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    Wyświetlanie 1-10 z 10
    Tytuł:
    Myosin molecule packing within the vertebrate skeletal muscle thick filaments. A complete bipolar model*
    Autorzy:
    Skubiszak, Ludmila
    Kowalczyk, Leszek
    Powiązania:
    https://bibliotekanauki.pl/articles/1043686.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    thick filament
    computer modelling
    myosin molecule packing
    vertebrate skeletal muscle
    cross-bridge action
    Opis:
    Computer modelling related to the real dimensions of both the whole filament and the myosin molecule subfragments has revealed two alternative modes for myosin molecule packing which lead to the head disposition similar to that observed by EM on the surface of the cross-bridge zone of the relaxed vertebrate skeletal muscle thick filaments. One of the modes has been known for three decades and is usually incorporated into the so-called three-stranded model. The new mode differs from the former one in two aspects: (1) myosin heads are grouped into asymmetrical cross-bridge crowns instead of symmetrical ones; (2) not the whole myosin tail, but only a 43-nm C-terminus of each of them is straightened and near-parallel to the filament axis, the rest of the tail is twisted. Concurrent exploration of these alternative modes has revealed their influence on the filament features. The parameter values for the filament models as well as for the building units depicting the myosin molecule subfragments are verified by experimental data found in the literature. On the basis of the new mode for myosin molecule packing a complete bipolar structure of the thick filament is created.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 4; 829-840
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The vertebrate skeletal muscle thick filaments are not three-stranded. Reinterpretation of some experimental data*
    Autorzy:
    Skubiszak, Ludmila
    Kowalczyk, Leszek
    Powiązania:
    https://bibliotekanauki.pl/articles/1043687.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    thick filament symmetry
    mass distribution
    Fourier transform
    myosin molecule packing
    cross-bridge movement
    Opis:
    Computer simulation of mass distribution within the model and Fourier transforms of images depicting mass distribution are explored for verification of two alternative modes of the myosin molecule arrangement within the vertebrate skeletal muscle thick filaments. The model well depicting the complete bipolar structure of the thick filament and revealing a true threefold-rotational symmetry is a tube covered by two helices with a pitch of 2 × 43 nm due to arrangement of the myosin tails along a helical path and grouping of all myosin heads in the crowns rotated by 240° and each containing three cross-bridges separated by 0°, 120°, and 180°. The cross-bridge crown parameters are verified by EM images as well as by optical and low-angle X-ray diffraction patterns found in the literature. The myosin tail arrangement, at which the C-terminus of about 43-nm length is near-parallel to the filament axis and the rest of the tail is quite strongly twisted around, is verified by the high-angle X-ray diffraction patterns. A consequence of the new packing is a new way of movement of the myosin cross-bridges, namely, not by bending in the hinge domains, but by unwrapping from the thick filament surface towards the thin filaments along a helical path.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 4; 841-853
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Genetic models to study adult neurogenesis.
    Autorzy:
    Filipkowski, Robert
    Kiryk, Anna
    Kowalczyk, Anna
    Kaczmarek, Leszek
    Powiązania:
    https://bibliotekanauki.pl/articles/1041415.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    olfactory bulb
    brain
    dentate gyrus
    hippocampus
    BrdU.
    knock-out mice
    Opis:
    In the central nervous system (CNS) generation of new neurons continues throughout adulthood, when it is limited to the olfactory bulb and hippocampus. The knowledge regarding the function of newly-generated neurons remains limited and is vigorously investigated using diverse approaches. Among these are genetically modified mice, most of them of knock-out type (KO). Results from 23 diverse KO mouse models demonstrate the importance of particular proteins (growth factors, nitric oxide synthases, receptors, cyclins/cyclin-associated proteins, transcription factors, etc.) in adult neurogenesis (ANGE) as well as separate it from developmental neurogenesis. These results bring us closer to revealing the function of newly generated neurons in adult brains.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 359-372
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Early detection of phosphorus deficiency stress in cucumber at the cellular level using chlorophyll fluorescence signals
    Autorzy:
    Sieczko, Leszek
    Dąbrowski, Piotr
    Kowalczyk, Katarzyna
    Gajc-Wolska, Janina
    Borucki, Wojciech
    Janaszek-Mańkowska, Monika
    Kowalczyk, Waldemar
    Farci, Domenica
    Kalaji, Hazem M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2203572.pdf
    Data publikacji:
    2022
    Wydawca:
    Instytut Technologiczno-Przyrodniczy
    Tematy:
    abiotic stress
    chlorophyll fluorescence
    cucumber
    JIP test
    multidimensional statistical analysis
    photosynthesis
    Opis:
    Abiotic stressors contribute to growth restriction and developmental disorders in plants. Early detection of the first signs of changes in plant functioning is very important. The objective of this study was to identify chlorophyll fluorescence parameters that change under phosphorus deficiency stress in cucumber. In this work, a trail to study the early changes caused by phosphorus deficiency in cucumber plants by analysing their photosynthetic performance is presented. Chlorophyll-a fluorescence (ChF) parameters were measured every 7 days for a period of 28 days. Measurements were made separately on young and old leaves and on cucumber fruit. Parameters that decreased during the stress were: p2G, PI abs, PI total, REo/CSo, and TRo/CSo. P deficiency decreased total electron carriers per RC (ECo/RC), yields (TRo/ABS (Fv/Fm), ETo/TRo, REo/ETo, ETo/ABS and REo/ABS), fluxes (REo/RC and REo/CSo) and fractional reduction of PSI end electron acceptors, and damaged all photochemical and non-photochemical redox reactions. Principal component analysis revealed a group of ChF parameters that may indicate early phosphorus deficiency in cucumber plants. Our results are used in the discovery of sensitive bioindicators of phosphorus deficiency in cucumber plants. Most JIP test parameters are linked to mathematical equations, so we recommend using of advanced statistical tools, such as principal component analysis, which should be considered very useful for stress identification. It has also been shown to be more effective in multivariate methods compared to univariate statistical methods was demonstrated.
    Źródło:
    Journal of Water and Land Development; 2022, Special Issue; 176--186
    1429-7426
    2083-4535
    Pojawia się w:
    Journal of Water and Land Development
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-10 z 10

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