Autor: Latajka, Rafał - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Peptydy i peptydomimetyki jako inhibitory tyrozynazy
Peptides and peptidomimetics as inhibitors of tyrosinase
Autorzy:: Ledwoń, Patrycja
Jewgiński, Michał
Latajka, Rafał
Powiązania:: https://bibliotekanauki.pl/articles/27310044.pdf
Data publikacji:: 2023
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: tyrozynaza
peptydy
peptydomimetyki
inhibitory tyrozynazy
kosmeceutyki
tyrosinase
peptides
peptidomimetics
tyrosinase inhibitors
cosmeceuticals
Opis:: The publication reviews the results on the tyrosinase inhibition capacity of a short peptide and peptide conjugates with known low molecular weight inhibitors of this enzyme. Tyrosinase is a widespread copper-dependent enzyme capable of catalyzing two reaction pathways for oxidizing monophenols to o-diphenols and o-diphenols to o-quinones. Despite the wide distribution in nature, the peptide chain that builds the catalytic cavity is relatively highly conserved for all organisms. As the research results collected in the work show, the creation of short peptide conjugates with known tyrosinase inhibitors, such as kojic acid, significantly reduces the toxicity of the inhibitor and improves its stability.
Źródło:: Wiadomości Chemiczne; 2023, 77, 5-6; 411--423
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Wpływ reszt ΔPhe na konformację łańcucha peptydowego
Influence of ΔPhe residues on Conformation of peptide chain
Autorzy:: Ledwoń, Patrycja
Staśkiewicz, Agnieszka
Jewgiński, Michał
Latajka, Rafał
Powiązania:: https://bibliotekanauki.pl/articles/171962.pdf
Data publikacji:: 2020
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: dehydroaminokwasy
dehydrofenyloalanina
nośniki leków
dehydroamino acids
dehydrophenylalanine
drug carriers
Opis:: In the past few years dehydropeptides have been highly investigated, mainly due to their biological activity: for instance, as antimicrobials or catalytic agents in some enzymes [1, 51-53]. In presented studies it was established that dehydrophenylalanine residue (ΔPhe) can be an interesting building block of various peptide chains, in order to control and modify a structure, conformation and function of the target molecule [3, 4, 5-7]. It was also pointed out that the length of a linker between dehydroamino acid residues (if two or more are present in a peptide chain) is a crucial factor in case of conformational dependence [23]. Short, one-residue spacers promote 3₁₀-helical structure, while longer ones increase the coexistence of 3₁₀-helical and α-helical conformers (Table 7). What is worth to notice, temperature or polarity of solvent can dramatically change the screw sense of obtained 3₁₀-helices (Table 11). Additionally, the screw sense can be altered by other variables, like chirality of C and N-terminus or dehydroamino acid isomer type (E or Z) [4-11]. Considering chain conformation, it can be disparate, depending on environment’s solid or liquid state (Table 7). Application of dehydropeptides is widely spread among assorted field of studies. As they can form a few self-assembled structures (e.g. nanotubes, nanovesicles or hydrogels), arise an opportunity of encapsulation of small drug molecules or trapping and releasing bioactive substances [47-49]. Sequences with incorporated dehydroamino acid residues were examined as a potential drug - interaction with negatively charged membrane of bacteria species is possible by virtue of positive polarization of peptide chain [51]. Part of the sequences exert an activity against E. coli, S. aureus, P. falciparum or highly dangerous MRSA, presenting versatile potential correlated with their secondary structure [50-53].
Źródło:: Wiadomości Chemiczne; 2020, 74, 1-2; 9-32
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Peptydomimetyki i foldamery aromatyczne w chemii biologicznej
Peptidomimetics and aromatic foldamers in biological chemistry
Autorzy:: Ledwoń, Patrycja
Staśkiewicz, Agnieszka
Jewgiński, Michał
Latajka, Rafał
Powiązania:: https://bibliotekanauki.pl/articles/2200585.pdf
Data publikacji:: 2022
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: inhibitors of enzymes
peptidomimetics
conformation
cosmeceutics
aromatic foldamers
SAR
inhibitor enzymu
peptydomimetyki
konformacja
kosmeceutyki
foldamery aromatyczne
Opis:: The interests of the research group working under the supervision of professor Rafał Latajka at the Department of Bioorganic Chemistry at the Wrocław University of Science and Technology are focused on several projects in the field of biological chemistry. Regardless of whether a given project concerns – the synthesis and activity of new enzyme inhibitors, peptides, peptidomimetics, or aromatic foldamers – the thread of correlation between the structure and activity of the studied systems always plays a pivotal role. In this article we are presenting current projects in our research group.
Źródło:: Wiadomości Chemiczne; 2022, 76, 5-6; 349--363
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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