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Tytuł:
Implementation of Printed Small Size Dual Frequency Antenna in MHz Range
Autorzy:
Eldamak, Angie R.
Ibrahim, Khalid M.
Elkattan, Mohamed
Powiązania:
https://bibliotekanauki.pl/articles/225998.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
dual frequency
meander line
MHz range
monopole antenna
Opis:
This paper presents a printed dual band monopole antenna working below 250 MHz using meander line and an added stub. Meander line approach is used to reduce the size of the low frequency monopole. The proposed antenna is fed by microstrip line and printed on FR-4 substrate with an overall size of 290 x 83 mm2. The added stub tuned dual band operation at 114 MHz and 221 MHz with measured reflection coefficient of -19 dB at both bands. The antenna has omni-directional characteristics with efficiency greater than 90% and gain of 1.87, 1.7 dBi at both bands respectively. The antenna design is optimized through a detailed parametric study. This study includes varying stub, Meander, feed and ground dimensions. The antenna has been fabricated and measured where dual band operation in the MHz range is verified.
Źródło:
International Journal of Electronics and Telecommunications; 2019, 65, 4; 565-570
2300-1933
Pojawia się w:
International Journal of Electronics and Telecommunications
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of water stress and planting system on growth, yield and quality of sweet potato
Autorzy:
Saqib, M.
Khalid, M.F.
Hussain, S.
Anjum, M.A.
Powiązania:
https://bibliotekanauki.pl/articles/11543590.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
Opis:
Sweet potato (Ipomoea batatas (L.) Lam) is an important crop due to its cultivation as staple food for millions of small farmers as well as for poor people in Latin America, Asia, Africa and in many other parts of the world. This tuberous crop is susceptible to drought stress especially during the period of crop establishment as well as vine development and tuber initiation. Yield of the crop vary widely among farmers due to improper planting systems. This current study was aimed to investigate the influence of various irrigation intervals and planting systems on vegetative growth, storage root yield and quality of sweet potato (Ipomoea batatas (L.) Lam) cv. ‘White star’ under field conditions. Three irrigation intervals (7, 14 and 21 days for summer crop, and 14, 28 and 42 days for winter crop) and two planting systems (bed planting and ridge planting) were adopted in this study. Vine length, number of branches and average leaf area significantly reduced as the irrigation interval was increased. Ridge planting produced longer vines with greater leaf area in winter crop as compared to bed planting. Yield parameters (storage root length, storage root diameter, number and fresh weight of marketable roots per plant) were directly linked with vegetative growth especially in summer crop. Under water stress conditions, as vegetative growth decreased storage root yield was also reduced. However, yield attributes were not affected by the planting systems. Vitamin C content decreased with water stress, whereas total soluble solids (TSS) and leaf proline content significantly increased with water stress in summer crop. Ridge planting also resulted in increased leaf proline content in summer crop. It is concluded that for attaining good vegetative growth and storage root yield, sweet potato should be irrigated at an interval of 7 days during summer and 14 days during winter crop and planted on ridges.
Źródło:
Acta Scientiarum Polonorum. Hortorum Cultus; 2017, 16, 6; 201-210
1644-0692
Pojawia się w:
Acta Scientiarum Polonorum. Hortorum Cultus
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Proposing Probabilistic Operational Risk Assessment Model for Textile Industry Using Bayesian Approach
Zaproponowanie modelu probabilistycznej oceny ryzyka operacyjnego dla przemysłu tekstylnego z wykorzystaniem podejścia bayesowskiego.
Autorzy:
Jan, M.
Khalid, M. S.
Awan, A. A.
Nisar, S.
Powiązania:
https://bibliotekanauki.pl/articles/234125.pdf
Data publikacji:
2018
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Biopolimerów i Włókien Chemicznych
Tematy:
operational risk
probabilistic risk assessment model
probability
impacts
Bayesian approach
ryzyko operacyjne
probabilistyczny model oceny ryzyka
prawdopodobieństwo
uderzenia
podejście bayesowskie
Opis:
Accidents, operational failures and losses prompt authorities to highlight the importance of adequate systems and controls to deal with operational risk (OR). Therefore risk assessment methodology has become a dire need of major industries for undertaking valuable measured in production and operation’s research. The paper describes methodology for conducting the risk assessment of the textile operational domain in general i.e. developing a conceptual risk assessment framework and conducting the methodological implementation of the selected operational risk element using the approach proposed. The risk assessment model proposed embraces the concept of probabilistic risk assessment structural modeling using the Bayesian Approach in its generalised form that may be applied to specific textile operational settings with the definition of dimensions and scales for a specific textile environment. The generalised model proposed can also be applied to different textile industries with the insertion of real data for testing and validation. The OR prediction model proposed is GUI-based, scalable, expandable and can be tested for any textile operations with little modification in parentend nodes under the specific risk element. The paper is helpful to ensure safety and a pro-active approach in textile risk management and also contributes towards the sustainable development of industry operations in the future.
Wypadki, awarie i straty operacyjne skłaniają do podkreślenia znaczenia odpowiednich systemów i mechanizmów kontroli w celu radzenia sobie z ryzykiem operacyjnym (OR). W artykule opisano metodologię przeprowadzania oceny ryzyka w zakresie ogólnej działalności włókienniczej, tj. opracowanie ram koncepcyjnej oceny ryzyka i przeprowadzenie metodycznej realizacji wybranego elementu ryzyka operacyjnego z wykorzystaniem proponowanego podejścia. Proponowany model oceny ryzyka obejmuje koncepcję modelowania strukturalnego probabilistycznej oceny ryzyka z wykorzystaniem podejścia bayesowskiego w swojej uogólnionej formie, która może być stosowana do określonych ustawień operacyjnych wyrobów włókienniczych z definicją wymiarów i skal dla określonego środowiska włókienniczego. Proponowany ogólny model może również znaleźć zastosowanie w różnych branżach tekstylnych, wprowadzając rzeczywiste dane do testowania i walidacji. Proponowany model prognozowania OR, oparty na interfejsie GUI, jest skalowalny, rozszerzalny i może być zastosowany w przypadku dowolnych operacji z niewielkimi modyfikacjami w węzłach nadrzędnych/końcowych w ramach określonego elementu ryzyka. Dane zaprezentowane w artykule mogą być przydatne w zakresie zarządzania ryzykiem włókienniczym, a także wnoszą wkład do zrównoważonego rozwoju działalności przemysłowej w przyszłości.
Źródło:
Fibres & Textiles in Eastern Europe; 2018, 1 (127); 10-20
1230-3666
2300-7354
Pojawia się w:
Fibres & Textiles in Eastern Europe
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physical Properties of $CsSnM_3$ (M = Cl, Br, I): A First Principle Study
Autorzy:
Hayatullah, -
Murtaza, G.
Muhammad, S.
Naeem, S.
Khalid, M.
Manzar, A.
Powiązania:
https://bibliotekanauki.pl/articles/1399518.pdf
Data publikacji:
2013-07
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
71.15.Mb
71.22.+i
71.15.Ap
Opis:
First principle calculations are carried out to investigate the structural, electronic and optical properties of cubic perovskites $CsSnM_3$ (M = Cl, Br, I). The theoretically calculated lattice constants are found to be in good agreement with the experimentally measured values as compared to previous calculations. It is found that these perovskites are direct band gap semiconductors. The electrons densities reveal strong ionic bonding between Cs and halide cations while strong covalent bonding between Sn and halide cations. Optical properties of these compounds like real and imaginary parts of the dielectric functions, refractive indices, extinction coefficients, reflectivities, optical conductivities and absorption coefficients are calculated. The direct band gap nature and high absorption power of these compounds in the infrared, visible and ultraviolet energy range predicts that these perovskites can be used in optical and optoelectronic devices working in this range of the spectrum.
Źródło:
Acta Physica Polonica A; 2013, 124, 1; 102-107
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Seed priming and foliar application of plant growth regulators affect the growth and yield of okra under calcareous soils
Autorzy:
Tahir, M.T.
Anjum, M.A.
Saqib, M.
Khalid, M.F.
Hussain, S.
Powiązania:
https://bibliotekanauki.pl/articles/12664203.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
Tematy:
Pakistan
plant cultivation
okra
Abelmoschus esculentus
seed priming
plant growth
growth regulator
growth regulator effect
foliar application
naphthaleneacetic acid
gibberellin A3
Opis:
A field study was conducted to evaluate the effect of different plant growth regulators (PGRs) applied through seed priming and foliar spray on growth and yield of three okra cultivars grown under calcareous soils. The cultivars of Punjab Selection and Sabzpari produced significantly higher number of branches and leaves per plant, pod length and diameter and pod yield as compared to cv. Green ferry, while, cv. Punjab selection produced significantly greater number of flowers and pods per plant as compared to other two cultivars. Seed germination (%), plant height, and fruit set (%) were not affected by the cultivars. Among the PGR treatments, seed primed with GA3 resulted in significantly higher germination percentage and greater plant height at flowering. Seed priming and foliar spray with NAA and GA3 were effective in increasing the final plant height, number of branches, number of leaves, number of flowers and number of pods per plant and fruit set (%), fresh weight per pod and pod yield. However, pod diameter, pod moisture content and dry weight per pod were not influenced by the PGR treatments applied. These results suggested that the PGRs have great potential to improve seed germination, enhance growth and increase yield of okra cultivars under calcareous soils.
Źródło:
Acta Scientiarum Polonorum. Hortorum Cultus; 2019, 18, 4; 25-33
1644-0692
Pojawia się w:
Acta Scientiarum Polonorum. Hortorum Cultus
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Heavy Metals Removal from Simulated Wastewater using Horizontal Subsurface Constructed Wetland
Autorzy:
M-Ridha, Mohanad J.
Zeki, Suhair L.
Mohammed, Sabah J.
Abed, Khalid M.
Hasan, Hassimi Abu
Powiązania:
https://bibliotekanauki.pl/articles/1955516.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
heavy metal removal
phytoremediation
horizontal subsurface constructed wetland
Nerium oleander
waste treatment
Opis:
This study aimed to assess the efficiency of Nerium oleander in removing three different metals (Cd, Cu, and Ni) from simulated wastewater using horizontal subsurface flow constructed wetland (HSSF-CW) system. The HSSF-CW pilot scale was operated at two hydraulic retention times (HRTs) of 4 and 7 days, filled with a substrate layer of sand and gravel. The results indicated that the HSSF-CW had high removal efficiency of Cd and Cu. A higher HRT (7 days) resulted in greater removal efficiency reaching up to (99.3% Cd, 99.5% Cu, 86.3% Ni) compared to 4 days. The substrate played a significant role in removal of metals due to adsorption and precipitation. The N. oleander plant also showed a good tolerance to the uptake of Cd, Cu, and Ni ions from water. The highest removal of the heavy metals indicated that the HSSF-CW would be a promising technology for heavy metal contaminated wastewater as well as in electroplating and manufacturing industries.
Źródło:
Journal of Ecological Engineering; 2021, 22, 8; 243-250
2299-8993
Pojawia się w:
Journal of Ecological Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structural, Chemical Bonding, Electronic and Magnetic Properties of $XY_{3}$ (X = Al, Ga and Y = V, Nb, Cr, Mo) Compounds
Autorzy:
Hafeez, R.
Murtaza, G.
Khenata, R.
Wong, Kin
Naeem, S.
Khalid, M.
Alahmed, Z.
Bin Omran, S.
Powiązania:
https://bibliotekanauki.pl/articles/1398966.pdf
Data publikacji:
2015-03
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
71.15.Ap
71.20.-b
Opis:
The metallic behavior of the band gap of intermetallic compounds has large applications in superconductivity, nickel-metal hydrides batteries, semiconductors, and heating materials. The presence of transition elements makes them more attractive for magnetic applications. In this work we studied the structural, electronic, chemical bonding, and magnetic properties of binary intermetallic compounds $XY_3$ (X = Al, Ga and Y = V, Nb, Cr, Mo). These compounds were investigated by using full potential linearized augmented plane wave plus local orbitals method. The exchange correlation potential of generalized gradient is used. Our calculated lattice constants are in good agreement with experimental values. The band structures of these compounds are purely overlapping across the Fermi level. The bonding is mainly covalent in these compounds. The density of states of the compounds shows that the major contribution arises from d-states of anions. The investigation carried out shows that the most of these compounds have ferromagnetic nature, while few are diamagnetic. On the basis of this study it is expected that these compounds can be used as a best moulds for future study on similar compounds.
Źródło:
Acta Physica Polonica A; 2015, 127, 3; 770-779
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Simultaneous Adsorption of Ternary Antibiotics (Levofloxacin, Meropenem, and Tetracycline) by SunFlower Husk Coated with Copper Oxide Nanoparticles
Autorzy:
Ibrahim, Mohammed A.
Shaban, Mohammed Ali A.
Hasan, Yaseen Rashid
M-Ridha, Mohanad J.
Hussein, Haitham A.
Abed, Khalid M.
Mohammed, Sabah J.
Muhamad, Mohd Hafizuddin
Hasan, Hassimi Abu
Powiązania:
https://bibliotekanauki.pl/articles/2105287.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
adsorption
antibiotics
neural network
wastewater
sustainable process
Opis:
In this study, a new adsorbent derived from sunflower husk powder and coated in CuO nanoparticles (CSFH) was investigated to evaluate the simultaneous adsorption of Levofloxacin (LEV), Meropenem (MER), and Tetracycline (TEC) from an aqueous solution. Significant improvements in the adsorption capacity of the sunflower husk were identified after the powder particles had been coated in CuO nanoparticles. Kinetic data were correlated using a pseudo-second-order model, and was successful for the three antibiotics. Moreover, high compatibility was identified between the LEV, MER, and TEC, isotherm data, and the Langmuir model, which produced a better fit to suit the isotherm curves. In addition, the spontaneous and exothermic nature of the adsorption process was crucial for transforming the three antibiotics into CSFH. The greatest CSFH adsorption capacity was in MER (131.83 mg/g), followed by TEC (96.95 mg/g), and LEV (62.24 mg/g). These findings thus indicate that CSFH is one of the most effective and efficient adsorbents to use for eliminating wastewater contaminated with antibiotic residue.
Źródło:
Journal of Ecological Engineering; 2022, 23, 6; 30--42
2299-8993
Pojawia się w:
Journal of Ecological Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of barrier on the hydraulic response of composite weir-gate structure
Autorzy:
Quasim, Rafi M.
Abdulhussein, Ihsan A.
Al-Asadi, Khalid
Powiązania:
https://bibliotekanauki.pl/articles/1849769.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
struktura hydrauliczna
przegroda
bariera
jaz kompozytowy
poziom wody
odpowiedź hydrauliczna
hydraulic structure
baffle
barrier
composite weir-gate
water level
hydraulic response
Opis:
The composite weir-gate structure is considered an important hydraulic structure. This is because of its widely used in civil engineering hydraulic works especially in an irrigation system to measure, control, divert and keep the required water level. This study focuses on the influence of barrier existence on the hydraulic parameters that described the hydraulic characteristics of composite weir-gate hydraulic structure. In this study, several experimental runs were conducted to determine the effect of barrier's location, spacing and number on the water level and depth at the downstream region of flume, discharge coefficient of composite hydraulic structure, and flow rate throughout the flume. Our experiments indicated that the turbulence intensity, inlet effect, and position, gap, and number of barriers have affected the hydraulic behavior of weir-gate structure. This appears clearly by obtaining different results of discharge coefficient and flow rate that cross the weir-gate structure comparing with same cases without barriers. Also this study gives some insights on the significance roles of fluid separation, eddies generation near the barrier, fluid resistance and overlap between overflow and underflow velocities and their effects on hydraulic factors that dominate the problem. These hydraulic factors must be considered in the design and construction of barrier/barriers in open channel to prevent any fluctuation or drop in discharge, water elevation and the required water depth at downstream region.
Źródło:
Archives of Civil Engineering; 2020, 66, 4; 97-118
1230-2945
Pojawia się w:
Archives of Civil Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gastro-oesophageal cancer related malnutrition: a challenge case to manage
Autorzy:
Elzohry, Alaa Ali M.
Mohammed, Khalid Fawzy
Aly, Asmaa Mohamed
Powiązania:
https://bibliotekanauki.pl/articles/1062963.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Gastro
ICU
SOFA score
esophageal cancer Hypoalbuminemia
major cancer surgery
Opis:
Gastro-esophageal cancer is a very common malignant tumours arising from the digestive tract. Hypoalbuminemia and weight loss often result from malnourishment. Malnourished patients have a higher incidence of mortality and morbidity causing prolonged hospital stay. To discuss the incidence and effects of Gastro-esophageal cancer related malnutrition and demonstrate different methods to solve this problem. The current review revealed that malnutrition increases the risk of complications and duration of stay in hospital and ICU in GIT cancer patients, as such, accounts for burden on ICU budget.
Źródło:
World Scientific News; 2019, 124, 2; 183-192
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sensitivity analysis of a new approach to photovoltaic parameters extraction based on the total least squares method
Autorzy:
Mesbahi, Oumaima
Tlemçani, Mouhaydine
Janeiro, Fernando M.
Hajjaji, Abdeloawahed
Kandoussi, Khalid
Powiązania:
https://bibliotekanauki.pl/articles/2052125.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
photovoltaic modules
parameter extraction
total least squares
MPP
sensitivity analysis
Opis:
The degradation of photovoltaic modules and their subsequent loss of performance has a serious impact on the total energy generation potential. The lack of real-time information on the output power leads to additional losses since the panels may not be operating at their optimal point. To understand the behaviour, numerically simulate the characteristics and identify the optimal operating point of a photovoltaic cell, the parameters of an equivalent electrical circuit must first be identified. The aim of this work is to develop a total least-squares based algorithm which can identify those parameters from the output voltage and current measurements, taking into consideration the uncertainties on both measured quantities. This work presents a comparative study of the Ordinary Least Squares (OLS) and Total Least Squares (TLS) approaches to the estimation of the parameters of a photovoltaic cell.
Źródło:
Metrology and Measurement Systems; 2021, 28, 4; 751-765
0860-8229
Pojawia się w:
Metrology and Measurement Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of aerosol optical depth products from multi-satellites over densely populated cities of Pakistan
Autorzy:
Butt, F.M.
Shahzad, M.I.
Khalid, S.
Iqbal, N.
Rasheed, A.
Raza, G.
Powiązania:
https://bibliotekanauki.pl/articles/11938.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Źródło:
International Letters of Natural Sciences; 2018, 69
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Updates in management of gastro-oesophageal cancer related pain
Autorzy:
Elzohry, Alaa Ali M.
Fikry, Nesma Mohamed
Elhamed, Mohammed Farghaly Abd
Mohammed, Khalid Fawzy
Powiązania:
https://bibliotekanauki.pl/articles/1077038.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Gastro-esophageal cancer
Interventional pain control
WHO step ladder
acute pain
Opis:
Gastro-esophageal cancer is one of the most common malignant tumours of the digestive tract. Pain is common in these cancer patients, particularly in the advanced stage of disease when the prevalence is estimated to be more than 70% contributing to poor physical and emotional well-being. The objective of this review is to illustrate the incidence of Gastro-esophageal cancer and demonstrate different methods to control pain related to Gastro-esophageal.
Źródło:
World News of Natural Sciences; 2019, 23; 94-103
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative evaluation of different techniques for herniorrhaphy in calves
Autorzy:
Fatima, A.
Arif Khan, M.
Aslam, S.
Ashraf, K.
Khalid Mahmood, A.
Asif, M.
Shah, S.
Hussain, N.
Powiązania:
https://bibliotekanauki.pl/articles/16539145.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
calves
mesh application
suture material
umbilical hernia
Opis:
Umbilical hernia is one of the most common problems in young calves. This problem occurs in dairy sector as well as in the local farmers. Present study was conducted to compare outcomes of four different techniques of herniorrhaphy. Twenty four young calves (n=24) were divided in 4 groups (A, B, C, and D) which underwent four different surgical techniques. Group A underwent vicryl plus suture material and pants-over-west technique, Group B underwent mesh application with Dexon suture material by using simple interrupted suture pattern, Group C underwent closed method with Nylon No. 3 suture material by using vertical mattress suture pattern and Group D underwent clamp application method with Silk No. 2 suture material by using simple interrupted suture pattern. The result showed that mesh application method was comparatively better with respect to feed intake, body weight gain and healing time. There was no reoccurrence with non-significant hematological changes (p≤0.05). It is concluded that mesh application method is safer than other three techniques and there are no systemic effects of this surgical intervention on calves’ health.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 2; 207-212
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
USE OF GLUTARIC ACID TO IMPROVE THE SOLUBILITY AND DISSOLUTION PROFILE OF GLIPIZIDE THROUGH PHARMACEUTICAL COCRYSTALLIZATION
Autorzy:
Batool, Fakhra
Ahmad, Mahmood
Minhas, Muhammad U.
Khalid, Qandeel
Idrees, Hafiz A.
Khan, Fahad M.
Powiązania:
https://bibliotekanauki.pl/articles/895470.pdf
Data publikacji:
2019-02-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
FTIR
SEM
PXRD
thermal analysis
glipizide
glutaric acid
Opis:
The purpose of current study was to improve the solubility and dissolution profile of BCS class-II drug Glipizide using glutaric acid as a coformer via various cocrystalization techniques i.e., dry grinding, liquid assisted grinding, slurry and solvent evaporation. Fourier Transform Infrared Spectroscopy (FTIR) was performed to determine the interaction between components of glipizide-glutaric acid (GPZ-GLU) cocrystals. Powder X-ray Diffraction (PXRD) studies confirmed the crystalline nature of formulated cocrystals. Scanning Electron Microscopy (SEM) revealed cylindrical to rectangular shape of cocrystals. Flow properties of GPZ-GLU cocrystals were evaluated by micromeritics analysis. Size and surface morphology was determined by zeta sizer analysis and optical microscopy. Differential scanning calorimetry (DSC) and Thermogravimetric (TGA) analysis were performed to determine the melting points as well as thermal stability of pure components and formulated GPZ-GLU cocrystals. In-vitro drug release studies were carried out using dissolution apparatus-II. GPZ-GLU cocrystals showed higher drug release at pH 6.8 as compared to pH 1.2. However, percent drug release of optimum formulations at pH 6.8 was determined as; 24%-92.2% (F3) and 12.0%-93.5% (F7). Solubility studies revealed improved solubility as compared to pure drug in water i.e., 53 folds and 54.27 folds from F3 and F7 cocrystals, respectively. Finally it was concluded that glutaric acid has improved the solubility and dissolution profile of glipizide. However, many cocrystal formers have been reported in literature that can be used to enhance the physicochemical properties as well as bioavailability of poorly soluble drugs via cocrystalization technique.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 103-114
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
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