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Tytuł:
Determination of the Protein-Binding Properties of Camptothecins by Means of Optical Spectroscopy Methods
Autorzy:
Ziomkowska, B.
Cyrankiewicz, M.
Wybranowski, T.
Kruszewski, S.
Powiązania:
https://bibliotekanauki.pl/articles/1197530.pdf
Data publikacji:
2014-04
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
87.64.K-
87.64.kv
87.15.kp
02.50.Sk
Opis:
Optical spectroscopy methods are widely used in studies of drugs. The affinity of camptothecins - anticancer agents - to human serum albumin (HSA) was determined in this work. Camptothecins (CPTs) exist in two forms: active lactone and open ring inactive carboxylate. In blood, the hydrolysis process of lactone form occurs which leads to deactivation of CPTs. Research is being done on biophysical properties of synthesized CPT compounds, in particular on binding to albumin. The affinity to plasma proteins is an important determinant of stability of CPTs in blood. The following analogues of CPT were tested in this paper: irinotecan, SN-38, topotecan, and 9-amino camptothecin. Using the method of fluorescence anisotropy measurement, the association constants of the studied compounds to HSA were determined. The authors attempted to determine the deactivation rate of topotecan in HSA solution using Principal Component Analysis and Factor Analysis of absorption spectra recorded during hydrolysis process of lactone form.
Źródło:
Acta Physica Polonica A; 2014, 125, 4A; A-61-A-65
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optical Spectroscopy Study of the Interaction Between Quercetin and Human Serum Albumin
Autorzy:
Wybranowski, T.
Kruszewski, S.
Powiązania:
https://bibliotekanauki.pl/articles/1197523.pdf
Data publikacji:
2014-04
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
87.64.K-
87.64.kv
87.15.kp
Opis:
Optical methods are very useful for the study on behavior of molecules in albumin-containing solutions. The interaction between quercetin (QUE) and human serum albumin (HSA) under physiological conditions was investigated by the methods of UV-Vis absorption and fluorescence spectroscopy. Fluorescence data show that enhancing of quercetin fluorescence in the presence of HSA is the result of formation of the HSA-QUE complex. On the basis of fluorescence data, the binding affinity constant of quercetin to HSA is determined. In this paper we have attempted to perform a kinetic study of the oxidation of quercetin in presence of human serum albumin by absorption spectroscopy. It has been shown that quercetin easily oxidizes at pH 7.4. The addition of HSA to quercetin solution induces changes in the absorption spectrum. In the human serum albumin solution, the time of quercetin oxidation is longer than in the case of quercetin diluted in phosphate buffered saline. Human albumin also contributes to stabilization of quercetin. These results suggest that HSA prevents degradation of quercetin in blood.
Źródło:
Acta Physica Polonica A; 2014, 125, 4A; A-57-A-60
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of displacement compounds on the binding of ochratoxin A to human serum albumin examined with fluorescence anisotropy methods
Autorzy:
Wybranowski, T
Ziomkowska, B.
Cwynar, A
Kruszewski, S.
Powiązania:
https://bibliotekanauki.pl/articles/173353.pdf
Data publikacji:
2014
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
ochratoxin A
binding of drug to albumin
flurbiprofen
ibuprofen
warfarin
Opis:
The subject of the research is the application of the methods of fluorescence anisotropy measurements to study the interaction between human serum albumin (HSA) and toxins and selected medicines (ibuprofen, warfarin, flurbiprofen). Optical spectroscopic methods are useful tools for the study of biologically active compounds. Determining binding intensity of ochratoxin A (OTA) to albumin may be helpful in explaining the effects of toxic influence of OTA. The main factor influencing the distribution of OTA is its affinity for plasma proteins. It was shown that ochratoxin binds strongly to albumin. By the use of the method of fluorescence anisotropy it was proved that the unbound fraction of OTA is higher due to competing interactions with drugs. As a result of separating ochratoxin from protein by competitive compounds, a decrease in the fluorescence anisotropy of the HSA-OTA complex was observed. The largest increase in free fraction of OTA is caused by flurbiprofen, then ibuprofen and warfarin. It will accelerate OTA transport to target organs and shortening its half-life period, leading consequently to a decrease in chronic toxic effects.
Źródło:
Optica Applicata; 2014, 44, 3; 357-364
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The rapid interphase chromosome assay (RICA) implementation : comparison with other PCC methods
Autorzy:
Sommer, S.
Buraczewska, I.
Sikorska, K.
Bartłomiejczyk, T.
Szumiel, I.
Kruszewski, M.
Powiązania:
https://bibliotekanauki.pl/articles/147263.pdf
Data publikacji:
2015
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
biodosimetry
ionizing radiation
premature chromosome condensation (PCC)
human lymphocytes
Opis:
A report is presented on the advantages of the rapid interphase chromosome assay (RICA) and the difficulties that may be met while implementing this method for application in biological dosimetry. The RICA test can be applied on unstimulated human lymphocytes; this is an advantage in comparison with the dicentric chromosomes or micronucleus tests. In the former two tests, stimulated lymphocytes are examined and hence, 48 h more are needed to obtain cells traversing the cell cycle. Due to the use of unstimulated nondividing cells, higher numbers of cells are available for RICA analysis than for dicentric chromosomes or micronuclei tests. Moreover, the method can be applied after exposure to ionizing radiation doses in excess of 5 Gy. Such doses cause a signifi cant cell cycle delay or result in the loss of G2 phase and mitotic cells because of apoptosis. Therefore, the traditional biodosimetry based on the evaluation of the incidence of damage to chromosomes is very difficult to carry out. This is due to the lack of an adequate number of mitotic cells for analysis. RICA is free of this disadvantage. An automatic microscope can be used to retrieve cell images; automatic image analysis can also be used.
Źródło:
Nukleonika; 2015, 60, No. 4, part 2; 933-941
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Activation of Silver Colloids for Enhancement of Raman Scattering
Autorzy:
Kruszewski, S.
Cyrankiewicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/1504412.pdf
Data publikacji:
2011-06
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
33.20.Fb
33.20.Kf
62.23.St
82.70.Dd
Opis:
Obtaining of systems that provide ever-increasing enhancement of the Raman scattered light is a big challenge. The silver colloids obtained by reduction of silver nitrate by trisodium citrate are the most promising enhancement systems. Nanoparticles of silver forming fresh colloid obtained by this way exhibit in extinction spectrum the absorption band proving of the surface plasmons excitation, but do not enhance the Raman scattered light, are not surface enhanced Raman scattering active. Adding of KCl or $HNO_3$ causes the surface enhanced Raman scattering activation, i.e. causes that the conditions for aggregation of nanoparticles and for adsorption on their surface of molecules providing Raman scattering are created. Increasing amount of added KCl or $HNO_3$ leads to significant changes in the extinction spectrum and to significant increase in intensity of surface enhanced Raman scattering. The observed changes in extinction spectrum are mainly due to progressive aggregations of nanoparticles. In junctions between nanoparticles existing inside aggregates the condition for single molecule surface enhanced Raman scattering are fulfilled and therefore aggregation leads to increase in average surface enhanced Raman scattering intensity. Silver colloid activated by using KCl provides about 10-fold higher surface enhanced Raman scattering than that treated with $HNO_3$.
Źródło:
Acta Physica Polonica A; 2011, 119, 6A; 1018-1022
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aggregated Silver Sols as SERS Substrates
Autorzy:
Kruszewski, S.
Cyrankiewicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/1490450.pdf
Data publikacji:
2012-01
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
33.20.Fb
33.20.Kf
33.50.-j
Opis:
The unique plasmonic properties of the noble metal colloidal nanoparticles make them promising enhancement substrates for surface-enhanced Raman scattering. Obtaining of systems that provide ever-increasing enhancement of the Raman scattered light is a big challenge. Silver colloids studied here are prepared by Lee-Meisel's method. Rhodamine 6G and rhodamine B are used as probe adsorbates. The "raw" colloids obtained in this way exhibit a characteristic extinction band proving surface plasmons excitation, but do not enhance the Raman signal. Theoretical calculations indicate that the extremely large electromagnetic field is induced in the junctions between metallic nanostructures so some degree of their aggregation is necessary to achieve a sufficient gain value. The addition of aggregating agents (KCl or HCl) leads to significant changes in the extinction spectrum and to significant increase in the intensity of surface-enhanced Raman scattering. The experiments show that chloride can not only promote the aggregation process but also effectively affect chemical mechanisms contributing to surface-enhanced Raman scattering.
Źródło:
Acta Physica Polonica A; 2012, 121, 1A; A-068-A-074
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enhancement of FITC Fluorescence by Silver Colloids and Silver Island Films
Autorzy:
Kruszewski, S.
Wybranowski, T.
Cyrankiewicz, M.
Ziomkowska, B.
Pawlaczyk, A.
Powiązania:
https://bibliotekanauki.pl/articles/1812349.pdf
Data publikacji:
2008-06
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
33.20.Fb
33.20.Kf
33.50.-j
Opis:
Silver colloids and silver island films as fluorescence enhancement systems are the subject of this paper. Enhancement of fluorescence of molecules placed near metallic nanoparticles is a result of resonance interaction of exciting and emitted lights with surface plasmons. Two models explaining this phenomenon are presented. Processes of silver colloids and silver island films forming are described. Results of extinction, absorption and scattering studies of fluorescence enhancement systems are presented. The influence of these systems, i.e. silver colloids and silver island films on the fluorescence of fluorescein-5-isothiocyanate was studied. 7-fold increase in fluorescence intensity of fluorescein-5-isothiocyanate molecules placed near silver nanoparticles was observed.
Źródło:
Acta Physica Polonica A; 2008, 113, 6; 1599-1608
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fluorescence Spectroscopy in Camptothecins Studies
Autorzy:
Kruszewski, S.
Kruszewska, D.
Powiązania:
https://bibliotekanauki.pl/articles/1537476.pdf
Data publikacji:
2010-07
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
87.64.kv
87.15.kp
Opis:
The application of fluorescence spectroscopy methods to determining the properties of analogues of camptothecin, promising anticancer agents, are described in this paper. The fluorescence anisotropy measurements provide useful information about the binding of camptothecin and its analogues to cell membranes and human serum albumin (HSA) that is important for potential clinical applications of these agents, and permit the selection from many camptothecin analogues those ones exhibiting desirable biomedical properties. Fluorescence anisotropy measurements prove that 3 new camptothecin analogues: 7-tert-butyldimethylsilyl-10-hydroxy-campthothecin, 7-trimethyl-silylethyl-10-hydroxy-camptothecin and 7-trimethyl-silyl-ethyl-10-amino-camptothecin exhibit high affinity of their lactone forms to membranes and low affinity of their carboxylate forms to HSA. Such properties should ensure high stability of these agents in physiological fluids, including blood.
Źródło:
Acta Physica Polonica A; 2010, 118, 1; 99-102
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rhodamine 6G as a Mediator of Silver Nanoparticles Aggregation
Autorzy:
Kruszewski, S.
Cyrankiewicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/1400066.pdf
Data publikacji:
2013-06
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
33.20.Fb
33.20.Kf
61.46.Df
78.67.Bf
87.83.+a
Opis:
Surface-enhanced Raman scattering is the phenomenon where a huge increase of Raman scattering intensity from molecules situated close to the metal nanoobjects is observed. Our study is focused on the method of SERS-activation of silver nanoparticles and, in the future, the application of thus obtained SERS substrates for biomedical purposes. As expected, the intensity of Raman scattering from rhodamine 6G used here as a SERS probe strongly increase during the early stages of aggregation of silver sol. Moreover, the evolution of extinction spectra and changes in the degree of the colloid aggregation observed in DLS measurements point out that molecules of the dye do not participate passively in the aggregation process but greatly affect its course.
Źródło:
Acta Physica Polonica A; 2013, 123, 6; 965-969
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Selective Resonance Raman Scattering of Peierls-Hubbard (TTF$\text{}^{+}$)$\text{}_{2}$ Dimers in (TTF)$\text{}_{2}$Mo$\text{}_{6}$O$\text{}_{19}$ and (TTF)$\text{}_{2}$W$\text{}_{6}$O$\text{}_{19}$ Salts
Autorzy:
Kruszewski, S.
Feltre, L.
Bozio, R.
Bellitto, C.
Powiązania:
https://bibliotekanauki.pl/articles/1929169.pdf
Data publikacji:
1993-04
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
34.70.+e
78.30.-j
Opis:
Raman investigation of Peierls-Hubbard (TTF$\text{}^{+}$)$\text{}_{2}$ dimers in (TTF)$\text{}_{2}$Mo$\text{}_{6}$O$\text{}_{19}$ and (TTF)$\text{}_{2}$W$\text{}_{6}$O$\text{}_{19}$ salts have been performed. It was found that the resonance enhancement of Raman intensity of intramolecular vibration modes exists only when the frequency of excitation light fits to the localised electron transition, however, the resonance enhancement of intermolecular modes occurs when the frequency of excitation light corresponds to the charge transfer transition.
Źródło:
Acta Physica Polonica A; 1993, 83, 4; 431-440
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Slimhole well casing design for high-temperature geothermal exploration and reservoir assessment
Autorzy:
Kruszewski, M.
Thorhallsson, S.
Assadi, M.
Śliwa, T.
Powiązania:
https://bibliotekanauki.pl/articles/298892.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
geothermal exploration wells
slimhole casing
Opis:
It is anticipated that utilization of geothermal resources for renewable energy production will continue to grow globally. Since cost of drilling and well construction constitutes a considerable share of the total cost of the geothermal installations, development and evaluation of low-cost alternatives is crucial for expansion of this industry. This paper describes slimhole casing design for geothermal exploration wells, as an alternative for reduced cost and improved environmental performance. The main goal of the paper is to contribute to cost effective casing design program that satisfies severe reservoir conditions of geothermal wells. A case study is presented for casing design for a 2000 m deep vertical well with water level at 200 m, where the New Zealand Code of Practice has been applied. The “worst case scenario”, i.e. when temperature and pressure follow the boiling point depth curve (BPD), has been considered as base case for the casing design, when drilling in a high-temperature geothermal area. Alternative methods are also presented for determining the minimum casing setting depths and the results are compared. Pressure and temperature conditions inside the well were established using X-steam program, an Excel add-in, and the final results, establishing loading criteria that the casing has to withstand i.e.: burst, collapse and tension/compression are presented.
Źródło:
AGH Drilling, Oil, Gas; 2017, 34, 2; 465-493
2299-4157
2300-7052
Pojawia się w:
AGH Drilling, Oil, Gas
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ zmian temperatury powierzchni oceanu na Morzu Norweskim na temperaturę powietrza na Svalbardzie i Jan Mayen (1982-2002)
The influence of the changes in sea surface temperature of the Norwegian Sea on the air temperature at Svalbard and Jan Mayen (1982-2002)
Autorzy:
Kruszewski, G.
Marsz, A. A.
Zblewski, S.
Powiązania:
https://bibliotekanauki.pl/articles/260931.pdf
Data publikacji:
2003
Wydawca:
Stowarzyszenie Klimatologów Polskich
Tematy:
temperatury powietrza
temperatury powierzchni oceanu
Morze Norweskie
air temperature
sea surface temperature
Norwegian Sea
Opis:
This work deals with correlations between SST in the Norwegian Sea and air temperature at selected stations located in the Atlantic sector of Arctic (Bjornoya, Hornsund, Svalbard-Lufthavn, Ny Alesund and Jan Mayen). The southern and central parts of the Norwegian Sea show the strongest correlation with the air temperature at the above mentioned stations, whereas the northern parts of this sea show weaker correlation. Apart from synchronic correlations (occurring in the same months) asynchronic correlations have been found. The latter are generally much stronger than the synchronic ones. The predominant influence on the changes in air temperature at the stations have the winter SST (JFMA) in the central part of the Norwegian Sea (grid 2° x 2°, 67°N, 010°E). These winter SST show quite strong correlations with monthly air temperature at Bjornoya, Hornsund, Svalbard-Lufthavn and Jan Mayen in July, August and September. At Ny Alesund station the period with statistically significant correlation between the air temperature and the winter SST is limited to September. The strongest correlation can be observed in August (see Table 4). The observed correlations result from modification in atmospheric circulation, caused by increased heat volume in the Norwegian Sea. Such modification is reflected in the increased frequency of occurrence of meridional atmospheric circulation, which is accompanied by the increase in the frequency of air advection from the S to this sector of Arctica. Some correlations which show more significant time shift have also been observed (see Table 5). Winter SST indicate positive correlations with air temperature observed at Bjornoya and Horn-sund in August and September the following year and at Svalbard-Lufthavn in September. At Ny Alesund station the coefficients of correlation with the air temperature in the following year are increased but they do not reach the statistically significant level. Another period with statistically significant correlations is November and December the following year; significant correlations with winter SST occur at Bjornoya (r = 0.71) and all stations located on Spitsbergen (r = 0.57). The correlations of SST with air temperature observed at Jan Mayen the following year are different, i.e. the presence of strong correlations is limited to summer season - July, August and September (r ~ 0.6). The correlations with winter SST occurring in November and December the following year is connected with warm masses carried to this region together with waters with the West Spitsbergen Current. Correlations between SST and air temperature present in summer and at the end of summer the following year may probably be influenced by the modification of atmospheric circulation. The only significant correlation with summer (July and August) SST indicates the temperature of February the following year at stations located on Spitsbergen and Jan Mayen. These correlations are negative (r ~ -0.55 - -0.50). The reason for occurrence of such correlations is not clear. The changeability of winter SST in the central part of the Norwegian Sea explains from 20% (Hornsund) to 32% (Bjornoya) of changeability in annual air temperature at the above mentioned stations in the same year and from 34% (Jan Mayen) to 41% (Hornsund) of changeability in annual air temperature in the following year. The increased level of explanation of changeability in air temperature the following year influenced by winter SST is connected with the delayed flowing of the Atlantic waters to high latitudes carried with the Norwegian Current and the West Spitsbergen Current.
Źródło:
Problemy Klimatologii Polarnej; 2003, 13; 59-78
1234-0715
Pojawia się w:
Problemy Klimatologii Polarnej
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Archiwum i księgozbiór Naukowego Instytutu Polsko-Skandynawskiego
Archives and book collection of The Polish-Scandinavian Research Institute
Autorzy:
Kruszewski, Eugeniusz S.
Powiązania:
https://bibliotekanauki.pl/articles/947166.pdf
Data publikacji:
2017-12-30
Wydawca:
Uniwersytet Warszawski. Wydział Dziennikarstwa, Informacji i Bibliologii
Tematy:
archiwalia
dokumentacja ikonograficzna
prace naukowe
księgozbiór specjalistyczny
przekazywanie materiałów do archiwów i bibliotek w Polsce
documentation of scientific dissertations
correspondences
iconography
collection of professional books
transferring to the archives and libraries in Poland
Opis:
Instytut Polsko-Skandynawski powstawał w ramach polskiego państwa na uchodźstwie, w okresie gdy Polska była częścią bloku sowieckiego. Założony w 1985 r. z sie dzibą w Kopenhadze IPS dysponuje starszymi o 15 lat archiwum i księgozbiorem. Dokumentacja zajmuje ok. 40 metrów bieżących. Składają się na nią materiały do rozpraw naukowych, korespondencja z członkami jednostki i instytucjami, źródła do dziejów emigracji polskiej i jej organizacji w krajach skandynawskich. Księgozbiór liczy ok. 2000 tomów. Znajdują się w nim prace naukowe członków instytutu, „Rocznik Polskiego Towarzystwa Naukowego na Obczyźnie”, „Acta Cassubiana”, publikacje własne placówki, literatura w językach skandynawskich dotycząca Polski, polska literatura poświęcona dziejom Gdańska i Pomorza, czasopisma ukazujące się poza Polską i inne. Instytut nie miał i nie ma specjalistycznej administracji tymi zbiorami, jak również finansowej możliwości zatrudnienia odpowiedniego personelu. Ze względu na te problemy, gdy stało się to możliwe po przemianach ustrojowych w kraju, dokumentacja oraz księgozbiór są sukcesywnie przekazywane do Archiwum Akt Nowych w Warszawie, Archiwum Emigracji UMK w Toruniu i specjalistycznych bibliotek w Polsce.
Źródło:
Z Badań nad Książką i Księgozbiorami Historycznymi; 2017, Polonika w zbiorach obcych, tom specjalny; 329-336
1897-0788
2544-8730
Pojawia się w:
Z Badań nad Książką i Księgozbiorami Historycznymi
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 29

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