- Tytuł:
- The growth differentiation factor-15 (GDF-15) can be useful in the detection of distant metastases in sera of colorectal cancer patients
- Autorzy:
-
Jakubowska, K.
Pryczynicz, A.
Dymicka-Piekarska, V.
Cepowicz, D.
Jagodzińska, D.
Lewczuk, Ł.
Lebelt, A.
Ozimkiewicz, M.
Kiszło, P.
Guzińska-Ustymowicz, K. - Powiązania:
- https://bibliotekanauki.pl/articles/1917712.pdf
- Data publikacji:
- 2016
- Wydawca:
- Uniwersytet Medyczny w Białymstoku
- Tematy:
-
Colorectal cancer
Growth differentiation factor-15
macrophage inhibitory cytokine-1
serum. - Opis:
- Purpose: Growth differentiation factor-15 (GDF- 15) protein belongs to a transforming growth factor-β family which determines the growth and differentiation of cells. In cancers, GDF-15 influences on the proliferation, differentiation, viability, migration and invasiveness of cancer cells. The aim of our study was to evaluate the expression of GDF-15 in the tissue and its levels in sera of patients with colorectal cancer. Materials and methods: The level of GDF-15 in the sera of 55 patients diagnosed with colorectal cancer was determined using the ELISA method whereas expression of this protein was performed by immunohistochemical method. Results: The mean value of GDF-15 levels in the sera of patients with colorectal cancer was significantly higher than in healthy control group (p<0.001). The expression of GDF-15 in the tissue was weak, moderate and strong in 23.6%, 15.7% and 60.7% cases, respectively. Statistical analysis showed that the expression of GDF-15 correlated with patients’ age (p<0.005) and non-mucinous type of cancer (p<0.001). The high GDF-15 levels in the serum was associated with tumor size (p<0.01) and distant metastases (p<0.05). Conclusions: According to our results, we postulate that the level of GDF-15 in serum can be use to assess the metastatic behavior of colorectal cancer
- Źródło:
-
Progress in Health Sciences; 2016, 6(1); 40-48
2083-1617 - Pojawia się w:
- Progress in Health Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł