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    Wyświetlanie 1-7 z 7
    Tytuł:
    Some People Probably Need to Make More Sense: An Exploratory Study on Individual Differences and the Need for Sense-Making
    Autorzy:
    Cantarero, Katarzyna
    van Tilburg, Wijnand A.P.
    Kuźma, Beata
    Gąsiorowska, Agata
    Wojciszke, Bogdan
    Powiązania:
    https://bibliotekanauki.pl/articles/2129747.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    need for sense-making
    individual differences
    personality traits
    Opis:
    We define the need for sense-making as the desire to find reliable connections between the objects, situations, and relationships that people encounter. We have proposed and tested that there are possible individual differences in the need for sense-making and that these individual differences are insightful in characterizing individuals and their behaviors. A correlational study (N = 229) showed that need for sense-making was positively related to self-esteem, extroversion, conscientiousness, openness, and sense of control. Additionally, a higher need for sense-making was associated with greater perception of it as an important part of people’s identity. Thus, need for sense-making is relevant to understanding individual differences and can furthermore comprise a significant element of people’s identity. These results break new ground in the study of individual differences in the need for sense-making and can be of great importance in work and organizational psychology.
    Źródło:
    Polish Psychological Bulletin; 2019, 50, 2; 114-118
    0079-2993
    Pojawia się w:
    Polish Psychological Bulletin
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain.
    Autorzy:
    Barańczyk-Kuźma, Anna
    Kuźma, Magdalena
    Gutowicz, Marzena
    Kaźmierczak, Beata
    Sawicki, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1043346.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    tricyclic antidepressants
    human brain
    glutathione S-transferase pi
    Opis:
    GST pi, the main glutathione S-transferase isoform present in the human brain, was isolated from various regions of the brain and the in vitro effect of tricyclic antidepressants on its activity was studied. The results indicated that amitripyline and doxepin - derivatives of dibenzcycloheptadiene, as well as imipramine and clomipramine - derivatives of dibenzazepine, inhibit the activity of GST pi from frontal and parietal cortex, hippocampus and brain stem. All these tricyclics are noncompetitive inhibitors of the enzyme with respect to reduced glutathione and noncompetitive (amitripyline, doxepin) or uncompetitive (imipramine, clomipramine) with respect to the electrophilic substrate. Their inhibitory effect is reversible and it depends on the chemical structure of the tricyclic antidepressants rather than on the brain localization of the enzyme. We conclude that the interaction between GST pi and the drugs may reduce their availability in the brain and thus affect their therapeutic activity. On the other hand, tricyclic antidepressants may decrease the efficiency of the enzymatic barrier formed by GST and increase the exposure of brain to toxic electrophiles. Reactive electrophiles not inactivated by GST may contribute in adverse effects caused by these drugs.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 1; 207-212
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Geoportal Centrum Infrastruktury Badawczej Danych GNSS
    Geoportal of the GNSS Data Research Infrastructure Center
    Autorzy:
    Araszkiewicz, Andrzej
    Całka, Beata
    Kiliszek, Damian
    Kuźma, Marta
    Mierzwiak, Michał
    Mościcka, Albina
    Nowak Da Costa, Joanna
    Pokonieczny, Krzysztof
    Szołucha, Marcin
    Wabiński, Jakub
    Zwirowicz-Rutkowska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/2174487.pdf
    Data publikacji:
    2022
    Wydawca:
    Polskie Towarzystwo Informacji Przestrzennej
    Tematy:
    otwarte dane
    geodezja satelitarna
    nauki o ziemi
    System Obserwacji Płyty Europejskiej
    open data
    satellite geodesy
    Earth science
    European Plate Observing System
    Opis:
    Artykuł przedstawia stworzenie portalu internetowego zapewniającego dostęp do polskich danych z Globalnego Systemu Nawigacji Satelitarnej (GNSS). Opracowane rozwiązanie jest jednym z elementów Centrum Infrastruktury Badawczej, zbudowanego w ramach polskiej odpowiedzi na program European Plate Observing System. W ramach projektu EPOS-PL utworzono Repozytorium Danych GNSS oraz Centrum Analiz Danych GNSS. Dostęp do danych i wyników ich przetwarzania zapewnia dedykowany geoportal. Prace obejmowały trzy etapy cyklu życia rozwoju systemu: projektowanie, implementację i testowanie. Portal ma za zadanie wspierać pracę zarządców infrastruktury GNSS, a przede wszystkim zaspokajać potrzeby środowiska naukowego zajmującego się badaniami stałej Ziemi.
    The paper presents the development of a web portal providing access to Polish Global Navigation Satellite Systems (GNSS) data. Developed solution is one of the Center of Research Infrastructure, built within the Polish response to the European Plate Observing System program. Within the EPOS-PL project, the GNSS Data Repository and GNSS Data Analysis Centre were created. Access to data and results of their processing is provided by a dedicated geoportal. The work included the following stages of the system development life cycle: design, implementation and testing. The portal is designed to support the work of GNSS infrastructu1re managers and, above all, to meet the needs of the scientific community involved in solid Earth research.
    Źródło:
    Roczniki Geomatyki; 2022, 20, 1(96); 7--16
    1731-5522
    2449-8963
    Pojawia się w:
    Roczniki Geomatyki
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Differences in glutathione S-transferase pi expression in transgenic mice with symptoms of neurodegeneration
    Autorzy:
    Kaźmierczak, Beata
    Kuźma-Kozakiewicz, Magdalena
    Usarek, Ewa
    Barańczyk-Kuźma, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039866.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    motor neuron disease
    Dync1h1 mutation
    SOD1G93A mutation
    central nervous system
    transgenic mice
    glutathione S-transferase pi
    Opis:
    Glutathione S-transferase pi (GST pi) is an enzyme involved in cell protection against toxic electrophiles and products of oxidative stress. GST pi expression was studied in transgenic mice hybrids (B6-C3H) with symptoms of neurodegeneration harboring SOD1G93A (SOD1/+), Dync1h1 (Cra1/+) and double (Cra1/SOD1) mutations, at presymptomatic and symptomatic stages (age 70, 140, 365 days) using RT-PCR and Western blotting. The main changes in GST pi expression were observed in mice with the SODG93A mutation. In SOD1/+ and Cra1/SOD1 transgenics, with the exception of cerebellum, the changes in GST pi-mRNA accompanied those in GST pi protein. In brain cortex of both groups the expression was unchanged at the presymptomatic (age 70 days) but was lower at the symptomatic stage (age 140 days) and at both stages in hippocampus and spinal cord of SOD1/+ but not of Cra1/SOD1 mice compared to age-matched wild-type controls. In cerebellum of the presymptomatic and the symptomatic SOD1/+ mice and presymptomatic Cra1/SOD1 mice, the GST pi-mRNA was drastically elevated but the protein level remained unchanged. In Cra1/+ transgenics there were no changes in GST pi expression in any CNS region both on the mRNA and on the protein level. It can be concluded that the SOD1G93A but not the Dync1h1 mutation significantly decreases detoxification efficiency of GST pi in CNS, however the Dync1h1 mutation reduces the effects caused by the SOD1G93A mutation. Despite similarities in neurological symptoms, the differences in GST pi expression between SOD1/+ and Cra1/+ transgenics indicate a distinct pathogenic entity of these two conditions.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 4; 621-626
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Changes in kinesin expression in the CNS of mice with dynein heavy chain 1 mutation
    Autorzy:
    Kuźma-Kozakiewicz, Magdalena
    Kaźmierczak, Beata
    Usarek, Ewa
    Barańczyk-Kuźma, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039605.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Dync1h1 mutation
    kinesins
    Cra1/+ mice
    expression
    central nervous system
    Cra1/SOD1 mice
    Opis:
    Dysfunction of fast axonal transport, vital for motor neurons, may lead to neurodegeneration. Anterograde transport is mediated by N-kinesins (KIFs), while retrograde transport by dynein 1 and, to a minor extent, by C-kinesins. In our earlier studies we observed changes in expression of N- and C-kinesins (KIF5A, 5C, C2) in G93ASOD1-linked mouse model of motor neuron degeneration. In the present work we analyze the profile of expression of the same kinesins in mice with a dynein 1 heavy chain mutation (Dync1h1, called Cra1), presenting similar clinical symptoms, and in Cra1/SOD1 mice with milder disease progression than SOD1 transgenics. We found significantly higher levels of mRNA for KIF5A and KIF5C but not the KIFC2 in the frontal cortex of symptomatic Cra1/+ mice (aged 365 days) compared to the wild-type controls. No changes in kinesin expression were found in the spinal cord of any age group and only mild changes in the hippocampus. The expression of kinesins in the cerebellum of the presymptomatic and symptomatic mice (aged 140 and 365 days, respectively) was much lower than in age-matched controls. In Cra1/SOD1 mice the changes in KIFs expression were similar or more severe than in the Cra1/+ groups, and they also appeared in the spinal cord. Thus, in mice with the Dync1h1 mutation, which impairs dynein 1-dependent retrograde transport, expression of kinesin mRNA is affected in various structures of the CNS and the changes are similar or milder than in mice with double Dync1h1/hSOD1G93A mutations.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 1; 51-55
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Arginase isoenzymes in human cirrhotic liver
    Autorzy:
    Chrzanowska, Alicja
    Gajewska, Beata
    Barańczyk-Kuźma, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1040542.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    arginase activity
    liver cirrhosis
    isoenzyme expression
    Opis:
    Cirrhosis leads to an inability of the liver to perform its biochemical functions. It can also lead to hepatocellular carcinoma in which, as we showed lately, arginase isoenzyme pattern changes. The present work presents our results on arginase isoenzymes and their possible role in liver cirrhosis. The study was performed on tissues obtained during liver transplantation from 60 patients with liver cirrhosis, and on samples of histologically normal liver (control) from 40 patients with benign or colorectal cancer liver metastases removed during surgery, 6-7 cm from the tumor border. Arginase isoenzymes AI (so-called liver-type arginase) and AII (called extrahepatic arginase) were identified by Western blotting and isolated by ion-exchange chromatography. Their expression on mRNA level was studied by RT-PCR. A significant decrease in arginase activity, dependent of the liver clinical stage, was observed in cirrhotic tissue. Arginase AI activity and its mRNA level were significantly decreased in cirrhotic liver, whereas the activity and expression of arginase AII were concurrently raised, as compared to normal liver. Since arginase AI is a key enzyme of the urea cycle, whereas arginase AII most probably takes part in the biosynthesis of ornithine and polyamines, the defective ammonia inactivation and increased collagen biosynthesis observed in cirrhotic liver may be related to the changes in arginase AI and AII levels, respectively.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 3; 465-469
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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