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Wyszukujesz frazę "Koj, Aleksander" wg kryterium: Autor


Wyświetlanie 1-5 z 5
Tytuł:
Simultaneous isolation and partial characterization of antithrombin III and α_1-proteinase inhibitor from horse plasma
Autorzy:
Kurdowska, Anna
Koj, Aleksander
Jaśkowska, Mariola
Powiązania:
https://bibliotekanauki.pl/articles/1046114.pdf
Data publikacji:
1982
Wydawca:
Polskie Towarzystwo Biochemiczne
Źródło:
Acta Biochimica Polonica; 1982, 29, 1-2; 95-103
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Regulatory mechanisms of gene expression: complexity with elements of deterministic chaos
Autorzy:
Jura, Jolanta
Węgrzyn, Paulina
Jura, Jacek
Koj, Aleksander
Powiązania:
https://bibliotekanauki.pl/articles/1041263.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
linear and nonlinear responses
somatic recombination
biallelic expression
alternative splicing
epigenetics
RNA editing
monoallelic expression
Opis:
Linear models based on proportionality between variables have been commonly applied in biology and medicine but in many cases they do not describe correctly the complex relationships of living organisms and now are being replaced by nonlinear theories of deterministic chaos. Recent advances in molecular biology and genome sequencing may lead to a simplistic view that all life processes in a cell, or in the whole organism, are strictly and in a linear fashion controlled by genes. In reality, the existing phenotype arises from a complex interaction of the genome and various environmental factors. Regulation of gene expression in the animal organism occurs at the level of epigenetic DNA modification, RNA transcription, mRNA translation, and many additional alterations of nascent proteins. The process of transcription is highly complicated and includes hundreds of transcription factors, enhancers and silencers, as well as various species of low molecular mass RNAs. In addition, alternative splicing or mRNA editing can generate a family of polypeptides from a single gene. Rearrangement of coding DNA sequences during somatic recombination is the source of great variability in the structure of immunoglobulins and some other proteins. The process of rearrangement of immunoglobulin genes, or such phenomena as parental imprinting of some genes, appear to occur in a random fashion. Therefore, it seems that the mechanism of genetic information flow from DNA to mature proteins does not fit the category of linear relationship based on simple reductionism or hard determinism but would be probably better described by nonlinear models, such as deterministic chaos.
Źródło:
Acta Biochimica Polonica; 2006, 53, 1; 1-10
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of dexamethasone and insulin on the acute phase response of Morris hepatoma cells and of rat hepatocytes in culture
Autorzy:
Magielska-Żero, Danuta
Guzdek, Amalia
Bereta, Joanna
Kurdowska, Anna
Cięszka, Krystyna
Koj, Aleksander
Powiązania:
https://bibliotekanauki.pl/articles/1045861.pdf
Data publikacji:
1988
Wydawca:
Polskie Towarzystwo Biochemiczne
Źródło:
Acta Biochimica Polonica; 1988, 35, 4; 287-295
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Complex analysis of genes involved in the inflammatory response: interleukin-1-induced differential transcriptome of cultured human hepatoma HepG2 cells.
Autorzy:
Koj, Aleksander
Jura, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1043427.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
proteome
transcriptome
microarray
hepatoma cells
gene expression
inflammatory reaction
acute phase response
differential display
Opis:
The systemic inflammatory reaction (acute phase response) is induced by many noxious stimuli but in all cases the inflammatory cytokines, such as interleukin-1-beta (IL-1β) and interleukin-6 (IL-6), are involved. Liver cell response to inflammation manifested by a characteristic change in the profile of synthesized plasma proteins (acute phase proteins) has been extensively studied. Here we describe a model system of cultured human hepatoma HepG2 cells stimulated with IL-1β to evaluate the transcriptome induced by this cytokine during 24 h of treatment. By using differential display analysis we found IL-1β-induced upregulation of several genes coding for cellular trafficking/motor proteins, proteins participating in the translation machinery or involved in posttranscription/posttranslation modifications, proteases, proteins involved in cellular metabolism, activity modulators, proteins of the cell cycle machinery and also some new proteins so far functionally not classified.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 573-582
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-5 z 5

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