- Tytuł:
- Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease
- Autorzy:
-
Krwawicz, Joanna
Arczewska, Katarzyna
Speina, Elzbieta
Maciejewska, Agnieszka
Grzesiuk, Elzbieta - Powiązania:
- https://bibliotekanauki.pl/articles/1040919.pdf
- Data publikacji:
- 2007
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
mutagenesis
AP endonuclease
SSBR
DNA damage
protein interaction
BER
DNA repair; glycosylase
SSB - Opis:
- Base excision repair (BER) pathway executed by a complex network of proteins is the major system responsible for the removal of damaged DNA bases and repair of DNA single strand breaks (SSBs) generated by environmental agents, such as certain cancer therapies, or arising spontaneously during cellular metabolism. Both modified DNA bases and SSBs with ends other than 3'-OH and 5'-P are repaired either by replacement of a single or of more nucleotides in the processes called short-patch BER (SP-BER) or long-patch BER (LP-BER), respectively. In contrast to Escherichia coli cells, in human ones, the two BER sub-pathways are operated by different sets of proteins. In this review the selection between SP- and LP-BER and mutations in BER and end-processors genes and their contribution to bacterial mutagenesis and human diseases are considered.
- Źródło:
-
Acta Biochimica Polonica; 2007, 54, 3; 413-434
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł