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    Wyświetlanie 1-8 z 8
    Tytuł:
    No effect of agmatine on the protective activity of clobazam and pregabalin against maximal electroshock-induced seizures in mice
    Autorzy:
    Luszczki, J.J.
    Jaskolska, A.
    Dworzanski, W.
    Kominek, M.
    Mazurkiewicz, L.P.
    Ossowska, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/3584.pdf
    Data publikacji:
    2010
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    agmatine
    protective activity
    clobazam
    pregabalin
    maximal electroshock-induced seizure
    mice
    mouse
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2010, 04, 1
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Imaging of the lenses of the human eye by ultrabiomicroscopy (UBM), ultrasonography (USG) and by anterior segment optical coherence tomography (AS OCT): - presentation of clinical cases
    Autorzy:
    Porwik, E.
    Ciszewski, M.
    Mrukwa-Kominek, E.
    Smużyńska, M.
    Formińska-Kapuścik, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/333417.pdf
    Data publikacji:
    2012
    Wydawca:
    Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
    Tematy:
    choroby oczu
    przypadki kliniczne
    obrazowanie soczewki
    ophthalmic diseases
    clinical cases
    lens imaging
    Opis:
    The nervous system's ability to receive light stimuli and its' processing in the brain in order to produce a visual impression is the definition of the sense of sight. The anatomical form of the sense organ of vision is comprised of the eyeball, the eye's protective apparatus, the eye's movement apparatus and the retinal nerve connections made to structures in the brain. The shape of the eye's lens, which gives the eye its refraction ability, depends on the voltage present in Zinn's ligaments that regulate the ciliary muscle. Sharpness of vision is produced by changing the shape of the lens, a reflexive adjustment. A domed lens causes stronger light inflexion and allows a sharp visual appearance of close objects. A flattening of the lens results in less light refraction and the seeing of more distant objects. The lens consists of a capsule, a cortex and a nucleus and it has two convex surfaces: the front and the rear. If we imagine the lens as a plum fruit, the capsule is its skin, the cortex is its flesh and the nucleus is its stone. Proper functioning of the lens is essential for accurate vision. Exact assessments of the eye's lens and the ability to monitor the status of associated diseases are extremely important. The lens may be tested using a slit lamp, but in any situation where an eye disease prevents this assessment of the lens this examination will obviously be inadequate. Thanks to today's imaging techniques, we can now assess the anatomical arrangement and condition of the lens, even in the eyes of those patients for whom the use of an imaging lens slit lamp is not possible [1, 2].
    Źródło:
    Journal of Medical Informatics & Technologies; 2012, 19; 49-57
    1642-6037
    Pojawia się w:
    Journal of Medical Informatics & Technologies
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of cross-sectional layers of corrosion using metallographic microscope
    Autorzy:
    Szala, B.
    Greiner-Wrona, E.
    Kwaśniak-Kominek, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/184775.pdf
    Data publikacji:
    2013
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
    Tematy:
    corrosion
    enamel on copperplate
    glass-metal
    corrosion build-up
    metallographic microscope
    cross section of corrosion products
    Opis:
    The aim of this study was to identify and recognize the phenomena of corrosion between glass-metal connections. Experiments were carried out on historical and contemporary samples treated with corrosion catalysts and the results helped to identify the most corrosive conditions for historic objects. Microscopic observations were carried out on cross-sectional layers of specially prepared samples of enamel on copperplate, corresponding to the chemical composition of historic samples-enamel from Limoges. Subsequently, a series of techniques were implemented improving the quality of the image. A 20-micron thick corrosion layer can be observed and recorded using this method. Observations allowed to determine the quality and technology aspects of the enamel exposed to the processes. The diagnosis of corrosion processes is extremely important in order to determine the application technique of enamel on the metal substrate. Microscopic images therefore revealed the formation of corrosion products. This proved an efficient and effective way to provide information on the thickness, color and structure of the observed layers. Micro-photographs from a metallographic microscope allowed for further planning and the subsequent use of a Scanning Electron Microscope (SEM) with an Energy Dispersive Spectrometer (EDS) and Raman Spectrometer (RS) - mitigating the need for the analysis of the entire sample's surface. Most corroded places have been identified and the metal proved to be more reactive material. The impact of factors such as: the technique of layering the enamel, structural inclusions, pitting corrosion, temperature and the environment's impact have been clearly linked to the overlap of the corrosion processes.
    Źródło:
    Geology, Geophysics and Environment; 2013, 39, 2; 125-132
    2299-8004
    2353-0790
    Pojawia się w:
    Geology, Geophysics and Environment
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    N-acetylokarnozyna - nowy lek, nowe nadzieje na zapobieganie powikłaniom ocznym cukrzycy
    N-acetylcarnosine - new drug, new hope for the prevention of diabetes-related ocular complications
    Autorzy:
    Mrukwa-Kominek, E.
    Sarnat, M.
    Drzyzga, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/9887.pdf
    Data publikacji:
    2013
    Wydawca:
    Okulistyka Weterynaryjna
    Tematy:
    choroby zwierzat
    choroby czlowieka
    cukrzyca
    powiklania
    objawy okulistyczne
    retinopatia cukrzycowa
    zacma cukrzycowa
    profilaktyka
    N-acetylokarnozyna
    wlasciwosci
    podawanie miejscowe
    Źródło:
    Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii; 2013, 4
    2082-9256
    Pojawia się w:
    Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of Ca-Pb and P-As substitutions on the solubulity of hydroxylapatites
    Autorzy:
    Młynarska, M.
    Puzio, B.
    Kwaśniak-Kominek, M.
    Manecki, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/184653.pdf
    Data publikacji:
    2016
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
    Tematy:
    biomaterials
    environment
    immobilization
    Opis:
    Hydroxylapatites are important biomaterials. Substitutions of Pb for Ca and As for P in hydroxylapatites are recently intensively studied due to their significance in the environmental immobilization of Pb and As (Lee et al. 2009, Chlebowska et al. 2015, Motyka et al. 2015). The general chemical formula of minerals in the apatite group is expressed by A 5 (XO 4 ) 3 Z, where A are bivalent cations (e.g., Ca 2+ or Pb 2+ , cations are distributed on two distinct crystallographic sites), XO 4 is a trivalent oxyanion (e.g., PO 4 3, AsO 4 3 - ), and Z is a monovalent anion (OH, F, Cl, or O). Positions Z and X may be partly filled with carbonate CO 3 2−. The structure of hydroxylapatite allows for unlimited substitutions of Pb 2+ for Ca 2+ and AsO 4 3− for PO 4 3−. The ability of lead and arsenic apatites to immobilize these toxic elements result from their high durability and low solubility at the conditions on the Earth surface. Various apatites possess different thermodynamic properties including different solubility in aqueous solutions but the systematic variation of these properties in solid solution series is poorly understood. The main objective of this research is determination of systematic variation in the solubilities of hydroxylapatites resulting from cationic substitutions of Pb 2+ for Ca 2+ and anionic substitutions of AsO 4 3− for PO 4 3− in their structure. Three solid solution series were synthesized: - HPY hydroxypyromorphite Pb 5 (PO 4 ) 3 OH – HAP hydroxyapatite Ca 5 (PO 4 ) 3 OH, HMi hydroxymimetite Pb 5 (AsO 4 ) 3 OH – JBM johnbaumite Ca 5 (AsO 4 ) 3 OH, - HAP hydroxyapatite Ca 5 (PO 4 ) 3 OH – JBM johnbaumite Ca 5 (AsO 4 ) 3 OH. The phases were synthesized from aqueous solutions at high pH above 8, at ambient temperature, by dropwise mixing of chemical reagents. The products are white, fine, homogeneous crystalline powders. Chemical composition determined by SEM/EDS is close to theoretical. X-ray diffraction confirms their crystalline structure and systematic changes in unit cell parameters with ionic substitution. Dissolution experiments were run in thermostatic bath at 25°C. An aliquot of 0.5 g of apatite was dissolved in 250 mL of 0.05M NH 4 NO 3 background solution at pH in the range of 3.5–5.0. Background solution was used to keep the ionic strength constant. The dissolution was carried out for 3 months. The bottles were manually stirred at least two times a week. The solution was syringe-sampled periodically and filtered through 0.2 μm polycarbonate filter to remove the suspended solids. The concentration of Pb and Ca was determined by atomic absorption spectroscopy. The concentration of dissolved phosphates and arsenates was determined by UV-vis colorimetry using a molybdenum blue method. The plateau on concentration evolution patterns from the dissolution experiments was observed to determine equilibrium in the suspensions. Dissolution of all the phases at the conditions of these experiments is incongruent. An increase in solution pH resulting from dissolution was observed in all cases. The system was considered in equilibrium when at least three consecutive samples showed identical concentration of Ca 2+ or AsO 4 3−. The equilibrium in HPY series was assumed by analogy. All the concentrations were recalculated to activities using PHREEQC model with Llnl database. The solubility K sp determined for the endmembers at 25°C conform with the literature data and equal to: HPY-K sp = 10 −7 7. 31 , HAP-K sp = 10 −55.66 , HMi-K sp = 10 −71. 56 , and JBM K sp = 10 −37.76. This confirms that, despite the incongruence of dissolution, the experimental procedure and the calculation scheme provide reliable approximation of the solubilities. The most soluble phase is johnbaumite Ca 5 (AsO 4 ) 3 OH. The solubility of all hydroxylapatites decreases linearly with the increase of Pb and P content. These trends do not correlate with the changes in Gibbs free energy of formation of the phases in question. This indicates that structural (e.g. the size of the ions) and the chemical factors (e.g. electronegativity) play the dominant role in the solubility of substituted hydroxylapatites.
    Źródło:
    Geology, Geophysics and Environment; 2016, 42, 1; 100-101
    2299-8004
    2353-0790
    Pojawia się w:
    Geology, Geophysics and Environment
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Weathering in a regolith on the Werenskioldbreen forefield (SW Spitsbergen) : modelling of pore water chemistry
    Autorzy:
    Kwaśniak-Kominek, M.
    Manecki, M.
    Rzepa, G.
    Płonka, A. M.
    Górniak, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/191820.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Geologiczne
    Tematy:
    retreating glaciers
    chronosequence
    hydrochemistry
    Werenskioldbreen
    Spitsbergen
    Opis:
    The mineral framework and pore waters of glacial sediments exposed in the foreland of Weren- skioldbreen in SW Spitsbergen were sampled and analyzed to model the evolution of pore water chemistry, representing the advancement of weathering in a chronosequence. Three samples were taken at distances representing snapshots of approximately 5, 45 and 70 years of exposure. Complementary mineralogical analyses of the mineral framework and chemical analyses of pore waters, coupled with thermodynamic modelling of mineral-water interactions were applied. Recently uncovered sediments of the bottom moraine underwent very little weathering underneath the glacier cover; both the sediments and pore waters in the forefield of the Werenskioldbreen represent a very immature system. Poorly sorted sediments were deposited by the glacier and not reworked by fluvioglacial waters. The ratio of ‘amorphous iron’ to ‘free iron’ Feo/Fed increases with distance from the glacier terminus from 0.30 through 0.36 to 0.49, typical for fresh glacial till. The increase in saturation with CO2 (from p(CO2) –3.8 to –2.4) and the concentration of all major ions in pore waters (from 123 to 748 mg/L total dissolved solids, TDS) was observed in this young chronosequence. The waters evolved from carbonate- dominated to sulphate-dominated, indicating that with progress in weathering the dominating processes are equilibration with carbonates, oxidation of sulphides and the influence of gypsum precipitation by seasonal freeze-thaw cycles. Mass balance calculations and inverse modelling of the composition of pore waters, verified by microscopic observations of alteration on the surfaces of mineral grains, allowed thermodynamic confirmation of the fact that the relative significance of carbonate weathering decreases and that of sulphate increases down the chronosequence. The participation of silicate minerals in weathering is low, indicating a relatively immature stage of weathering within this particular chronosequence. It is significant that the morphology of etch pits and the formation of secondary phases apparent on mineral surfaces were identical, regardless of the distance from the glacier terminus. This might indicate that the mechanisms of particular weathering processes at the mineral-water interface are the same at the initial as well as at the more mature stages and do not change at least within ca. 70 years of exposure.
    Źródło:
    Annales Societatis Geologorum Poloniae; 2016, 86, 3; 249-264
    0208-9068
    Pojawia się w:
    Annales Societatis Geologorum Poloniae
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Three-drug combination of lacosamide, phenobarbital and valproate exerts additive interaction in the tonic-clonic seizure model in mice
    Autorzy:
    Kondrat-Wrobel, M.
    Marzeda, P.
    Bojar, H.
    Wroblewska-Luczka, P.
    Kozinska, J.
    Jankiewicz, M.
    Kominek, M.
    Luszczki, J.J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2097824.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    valproate
    drug interactions
    phenobarbital
    isobolographic analysis
    lacosamide
    Tonic-clonic seizures
    Opis:
    Introduction. Triple-therapy with antiepileptic drugs (AEDs) is usually prescribed for epilepsy patients, whose seizures are not fully controlled with standard medications. Although 25 various AEDs are currently licensed for treating epilepsy, no algorithms allowing for the proper combination of AEDs are available. Objective. The aim of the study is to isobolographically assess the type of interaction among three AEDs (lacosamide [LCM], phenobarbital [PB] and valproate [VPA]), in the model of tonic-clonic seizures in mice. Materials and Method. The electrically-evoked (25 mA, 500 V, 50 Hz, 0.2 s of stimulus duration) tonic-clonic seizures in male albino Swiss mice allowed determination of the anticonvulsant action of the three-drug mixture of LCM, PB and VPA combined in a dose ratio of 1:1:1 by means of type I isobolographic analysis of interaction. Results. The experimentally-determined ED50 exp value for the three-drug mixture was 112.04 mg/kg and did not differ from the theoretically calculated ED50 add value, which was 112.36 mg/kg. Lack of statistical significance confirmed that the mixture of LCM, PB and VPA in a dose-ratio of 1:1:1 exerted additive interaction in the mouse tonic-clonic seizure model. Conclusions. Although the three-drug combination of LCM, PB and VPA produced additive interaction in the mouse tonic-clonic seizure model, the three-drug combination could be recommended for epilepsy patients whose seizures are refractory to the standard medication.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2020, 14, 3; 102-106
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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