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Wyszukujesz frazę "Khan, Sajid M." wg kryterium: Autor

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    Wyświetlanie 1-4 z 4
    Tytuł:
    BOX BEHNKEN DESIGN: A STATISTICAL APPROACH TO EVALUATE THE EFFECT OF CROSSLINKED CARBOXYMETHYL CELLULOSE AND SODIUM STARCH GLYCOLATE ON RELEASE KINETICS OF DRUG
    Autorzy:
    Hanif, Muhammad
    Abbas, Ghulam
    Rasul, Akhtar
    Khan, Sajid M.
    Amir, Muhammad N.
    Powiązania:
    https://bibliotekanauki.pl/articles/895395.pdf
    Data publikacji:
    2018-08-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    FTIR
    XRD
    DSC
    quality by design
    domperidone maleate
    drug release kinetics
    Opis:
    The aim of study was to evaluate the release kinetics of domperidone maleate (DM) from immediate release (IR) tablets prepared by wet granulation method. Box behnken design (BBD) was used to optimize and evaluate the main, interaction and quadratic effects of independent variables i.e. crosslinked carboxymethyl cellulose (CMC) (X1), sodium starch glycolate (SSG) (X2) and starch (X3) on responses R2 of first order (YI) and β value of weibull model (Y2). Prepared tablets were characterized by various physical tests, in-vitro drug release, fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). Accelerated stabilities studies were performed on optimized formulation D9. Y1 and Y2 were ranged from 0.9959 to 0.9994 and 0.041 to 0.912 respectively. β value of weibull model indicated the parabolic shape of dissolution curve. The quadratic model fit the data well and the resulting equations were used to predict the responses in the box behnken design. FTIR spectra showed the compatibility of DM with CMC and SSG. XRD presented diffraction lines indicates crystalline nature of drug. DSC thermograms indicated endothermic peak at 220 0C for DM. Stabilities studies revealed that no significant change in hardness, friability, disintegration time and dissolution release profile of DM. It is concluded that a combination of CMC and SSG can be used to enhance the dissolution and release kinetics of IR tablets of DM.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 965-975
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of chilling exposure and vapor heat treatment duration on the quality of sweet orange during simulated marketing
    Autorzy:
    Hussain, I.
    Rab, A.
    Khan, N.U.
    Sajid, M.
    Ali, N.
    Khan, S.M.
    Ali, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/11543553.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
    Opis:
    Sweet orange fruits were exposed to vapor heat treatment (50°C) in water bath for 0, 5, 10, 15 and 20 min in plastic covered structure. The data were recorded on different physico chemical factors immediately after the storage and after seven days simulated marketing under ambient condition (20°C). Low temperature storage enhanced weight loss, surface pitting, disease incidence, total soluble solids accumulation, TSS/Acid ratio but decreased reducing sugars, acidity and ascorbic acid content. Chilling exposure up to 45 days had no significant effect on weight loss and TSS. However, increased weight loss (2.63%), TSS (11.75), TSS/Acid ratio (8.45 ºBrix), disease incidence (8.93%) and lowest reducing sugars (3.90) were noted in sweet orange exposed to chilling temperature for 75 days. Among the VHT durations, the highest weight loss (2.29%) was found in VHT for 0 min while the highest TSS (11.81 ºBrix), TSS/Acid ratio (8.10) and disease incidence (6.22%) and least reducing sugars (4.12%) were found in VHT 20 for min. Vapor heat treatment ranging from 5–10 min resulted in lowest weight loss (1.79%), TSS (10.81 ºBrix) TSS/Acid ratio (7.33), disease incidence (1.00%) and highest reducing sugars (4.75%) in sweet orange fruits. However, non-reducing sugars were least affected by both LTSs and VHTs. It is concluded that the chilling exposure (5°C) beyond 45 days aggravated the decline of fruit physio-chemical quality characteristics. Whereas, VHT with 5–10 min maintained the sweet orange fruit quality during simulated marketing; however, VHT of 15–20 min adversely affected the sweet orange fruit quality attributes.
    Źródło:
    Acta Scientiarum Polonorum. Hortorum Cultus; 2017, 16, 5; 39-47
    1644-0692
    Pojawia się w:
    Acta Scientiarum Polonorum. Hortorum Cultus
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Peach antioxidant and phenolic activities influenced by the application of 1-methylcyclopropene (1-MCP) at post-harvest
    Autorzy:
    Shah, S.T.
    Sajid, M.
    Khan, N.U.
    Rab, A.
    Amin, N.U.
    Arif, M.
    Haleema, B.
    Saeed, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/12297475.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
    Tematy:
    plant cultivation
    peach tree
    Prunus persica
    fruit tree
    antioxidant activity
    phenolic compound activity
    1-methylcyclopropene
    catalase activity
    fruit
    fruit decay
    storage durability
    shelf life
    Opis:
    Early maturing peach (Prunus persica) cultivars can fetch good market value but face a lot of post-harvest problems that lead to the post-harvest losses. The 1-methylcyclopropene (1-MCP) can provide new insights into plant ethylene responses and extend the shelf life and quality of fruits. Therefore, fruits of peach cultivar ‘Early Grand’ were dipped in various concentrations of 1-MCP (0, 0.3, 0.6 and 0.9 µg l–1), stored for 40 days at 8 ±2°C with 50% relative humidity and analyzed the fruits for physicochemical attributes at 10 days interval. The highest concentration of 1-MCP at 0.9 µg l–1 significantly improved the activity of antioxidants, catalase, free radical scavenging assay and total phenols. However, the peach fruits treated with 1MCP at 0.6 µgL–1 was effective in retaining the ascorbic acid, lowering the weight loss and fruit decay. Therefore, peach fruits can be treated with 1-MCP (0.6 µg l–1) solution for prolonging its shelf life up to 40 days under low temperature.
    Źródło:
    Acta Scientiarum Polonorum. Hortorum Cultus; 2019, 18, 2; 71-85
    1644-0692
    Pojawia się w:
    Acta Scientiarum Polonorum. Hortorum Cultus
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Potential of endochitinase gene to control Fusarium wilt and early blight disease in transgenic potato lines
    Autorzy:
    Fatima, Neelam
    Tabassum, B.
    Yousaf, I.
    Malik, M.
    Khan, A.
    Sajid, I.A.
    Tariq, M.
    Toufiq, N.
    Riaz, S.
    Nasir, I.A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2084713.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    early blight disease
    Fusarium
    potato
    Trichoderma
    Opis:
    Potato (Solanum tuberosum L.), an important food crop in the world, is susceptible to many fungal pathogens including Alternaria solani and Fusarium oxysporum causing Fusarium wilt and early blight diseases. Mycoparasitic fungi like Trichoderma encode chitinases, cell wall degrading enzymes, with high antifungal activity against a wide range of phytopathogenic fungi. In this study, a binary vector harboring endochitinase gene of ~1,000 bp was constructed and used to transform potato nodes through Agrobacterium-mediated transformation. Out of several primary transformants, two transgenic potato lines were verified for transgene insertion and integration by Southern blot. In a pot experiment for Fusarium resistance, the transgenic potato lines didn’t show any symptoms of disease, instead they remained healthy post infection. The transgenic potato lines exhibited 1.5 fold higher mRNA expression of endochitinase at 7 days as compared to 0 day post fungus inoculation. It was evident that the mRNA expression decreased over days of inoculation but was still higher than at 0 day and remained stable upto 30 days post inoculation. Similarly, for A. solani infection assay, the mRNA expression of the endochitinase gene was 3 fold higher 7 days post inoculation compared to expression at 0 day. Although the expression decreased by1.2 fold during subsequent days post infection, it remained stable for 30 days, suggesting that protection in transgenic potato plants against fungal pathogens was achieved through an increase in endochitinase transcript.
    Źródło:
    Journal of Plant Protection Research; 2019, 59, 3; 376-382
    1427-4345
    Pojawia się w:
    Journal of Plant Protection Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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