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    Wyświetlanie 1-4 z 4
    Tytuł:
    Potent antifungal properties of gallic acid in Sarcochlamys pulcherrima against Candida auris
    Autorzy:
    Akhtar, Nahid
    Mannan, M. Amin-Ul
    Pandey, Deeksha
    Sarkar, Amon
    Sharma, Himanshi
    Kumar, Manish
    Ghosh, Anup
    Powiązania:
    https://bibliotekanauki.pl/articles/16698568.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    Sarcochlamys pulcherrima
    antifungal
    gallic acid
    Candia auris
    molecular docking
    carbonic anhydrase
    Opis:
    Candida auris is a major public health concern due to its high transmission and mortality rates, as well as the emergence of pan-resistant strains. This study aimed to identify an antifungal compound from Sarcochlamys pulcherrima , an ethnomedicinal plant, that can inhibit the growth of C. auris. Methanol and ethyl acetate extracts of the plant were obtained, and high-performance thin-layer chromatography (HPTLC) analysis was conducted to identify the major compounds in the extracts. The major compound detected by HPTLC was subjected to in vitro antifungal activity testing, and its antifungal mechanism was determined. The plant extracts inhibited the growth of both C. auris and Candida albicans. HPTLC analysis revealed the presence of gallic acid in the leaf extract. Furthermore, the in vitro antifungal assay showed that gallic acid inhibited the growth of different C. auris strains. In silico studies indicated that gallic acid can bind to the active sites of carbonic anhydrase (CA) proteins in both C. auris and C. albicans, affecting their catalytic activities. Compounds that target virulent proteins such as CA can aid in the reduction of drug-resistant fungi and the development of novel antifungal compounds with unique modes of action. However, additional in vivo and clinical studies are required to conclusively determine gallic acid’s antifungal properties. Gallic acid derivatives may be developed in the future to possess more potent antifungal properties and target various pathogenic fungi.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2023, 104, 2; 105-119
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Molecular docking studies on the phytoconstituents as therapeutic leads against SARS-CoV-2
    Molekularne badania dokujące nad zastosowaniem fitoskładników w terapii przeciw SARS-CoV-2
    Autorzy:
    Tiwari, Abhishek
    Tiwari, Varsha
    Verma, Navneet
    Singh, Anita
    Kumar, Manish
    Saini, Vipin
    Sahoo, Biswa Mohan
    Kaushik, Deepak
    Verma, Ravinder
    Sagadevan, Suresh
    Powiązania:
    https://bibliotekanauki.pl/articles/2202611.pdf
    Data publikacji:
    2022
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
    Tematy:
    Covid-19
    spike glycoprotein
    AutoDock Vina
    Mpro
    docking
    artemisinin
    withaferin A
    glikoproteina kolca
    dokowanie
    artemizynina
    witaferyna A
    Opis:
    Because of the present pandemic researchers are seeking for phytocandidates that can inhibit or stop SARS-CoV-2. The main protease (Mpro) of SARS-CoV-2 and spike glycoprotein (S) are both suppressed by bioactive compounds found in plants that work by docking them together. The Mpro proteins 6LU7 (complex with an inhibitor N3) and 5C3N (space group C2221) were employed in docking research. PyRx and AutoDock Vina software were used as docking engine. 22 identified phytoconstituents were selected from IMPPAT, a manually curated database, on the basis of their antiviral effects. Docking studies showed that phytoconstituents β-amyrin (-8.4 kcal/mol), withaferin A (-8.3 kcal/mol), oleanolic acid (-7.8 kcal/mol), and patentiflorin A (-8.1 kcal/mol) had the best results against 5C3N Mpro protein whereas kuwanon L (-7.1 kcal/mol), β-amyrin (-6.9 kcal/mol), oleanolic acid (-6.8 kcal/mol), cucurbitacin D (-6.5 kcal/mol), and quercetin (-6.5 kcal/mol) against 6LU7 Mpro protein. All the compounds were examined for their ADMET characteristics using SwissDock. Present research reports that the phytoconstituents along with docking score will be helpful for future drug development against Covid-19.
    W związku z pandemią prowadzone są badania mające na celu znalezienie fitosubstancji, które mogą hamować lub zatrzymywać rozwój SARS-CoV-2. Działanie głównych białek proteazy (Mpro) SARS-CoV-2 i glikoproteiny kolca (S) jest osłabiane przez związki bioaktywne występujące w roślinach poprzez proces dokowania. Do badań dokujących użyto białka Mpro 6LU7 (kompleks z inhibitorem N3) i 5C3N (grupa przestrzenna C2221). Jako silnik dokujący zastosowano PyRx i AutoDock Vina. Zidentyfikowano 22 fitoskładniki wybrane z bazy danych IMPPAT, z uwzględnieniem ich działania przeciwwirusowego. Najbardziej skuteczne w przypadku białka Mpro 5C3N okazały się fitoskładniki β-amyryna (-8,4 kcal/mol), witaferyna A (-8,3 kcal/mol), kwas oleanolowy (-7,8 kcal/mol) i patentifloryna A (-8,1 kcal/mol), a w przypadku białka Mpro 6LU7 kuwanon L (-7,1 kcal/mol), β-amyryna (-6,9 kcal/mol), kwas oleanolowy (-6,8 kcal/mol), kukurbitacyna D (-6,5 kcal/mol) i kwercetyna (-6,5 kcal/mol). Wszystkie substancje zbadano pod kątem ich właściwości ADMET przy użyciu SwissDock. Wykazano, że fitoskładniki mogą być pomocne w pracach nad lekami przeciwko Covid-19.
    Źródło:
    Polimery; 2022, 67, 7-8; 355---374
    0032-2725
    Pojawia się w:
    Polimery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Efficacy of plant leaf extracts against mustard aphid Lipaphis erysimi (Kalt.) under field condition
    Autorzy:
    Pal, Manish Kumar
    Kafle, Kapil
    Powiązania:
    https://bibliotekanauki.pl/articles/1166855.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Cypermethrin
    Efficacy
    Lipaphis erysimi
    Mustard aphid
    Plant extracts and Rapeseed
    Opis:
    The bio-efficacy of five plant leaf extracts were tested in Morang-2 variety of Rapeseed against Mustard aphid (Lipaphis erysimi Kalt.) during November to March, 2016/17 at research field of Institute of Agriculture and Animal Science (IAAS), Lamjung Campus, Lamjung, Nepal. The plant leaf extracts were prepared by decomposing chopped leaves of Neem, Bakaino, Hattibar, Khirro, and Bojho in cow urine for one month period. Total five extracts were prepared, one by mixing all the leaf while remaining four extracts were prepared excluding one ingredient in each mixture but keeping Tobacco and Bojho in all five extracts. The experiment was laid out in Randomized Completely Block Design using five botanical extracts, chemical (Cypermethrin 10% EC) and control which were replicated thrice. The Rapeseed plant was sprayed with prepared extracts at 30 days after sowing (DAS), 45 DAS and 60 DAS and aphid number counted after 5, 10 and 15 days of each spray from 10 cm apical shoot. The greatest reduction of aphid population was found in chemical followed by complete mixture treated plots but their reduction was not statistically different. While control and plant extracts of without Neem treated plots had resulted less reduction in the number of aphid. Grain yield was also found highest (1436.75 kg/ha) in complete mixture treated plots indicating complete mixture of plant extracts might be the best alternative for aphid management in Rapeseed. It is concluded that all the plant extracts showed insecticidal properties against aphid in rapeseed crop and successfully be integrated, as a part of Integrated Pest Management.
    Źródło:
    World Scientific News; 2018, 105; 29-39
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Minimized Group Delay FIR Low Pass Filter Design Using Modified Differential Search Algorithm
    Autorzy:
    Prajapati, Sonelal
    Rai, Sanjeev
    Tiwari, Manish
    Dwivedi, Atul Kumar
    Powiązania:
    https://bibliotekanauki.pl/articles/24200750.pdf
    Data publikacji:
    2023
    Wydawca:
    Instytut Łączności - Państwowy Instytut Badawczy
    Tematy:
    differential search optimization algorithm
    FIR filter
    optimization
    small group delay
    Opis:
    Designing a finite impulse response (FIR) filter with minimal group delay has proven to be a difficult task. Many research studies have focused on reducing pass band and stop band ripples in FIR filter design, often overlooking the optimization of group delay. While some works have considered group delay reduction, their approaches were not optimal. Consequently, the achievement of an optimal design for a filter with a low group delay value still remains a challenge. In this work, a modified differential search optimization algorithm has been used for the purpose of designing a minimal group delay FIR filter. The results obtained have been compared with the classical techniques and they turned out to be promising.
    Źródło:
    Journal of Telecommunications and Information Technology; 2023, 3; 78--84
    1509-4553
    1899-8852
    Pojawia się w:
    Journal of Telecommunications and Information Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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