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    Wyświetlanie 1-9 z 9
    Tytuł:
    THE INFLUENCE OF KETOPROFEN AND ZINC OXIDE NANOPARTICLES ON SERUM COPPER LEVEL IN RATS
    Autorzy:
    Olbert, Magdalena
    Krośniak, Mirosław
    Gdula-Argasińska, Joanna
    Librowski, Tadeusz
    Zygmunt, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/956850.pdf
    Data publikacji:
    2018
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    inflammation
    ketoprofen
    serum copper level
    zinc oxide nanoparticles
    zinc-copper antagonism
    Opis:
    The role of copper in anti-inflammatory response includes several mechanisms. Antagonism between zinc (Zn) and copper (Cu) and proper balance between the two elements in the organism may affect the course of inflammatory diseases. Copper is a component of Zn/Cu superoxide dismutase (Zn/Cu SOD) and other enzymes involved in the anti-inflammatory response of the organism. To investigate the serum copper level during inflammation and diseases, numerous researches were conducted. Copper deficiency or copper intoxication may lead to biological consequences. Copper deficiency may be caused by various factors, one of them is excessive zinc supplementation. The aim of the study was to investigate the alterations in the serum copper level after 2-week zinc oxide nanoparticles (NPs-ZnO) administration. The second aim was to investigate serum copper level alterations after 2-week NPs-ZnO and single ketoprofen administration. The inflammatory state was induced in each group by the carrageenan injection at the 15th day of the experiment. The results indicate for the decrease in serum copper level in group receiving NPs-ZnO compared to control. Moreover, in groups receiving NPs-ZnO as well as ketoprofen, a decrease in serum copper level was observed. We may conclude that NPs-ZnO administration and also ketoprofen administration acts as anti-inflammatory agents and may induce a decrease in serum copper level.
    Źródło:
    Medicina Internacia Revuo; 2018, 28, 110; 11-22
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of anti-manic activity of pregabalin in a mouse model of methylphenidate-induced mania
    Autorzy:
    MALIKOWSKA, Natalia
    GRZYWA, Anna
    ŚLADOWSKA, Joanna
    SAŁAT, Kinga
    LIBROWSKI, Tadeusz
    GDULA-ARGASIŃSKA, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1033806.pdf
    Data publikacji:
    2017
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    anxiety
    bipolar disorder
    depression
    mania
    metylphenidate
    pregabalin
    Opis:
    Mania is a psychiatric disorder which may occur alternately with depression as a bipolar disorder, or much less often as an individual disease. It might be accompanied by other disorders, i.e. schizophrenia, dementia or withdrawal syndrome. Only a few effective drugs are used for the treatment of mania. Patients suffering from bipolar disorder are treated with mood-stabilizing drugs, administered during the course of the disease, and drugs that are implemented when mania or depression episodes occur. Some studies report effectiveness of anticonvulsant drugs in the cessation of mania, thus in our study we assessed the effectiveness of pregabalin in a mouse model of mania induced by administration of metylphenidate (5 mg/kg; s.c). Pregabalin was tested in the forced swim test (75 mg/kg, 100 mg/kg; i.p.) and the elevated plus maze test (75 mg/kg; i.p.) to assess its antidepressant-like and anxiolytic-like properties, respectively. In the elevated plus maze in MPH-treated mice pregabalin significantly reduced time spent in open arms (p<0.001 vs. MPH-treated control). In the forced swim test MPH compared to vehicle significantly (p<0.001) reduced duration of immobility. In MPH-treated mice pregabalin partially reversed this effect of MPH. This effect was significant only for the dose of 75 mg/ kg (p<0.05). In the rotarod test neither MPH, nor its combination with pregabalin (75 mg/kg; 100 mg/kg) influenced motor coordination of mice at any speed tested. To conclude our study revealed that pregabalin might reverse manic-like action of MPH related to hyperlocomotion, which may indicate for its possible effectiveness in mania episodes.
    Źródło:
    Medicina Internacia Revuo; 2017, 28, 108; 196-201
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
    Autorzy:
    Grzywacz, Agata
    Gdula-Argasińska, Joanna
    Muszyńska, Bożena
    Tyszka-Czochara, Małgorzata
    Librowski, Tadeusz
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1038990.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    metal responsive-transcription factor 1
    cell signaling
    inflammation
    NF-κB
    Opis:
    Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. MTF-1 acts in the process of binding of toxic metal ions in the cell, due to the activation of the expression of metallothioneins (MTs). Additionally, MTF-1 regulates transcription of genes involved in the sequestration of zinc and its intracellular transport. Disruption of zinc and MT homeostasis has an indispensable influence on the development of several pathological states. Moreover, by increasing MT activity, MTF-1 can effectively protect cells from oxidative and hypoxic stresses. The mechanism of MTF-1 action in cells includes the regulation of the proper immune response through activation/repression of anti- and pro-inflammatory cytokines. MTF-1 function in immune response is related to nuclear factor-κB (NF-κB) activity. Synthesis of insulin is also related to the activity of this transcription factor and zinc balance. Insulin transport also depends on zinc. In pancreatic β-cells, several types of the zinc transporters are found. Zinc transporters coordinated action is crucial for the synthesis and secretion of insulin. Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 491-498
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of zinc oxide nanoparticles on the expression of proinflammatory proteins in murine macrophages raw 264.7 cells
    Autorzy:
    OLBERT, Magdalena
    GRYC, Karolina
    SROCZYŃSKA, Katarzyna
    ZAJĄC, Anna
    LIPKOWSKA, Anna
    LIBROWSKI, Tadeusz
    GDULA-ARGASIŃSKA, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1033697.pdf
    Data publikacji:
    2017
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    COX-2
    Nrf2
    inflammation
    zinc oxide nanoparticles
    Opis:
    Zinc is a microelement essential for the body. It has a great impact on the proper development and renewal of tissues, reproductive system, skin condition, or immune processes. Zincis involved practically in all aspects of the immune system and the production and activation of white blood cells. This work aimed to determine the effect of zinc oxide nanoparticles (ZnONP) on the expression of pro-inflammatory proteins in murine macrophages RAW 264.7, activated with lipopolysaccharide (LPS). Using the immunodetection technique the expression of cyclooxygenase 2 (COX-2), prostaglandin E2 synthase (cPGES), prostaglandin F2α receptor (FP receptor) and nuclear factor Nrf2 was determined. Statistically the highest expression of COX-2, cPGES, and FP receptor was observed in LPS-activated macrophages. RAW 264.7 cells supplementation with ZnONP 100 nmol and 500 nmol and LPS activation resulted in repression of COX-2 and cPGES, and an increased expression of Nrf2 protein when compared to control. The results suggest an anti-inflammatory effect and activation of the antioxidant system by ZnONP in RAW 264.7 macrophages. It seems appropriate to conduct further research on the molecular mechanism of action of ZnONP in eukaryotic cells.
    Źródło:
    Medicina Internacia Revuo; 2017, 28, 109; 262-265
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zinc, the Trace Element Essential in Living Organisms
    Autorzy:
    SOLÉ PASCUAL, Anna
    TYSZKA-CZOCHARA, Małgorzata
    GDULA-ARGASIŃSKA, Joanna
    LIBROWSKI, Tadeusz
    GRZYWACZ, Agata
    OPOKA, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1033792.pdf
    Data publikacji:
    2012
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    biochemistry of zinc
    zinc functions
    Opis:
    Zinc is a metallic element, of symbol Zn and atomic number 30, that is placed in the group 12 of the periodic table. As an essential trace element, zinc is required to support human biochemical processes. It is found in nearly 200 specific enzymes in the living organisms, and it also serves as structural cofactor for many cellular proteins. [1] Zinc may exert pleiotropic effects in organism; for that, deficits of cellular zinc content can have catastrophic consequences and are linked to major pathophysiology, such as diabetes, stroke and malformations of brain function [2]. The complexity and importance of zinc homeostasis is reflected by the large variety and number of zinc-related proteins found in almost every cell compartment; for example, this biometal is transported through ZnT (Zn2+ transporter) family and ZIP family, proteins that are completely dedicated to zinc transport [2]. It is also noticeable, that between three and ten percent of all protein products of genes in mammalian genomes bind zinc, which is essential for their folding, activity or conformational change [2].
    Źródło:
    Medicina Internacia Revuo; 2012, 25, 99; 55-59
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Role of Adenosine A2a Receptors in Antidepressant Activity in An Experimental Animal Model of Depression
    Autorzy:
    DZIUBINA, Anna
    ZYGMUNT, Małgorzata
    FILIPEK, Barbara
    SAŁAT, Kinga
    BRYŁA, Adrian
    LIBROWSKI, Tadeusz
    GDULA-ARGASIŃSKA, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1033607.pdf
    Data publikacji:
    2017
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    A2A receptor
    Parkinson’s disease
    adenosine
    antidepressant activity
    depression
    Opis:
    Intensive studies on the role of adenosine A2A receptors in Parkinson’s disease have been carried out for many years,. These studies have indicated that the antagonists of these receptors not only alleviate motor deficits but also exhibit neuroprotective effects in various animal models. Little is known about the role of these receptors in ailments accompanying Parkinson’s disease, such as depression and anxiety. This paper provides a summary of existing research on the role of A2A receptors in comorbid depression in Parkinson’s disease.
    Źródło:
    Medicina Internacia Revuo; 2017, 28, 109; 228-236
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fructose Affects Fatty Acids Profile in Liver Cells in Vitro and In Vivo Models in Rats
    Autorzy:
    TYSZKA- CZOCHARA, Malgorzata
    GDULA- ARGASIŃSKA, Joanna
    PAŚKO, Paweł
    LIBROWSKI, Tadeusz
    GAWEŁ, Magdalena
    OLBERT, Magdalena
    LIPKOWSKA, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1033740.pdf
    Data publikacji:
    2014
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    Diet
    Fatty acids profile
    Fructose
    Hep G2 cell culture
    Lipid metabolism
    Opis:
    It was reported that dietary fructose imposes a number of effects on lipid metabolism including hypertriglyceridemia. The daily intake of fructose in humans is mainly due to sucrose. It was reported that the consumption is still increasing, making a background for health implications. The mechanism of metabolic disorders is poorly understood, but a lot of studies indicate that the liver lipid homeostasis deregulation is essential for a fructose effect on metabolism. The aim of the study is to estimate if fructose affects the profile of fatty acids in in vitro and in vivo models. In this study in vitro and in vivo experiments were conducted to assess the effect of dietary fructose on the fatty acid profile in the cell culture or in the liver of rats. The results showed that in the fructose experimental groups, both in the cell and liver homogenates, the content of the saturated fatty acids were significantly higher than in control groups. According to the obtained data fructose in the medium and in the diet affects saturation of fatty acids in the cell cultures and in the livers of rats. The findings obtained in the experiments support the thesis that fructose influences the homeostasis of lipid metabolism in the liver and may give an opportunity to discuss the limitation of the content of this kind of sugar in food.
    Źródło:
    Medicina Internacia Revuo; 2014, 26, 102; 42- 46
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of αlpha-linolenic acid supplementation on murine macrophages RA W 264.7 activated with lipopolisaccharide
    Autorzy:
    ZAJĄC, Anna
    SROCZYŃSKA, Katarzyna
    LIPKOWSKA, Anna
    OLBERT, Magdalena
    LIBROWSKI, Tadeusz
    SAŁAT, Kinga
    MALIKOWSKA, Natalia
    GDULA-ARGASIŃSKA, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1033804.pdf
    Data publikacji:
    2017
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    COX-2
    FP receptor
    cPGES
    lipopolysaccharide
    macrophage RAW 264.7
    α – linolenic acid
    Opis:
    Chronic inflammation is characterized by excessive production of cytokines and eicosanoids and is associated with unsufficient resolution. Supplementation with n-3 fatty acids may result in a lower incidence of many inflammatory diseases. The aim of this study was to determine the effect of α – linolenic acid (ALA) on the fatty acids profile of cell membranes and on the pro-inflammatory proteins cyclooxygenase – 2 (COX-2), prostaglandin E2 synthase (cPGES) and prostaglandin F2α receptor (FP) expression in murine RAW 264.7 macrophages, activated with lipopolysaccharide (LPS). It has been shown that COX-2, cPGES as well as FP receptor expression was highest in cells activated by LPS. In macrophages supplemented with ALA and activated with LPS a pro-inflammatory protein levels were significantly reduced, suggesting anti-inflammatory activity of α-linolenic acid. There were also statistically significant changes in the fatty acid profile after incubation of the RAW 264.7 cells for 48 hours with ALA. A deficiency or excess of specific fatty acids affect the cellular membrane fluidity, can also cause changes in cell morphology. Therefore it is appropriate to carry out further research on the ALA properties.
    Źródło:
    Medicina Internacia Revuo; 2017, 28, 108; 176-181
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fatty Acids Profile in Phospholipids of The Erythrocyte Membranes in Swimming Rats
    Autorzy:
    GDULA-ARGASIŃSKA, Joanna
    TYSZKA-CZOCHARA, Małgorzata
    TELEGŁÓW, Aneta
    DĄBROWSKI, Zbigniew
    PAŚKO, Paweł
    LIBROWSKI, Tadeusz
    GAWEŁ, Magdalena
    OLBERT, Magdalena
    LIPKOWSKA, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1033756.pdf
    Data publikacji:
    2014
    Wydawca:
    Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
    Tematy:
    erythrocyte membranes
    fatty acids
    physical activity
    rats
    Opis:
    Alterations in membrane lipid composition, particularly fatty acids content is known to result in functional and structural changes. Dietary lipids and physical activity or stress play an important role in this change. It was of interest to study the influence of swimming in different temperatures on the content of fatty acids in the phospholipids of the erythrocyte membranes of rats. Our research demonstrated a significant influence of swimming on the content of fatty acids in the phospholipids of the erythrocyte membranes of rats. These changes of fatty acids, particularly the decrease of arachidonic acid and significant increase of saturated fatty acids in the phospholipids of the erythrocyte membranes in swimming rats may be induced by oxygen radicals generated in different kinds of stress.
    Źródło:
    Medicina Internacia Revuo; 2014, 26, 102; 19-23
    0465-5435
    Pojawia się w:
    Medicina Internacia Revuo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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