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Wyświetlanie 1-8 z 8
Tytuł:
1000 Liver Transplantations at the Department of General, Transplant and Liver Surgery, Medical University of Warsaw - Analysis of Indications and Results
Autorzy:
Krawczyk, Marek
Grąt, Michał
Barski, Krzysztof
Ligocka, Joanna
Antczak, Arkadiusz
Kornasiewicz, Oskar
Skalski, Michał
Patkowski, Waldemar
Nyckowski, Paweł
Zieniewicz, Krzysztof
Grzelak, Ireneusz
Pawlak, Jacek
Alsharabi, Abdulsalam
Wróblewski, Tadeusz
Paluszkiewicz, Rafał
Najnigier, Bogusław
Dudek, Krzysztof
Remiszewski, Piotr
Smoter, Piotr
Grodzicki, Mariusz
Korba, Michał
Kotulski, Marcin
Cieślak, Bartosz
Kalinowski, Piotr
Gierej, Piotr
Frączek, Mariusz
Rdzanek, Łukasz
Stankiewicz, Rafał
Kobryń, Konrad
Nazarewski, Łukasz
Leonowicz, Dorota
Urban-Lechowicz, Magdalena
Skwarek, Anna
Giercuszkiewicz, Dorota
Paczkowska, Agata
Piwowarska, Jolanta
Gelo, Remigiusz
Andruszkiewicz, Paweł
Brudkowska, Anna
Andrzejewska, Renata
Niewiński, Grzegorz
Kilińska, Beata
Zarzycka, Aleksandra
Nowak, Robert
Kosiński, Cezary
Korta, Teresa
Ołdakowska-Jedynak, Urszula
Sańko-Resmer, Joanna
Foroncewicz, Bartosz
Ziółkowski, Jacek
Mucha, Krzysztof
Senatorski, Grzegorz
Pączek, Leszek
Habior, Andrzej
Lechowicz, Robert
Polański, Sławomir
Leowska, Elżbieta
Pacho, Ryszard
Andrzejewska, Małgorzata
Rowiński, Olgierd
Kozieł, Sławomir
Żurakowski, Jerzy
Ziarkiewicz-Wróblewska, Bogna
Górnicka, Barbara
Hevelke, Piotr
Michałowicz, Bogdan
Karwowski, Andrzej
Szczerbań, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1396689.pdf
Data publikacji:
2012-06-01
Wydawca:
Index Copernicus International
Tematy:
liver transplantation
indications
results
mortality
Opis:
The aim of the study was to analyze indications and results of the first one thousand liver transplantations at Chair and Clinic of General, Transplantation and Liver Surgery, Medical University of Warsaw.Material and methods. Data from 1000 transplantations (944 patients) performed at Chair and Clinic of General, Transplantation and Liver Surgery between 1994 and 2011 were analyzed retrospectively. These included 943 first transplantations and 55 retransplantations and 2 re-retransplantations. Frequency of particular indications for first transplantation and retransplantations was established. Perioperative mortality was defined as death within 30 days after the transplantation. Kaplan-Meier survival analysis was used to estimate 5-year patient and graft survival.Results. The most common indications for first transplantation included: liver failure caused by hepatitis C infection (27.8%) and hepatitis B infection (18%) and alcoholic liver disease (17.7%). Early (< 6 months) and late (> 6 months) retransplantations were dominated by hepatic artery thrombosis (54.3%) and recurrence of the underlying disease (45%). Perioperative mortality rate was 8.9% for first transplantations and 34.5% for retransplantations. Five-year patient and graft survival rate was 74.3% and 71%, respectively, after first transplantations and 54.7% and 52.9%, respectively, after retransplantations.Conclusions. Development of liver transplantation program provided more than 1000 transplantations and excellent long-term results. Liver failure caused by hepatitis C and B infections remains the most common cause of liver transplantation and structure of other indications is consistent with European data.
Źródło:
Polish Journal of Surgery; 2012, 84, 6; 304-312
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biobankowanie ludzkiego materiału biologicznego dla celów naukowych w Polsce i w Europie
Autorzy:
Łukasz, Kozera,
Dominik, Strapagiel,
Joanna, Gleńska-Olender,
Anna, Chrościcka,
Katarzyna, Ferdyn,
Jarosław, Skokowski,
Leszek, Kalinowski,
Jakub, Pawlikowski,
Błażej, Marciniak,
Markus, Pasterk,
Agnieszka, Matera-Witkiewicz,
Małgorzata, Lewandowska-Szumieł,
Michał, Piast,
Małgorzata, Witoń,
Powiązania:
https://bibliotekanauki.pl/articles/902739.pdf
Data publikacji:
2018-06-22
Wydawca:
Uniwersytet Warszawski. Wydawnictwa Uniwersytetu Warszawskiego
Tematy:
Consortium of Polish Biobanks
BBMRI
data protection
Konsorcjum Polskich Biobanków
rejestr biobanków
ochrona danych
Opis:
Biobanks are one of the 10 Ideas Changing the World Right now – according to Time Magazine (2009). Samples and data deposition have become an increasing. trend in the world. Europe has invested a lot of money into infrastructures responsible for collection and storage of human biological samples. Poland, a country with a population of over 38.5 million people has just started investing funds into this powerful and indispensable tool for scientific research. Consortium of Polish Biobanks named as BBMRI.pl consisting of seven well-established biobanks developed a project for the Creation of the Polish Biobanking Network in order to organise our infrastructures according to world-recognized standards. The main tasks include: creation of Consortium of Polish Biobanks, development of IT solutions coherent with pan European needs, development of quality assurance tools, establishment of the Biobanking National Node, development of quality control programme and analysis of Ethical, Legal and Social Implications of research using human samples. Results of this project will increase Poland’s position in the international research arena of biomedicine, make our biorepositories open for international collaboration and in the future will contribute to the development of personalized medicine.
Źródło:
Studia Iuridica; 2018, 73; 13-28
0137-4346
Pojawia się w:
Studia Iuridica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Endothelial NADH/NADPH-dependent enzymatic sources of superoxide production: relationship to endothelial dysfunction.
Autorzy:
Kalinowski, Leszek
Malinski, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/1043282.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
peroxynitrite
endothelial dysfunction
NAD(P)H oxidase
nitric oxide
superoxide
eNOS
Opis:
There is growing evidence that endothelial dysfunction, which is often defined as the decreased endothelial-derived nitric oxide (NO) bioavailability, is a crucial factor leading to vascular disease states such as hypertension, diabetes, atherosclerosis, heart failure and cigarette smoking. This is due to the fact that the lack of NO in endothelium-dependent vascular disorders contributes to impaired vascular relaxation, platelet aggregation, increased vascular smooth muscle proliferation, and enhanced leukocyte adhesion to the endothelium. During the last several years, it has become clear that reduction of NO bioavailability in the endothelium-impaired function disorders is associated with an increase in endothelial production of superoxide (O2̇̄). Because O2̇̄ rapidly scavenges NO within the endothelium, a reduction of bioactive NO might occur despite an increased NO generation. Among many enzymatic systems that are capable of producing O2̇̄, NAD(P)H oxidase and uncoupled endothelial NO synthase (eNOS) apparently are the main sources of O2̇̄ in the endothelial cells. It seems that O2̇̄ generated by NAD(P)H oxidase may trigger eNOS uncoupling and contribute to the endothelial balance between NO and O2̇̄. That is maintained at diverse levels.
Źródło:
Acta Biochimica Polonica; 2004, 51, 2; 459-469
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evolution Of The Results Of 1500 Liver Transplantations Performed In The Department Of General, Transplant And Liver Surgery Medical University Of Warsaw
Autorzy:
Krawczyk, Marek
Grąt, Michał
Grąt, Karolina
Wronka, Karolina
Krasnodębski, Maciej
Stypułkowski, Jan
Masior, Łukasz
Hołówko, Wacław
Ligocka, Joanna
Nyckowski, Paweł
Wróblewski, Tadeusz
Paluszkiewicz, Rafał
Patkowski, Waldemar
Zieniewicz, Krzysztof
Pączek, Leszek
Milkiewicz, Piotr
Ołdakowska-Jedynak, Urszula
Najnigier, Bogusław
Dudek, Krzysztof
Remiszewski, Piotr
Grzelak, Ireneusz
Kornasiewicz, Oskar
Kotulski, Marcin
Smoter, Piotr
Grodzicki, Mariusz
Korba, Michał
Kalinowski, Piotr
Skalski, Michał
Zając, Krzysztof
Stankiewicz, Rafał
Przybysz, Marta
Cieślak, Bartosz
Nazarewski, Łukasz
Nowosad, Małgorzata
Kobryń, Konrad
Wasilewicz, Michał
Raszeja-Wyszomirska, Joanna
Piwowarska, Jolanta
Giercuszkiewicz, Dorota
Sańko-Resmer, Joanna
Rejowski, Sławomir
Szydłowska-Jakimiuk, Monika
Górnicka, Barbara
Wróblewska-Ziarkiewicz, Bogna
Mazurkiewicz, Michał
Niewiński, Grzegorz
Pawlak, Jacek
Pacho, Ryszard
Powiązania:
https://bibliotekanauki.pl/articles/1395614.pdf
Data publikacji:
2015-05-01
Wydawca:
Index Copernicus International
Tematy:
liver transplantation
survival
outcomes
donors
center experience
center volume
Opis:
Liver transplantation is a well-established treatment of patients with end-stage liver disease and selected liver tumors. Remarkable progress has been made over the last years concerning nearly all of its aspects. The aim of this study was to evaluate the evolution of long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery (Medical University of Warsaw). Material and methods. Data of 1500 liver transplantations performed between 1989 and 2014 were retrospectively analyzed. Transplantations were divided into 3 groups: group 1 including first 500 operations, group 2 including subsequent 500, and group 3 comprising the most recent 500. Five year overall and graft survival were set as outcome measures. Results. Increased number of transplantations performed at the site was associated with increased age of the recipients (p<0.001) and donors (p<0.001), increased rate of male recipients (p<0.001), and increased rate of piggyback operations (p<0.001), and decreased MELD (p<0.001), as well as decreased blood (p=0.006) and plasma (p<0.001) transfusions. Overall survival was 71.6% at 5 years in group 1, 74.5% at 5 years in group 2, and 85% at 2.9 years in group 3 (p=0.008). Improvement of overall survival was particularly observed for primary transplantations (p=0.004). Increased graft survival rates did not reach the level of significance (p=0.136). Conclusions. Long-term outcomes after liver transplantations performed in the Department of General, Transplant and Liver Surgery are comparable to those achieved in the largest transplant centers worldwide and are continuously improving despite increasing recipient age and wider utilization of organs procured from older donors.
Źródło:
Polish Journal of Surgery; 2015, 87, 5; 221-230
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inflammatory response to a marathon run in amateur athletes
Autorzy:
Kaleta-Duss, Anna Maria
Lewicka-Potocka, Zuzanna
Dąbrowska-Kugacka, Alicja
Raczak, Grzegorz
Siekierzycka, Anna
Woźniak, Marcin
Kalinowski, Leszek
Lewicka, Ewa Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1197575.pdf
Data publikacji:
2021-05-26
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
neopterin
endothelin-1
pentraxin-3
marathon
amateur runners
Opis:
Background: While moderate physical exercise has positive effects on the cardiovascular system, the data regarding intensive endurance sports is biased with studies suggesting that the inflammatory response to strenuous exercise may act proarrhythmogenic. In amateurs, the effects of intensive endurance exercise on the cardiovascular system have not been studied. Analysis of the effects of a marathon on the kinetics of inflammatory biomarkers may bring new insights into this issue. Material and methods: We studied the effect of a marathon on the kinetics of inflammatory biomarkers: Endothelin-1 (ET-1), Pentraxin-3 (PTX-3), Neopterin and Interleukin-6 (IL-6) in the population of 35 amateur male marathoners. The study was divided into 3 stages: two weeks prior to the marathon (S1), at the finish line (S2) and two weeks after (S3). Blood analyses for biomarkers were performed at each stage. Results: The concentrations of ET-1 (3.20 ± 0.90 vs. 1.30 ±0.34 pg/ml, p <0,001), PTX-3 (441.09 ± 295.64 vs. 279.99 ± 125.68 pg/ml, p < 0,001), Neopterin (9.97 ± 2.17 vs. 8.36 ± 2.68 nmol/l, p < 0,05) and IL-6 (32.5 ± 13.90 vs. 0.97 ± 0.77 pg/ml, p < 0,001) were significantly higher at S2 compared to S1. Conclusions: Running a marathon causes an acute rise in concentrations of inflammatory biomarkers. Further research is needed on the long-term effects of intensive endurance exercise on the cardiovascular system.
Źródło:
European Journal of Translational and Clinical Medicine; 2021, 4, 1; 43-49
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-8 z 8

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