Autor: Kozakiewicz, Andrzej - Katalog OPAC zbiorów

Tytuł:: Modeling studies of potato nucleoside triphosphate diphosphohydrolase NTPDase1: an insight into the catalytic mechanism
Autorzy:: Kozakiewicz, Anna
Neumann, Piotr
Banach, Mariusz
Komoszyński, Michał
Wojtczak, Andrzej
Powiązania:: https://bibliotekanauki.pl/articles/1040830.pdf
Data publikacji:: 2008
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: potato apyrase
NTPDase1
enzymatic mechanism
homology modeling
Opis:: Nucleoside triphosphate diphosphohydrolase - NTPDase1 (apyrase, EC 3.6.1.5) was modeled based on sequence homology. The single polypeptide chain of apyrase is folded into two domains. The putative catalytic site with the apyrase conserved regions (ACR 1-5) is located between these two domains. Modeling confirmed that apyrase belongs to the actin superfamily of proteins. The amino acids interacting with the nucleoside triphosphate substrate and probably involved in the catalyzed hydrolysis were identified. The proposed two-step catalytic mechanism of hydrolysis involves Thr127 and Thr55 as potential nucleophilic factors responsible for the cleavage of the Pγ and Pβ anhydride bonds, respectively. Their action seems to be assisted by Glu170 and Glu78 residues, respectively. The presence of two nucleophiles in the active site of apyrase explains the differences in the hydrolytic activity between apyrases and other enzymes belonging to the NTPDase family.
Źródło:: Acta Biochimica Polonica; 2008, 55, 1; 141-150
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 8.

Tytuł:: Psychospołeczne uwarunkowania nałogu palenia w populacji polskiej. Wyniki Ogólnopolskiego Badania Stanu Zdrowia Ludności Polski – WOBASZ
Autorzy:: Polakowska, Maria
Broda, Grażyna
Drygas, Wojciech
Głuszek, Jerzy
Kozakiewicz, Krystyna
Pająk, Andrzej
Wyrzykowski, Bogdan
Powiązania:: https://bibliotekanauki.pl/articles/635312.pdf
Data publikacji:: 2009
Wydawca:: Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:: smoking, psychosocial factors
Opis:: Psycho-social factors related with smoking in the Polish populationAim of the study is to examine the relationship between smoking and psychosocial factors – in the Polish population aged 20–74 years. Methodology: Results are based on data from WOBASZ. Survey covered a representative sample of men and women aged 20–74 years. Data was collected from the response to the questions from the questionnaire. Smoker was defined as the person who regularly smokes at least 1 cigarette per day.Results: From the drawn sample 13,285 people were examined – 6291 men and 6994 women. Smokers were 42% of men and 25% of women. Most smokers were pointed out in the groups aged 35–44 (44% M, 32% W) and 45–54 years (46% M and 31% W). The least smokers were in the oldest group aged 65–74 22% M and 5% W. The average age of initiation is low – 18 ± 3.6 years for men and 20 ± 4.9 years for women. Most smokers have primary education (69% M and 53% W), several times more in compare to those with higher education (6% M and 10% W). Most often smoker is a person doing physical work (43% M and 29% W). Single men smoked more often (43% M). Most smokers were in the lowest income group (44% M and 27% W) compared to those with the highest income (25% M, 18% W). People with low social support have a higher frequency of smoking (35% M, 41% W), and persons with depressive symptoms (23% M, 30% W). Most of the smokers declared intention to quit smoking (85% M and 83% W). The most common reasons for quitting were self-motivation (more than 40% of smokers), and fear of disease (17% W, 18% M).
Źródło:: Zdrowie Publiczne i Zarządzanie; 2009, 7, 2
2084-2627
Pojawia się w:: Zdrowie Publiczne i Zarządzanie
Dostawca treści:: Biblioteka Nauki