Autor: Kniotek, Monika - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3)
Autorzy:: Jerzak, Malgorzata
Nowakowski, Andrzej
Górski, Andrzej
Baranowski, Włodzimierz
Kniotek, Monika
Powiązania:: https://bibliotekanauki.pl/articles/989476.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: vulvar cancer
nk cell
pregnancy
t reg
Opis:: Introduction and objective. The study presents the problem of immune disturbances in pregnant women with vulvar carcinoma in situ (VIN3). Material and methods. NK cell and T reg activity in the study patient were analysed using flow cytometry. Results. Decreased NK cell activity and but increased T reg activity were observed after vulvectomy, with subsequent successful pregnancy outcome. Conclusions. Although vulvar cancer may influence immune cell activity, this issue merits further study.
Źródło:: Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Levels of interleukin-2 in patients with colon cancer and diabetes type 2
Autorzy:: Bosek, Irina
Sulich, Agnieszka
Rabijewski, Michał
Kaleta, Beata
Kniotek, Monika
Miłek, Tomasz
Piątkiewicz, Paweł
Powiązania:: https://bibliotekanauki.pl/articles/972606.pdf
Data publikacji:: 2016
Wydawca:: Instytut Medycyny Wsi
Tematy:: diabetes type 2
colon cancer
interleukin-2
Opis:: Introduction and objective: The risk of development colon cancer (CC) is increased significantly among patients with the type 2 diabetes (T2DM). A mechanism responsible for the higher prevalence of CC among diabetic patients may be associated with the immunity system. The aim of this study is to point out the differences in the immunity state in terms of interleukin 2 level among patients with T2DM suffering from CC, and patients without these diseases Material and Methods: 79 patients were included the tests, divided into 4 groups: Group 1–23 people with T2DM, Group 2–23 people with large intestine CC, Group 3–10 people with large CC and T2DM, and Group 4–23 people without T2DM or CC. Each patient had a colonoscopy and those with cancer were confirmed in a histopathological examination. Laboratory measurements included fasting glucose, insulin, C-peptide. The concentration of interleukin-2 in serum was determined with the immunoenzymatic (ELISA) method. Results: The results obtained showed that in patients with T2DM and CC the concentration of interleukin-2 was statistically higher than in the other groups.(4.21±1.61 pg/ml vs. Group 1 -1.64±0.44 pg/ml, Group 2–1.54±0.21 pg/ml, and Group 4–1.70±0.36 pg/ml; p<0.05). Insulin levels, C-peptide and HOMA-IR did not differ significantly between groups, but a tendency was observed to higher values of HOMA-IR and insulin levels in the groups with T2DM alone and T2DM with concomitant CC. Conclusions: The data show differences in the immunity state of patients with T2DM and CC, compared with people without those two diseases. Elevated level of interleukin 2 found in this group, after confirmation in other studies with more patients, could be used as a marker of an increased risk of CC in people with T2DM
Źródło:: Journal of Pre-Clinical and Clinical Research; 2016, 10, 1; 1-5
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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