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Wyświetlanie 1-15 z 33
Tytuł:
Isolation and expression pattern of RGS21 gene, a novel RGS member
Autorzy:
Li, Xin
Chen, Lei
Ji, Chaoneng
Liu, Bing
Gu, Jiefeng
Xu, Jian
Zou, Xianqiong
Gu, Shaohua
Mao, Yumin
Powiązania:
https://bibliotekanauki.pl/articles/1041351.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
RGS21
G-protein signaling pathway
G-protein α subunit (Gα)
Opis:
Regulators of G-protein signaling (RGS) proteins are known for the RGS domain that is composed of a conserved stretch of 120 amino acids, which binds directly to activated G-protein α subunits and acts as a GTPase-activating protein (GAP), leading to their deactivation and termination of downstream signals. In this study, a novel human RGS cDNA (RGS21), 1795 bp long and encoding a 152-amino acid polypeptide, was isolated by large-scale sequencing analysis of a human fetal brain cDNA library. Unlike other RGS family members, RGS21 gene has no additional domain/motif and may represent the smallest known member of RGS family. It may belong to the B/R4 subfamily, which suggests that it may serve exclusively as a negative regulator of αi/o family members and/or αq/11. PCR analysis showed that RGS21 mRNA was expressed ubiquitously in the 16 tissues examined, implying general physiological roles.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 943-946
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
High-Pressure Phase Transitions and Thermodynamic Behaviors of Cadmium Sulfide
Autorzy:
Tan, J.
Li, Y.
Ji, G.
Powiązania:
https://bibliotekanauki.pl/articles/1493632.pdf
Data publikacji:
2011-09
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
71.15.Mb
65.40.-b
Opis:
The pressure-induced phase transitions of cadmium sulfide semiconductor in both zinc-blende and wurtzite structures are investigated by ab initio plane-wave pseudopotential density functional theory with the local density approximation. On the basis of the fourth-order Birch-Murnaghan equation of state, the phase transition pressures $P_{t}$ are determined by the enthalpy criterion. It is found that the phase transitions occur at pressure of 2.57 GPa (zinc blende-rocksalt structure) and 2.60 GPa (wurtzite-rocksalt structure), respectively. The equilibrium structural parameters, elastic constants, and phase transition pressures are calculated and compared with the experimental data available and other theoretical results. According to linear-response approach, the thermodynamic properties such as the free energy, enthalpy, entropy, and heat capacity are also obtained successfully from the phonon density of state.
Źródło:
Acta Physica Polonica A; 2011, 120, 3; 501-506
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Myocardial remodeling in rats with metabolic syndrome: role of Rho-kinase mediated insulin resistance
Autorzy:
Li, Chuan-Bao
Li, Xiao-Xing
Chen, Yu-Guo
Gao, Hai-Qing
Bao, Cheng-Mei
Liu, Xiang-Qun
Bu, Pei-Li
Zhang, Juan
Zhang, Yun
Ji, Xiao-Ping
Powiązania:
https://bibliotekanauki.pl/articles/1039743.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Rat
Metabolism
Myocardium
Phosphorylation
Insulin resistance
Opis:
Insulin resistance (IR) plays a critical role in metabolic syndrome (MS). Previous studies have demonstrated that activated ROCK is increased in MS patients. However, the effect of Rho-kinase (ROCK) on IR has not been definitely determined. Thus, the aims of the present study were to determine whether ROCK activation induces IR or affects myocardial structure and function, as well as the possible mechanisms underlying this process. Wistar rats fed high fat, high glucose and high salt diet sewed as model of MS and we used transmission electron microscopy, echocardiogram technology, and terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling staining to identify any myocardial damage. The protein levels of MYPT-1 (characteristic of ROCK activation), IRS-1 and AKT were analyzed by immunohistochemistry and Western blotting. In hearts from MS rats, we found increased protein levels of phospho-MYPT-1 and phospho-IRS-1 (Ser307) and decreased phospho-AKT compared to levels in normal rats. In conclusion, the results suggest that ROCK-mediated IR is involved in the development of myocardial impairments in MS rats and that this effect is mediated probably via the IRS-1/PI3-kinase/AKT pathway.
Źródło:
Acta Biochimica Polonica; 2012, 59, 2; 249-254
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation on co-pyrolysis of sewage sludge with coal
Autorzy:
Tan, Z.-X.
Ai, P.
Li, Y.-M.
Ji, X.-Y.
Feng, W.
Powiązania:
https://bibliotekanauki.pl/articles/207582.pdf
Data publikacji:
2014
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
coal
carbon dioxide
sewage sludge
co-pyrolysis
FTIR analysis
coal sludge
thermal reactions
węgiel
dwutlenek węgla
osady ściekowe
FTIR
szlam węglowy
reakcje termiczne
kopiroliza
piroliza osadów ściekowych
Opis:
Co-pyrolysis characteristics of sludge with coal and sludge briquetted with coal were studied by the TG-FTIR method. From TG data, weight loss of sludge briquetted was higher than that of sludge and sludge and coal which means that thermal reaction effect of sludge briquetted is better than those of other two materials. Gas products of pyrolysis were CO, CO2, H2O, alcohol, ketone, acid, hydrocarbon, amine and azine from the FTIR analysis. At last, evolving patterns of the pyrolyses and the yields of their gas products have been recorded, providing extremely important data on the mechanism of the process.
Źródło:
Environment Protection Engineering; 2014, 40, 1; 117-126
0324-8828
Pojawia się w:
Environment Protection Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Other-projected environmental image: A conceptual framework
Autorzy:
Ji, Li
Powiązania:
https://bibliotekanauki.pl/articles/471181.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Komunikacji Społecznej
Tematy:
conceptual framework
deductive content analysis
environmental image
generic
frames
inductive framing analysis
Opis:
Th is paper aims to develop a conceptual framework for the evaluation of other-projected1 environmental image in an international context. It is based on a case study of an Australian projection of China’s environmental image. By conducting inductive framing analysis and inductive content analysis, the research analyses 315 articles from two of the most important broadsheets in Australia — Th e Australian and Th e Sydney Morning Herald,2 from the year 2000 to 2011, and focuses on three special events. Th e fi ndings reveal four generic frames — environmental problems, environmental governance, global role, and international cooperation and other issue-specifi c frames. Th e research is a fi rst try at conceptualizing a framework for other-projected environmental image.
Źródło:
Central European Journal of Communication; 2014, 7, 1(12); 97-118
1899-5101
Pojawia się w:
Central European Journal of Communication
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
3D morphological reconstruction of the red blood cell based on two phase images
Autorzy:
Wang, Y
Li, Z
Ji, Y
Xu, Y
Bu, M
Powiązania:
https://bibliotekanauki.pl/articles/174332.pdf
Data publikacji:
2015
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
phase imaging
red blood cell
3D morphological reconstruction
maximum entropy
Opis:
As an important component of blood cells, the red blood cell plays a vital role in many diseases such as malaria and so on. Although quantitative phase imaging techniques can be used for homogeneous cellular thickness distribution to obtain ideal results, they cannot achieve 3D morphological distribution. In this paper, a new method is presented to get a 3D morphology image of red blood cell. With this method, only two cellular quantitative phase images obtained from two orthogonal directions are needed as original information. By using the grid method, the sample is divided into many small phase cubes, and then we take a layer’s cubes into calculation so that the 3D problem could be transformed into a 2D problem to elaborate. Then it can be applied to the tomographic imaging combined with the maximum entropy method according to the two orthogonal phase images. This method has been proved by a simulation of red blood cell. The results show that cellular morphological distribution can be achieved in detail very well just based on only two orthogonal phase images.
Źródło:
Optica Applicata; 2015, 45, 2; 173-182
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation and Characterization of CL-20/EPDM by a Crystal Refinement and Spray Drying Method
Autorzy:
Ji, W.
Li, X.
Wang, J.
Powiązania:
https://bibliotekanauki.pl/articles/358349.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
CL-20/EPDM
spray drying
impact sensitivity
thermal stability
Opis:
A 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) based mixed explosive was prepared by a spray drying method using CL-20 suspended in hexane containing EPDM rubber (ethylene-propylene-diene monomer), and made into a stable suspension. The samples were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD), and their thermal stability and impact sensitivity were also measured. The results showed that the ethylene-propylene-diene-monomer rubber (EPDM) can be successfully coated on to the CL-20 crystal surface. Compared to refinement-spray CL-20, the impact sensitivity of CL-20/EPDM was significantly reduced. The characteristic drop height was increased from 28.12 to 39.78 cm. The thermal stability was better than refinement-spray CL-20.
Źródło:
Central European Journal of Energetic Materials; 2015, 12, 4; 831-840
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Process Optimization and Characterization of an HMX/Viton Nanocomposite
Autorzy:
Shi, X.
Wang, C.
Wang, J.
Li, X.
An, C.
Ji, W.
Powiązania:
https://bibliotekanauki.pl/articles/358667.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
HMX
spray drying
processing parameters
optimization
impact sensitivity
nanoparticles
Opis:
HMX/Viton A nanocomposites were prepared by a spray drying process using different processing parameters, which included the dry gas inlet temperature, the air flow rate, and the solution feed flow rate. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) were used to characterize the nanocomposites. The effects of the processing parameters on the morphology of the samples were investigated and are discussed. The thermal decomposition behaviour and impact sensitivity of the raw HMX and HMX/Viton A nanocomposites were also measured and compared. Optimal morphology and dispersion of the coated samples was achieved when the dry gas inlet temperature and the air and solution feed flow rates were 55 °C, 660 L/h and 1.5 mL/min, respectively. Under these optimal processing conditions, the nanocomposites were spherical in shape, ranged from 0.2-2 μm in size, and were composed of many tiny particles of 50-100 nm in size. The crystal phase of the nanocomposites was the same as that of raw HMX. Compared with those of raw HMX, the melting point and impact sensitivity of the nanocomposites were lower and the thermal decomposition rate was slightly higher.
Źródło:
Central European Journal of Energetic Materials; 2015, 12, 3; 487-495
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Preheating Temperature on Microstructure and Optical Properties of ZnO Thin Films Prepared by Sol-Gel Spin Coating Technique
Autorzy:
Ji, Qiang-min
Wang, Ya-li
Gao, Xiao-yong
Gao, Hui
Zhai, Yao-fei
Powiązania:
https://bibliotekanauki.pl/articles/1398971.pdf
Data publikacji:
2016-06
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
78.55.Et
78.55.-m
Opis:
Highly-oriented ZnO thin films prepared by using low-cost technique such as sol-gel technique are of much importance to ZnO-based white light-emitting diodes. The chose of proper preheating temperature in sol-gel technique is still critical for highly-oriented ZnO thin film so far. The mechanisms for the preheating in the formation of ZnO thin film and for the reactions involved in the sol solution have not been clearly stated yet. Thus, in this work, the highly-oriented ZnO thin films were prepared on glass substrates by using sol-gel spin-coating technique. The sol solution was prepared by using the two-step method rather than usual one-step method, which facilitates the understanding of the mechanism for the reactions involved in the sol solution. The effect of the preheating temperature on the microstructure and the optical properties of the films were in particular investigated. The mechanisms for the preheating in the formation of the films and for the reactions involved in the sol solution prepared by the two-step method were also proposed in terms of the experimental results. The preheating not only enhances the volatilization of the solvent 2-methoxyethanol and the decomposition of the residual organic species, but also results into the formation of small number of ZnO particles. The preheating temperature of 300°C is most favorable for the highly-oriented ZnO thin film. Increasing the preheating temperature results into the blue shift of the absorption edges of the films. This can be explained by using the quantum-size effect. The photoluminescence spectra of the films show an UV emission at the near-band edge and a broad green-yellow emission at 470-620 nm. The former is closely related to the excitons, while the latter is to the intrinsic defect species in the film.
Źródło:
Acta Physica Polonica A; 2016, 129, 6; 1191-1196
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Small-for-gestational age prevalence risk factors in central Appalachian states with mountain-top mining
Autorzy:
Ferdosi, Hamid
Lamm, Steve H.
Afari-Dwamena, Nana A.
Dissen, Elisabeth
Chen, Rusan
Li, Ji
Feinleib, Manning
Powiązania:
https://bibliotekanauki.pl/articles/2161794.pdf
Data publikacji:
2017-10-18
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
tobacco
mining
maternal smoking
small for gestational age
mountain-top mining
SGA prevalence
Opis:
Objectives: To identify risk factors for small-for-gestational age (SGA) for counties in central Appalachian states (Kentucky (KY), Tennessee (TN), Virginia (VA), and West Virginia (WV)) with varied coal mining activities. Material and Methods: Live birth certificate files (1990–2002) were used for obtaining SGA prevalence rates for mothers based on the coal mining activities of their counties of residence, mountain-top mining (MTM) activities, underground mining activities but no mountain-top mining activity (non-MTM), or having no mining activities (non-mining). Co-variable information, including maternal tobacco use, was also obtained from the live birth certificate. Adjusted odds ratios were obtained using multivariable logistic regression comparing SGA prevalence rates for counties with coal mining activities to those without coal mining activities and comparing SGA prevalence rates for counties with coal mining activities for those with and without mountain-top mining activities. Comparisons were also made among those who had reported tobacco use and those who had not. Results: Both tobacco use prevalence and SGA prevalence were significantly greater for mining counties than for non-mining counties and for MTM counties than for non-MTM counties. Adjustment for tobacco use alone explained 50% of the increased SGA risk for mining counties and 75% of the risk for MTM counties, including demographic pre-natal care co-variables that explained 75% of the increased SGA risk for mining counties and 100% of the risk for MTM. The increased risk of SGA was limited to the third trimester births among tobacco users and independent of the mining activities of their counties of residence. Conclusions: This study demonstrates that the increased prevalence of SGA among residents of counties with mining activity was primarily explained by the differences in maternal tobacco use prevalence, an effect that itself was gestational-age dependent. Self-reported tobacco use marked the population at the increased risk for SGA in central Appalachian states. Int J Occup Med Environ Health 2018;31(1):11–23
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 1; 11-23
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Theoretical Predictions of Lattice Parameters and Mechanical Properties of Pentaerythritol Tetranitrate under the Temperature and Pressure by Molecular Dynamics Simulations
Autorzy:
Tan, J.J.
Hu, C.
Li, Y.
Ge, N.
Chen, T.
Ji, G.
Powiązania:
https://bibliotekanauki.pl/articles/1033453.pdf
Data publikacji:
2017-02
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
molecular dynamics
lattice parameter
equation of state
elasticity
mechanical properties
Opis:
Molecular dynamics simulations with condensed-phase optimized molecular potentials for atomistic simulation studies force field are performed to investigate the structure, equation of state, and mechanical properties of high energetic material pentaerythritol tetranitrate. The equilibrium structural parameters, pressure-volume relationship and elastic constants at ambient conditions agree excellently with experiments. In addition, fitting the pressure-volume data to the Birch-Murnaghan or Murnaghan equation of state, the bulk modulus B₀ and its first pressure derivative B'₀ are obtained. Moreover, the elastic constants are calculated in the pressure range of 0-10 GPa at room temperature and in the temperature range of 200-400 K at the standard pressure, respectively. By the Voigt-Reuss-Hill approximation, the mechanical properties such as bulk modulus B, shear modulus G, and the Young modulus E are also obtained successfully. The predicted physical properties under temperature and pressure can provide powerful guidelines for the engineering application and further experimental investigations.
Źródło:
Acta Physica Polonica A; 2017, 131, 2; 318-323
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Yellowfin tuna (Thunnusalbacares) fishing ground forecasting model based on bayes classifier in the South China Sea
Autorzy:
Zhou, W.
Li, A.
Ji, S.
Qiu, Y.
Powiązania:
https://bibliotekanauki.pl/articles/258994.pdf
Data publikacji:
2017
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
Bayes classifier
South China Sea
yellowfin tuna
fishing ground forecasting
Opis:
Using the yellowfin tuna (Thunnusalbacares,YFT)longline fishing catch data in the open South China Sea (SCS) provided by WCPFC, the optimum interpolation sea surface temperature (OISST) from CPC/NOAA and multi-satellites altimetric monthly averaged product sea surface height (SSH) released by CNES, eight alternative options based on Bayes classifier were made in this paper according to different strategies on the choice of environment factors and the levels of fishing zones to classify the YFT fishing ground in the open SCS. The classification results were compared with the actual ones for validation and analyzed to know how different plans impact on classification results and precision. The results of validation showed that the precision of the eight options were 71.4%, 75%, 70.8%, 74.4%, 66.7%, 68.5%, 57.7% and 63.7% in sequence, the first to sixth among them above 65% would meet the practical application needs basically. The alternatives which use SST and SSH simultaneously as the environmental factors have higher precision than which only use single SST environmental factor, and the consideration of adding SSH can improve the model precision to a certain extent. The options which use CPUE’s mean ± standard deviation as threshold have higher precision than which use CPUE’s 33.3%-quantile and 66.7%-quantile as the threshold
Źródło:
Polish Maritime Research; 2017, S 2; 140-146
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Coated Ammonium Dinitramide on the Properties of Nitrate-ester Plasticized Polyether Solid Rocket Propellants
Autorzy:
Pang, W. Q.
Li, J. Q.
DeLuca, L. T.
Ke, W.
Fu, X. L.
Zhong, F. X.
Li, H.
Ji, Y. P.
Powiązania:
https://bibliotekanauki.pl/articles/358292.pdf
Data publikacji:
2018
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
energetic materials
NEPE composite solid propellants
ADN
hazardous properties
combustion characteristics
Opis:
Several industrial and research types of nitrate-ester plasticized polyether (NEPE) solid propellants were experimentally analyzed. In general, their compositions differed in the mass fraction of ammonium dinitramide (ADN), which was used as a promising highly energetic filler, as an alternative to ammonium perchlorate (AP). ADN exhibits high performance, low signature and non-polluting characteristics. The propellant composition without ADN, but with AP, was used as the reference. The microstructure and granularity distribution of the uncoated and coated ADN particles were experimentally analyzed. It was found that uncoated ADN particles exhibited irregular shape, while the ADN particles after coating are spherical. Because of their irregular shape, uncoated ADN particles caused inferior processability of the propellant slurry when added to the propellant formulation. Consequently, the NEPE propellants with coated ADN were studied in further detail. The rheological properties, energetic properties, mechanical sensitivities and combustion properties (burning rate and pressure exponent) of the NEPE propellants with coated ADN were studied and compared with the reference NEPE propellant. The addition of ADN particles to the propellant formulations increased the standard theoretical specific impulse and heat of explosion of the propellants, while decreasing the density. The propellants containing ADN particles were much more sensitive to impact and friction compared to the reference sample. Moreover, increasing the ADN mass fraction in the propellant formulation can significantly affect the combustion behaviour and increase the burning rate and pressure exponent compared to of the reference formulation. However it appears that ADN is a very promising candidate as a new energetic material in compositions of NEPE propellants, although several important questions concerning ADN’s suitability, especially in the context of its sensitivity to friction and impact, remain to be answered.
Źródło:
Central European Journal of Energetic Materials; 2018, 15, 4; 590-609
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ethnobotany of Acorus in China
Autorzy:
Shu, H.
Zhang, S.
Lei, Q.
Zhou, J.
Ji, Y.
Luo, B.
Hong, L.
Li, F.
Liu, B.
Long, C.
Powiązania:
https://bibliotekanauki.pl/articles/59160.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Botaniczne
Opis:
In China, species in the genus Acorus are used for many different purposes, viz., in traditional medicine, for rituals, and as ornamental plants. Acorus calamus (sweet flag) has been a symbolic plant in Chinese culture for many centuries and is used as a ceremonial object in festivals throughout the country. For other Acorus species in China, ethnobotanical records are few. During field investigations from 2006 to 2017, we interviewed 573 individuals representing ethnic groups such as the Miao, Yao, Buyi, Shui, Tujia, Dong, She, Maonan, Zhuang, Yi, and Han people. Various ethnobotanical approaches were adopted in the field surveys, including key informant interviews, semistructured interviews, participatory observation, direct observation, etc. The results have revealed a rich treasure trove of traditional knowledge on Acorus in China. Two species (A. macrospadiceus and A. gramineus) were used by ethnic groups as spices to add flavor to meat. Through the study found that all the species of Acorus had medicinal value, especially A. tatarinowii, deafness, blindness, and digestive disorders were among the conditions commonly treated using these plants. Traditional knowledge of the cultural, ethnomedicinal, and food values of Acorus, based on our recent literature surveys and field investigations in China is presented here. A better understanding of Acorus is vital for conserving the plants and the traditional knowledge associated with them.
Źródło:
Acta Societatis Botanicorum Poloniae; 2018, 87, 2
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ezetimibe prevents myocardial remodeling in an obese rat model by inhibiting inflammation
Autorzy:
Li, Xiao-Xing
Zhao, Lang
Chang, Ying
Liu, Bao-Shan
Xu, Feng
Zhang, Cheng
Ji, Xiao-Ping
Chen, Yu-Guo
Li, Chuan-Bao
Powiązania:
https://bibliotekanauki.pl/articles/1038380.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
obese
inflammation
remodeling
ezetimibe
IL-6
Opis:
Inflammation plays an important role in the development of many obesity-related diseases. This study aimed to investigate the effect of ezetimibe on inflammation and myocardial remodeling in obese rats. A rat model of obesity was established, and myocardial damage was examined by transmission electron microscopy and Masson staining. Twenty obese rats were divided into two groups (n=10): obese group and ezetimibe group. Ten SD rats were used as controls. Western blot was performed to monitor the expression of P-p38MAPK and interleukin (IL)-6. Immunohistochemical staining was used to monitor the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. In the obese rats group, we observed increased inflammatory factors and myocardial hypertrophy. In contrast, the ezetimibe group exhibited decreased expression of inflammatory factors and an improvement in myocardial remodeling compared to the obese group. Mechanistically, we found that ezetimibe decreased P-p38MAPK, IL-6, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 levels in the hearts of the obese rats. Taken together, these results indicate that ezetimibe may improve myocardial remodeling in obese rats by inhibiting inflammation.
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 465-470
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 33

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