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    Wyświetlanie 1-6 z 6
    Tytuł:
    Analysis of the G/C polymorphism in the 5-untranslated region of the RAD51 gene in breast cancer.
    Autorzy:
    Blasiak, Janusz
    Przybyłowska, Karolina
    Czechowska, Agnieszka
    Zadrożny, Marek
    Pertyński, Tomasz
    Rykała, Jan
    Kołacińska, Agnieszka
    Morawiec, Zbigniew
    Drzewoski, Józef
    Powiązania:
    https://bibliotekanauki.pl/articles/1043672.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    genetic polymorphism
    RAD51 gene
    RFLP-PCR
    breast cancer
    Opis:
    The breast cancer suppressor proteins BRCA1 and BRCA2 interact with RAD51, a protein essential for maintaining genomic stability by playing a central role in homology-dependent recombinational repair of the DNA double-strand breaks. Therefore, genetic variability in the RAD51 gene may contribute to the appearance and/or progression of breast cancer. A single nucleotide polymorphism in the 5'- untranslated region of RAD51 (a G to C substitution at position 135, the G/C polymorphism) is reported to modulate breast cancer risk. We investigated the distribution of genotypes and frequency of alleles of the G/C polymorphism in breast cancer. Tumor tissues were obtained from postmenopausal women with node-negative and node-positive breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The G/C polymorphism was determined by PCR-based MvaI restriction fragment length polymorphism. The distribution of the genotypes of the G/C polymorphism did not differ significantly (P >0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distribution and allele frequencies between node-positive and node-negative patients. There were no significant differences between distributions of the genotypes in subgroups assigned to histological grades according to Scarf-Bloom-Richardson criteria and the distribution predicted by Hardy-Weinberg equilibrium (P >0.05). Our study implies that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer and so it may not be useful as an independent marker in this disease.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 1; 249-253
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Does the Choice of Hospital Increase a Chance of Survival in Rectal Cancer?
    Autorzy:
    Pawlak, Mariusz
    Morawiec, Zbigniew
    Dziki, Łukasz
    Morawiec, Jan
    Kolacińska, Agnieszka
    Dziki, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1397012.pdf
    Data publikacji:
    2012-12-01
    Wydawca:
    Index Copernicus International
    Tematy:
    rectal cancer
    prognostic factors
    hospital caseload
    5-year survival
    local recurrence
    Opis:
    was to assess the impact of hospital caseload on long-term outcomes of rectal cancer patients. We posed two questions: 1. Does the number of operations carried out in the surgical department influence five year survival and local recurrence rates? 2. Does surgery alone without adjuvant therapy performed in the particular department affect long-term results? Material and methods. 215 consecutive rectal cancer patients treated in six hospitals of the Łódź district between 1994 and 1998 were enrolled into this prospective study. We analyzed patients in whom local excision, low anterior resection, abdominoperineal resection and Hartmann’s procedure were performed. 27 percent of patients received adjuvant therapy such as radio- or chemotherapy or both. Long-term results were compared between high and low volume institutions by means of local recurrence and five year survival rates. Results. In high volume departments; 69.2% of five year survival rates were obtained versus 46.6% for low volume institutions (p=0.00433). Similar differences were noted comparing local recurrence rates between the aforementioned groups: 19.7% versus 36.5%, respectively (p=0.00430). In surgically treated patients who did not receive adjuvant therapy statistically significant differences were found: 76.5% of patients operated on in high volume hospitals survived five years as compared with 42.9% for low caseload institutions (p=0.00013). Local recurrence rates were 15.5% for high caseload institutions and 38.5% for low caseload hospitals (p=0.00042). Conclusions. High volume hospitals achieved better results in rectal cancer patients with regard to five year survival and local recurrence rates. Better outcomes were also obtained in high caseload departments regarding surgically treated patients who did not receive adjuvant therapy.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 12; 638-645
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Landscape of oncoplastic breast surgery across Poland
    Autorzy:
    Kolacinska, Agnieszka
    Hodorowicz-Zaniewska, Diana
    Bocian, Artur
    Michalik, Dariusz
    Matkowski, Rafal
    Kurylcio, Andrzej
    Pyka, Pawel
    Charytonowicz, Michal
    Berkan, Maciej
    Powiązania:
    https://bibliotekanauki.pl/articles/1393135.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    breast cancer
    oncoplastic surgery
    patient reported outcomes
    Opis:
    Oncoplastic and reconstructive techniques are essential tools in the armamentarium of contemporary breast surgeons. The aim of the study was to identify oncoplastic reconstructive patterns in breast cancer centers across Poland. A questionnaire of 18 questions was sent by email to the members of the Polish Society of Surgical Oncology and the Polish Society of Plastic, Reconstructive and Esthetic Surgery via their dedicated websites. The numbers of breast cancer patients operated on in each center ranged from 120 to 904 per year. Breast-conserving surgery (BCS) predominated in all but one center (range 50-70%). Immediate breast reconstructions (IBR) accounted for 6-42% of procedures, The most frequent type of IBR was either a two-stage expander followed by a permanent implant or one-stage implant- based with or without synthetic mesh. The most frequent type of delayed breast reconstruction (DBR) was a two-stage expander followed by implant-based reconstruction. None of the surveyed cancer centers performed free flap reconstruction. Deep inferior epigastric perforator (DIEP) flaps were performed in the plastic surgery department. Reconstructions based on pedicled flaps were performed in cancer centers. Acellular dermal matrices (ADM) and fat transfer were used in selected centers. In the clinical scenario of adjuvant radiotherapy, delayed breast reconstruction was favored. The full range of oncoplastic BCS was performed. Patient-reported outcome measures (PROM) and complications were assessed. Our findings can act as a platform for further improvement in skills, certification, data collection and audit, including patient reported expectation measures. There is also an urgent need to address pan-European inconsistencies in procedural reimbursement.
    Źródło:
    Polish Journal of Surgery; 2017, 89, 6; 14-19
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Local Antibiotic Therapy in Rectal Cancer Surgery
    Autorzy:
    Morawiec, Zbigniew
    Pawlak, Mariusz
    Kołacińska, Agnieszka
    Dziki, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1397022.pdf
    Data publikacji:
    2012-12-01
    Wydawca:
    Index Copernicus International
    Tematy:
    rectal cancer
    infectious complications
    local antibiotic use
    Opis:
    Infectious complications and their consequences are still key issues in rectal cancer surgery. Currently, intravenous antibiotic administration is a recognized method for lowering the rate of these complications. The aim of the study was to assess the efficacy of complementary application of a gentamicin-impregnated sponge in the perineal wound or in the vicinity of intestinal anastomosis after abdominoperineal resection or low anterior resection. Material and methods. 112 patients with primary rectal cancer were enrolled in this study. 42 patients were treated with a gentamicin sponge and drainage (group A) and 70 individuals were treated with drainage alone (group B). In the aforementioned groups a routine short-term regimen of antibiotic prophylaxis was used. We applied gentamicin-impregnated sponges in 27 patients in whom anterior resection was performed and in 15 patients from the abdominoperineal resection group (64% and 36%, respectively). In the control group, 44 anterior resections and 26 abdominoperineal resections were carried out (63% and 37%, respectively). Results. We did not observe statistically significant differences in the incidence of suppurative complications (intraabdominal abscess, perineal wound infection): 4 cases (9.52%) in group A and 9 (12.58%) in group B and anastomotic leakage with clinical manifestation after low anterior resection: 1 case (3.7%) in group A and 2 (4.5%) in group B. Postoperative fever of unknown origin was noted more often in group B: 23 patients (32.8%) versus 10 patients (23.8%) in group A and this difference was statistically significant (p<0.05). Hospitalization after surgery was also significantly longer in group B (9-37 days, median 11 days) as compared with group A (8-26 days, median 13 days) (p<0.05). Conclusions. Local antibiotic therapy in rectal cancer surgery lowered the incidence of postoperative fever of unknown origin and permitted shorter hospitalization after surgery. Local gentamicin application in rectal cancer surgery did not change significantly the rate of infectious complications.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 12; 613-617
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Obraz chirurgii onkoplastycznej piersi w Polsce
    Autorzy:
    Kolacinska, Agnieszka
    Hodorowicz-Zaniewska, Diana
    Bocian, Artur
    Michalik, Dariusz
    Matkowski, Rafal
    Kurylcio, Andrzej
    Pyka, Pawel
    Charytonowicz, Michal
    Berkan, Maciej
    Powiązania:
    https://bibliotekanauki.pl/articles/1393170.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    rak piersi
    chirurgia onkoplastyczna
    ocena wyników na podstawie opinii pacjentów
    Opis:
    Techniki onkoplastyczne i rekonstrukcyjne stanowią podstawowe narzędzia pracy współczesnych chirurgów piersi. Celem badania było ustalenie rodzajów rekonstrukcji onkoplastycznych przeprowadzanych w ośrodkach leczenia raka piersi w Polsce. Drogą e-mailową rozesłano kwestionariusz zawierający 18 pytań do członków Polskiego Towarzystwa Chirurgii Onkologicznej oraz Polskiego Towarzystwa Chirurgii Plastycznej, Rekonstrukcyjnej i Estetycznej poprzez ich portale internetowe. Liczba pacjentek z rakiem piersi poddawana operacji sięgała od 120 do 904 rocznie w każdym z ośrodków. Wykonywano głównie operacje oszczędzające pierś (breast conserving surgery - BCS) z wyjątkiem jednego ośrodka (zakres 50 – 70%). Jednoczasową rekonstrukcję piersi (immediate breast reconstruction - IBR) wykonywano w 6-42% zabiegów. Najczęstszym rodzajem IBR była dwuetapowa rekonstrukcja z użyciem ekspandera i wszczepieniem implantu lub jednoetapowa rekonstrukcja przy użyciu implantu z lub bez wszczepienia siatki syntetycznej. Najczęściej wykonywanym zabiegiem odroczonej rekonstrukcji piersi (delayed breast reconstruction - DBR) była dwuetapowa rekonstrukcja z użyciem ekspandera i następnie z wszczepieniem implantu. W żadnym z badanych ośrodków nie wykonywano rekonstrukcji z użyciem wolnego płata. W ośrodku chirurgii plastycznej wykonywano rekonstrukcję z wykorzystaniem płata perforatorów głębokich naczyń nabrzusznych dolnych (DIEP). W ośrodkach onkologicznych wykonywano rekonstrukcje z użyciem płatów uszypułowanych. W wybranych ośrodkach stosowano bezkomórkowe macierze skórne (ADM) oraz przeszczep tkanki tłuszczowej. Oceniono wyniki na podstawie opinii pacjentów (patient-reported outcome measures - PROM) oraz powikłania po zabiegach. Nasze wyniki mogą stanowić podstawę do dalszego doskonalenia umiejętności, akredytacji, zbierania danych i audytu, w tym oceny na podstawie opinii pacjentów. Istnieje również pilna potrzeba rozwiązania problemu nierówności w refundacji procedur w różnych państwach Europy.
    Źródło:
    Polish Journal of Surgery; 2017, 89, 6; 12-16
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Retrospective analysis of local recurrence rate in breast cancer patients treated at the department of surgical oncology in Łódź between 2009 and 2013
    Autorzy:
    Morawiec, Jan
    Dziki, Adam
    Morawiec, Zbigniew
    Kołacińska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/1395718.pdf
    Data publikacji:
    2014-02-01
    Wydawca:
    Index Copernicus International
    Tematy:
    breast cancer
    local recurrence
    Opis:
    The aim of the study was to analyze clinicopathological features in breast cancer patients with local recurrence (LR). Material and methods. A retrospective analysis of database of breast cancer patients operated on in the Department of Surgical Oncology in Łódź from 2 January 2009 to 30 June 2013, identified 1080 women with primary breast cancer and 11 patients with LR. Results. LR rate was 0.23% per year. True recurrence (TR) occurred more frequently in patients with luminal B molecular subtype, in HER-2 positive and in triple-negative subgroups. In one patient with luminal -A subtype new primary (triple negative) occurred. TR were noted predominantly in patients with axillary lymph nodes metastases and with luminal B subtype who did not receive adjuvant chemotherapy but were given only endocrine therapy. LR were observed more frequently in patients who did not receive adjuvant radiotherapy or this treatment was delayed. Minimal surgical margins in postoperative specimens measured by pathologist were 4-25 mm, mean 9.5 mm. Conclusions. The LR rate in patients operated on breast cancer in the Department of Surgical Oncology between 2009 and 2013 was low. TR was diagnosed in patients with non- luminal A breast cancer despite wide surgical margins, especially if the patients did not receive optimal adjuvant systemic treatment or radiotherapy was delayed or omitted. Complete cancer excision followed by an immediate implementation of optimal adjuvant treatment seems to be crucial especially in patients with poor tumor biology.
    Źródło:
    Polish Journal of Surgery; 2014, 86, 2; 77-81
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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