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    Wyświetlanie 1-4 z 4
    Tytuł:
    Intranasal (IN) COVID-19 vaccines - a breakthrough
    Autorzy:
    Gambhir, R.S.
    Kaur, K.
    Matariya, R.
    Singh, B.
    Sood, R.
    Singh, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/28765534.pdf
    Data publikacji:
    2023
    Wydawca:
    Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
    Opis:
    Emerging variants of COVID-19 have threatened the effectiveness of intramuscular (IM) vaccines since that are made to target only the spike protein. Development of Intranasal (IN) vaccination has been proven to provide both the mucosal and systemic immune responses for broader and long lasting protection. Many IN vaccine candidates (virus-vectored vaccines, recombinant subunit vaccines and live attenuated vaccines) are in different phases of clinical trials and in near future many companies would be releasing their vaccines into the drug market. Potential advantages of IN vaccination over IM vaccination makes them ideal to be administered in children and developing populations of the world. This paper focuses on the very recent developments in intranasal vaccination with a spotlight on their safety and efficacy concerns. IN vaccination can prove to be game-changer in handling COVID-19 and potential viral contagious diseases in future.
    Źródło:
    Roczniki Państwowego Zakładu Higieny; 2023, 74, 1; 15-18
    0035-7715
    Pojawia się w:
    Roczniki Państwowego Zakładu Higieny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Spectral fingerprinting revealed modulation of plant secondary metabolites in providing abiotic stress tolerance to invasive alien plants Lantana camara (L.), Parthenium hysterophorous (L.), Ricinus communis (L.), and Ageratum conyzoides (L.) (plant metabolites in stress tolerance to invasive plants)
    Autorzy:
    Sharma, A.D.
    Kaur, J.
    Chand, T.S.P.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096781.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    chemical fingerprinting
    invasiveness
    lipid peroxidation
    secondary metabolites
    Opis:
    Invasive alien species are non-native plant species that displace native species and pose adverse effects to environment, ecosystem, economy, and human health by diminishing the growth of native plants and by exhibiting higher stress tolerance. In our present study, four invasive alien species, namely Lantana camara, Parthenium hysterophorous, Ricinus communis, and Ageratum conyzoides, were studied from different locations. Plants growing under natural environmental conditions were sampled at random in the vicinity of Jalandhar. To gain insights into the biochemical basis of invasiveness of these plants, the samples were subjected to chemical fingerprinting by using UV-Vis, fluorescent, and Fourier transform-infrared (FT-IR) techniques under natural abiotic stress conditions (moderate and hot conditions). Indices of oxidative stress, such as malondialdehyde (MDA), were also studied. MDA levels were enhanced under hot conditions. Elevated peaks (major and minor) were observed in UV fingerprinting during adverse abiotic conditions. Fluorescent spectroscopy also validated the enhanced levels of secondary metabolites. FT-IR spectroscopy confirmed the presence of alkaloids and phenolics during stress conditions. Peaks were identified as rutin, vanillic acid, ascorbic acid, and glutathione reduced. The obtained results showed that under stressful conditions, the studied plants may produce an increased level of metabolites that might play a role in minimizing the oxidative stress faced by these plants. It was concluded that the studied plants, namely P. hysterophorus, L. camara, R. communis, and A. conyzoides, have the potential to cope with abiotic stress such as high temperature, which could be the reason for their invasiveness and vast adaptability.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 3; 307-319
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of the thermo-mechanical and explosive properties of bimodal and hybrid polymer bonded explosive (PBX) compositions based on HNS and HMX
    Autorzy:
    Kaur, J.
    Arya, V. P.
    Kaur, G.
    Lata, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/358078.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    HNS
    HMX
    Viton-A
    Bimodal PBX
    Hybrid PBX
    characterization
    Opis:
    In the present paper, a series of bimodal PBX compositions containing coarse (90 μm) and fine (<1 μm) HNS (2,2’4,4’6,6’-hexanitrostilbene) and hybrid PBX compositions based on HNS and HMX (1,3,5,7-tetranitro-1,3,5,7- tetraazacyclooctane) in varying mass ratios, along with the fluoropolymer Viton-A, a vinylidene fluoride and hexafluoropropylene copolymer, as a binder (5%), have been prepared on the lab scale. In order to observe any effect of incorporating fine HNS particles with coarse ones and the effect of replacing HNS with HMX in all types of bimodal and hybrid PBX compositions, the samples were characterized for composition analysis, thermal behavior and morphological analysis as well as evaluated for their mechanical and explosive properties including sensitiveness tests and detonic properties. The data showed that incorporation of fine HNS into coarse particles of HNS in the bimodal PBX resulted in an increase in mechanical strength and a decrease in friction and impact sensitivity, as well as an enhanced performance compared to PBXs based on coarse HNS alone. Viton-A based hybrid PBX compositions provided better mechanical and sensitivity properties as compared to conventional explosive compositions based exclusively on HMX or HNS and the performance of the PBX compositions increased with increasing HMX content.
    Źródło:
    Central European Journal of Energetic Materials; 2013, 10, 3; 371-391
    1733-7178
    Pojawia się w:
    Central European Journal of Energetic Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Unique fuzzy optimal value of fully fuzzy linear programming problems
    Autorzy:
    Kaur, J.
    Kumar, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/206342.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Instytut Badań Systemowych PAN
    Tematy:
    fully fuzzy linear programming
    unique fuzzy optimal value
    fuzzy number
    Opis:
    Kumar, Kaur and Singh (2011), proposed a new method to find the exact fuzzy optimal solution of fully fuzzy linear programming (FFLP) problems with equality constraints. In this paper, an FFLP problem is chosen to show that the fuzzy optimal value, obtained by using the existing method, is not necessarily a unique fuzzy number i.e., the fuzzy optimal value of the FFLP problem, obtained by the existing method, does not conform to the uniqueness property of fuzzy optimal value. To overcome this shortcoming of the existing method, a new method is proposed for solving FFLP problems with equality constraints. To show the advantage of the proposed method the results of the chosen FFLP problem, obtained by using the existing and the proposed methods, are compared.
    Źródło:
    Control and Cybernetics; 2012, 41, 2; 497-508
    0324-8569
    Pojawia się w:
    Control and Cybernetics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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