- Tytuł:
- Eliminating side effects of pain therapies
- Autorzy:
-
Różycki, Krzysztof
Rapacz, Jacek
Fichna, Jakub
Kosson, Piotr - Powiązania:
- https://bibliotekanauki.pl/articles/1177402.pdf
- Data publikacji:
- 2018
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
PAMORA
cancer
constipation
morphine
opioid
pain
peptide - Opis:
- Pain is a very serious problem associated with many types of health conditions. Unfortunately, patients suffering from intense pain often give up or cut down on taking analgesics because of side effects of such treatment. New generation drugs create an opportunity for supporting therapies effectively. Persistent constipation is one of the more acute side effects of administration of opioids. This article gives an extensive coverage of the PAMORA group of drugs that eliminate opioid-induced constipation. It also proposes future directions for contemporary studies on the subject and other feasible therapeutic applications for this group of medicines. The molecule developed under the POIG.01.04.00-14-213/12 project “New intestinal drug for control of side effects of opioid therapies” is one of the prospects. [The project] researched structures based on opioid peptide analogs behaving like opioid antagonists vs. intestinal μ receptors. In addition, [the structures] feature properties that can be used in oncological therapies because they inhibit growth of malignant cells. The structures are being tested on animal models.
- Źródło:
-
World Scientific News; 2018, 104; 400-410
2392-2192 - Pojawia się w:
- World Scientific News
- Dostawca treści:
- Biblioteka Nauki
Artykuł