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Wyświetlanie 1-4 z 4
Tytuł:
Knowledge of vitamin D and its supplementation among students of northern Poland
Autorzy:
Waszak, Przemysław M
Mędza, Aleksandra
Springer, Janusz
Zgłobicka, Martyna
Ogrodnik, Paula
Kalinowska, Paulina
Kmieć, Piotr
Lizakowska-Kmieć, Maria
Sworczak, Krzysztof
Żmijewski, Michał
Powiązania:
https://bibliotekanauki.pl/articles/895781.pdf
Data publikacji:
2018-10-01
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
knowledge
vitamin D
vitamin D deficiency
students
Opis:
Introduction: Vitamin D deficiency is a worldwide public health problem. The objective of this survey was to assess the undergraduate students’ vitamin D status and knowledge about this vitamin. Materials and methods: An online multi-choice survey was designed and launched in Northern Poland (Gdańsk region). The first part of the survey assessed diet, supplementation, UV radiation exposure (UVE) and general health of respondents. The second part was a vitamin D knowledge test (vitamin D optimal level, deficiency-related diseases). 1766 student volunteers responded to the survey: 369 male and 1397 female. Data was divided according to the respondents’ sex and university affiliation. Appropriate parametric or non-parametric statistical tests were used with statistical significance set at p<0.05. Results: Regular consumption of vitamin D-rich food was high, except for fish (only 18; 22%). High number of participants did not declare any type of supplementation (43; 44%) and only occasionally were exposed to UV (77%; 80%). The most frequently recognized disease linked to vitamin D was osteoporosis. Medical University students obtained higher test scores (4,55), however this did not correlate with healthy vitamin D habits. Conclusion: Undergraduate medical and non-medical students have unsatisfactory vitamin D status and poor understanding of its function and impact on health, which implies the need for changes in the educational program.
Źródło:
European Journal of Translational and Clinical Medicine; 2018, 1, 1; 48-56
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children
Autorzy:
Kotłowska-Kmieć, Aldona
Bąkowska, Alicja
Szarszewski, Adam
Kamińska, Barbara
Łuczak, Grażyna
Radys, Wojciech
Landowski, Piotr
Brodzicki, Jacek
Korzon, Maria
Liberek, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1040535.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
T cell
H. pylori
FasL
Fas
apoptosis
lymphocyte
Opis:
The pathomechanism of Helicobacter pylori action upon gastric mucosa and its role in the pathogenesis of gastritis have not been fully elucidated. The aim of this study was to evaluate the most prevalent lymphocyte subpopulations of the gastric mucosa in gastritis in children, as well as to evaluate the expression of Fas and Fas ligand receptors (FasL), periapoptotic markers of gastric mucosa lymphocytes before and after H. pylori eradication. Forty nine patients aged 6 to 17 years, investigated due to chronic abdominal pain, were studied. The obtained tissue samples were analysed by immunohistochemistry. Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNγ) and Fas and FasL proteins in the gastric mucosa. B and T helper lymphocytes were found to play a major role in the inflammatory infiltration in the gastric mucosa in children during H. pylori infection. Their expression was found to decrease after eradication. The enhanced expression of Fas receptor on lymphocytes before treatment and a decrease of this expression after eradication of H. pylori were shown. It was demonstrated that there is a correlation between CD4 and Fas receptor expression that may induce apoptosis of the helper lymphocytes in infected children.
Źródło:
Acta Biochimica Polonica; 2009, 56, 3; 433-438
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Transforming growth factor β1 protein and mRNA levels in inflammatory bowel diseases: towards solving the contradictions by longitudinal assessment of the protein and mRNA amounts
Autorzy:
Liberek, Anna
Kmieć, Zbigniew
Wierzbicki, Piotr
Jakóbkiewicz-Banecka, Joanna
Liberek, Tomasz
Łuczak, Grażyna
Plata-Nazar, Katarzyna
Słomińska-Frączek, Magdalena
Kaszubowska, Lucyna
Gabig-Cimińska, Magdalena
Węgrzyn, Alicja
Powiązania:
https://bibliotekanauki.pl/articles/1039466.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Crohn's disease
ulcerative colitis
Transforming Growth Factor-β1
longitudinal assessment of TGF-β1 level
Opis:
Previously published studies on levels of the transforming growth factor-β1 (TGF-β1) protein and mRNA of the corresponding gene in patients suffering from inflammatory bowel diseases (IBD) gave varying results, leading to contradictory conclusions. To solve the contradictions, we aimed to assess longitudinally TGF-β1 protein and mRNA levels at different stages of the disease in children suffering from IBD. The study group consisted of 19 pediatric patients with IBD at the age between 3.5 and 18.4 years. The control group consisted of 42 children aged between 2.0 and 18.0 years. The plasma TGF-β1 concentration was measured with ELISA. mRNA levels of the TGF-β1 gene isolated from samples of the intestinal tissue were assessed by reverse transcription and real-time PCR. Levels of TGF-β1 protein in plasma and corresponding mRNA in intestinal tissue were significantly higher in IBD patients than in controls. TGF-β1 and corresponding transcripts were also more abundant in plasma and intestinal tissue, respectively, in patients at the active stage of the disease than during remission. In every single IBD patient, plasma TGF-β1 level and mRNA level in intestinal tissue was higher at the active stage of the disease than during remission. Levels of TGF-β1 and corresponding mRNA are elevated during the active stage of IBD but not during the remission. Longitudinal assessment of this cytokine in a single patient may help to monitor the clinical course of IBD.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 683-688
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical parameters of inflammatory bowel disease in children do not correlate with four common polymorphisms of the transforming growth factor β1 gene
Autorzy:
Liberek, Anna
Jakóbkiewicz-Banecka, Joanna
Kloska, Anna
Świderska, Joanna
Kmieć, Zbigniew
Łuczak, Grażyna
Wierzbicki, Piotr
Liberek, Tomasz
Marek, Krzysztof
Plata-Nazar, Katarzyna
Sikorska-Wiśniewska, Grażyna
Kamińska, Barbara
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1039871.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
pediatric patients
gene polymorphism
Transforming growth factor β1
inflammatory bowel disease
Opis:
Transforming growth factor β1 (TGF-β1) is a cytokine affecting cell proliferation and development, which also has an immunomodulatory activity. Correlations between polymorphisms of the TGF-β1 gene and clinical parameters of inflammatory bowel disease (IBD) were reported previously in adults. Here, we tested whether such correlations occur in pediatric patients suffering from IBD. One hundred and four pediatric IBD patients were involved in this study. Among them, 36 were diagnosed with Crohn's Disease (CD) and 68 were diagnosed with ulcerative colitis (UC). The control group consisted of 103 children, in which IBD was excluded. TGF-β1 levels were determined in plasma and intestinal mucosa samples. The presence of the TGF β1 protein and the amount of TGF β1 mRNA were estimated in intestinal mucosa by immunohistochemistry and reverse transcription Real-Time PCR, respectively. Four common polymorphisms of the TGF-β1 gene were investigated: -800G/A, -509C/T, 869T/C and 915G/C. No significant correlation between TGF-β1 genotypes and (i) TGF-β1 levels in plasma and tissue samples, (ii) TGF-β1 gene expression efficiency in intestinal mucosa, (iii) IBD clinical parameters and (iv) inflammatory activity could be detected in children suffering from IBD. We conclude that, contrary to previous suggestions, the four common polymorphisms of the TGF-β1 gene do not influence the susceptibility to or clinical parameters of IBD in the tested population of children.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 641-644
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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