damaged groups based on the normal reference value of micronuclei frequencies determined for two control groups. Results: MGMT promoter methylation was detectable in 5 out of 49 chromosome damaged subjects, but not in the chromosome non-damaged subjects; there was a signifi cant difference in MGMT methylation between the two groups (p < 0.05). Conclusions: We detected aberrant promoter methylation of MGMT in a small number of chromosome damaged VCM-exposed workers, but not in the chromosome non-damaged subjects. This preliminary observation warrants further investigation in a larger study.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 1; 173-182
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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