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    Wyświetlanie 1-9 z 9
    Tytuł:
    Cellulose as a matrix for synthesis of the library of molecular receptors useful for screening of antihistamine compounds
    Autorzy:
    Walczak, M. E.
    Fraczyk, J.
    Kaminski, Z. J.
    Kolesinska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/285804.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    biopolymers
    antihistamine compounds
    molecular receptors
    Źródło:
    Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 50
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Functionalized cellulose as a matrix for the synthesis of library of molecular receptors useful for screening of compounds with anti-histamine activity
    Autorzy:
    Walczak, M. E.
    Frączyk, J.
    Kamiński, Z. J.
    Kolesińska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/285956.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    molecular receptors
    immobilized peptides
    binding pocket
    agonist/antagonist
    histamine receptors
    Opis:
    The library of molecular receptors was formed by self-organization of N-heptanoylated dipeptides anchored in the regular fashion via aminophenylamino- 1,3,5-triazine linker to the surface of cellulose membrane. SPOT method was used for the synthesis of peptide library. As C-terminal amino acids of peptide fragments were attached: Ala, Pro and Phe, while as a N-terminal amino acids were applied all natural amino acids. DMT/NMM/TosO- was selected as a coupling reagent for synthesis of library of N-heptanoylated dipeptides. These constructs were used as a tool for distinguishing pharmaceutically active compounds acting on histamine receptors. In the studies as active compounds were tested: Doxylamine and Difenhydramine with histamine agonist activity, Ranitidine and Cimetidine with antagonist activity as well as Histamine – natural ligand. The binding of colourless ligands was monitored by staining with Brilliant Black used as reporter dye and quantitative colour measurement was performed in 256 grade gray scale by using Image-Quant software. Substantial differences in the ability of interactions of agonists and antagonists with bounding pockets were observed with selected molecular receptors. From 60 elements library of molecular receptors were selected 12, which were able to distinguish between agonists or antagonists. It has been found that even small changes (Leu residue vs Val residue) in the structure of molecular receptor influenced specificity of agonist or antagonist binding.
    Źródło:
    Engineering of Biomaterials; 2017, 20, 142; 2-6
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aromatic peptides as components of potential scaffolds for regenerative medicine
    Autorzy:
    Strzempek, W.
    Menaszek, E.
    Dziadek, M.
    Stodolak-Zych, E.
    Boguń, M.
    Kolesińska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/284726.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    peptides
    components
    regenerative medicine
    Źródło:
    Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 74
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fibrous structures based of natural polymers for tissue engineering applications
    Autorzy:
    Stodolak-Zych, E.
    Ścisłowska-Czarnecka, A.
    Kolesinska, B.
    Cieślak, M.
    Puchowicz, D.
    Kaminska, I.
    Bogun, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/285455.pdf
    Data publikacji:
    2018
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    polymers
    tissue engineering
    spectroscopy
    Źródło:
    Engineering of Biomaterials; 2018, 21, 148; 63
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fabrication of Pure Electrospun Materials from Hyaluronic Acid
    Materiały z kwasu hialuronowego otrzymywane metodą elektroprzędzenia przeznaczone do zastosowań w inżynierii tkankowej
    Autorzy:
    Pabjańczyk-Wlazło, E.
    Krucińska, I.
    Chrzanowski, M.
    Szparaga, G.
    Chaberska, A.
    Kolesińska, B.
    Komisarczyk, A.
    Boguń, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/234250.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Biopolimerów i Włókien Chemicznych
    Tematy:
    biocompatible polymers
    natural polymers
    biomimetism
    biomimetic scaffolds
    regenerative medicine
    electrospinning
    hyaluronic acid
    polimery biokompatybilne
    polimery naturalne
    biomimetyzm
    szkielety biomimetyczne
    medycyna regeneracyjna
    elektrospining
    kwas hialuronowy
    Opis:
    The aim of the research was to develop optimal conditions for manufacturing materials based on hyaluronic acid by the electrospun method. The studies were composed of three stages: the process of selection of the optimal solvent (mixture of solvents), the molecular weight of hyaluronic acid, and the concentration of biopolymer in the spinning solution. The influence of variable parameters on the rheological properties of the spinning solutions and electrospinning trails was tested. Depending on the electrospinning regime applied, the fibers obtained were characterised by a diameter of the order of 20 to 400 nm. As a result of the development works presented, an optimal molecular weight of the polymer, its concentration and system of solvents were determined, together with process parameters, ensuring a stable electrospinning process and relatively homogeneous nanofibers. Additionally studies on the residues of solvents used during electrosun formation were done and parameters of drying of the final materials were examined. This approach (verification of the presence of organic solvent residue in the nanofibrous formed) is important for the suitability of nanofibres as scaffolds for regenerative medicine. This study provides an opportunity for the understanding and identification of process parameters, allowing for predictable manufacturing nanofibers based on natural biopolymers, which makes it tremendously beneficial in terms of customisation.
    Celem badań było opracowanie optymalnych warunków otrzymywania nanowłókien z kwasu hialuronowego. Badania obejmowały następujące etapy realizacji pracy: proces doboru optymalnego rozpuszczalnika dla polimeru oraz dobór masy cząsteczkowej kwasu hialuronowego. Zbadano właściwości reologiczne roztworów oraz wpływ zmiennych parametrów procesowych na strukturę mikroskopową włókien. W zależności od zastosowanych parametrów elektroprzędzenia otrzymane włókna charakteryzowały się średnią rzędu od 20 do 400 nm. Dodatkowo przeprowadzono badania dotyczące pozostałości rozpuszczalników stosowanych w przygotowaniu roztworów przędzalniczych, co jest istotne z punktu widzenia wykorzystania tych materiałów w obrębie medycyny regeneracyjnej.
    Źródło:
    Fibres & Textiles in Eastern Europe; 2017, 3 (123); 45-52
    1230-3666
    2300-7354
    Pojawia się w:
    Fibres & Textiles in Eastern Europe
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Detonation nanodiamond particles modified by non-steroidal anti-inflammatory drugs in vitro examination
    Autorzy:
    Mitura, K.
    Wilczek, P.
    Niemiec-Cyganek, A.
    Morenc, M.
    Dudek, M.
    Sobczyk-Guzenda, A.
    Fraczyk, J.
    Kolesińska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/284974.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    detonation nanodiamond particles
    chemical modification
    anti-inflammatory drugs
    FTIR spectroscopy
    mouse fibroblasts
    Opis:
    Most recently it has been found that nanodiamond particles have very interesting properties. There are number of research communications that detonation nanodiamond particles (NDPs) are fairly reactive and their surface can be effectively modified by chemical methods. The hydroxyl-modified NDPs were obtained by Fenton reaction, amine-functionalized NDPs were obtained by chemical reduction of the nitro- -functionalized surface and carboxyl-modified NDPs by oxidation by using H2O2 under acidic conditions. NDPs functionalized by hydroxyl- and amine- groups and amino groups were used for covalent binding of non-steroidal anti-inflammatory pharmaceuticals (aspirin, ketoprofen, ibuprofen, naproxen) via ester or amide bonds. These results of the studies proved the activity of the conjugates of active substance-NDP and study the rate of release of active substance from the NDPs surface by in vitro examinations with mouse fibroblasts. The progress of the reaction and the characteristics of the products were determined by using FT-IR. Chemical and physical structures of materials were also investigated by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS). DRIFT spectra show the modification of nanodiamond by ketoprofen, naproxen, ibuprofen and aspirin.
    Źródło:
    Engineering of Biomaterials; 2017, 20, 140; 12-20
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modulowanie właściwości peptydów penetrujących do komórek
    Modulating properties of the cell penetrating peptides
    Autorzy:
    Lipiński, W.
    Kolesińska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/172238.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    peptydy penetrujące do komórek
    CPPs
    aktywowalne peptydy zdolne do przenikania przez błony komórkowe
    cargo
    transport związków chemicznych do komórek
    mechanizm przenikania
    diagnostyka nowotworów
    cell penetrating peptides
    activatable cell penetrating peptides
    ACPPs
    transport into the cells
    mechanism of penetration
    Opis:
    Cell penetrating peptides (CPPs) are short peptides able to efficiently cross cellular membrane. The group includes great diversity of sequences and besides capability to enter various types of cells, their characteristic feature is lack of toxicity. CPPs can be divided according to their origin (natural and synthetic) or according to their physicochemical properties responsible for the cellpenetrating ability (cationic, amphipathic and hydrophobic). Properties of CPPs are closely related to their mechanism of internalisation. Endocytic pathway is probably the dominating mechanism for majority of CPPs, but less common energyindependent internalisation (occurring via inverted micelle, carpet-like, barrel stave pore or toroidal pore model may also play a relevant part in the uptake across membranes. CPPs have been applied in transporting various compounds. They are very effective in delivering small molecules (fluorophores, drugs, peptides), macromolecules (proteins, nucleic acids) and even nanoparticles (metal nanoparticles, liposomes). Conjunction of CPP and cargo can be achieved either covalently (peptide bond, sulphide bridge etc.) or noncovalently (electrostatic or hydrophobic interaction, hydrogen bonding). Ability to unspecific enter almost any kind of cell and tissue becomes a great problem in the case of in vivo applications. Another disadvantage of CPPs is their low plasma stability. Many strategies have been suggested to overcome these issues. Selectivity can be improved by attaching targeting ligands (e.g. short peptides, antibodies, proteins, folic acid or hyaluronic acid) or by incorporating CPPs into macromolecular drug carriers, which exploit the so called enhanced permeability and retention (EPR) effect. The most recent and most sophisticated way of improving CPPs’ stability and selectivity is the synthesis of activatable cell penetrating peptides (ACPPs). The deactivating moiety may consist of anionic sequence, polymer chain or smaller protecting groups. The deactivating parts are connected to the delivery system via linker that can be cleaved under conditions characteristic for the site of action. ACPPs may be activated by enzymes, pH and oxidative potential change, temperature or radiation. CPPs may find application in tumour therapy, diagnostics and the combination of both – theranostics. Despite many successful studies in delivering drugs and tags in vivo and in vitro, CPPs have passed only few clinical trials (some are being run currently). It is sure that this research area will develop in next years
    Źródło:
    Wiadomości Chemiczne; 2017, 71, 9-10; 695-726
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Selection of active fragments of collagen
    Autorzy:
    Kolesińska, B.
    Frączyk, J.
    Kamński, Z. J.
    Rosiak, P.
    Becht, A.
    Czerchawy, A.
    Chaberska, A.
    Waśko, J.
    Czerczak, K.
    Walczak, M. E.
    Powiązania:
    https://bibliotekanauki.pl/articles/286048.pdf
    Data publikacji:
    2018
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    collagen
    regeneration
    biocompatibility
    Źródło:
    Engineering of Biomaterials; 2018, 21, 148; 41
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Rusztowania (scaffolds) stosowane w medycynie regenaracyjnej
    Scaffolds for regenerative medicine
    Autorzy:
    Chaberska, A.
    Rosiak, P.
    Kamiński, Z. J.
    Kolesińska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/172308.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    medycyna regeneracyjna
    samoorganizacja peptydów
    biomimetyczne rusztowania
    macierz pozakomórkowa
    ECM
    składniki funkcjonalne ECM
    regenerative medicine
    selfassembled peptides
    biomimetic scaffolds
    extracellular matrix
    functional components of ECM
    Opis:
    The presence of three dimensional support is indispensable condition for successful regeneration of the tissue. In the absence of natural scaffold, or absence of its artificial substitute, regeneration is not possible. The advantage of natural building blocks to create new scaffolds results from the requirements of the materials structures used for tissue regeneration: biocompatibility, biodegradability, lack of cytotoxicity and desirable mechanical properties. Application of these building blocks for the preparation of three dimensional materials should ensure completely biocompatibility of the temporary extracellular matrix equivalent, thus offering construct resembling a natural milieu for the cells and finally regeneration of tissues. These include framework with elements stimulating adhesion of in vitro grown cells, growth factors, hormones and vitamins offered as a completed ingredients in the commercially available culture media. 3D frameworks applied for cell growing should facilitate formation of required tissue shape and size as well as appropriate functioning of the cells. The key factor for the successful regeneration of tissues is the function of the scaffold determining the environment for growing cells, directing proliferation and regulating differentiation processes. The basic feature of the cellular scaffold, determining its functioning is porosity. Pore diameter and their abundance consists a critical factor for penetration of cells into the interior of the implant and finally for successful regeneration of damaged tissue. The progress of tissue regeneration in vitro depends on the presence of cytokines and growth factors, which are controlling cell differentiation process. Nowadays neither of implant material offered on the market has a property comparable to the natural tissue. However, there are many reports presenting preliminary experiments conducted towards attaining novel supports for regenerative medicine derived from peptides and formed by their self-organization. The most advanced of them are known under trade name PuraMatrix, which recently were applied for the regeneration of soft tissues. However, due to tendency of this materials for hydrogels formation, characteristic for them are disadvantageous mechanical properties. The alternative approach based on application of native ECM proteins was also taken into consideration. The weak points of this materials are the susceptibility of proteins towards proteolytic enzymes and theirs immunogenic properties. The diversity of peptide modules give the opportunity to design and synthesize a variety of biomaterials that mimic the structural complexity of the natural ECM.
    Źródło:
    Wiadomości Chemiczne; 2017, 71, 3-4; 263-286
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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